The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Functional Architecture of an Optic Flow-Responsive Area that Drives Horizontal Eye Movements in Zebrafish
Open accessAbstract
Animals respond to whole-field visual motion with compensatory eye and body movements in order to stabilize both their gaze and position with respect to their surroundings. In zebrafish, rotational stimuli need to be distinguished from translational stimuli to drive the optokinetic and the optomotor responses, respectively. Here, we systematically characterize the neural circuits responsible for these operations using a combination of optogenetic manipulation and in vivo calcium imaging during optic flow stimulation. By recording the activity of thousands of neurons within the area pretectalis (APT), we find four bilateral pairs of clusters that process horizontal whole-field motion and functionally classify eleven prominent neuron types with highly selective response profiles. APT neurons are prevalently direction selective, either monocularly or binocularly driven, and hierarchically organized to distinguish between rotational and translational optic flow. Our data predict a wiring diagram of a neural circuit tailored to drive behavior that compensates for self-motion.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“recently identified as involved in processing whole-field motion in zebrafish (Kubo et al., 2014; Portugues et al., 2014).”
From Neural control and modulation of swimming speed in the larval zebrafish (2014) · cites this paper as Kubo et al., 2014
The cited source says what the claim attributes to it.
In the citing paper
“Benefitting from detailed experimental data (25, 29–34) and recent advances in physics simulation technologies (35), our open-source simZFish faithfully reproduces the zebrafish OMR, utilizing experimentally observed neural activity (25).”
From Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors (2025) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Global Geometric Framework for Nonlinear Dimensionality Reduction
Tenenbaum, J. B., Silva, V. D., & Langford, J. C. (2000) · Science · doi:10.1126/science.290.5500.2319 · Cited by 13,585
Whole-brain functional imaging at cellular resolution using light-sheet microscopy
Ahrens, M. B., Orger, M. B., Robson, D. N., Li, J. M., & Keller, P. J. (2013) · Nature Methods · doi:10.1038/nmeth.2434 · Cited by 1,392
Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging
Akerboom, J., Chen, T., Wardill, T. J., Tian, L., Marvin, J. S., Mutlu, S., Calderón, N. C., Esposti, F., Borghuis, B. G., Sun, X. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2601-12.2012 · Cited by 1,289
Self-citationForebrain gene expression domains and the evolving prosomeric model
Puelles, L., & Rubenstein, J. L. R. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00234-0 · Cited by 734
Higashijima, S., Hotta, Y., & Okamoto, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00206.2000 · Cited by 562
A behavioral screen for isolating zebrafish mutants with visual system defects.
Brockerhoff, S. E., Hurley, J. B., Janssen‐Bienhold, U., Neuhauss, S. C. F., Driever, W., & Dowling, J. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10545 · Cited by 481
Self-citationSelective Sensitivity to Direction of Movement in Ganglion Cells of the Rabbit Retina
Barlow, H. B., & Hill, R. M. (1963) · Science · doi:10.1126/science.139.3553.412 · Cited by 435
Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish
Neuhauss, S. C. F., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A., & Baier, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08603.1999 · Cited by 414
Self-citationThe accessory optic system of rabbit. II. Spatial organization of direction selectivity
Simpson, J. I., Leonard, C. S., & Soodak, R. E. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.6.2055 · Cited by 333
Direction selectivity in the retina: symmetry and asymmetry in structure and function
Vaney, D. I., Sivyer, B., & Taylor, W. R. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3165 · Cited by 330
Flagged first, then by citations
Cited by
Sorted by citations
Neural circuits underlying visually evoked escapes in larval zebrafish
Dunn, T. W., Gebhardt, C., Naumann, E. A., Riegler, C., Ahrens, M. B., Engert, F., & Del Bene, F. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.021 · Cited by 347
“…of tectal processing have remained descriptive and treat single cells in isolation (Gabriel et al., 2012; Grama and Engert, 2012), independent of behavior and the activity of other visual, motion-sensitive midbrain structures such as the pretectum (Kubo et al., 2014; Portugues et al., 2014).”
Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans
Nguyen, J. P., Shipley, F. B., Linder, A. N., Plummer, G. S., Liu, M., Setru, S. U., Shaevitz, J. W., & Leifer, A. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507110112 · Cited by 398
Mapping brain activity at scale with cluster computing
Freeman, J., Vladimirov, N., Kawashima, T., Mu, Y., Sofroniew, N. J., Bennett, D. V., Rosen, J., Yang, C.-T., Looger, L. L., & Ahrens, M. B. (2014) · Nature Methods · doi:10.1038/nmeth.3041 · Cited by 299
“This analysis revealed a coordinated sequence of events after the onset of stimulus across the brain ( Fig.”
BackgroundKey, B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1011 · Cited by 318
“Whole brain imaging during visuomotor reflexes reveals widespread neural activity in the diencephalon, midbrain and hindbrain in zebrafish, but these regions appear to act mostly as feedforward pathways (Sarvestani et al., 2013; Kubo et al., 2014; Portugues et al., 2014).”
BackgroundFrom Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response
Naumann, E. A., Fitzgerald, J. E., Dunn, T. W., Rihel, J., Sompolinsky, H., & Engert, F. (2016) · Cell · doi:10.1016/j.cell.2016.10.019 · Cited by 315
“In zebrafish, OMR circuitry overlaps with circuits activated in other stabilizing reflexes, such as the optokinetic reflex (OKR) of the eyes (Kubo et al., 2014; Portugues et al., 2014).”
Metadata
- Authors
- Kubo, F., Hablitzel, B., Dal Maschio, M., Driever, W., Baier, H., & Arrenberg, A. B.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- University of Freiburg (DE)
- Max Planck Society (DE)
- Corresponding author
- Baier, Herwig
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 81
- Issue
- 6
- Pages
- 1344-1359
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2067473018
- Cited by
- 182
- References
- 60
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 21 · 2019: 16 · 2018: 12 · 2017: 19 · 2016: 14 · 2015: 13 · 2014: 10
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (EXC‐294‐BIOSS, SFB780, (EXC 294))
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- optical flow, horizontal eye movements, optokinetic response, optomotor response, zebrafish, direction selectivity, binocular vision, neural circuit organization, optogenetic manipulation, in vivo calcium imaging
- MeSH terms
- Animals, Eye Movements, Motion Perception, Neurons, Photic Stimulation, Visual Fields, Visual Pathways, Zebrafish, Nystagmus, Optokinetic, Optic Flow
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
