Effects of Gender and Apolipoprotein E on Novelty MMN and P3a in Healthy Elderly and Amnestic Mild Cognitive Impairment
Open accessAbstract
Background: The apolipoprotein E epsilon4 (ApoE ε4) allele and female gender may be important risk factors for the development of Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). Novelty mismatch negativity (MMN) represents the pre-attentive index of deviance detection and P3a represents the attention orienting response. Furthermore, MMN and P3a components have been reported to be potential markers in aMCI. Therefore, this study will investigate the effects of gender and ApoE on auditory novelty MMN and P3a and their relationship to neuropsychological performance in aMCI. Methods: 39 aMCI subjects and 44 controls underwent neuropsychological assessment and ApoE genotyping. Novelty MMN and P3a components were investigated during an auditory novelty oddball task. Results: Firstly, novelty MMN latency was significantly shorter in aMCI than in the healthy control (HC) group. Secondly, novelty MMN latency was negatively correlated with episodic memory in aMCI, but not in HC. Novelty P3a latency was negatively correlated with information speed processing in all subjects. For gender effect, novelty MMN latency was shorter in aMCI females than in HC females. Moreover, novelty P3a amplitudes were lower in males than in females in both aMCI and HC. For the effect of ApoE status, novelty MMN latency was shorter in aMCI ApoE ε4- than HC ApoE ε4-. Conclusions: aMCI present altered pre-attentive processing indexed by novelty MMN components. Furthermore, there may be a compensatory mechanism on the impaired processing in aMCI. It further suggest that aMCI female and ApoE ε4- recruited the compensatory mechanism.
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The mismatch response is correlated with episodic memory in people at risk of AD.
“it is correlated with episodic memory in people at risk of AD 36 , 37”
From Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity (2025) · cites this paper as [37]
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- Authors
- Gao, L., Chen, J., Gu, L., Shu, H., Wang, Z., Liu, D., Yan, Y., & Zhang, Z.
- Affiliations
- Zhongda Hospital Southeast University (CN)
- Henan Medical University (CN)
- Corresponding author
- Chen, Jiu
- Zhang, Zhijun
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-08-21
- Volume
- 10
- Pages
- 256-256
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC6110901
- OpenAlex
- W2888485725
- Cited by
- 21
- References
- 54
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 1
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81701675, 81420108012, JCRCA2016006)
- Government of Jiangsu Province (JCRCA2016006)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Keywords
- amnestic mild cognitive impairment, APOE ε4, gender differences, P3a, auditory oddball paradigm, preattentive processing, episodic memory, compensatory mechanisms, Alzheimer's disease risk, older adults
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