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Functional Architecture of an Optic Flow-Responsive Area that Drives Horizontal Eye Movements in Zebrafish
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Animals respond to whole-field visual motion with compensatory eye and body movements in order to stabilize both their gaze and position with respect to their surroundings. In zebrafish, rotational stimuli need to be distinguished from translational stimuli to drive the optokinetic and the optomotor responses, respectively. Here, we systematically characterize the neural circuits responsible for these operations using a combination of optogenetic manipulation and in vivo calcium imaging during optic flow stimulation. By recording the activity of thousands of neurons within the area pretectalis (APT), we find four bilateral pairs of clusters that process horizontal whole-field motion and functionally classify eleven prominent neuron types with highly selective response profiles. APT neurons are prevalently direction selective, either monocularly or binocularly driven, and hierarchically organized to distinguish between rotational and translational optic flow. Our data predict a wiring diagram of a neural circuit tailored to drive behavior that compensates for self-motion.
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“recently identified as involved in processing whole-field motion in zebrafish (Kubo et al., 2014; Portugues et al., 2014).”
From Neural control and modulation of swimming speed in the larval zebrafish (2014) · cites this paper as Kubo et al., 2014
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“Benefitting from detailed experimental data (25, 29–34) and recent advances in physics simulation technologies (35), our open-source simZFish faithfully reproduces the zebrafish OMR, utilizing experimentally observed neural activity (25).”
From Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors (2025) · cites this paper as [33]
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A Global Geometric Framework for Nonlinear Dimensionality Reduction
Tenenbaum, J. B., Silva, V. D., & Langford, J. C. (2000) · Science · doi:10.1126/science.290.5500.2319 · Cited by 13,585
Whole-brain functional imaging at cellular resolution using light-sheet microscopy
Ahrens, M. B., Orger, M. B., Robson, D. N., Li, J. M., & Keller, P. J. (2013) · Nature Methods · doi:10.1038/nmeth.2434 · Cited by 1,392
Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging
Akerboom, J., Chen, T., Wardill, T. J., Tian, L., Marvin, J. S., Mutlu, S., Calderón, N. C., Esposti, F., Borghuis, B. G., Sun, X. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2601-12.2012 · Cited by 1,289
Self-citationForebrain gene expression domains and the evolving prosomeric model
Puelles, L., & Rubenstein, J. L. R. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00234-0 · Cited by 734
Higashijima, S., Hotta, Y., & Okamoto, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00206.2000 · Cited by 562
A behavioral screen for isolating zebrafish mutants with visual system defects.
Brockerhoff, S. E., Hurley, J. B., Janssen‐Bienhold, U., Neuhauss, S. C. F., Driever, W., & Dowling, J. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10545 · Cited by 481
Self-citationSelective Sensitivity to Direction of Movement in Ganglion Cells of the Rabbit Retina
Barlow, H. B., & Hill, R. M. (1963) · Science · doi:10.1126/science.139.3553.412 · Cited by 435
Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish
Neuhauss, S. C. F., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A., & Baier, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08603.1999 · Cited by 414
Self-citationThe accessory optic system of rabbit. II. Spatial organization of direction selectivity
Simpson, J. I., Leonard, C. S., & Soodak, R. E. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.6.2055 · Cited by 333
Direction selectivity in the retina: symmetry and asymmetry in structure and function
Vaney, D. I., Sivyer, B., & Taylor, W. R. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3165 · Cited by 330
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Neural circuits underlying visually evoked escapes in larval zebrafish
Dunn, T. W., Gebhardt, C., Naumann, E. A., Riegler, C., Ahrens, M. B., Engert, F., & Del Bene, F. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.021 · Cited by 347
“…of tectal processing have remained descriptive and treat single cells in isolation (Gabriel et al., 2012; Grama and Engert, 2012), independent of behavior and the activity of other visual, motion-sensitive midbrain structures such as the pretectum (Kubo et al., 2014; Portugues et al., 2014).”
Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans
Nguyen, J. P., Shipley, F. B., Linder, A. N., Plummer, G. S., Liu, M., Setru, S. U., Shaevitz, J. W., & Leifer, A. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507110112 · Cited by 398
Mapping brain activity at scale with cluster computing
Freeman, J., Vladimirov, N., Kawashima, T., Mu, Y., Sofroniew, N. J., Bennett, D. V., Rosen, J., Yang, C.-T., Looger, L. L., & Ahrens, M. B. (2014) · Nature Methods · doi:10.1038/nmeth.3041 · Cited by 299
“This analysis revealed a coordinated sequence of events after the onset of stimulus across the brain ( Fig.”
BackgroundKey, B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1011 · Cited by 318
“Whole brain imaging during visuomotor reflexes reveals widespread neural activity in the diencephalon, midbrain and hindbrain in zebrafish, but these regions appear to act mostly as feedforward pathways (Sarvestani et al., 2013; Kubo et al., 2014; Portugues et al., 2014).”
BackgroundFrom Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response
Naumann, E. A., Fitzgerald, J. E., Dunn, T. W., Rihel, J., Sompolinsky, H., & Engert, F. (2016) · Cell · doi:10.1016/j.cell.2016.10.019 · Cited by 315
“In zebrafish, OMR circuitry overlaps with circuits activated in other stabilizing reflexes, such as the optokinetic reflex (OKR) of the eyes (Kubo et al., 2014; Portugues et al., 2014).”
Neural control and modulation of swimming speed in the larval zebrafish
Severi, K. E., Portugues, R., Marques, J. C., O’Malley, D. M., Orger, M. B., & Engert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.032 · Cited by 239
“This suggests connections are indirect and via nontectal retino-recipient areas such as the pretectum, recently identified to be involved in processing whole-field motion in zebrafish (Kubo et al., 2014; Portugues et al., 2014).”
Zebrafish Behavior: Opportunities and Challenges
Orger, M. B., & de Polavieja, G. G. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033857 · Cited by 301
“Several clusters of neurons in a pretectal area respond to horizontal motion and integrate inputs from the two eyes in ways that could distinguish rotational and translational flow, suggesting that this region could provide a common input for OMR and OKR behaviors (Kubo et al. 2014).”
BackgroundA Cellular-Resolution Atlas of the Larval Zebrafish Brain
Kunst, M., Laurell, E., Mokayes, N., Kramer, A., Kubo, F., Fernandes, A. M., Förster, D., Maschio, M. D., & Baier, H. (2018) · Neuron · doi:10.1016/j.neuron.2019.04.034 · Cited by 287
Self-citationMolecular psychiatry of zebrafish
Stewart, A. M., Ullmann, J. F. P., Norton, W., Parker, M. O., Brennan, C. H., Gerlai, R. T., & Kalueff, A. V. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.128 · Cited by 235
Chen, X., Mu, Y., Hu, Y., Kuan, A. T., Nikitchenko, M., Randlett, O., Chen, A. B., Gavornik, J. P., Sompolinsky, H., Engert, F., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.042 · Cited by 199
Zebrafish models in neuropsychopharmacology and CNS drug discovery
Khan, K. M., Collier, A. D., Мешалкина, Д. А., Kysil, E. V., Khatsko, S. L., Kolesnikova, T. O., Morzherin, Y. Y., Warnick, J. E., Kalueff, A. V., & Echevarria, D. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13754 · Cited by 217
“To date, optogenetic studies in zebrafish have largely focused on several simpler behaviours, such as escape (Douglass et al., 2008), locomotion (Arrenberg et al., 2009; Ljunggren et al., 2014) and sensory processing (Kubo et al., 2014).”
BackgroundRobles, E., Laurell, E., & Baier, H. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.080 · Cited by 201
Self-citationdal Maschio, M., Donovan, J. C., Helmbrecht, T. O., & Baier, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.034 · Cited by 169
Self-citationNeural circuits for evidence accumulation and decision making in larval zebrafish
Bahl, A., & Engert, F. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0534-9 · Cited by 166
Sensorimotor Decision Making in the Zebrafish Tectum
Barker, A. J., & Baier, H. (2015) · Current Biology · doi:10.1016/j.cub.2015.09.055 · Cited by 138
“Whereas more than 95% of RGC axons make synaptic connections in the tectum, visually guided behaviors can be mediated by other retinorecipient brain areas [2, 26].”
Self-citationMolecular Spies for Bioimaging—Fluorescent Protein-Based Probes
Miyawaki, A., & Niino, Y. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.002 · Cited by 147
“(Portugues et al., 2014; Kubo et al., 2014; Freeman et al., 2014), and GCaMP6s (Freeman et al.”
Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway
Zhang, B.-B., Yao, Y.-Y., Zhang, H.-F., Kawakami, K., & Du, J.-L. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.011 · Cited by 115
Topography of a Visuomotor Transformation
Helmbrecht, T. O., dal Maschio, M., Donovan, J. C., Koutsouli, S., & Baier, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.021 · Cited by 113
Self-citationAutomated synapse-level reconstruction of neural circuits in the larval zebrafish brain
Svara, F., Förster, D., Kubo, F., Januszewski, M., dal Maschio, M., Schubert, P. J., Kornfeld, J., Wanner, A. A., Laurell, E., Denk, W., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01621-0 · Cited by 124
“https://doi.org/10.1038/s41592-022-01621-0 of eight drifting grating stimuli, designed to cover all combinations of horizontal optic flow 25 .”
BackgroundMethodInfluentialSelf-citationThe Zebrafish Visual System: From Circuits to Behavior
Bollmann, J. H. (2019) · Annual Review of Vision Science · doi:10.1146/annurev-vision-091718-014723 · Cited by 123
A faithful internal representation of walking movements in the Drosophila visual system
Fujiwara, T., Cruz, T. L., Bohnslav, J. P., & Chiappe, M. E. (2016) · Nature Neuroscience · doi:10.1038/nn.4435 · Cited by 104
A Convergent and Essential Interneuron Pathway for Mauthner-Cell-Mediated Escapes
Lacoste, A. M. B., Schoppik, D., Robson, D. N., Haesemeyer, M., Portugues, R., Li, J., Randlett, O., Wee, C. L., Engert, F., & Schier, A. F. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.025 · Cited by 103
Classification of Object Size in Retinotectal Microcircuits
Preuß, S., Trivedi, C. A., Berg, C. V., Ryu, S., & Bollmann, J. H. (2014) · Current Biology · doi:10.1016/j.cub.2014.09.012 · Cited by 102
Functional Assembly of Accessory Optic System Circuitry Critical for Compensatory Eye Movements
Sun, L. O., Brady, C. M., Cahill, H. B., Al‐Khindi, T., Sakuta, H., Dhande, O. S., Noda, M., Huberman, A. D., Nathans, J., & Kolodkin, A. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.064 · Cited by 101
“cessory Optic System”
Cellular-Resolution Imaging of Vestibular Processing across the Larval Zebrafish Brain
Favre‐Bulle, I. A., Vanwalleghem, G. C., Taylor, M. A., Rubinsztein-Dunlop, H. H., & Scott, E. K. (2018) · Current Biology · doi:10.1016/j.cub.2018.09.060 · Cited by 89
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Dragomir, E. I., Štih, V., & Portugues, R. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0535-8 · Cited by 89
Large-scale imaging in small brains
Ahrens, M. B., & Engert, F. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.01.007 · Cited by 81
“Here we review several imaging techniques that have been used to advance our understanding of different aspects of brain function, including sensorimotor processing [5,16,17 ,18,19,20 ], learning [21], sensation [16,22 ,23 ,24 ,25,26] and the development of functional circuits [27].”
Förster, D., Arnold-Ammer, I., Laurell, E., Barker, A. J., Fernandes, A. M., Finger‐Baier, K., Filosa, A., Helmbrecht, T. O., Kölsch, Y., Kuehn, E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04657-x · Cited by 80
Self-citationPanser, K., Tirián, L., Schulze, F., Villalba, S. D., Jefferis, G. S. X. E., Bühler, K., & Straw, A. D. (2016) · Current Biology · doi:10.1016/j.cub.2016.05.052 · Cited by 81
“Such an effort in Zebrafish could be used to suggest driver lines corresponding to functional units identified in brain-wide activity-based experiments (Ahrens et al., 2012; Kubo et al., 2014; Portugues et al., 2014; Randlett et al., 2015).”
Comparison of optomotor and optokinetic reflexes in mice
Kretschmer, F., Tariq, M., Chatila, W. K., Wu, B. P., & Badea, T. C. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00055.2017 · Cited by 80
Neuronal Architecture of a Visual Center that Processes Optic Flow
Kramer, A., Wu, Y., Baier, H., & Kubo, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.018 · Cited by 78
Self-citationParallel Channels for Motion Feature Extraction in the Pretectum and Tectum of Larval Zebrafish
Wang, K., Hinz, J., Zhang, Y., Thiele, T. R., & Arrenberg, A. B. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.031 · Cited by 66
Self-citationT-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse
Dong, H., Othy, S., Jairaman, A., Skupsky, J., Zavala, A., Parker, I., Dynes, J. L., & Cahalan, M. D. (2017) · eLife · doi:10.7554/elife.32417 · Cited by 76
“The high brightness and dynamic range of modern GECIs like Salsa6f contribute to detection of rare Ca signaling events inside intact tissues or even whole transgenic animals (Kubo et al., 2014; Portugues et al., 2014).”
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Reinig, S., Driever, W., & Arrenberg, A. B. (2017) · Current Biology · doi:10.1016/j.cub.2016.11.059 · Cited by 64
Self-citationLuminance Changes Drive Directional Startle through a Thalamic Pathway
Heap, L. A., Vanwalleghem, G. C., Thompson, A. W., Favre‐Bulle, I. A., & Scott, E. K. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.013 · Cited by 66
“Wethenperformed morphological segmentation to identify regions of interest (ROIs) roughly corresponding to individual neurons and used a Boolean based ‘‘bar code’’ approach (Kubo et al., 2014; Naumannet al., 2016) to identifyROIs responding toeachstimulus (FigureS3).”
A cerebellar internal model calibrates a feedback controller involved in sensorimotor control
Markov, D. A., Petrucco, L., Kist, A. M., & Portugues, R. (2021) · Nature Communications · doi:10.1038/s41467-021-26988-0 · Cited by 68
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Kutsarova, E., Munz, M., & Ruthazer, E. S. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00111 · Cited by 62
“In fish and frogs the RGCs project to at least 10 distinct tectal and pretectal arborization fields believed to mediate important behavioral responses such as eye movements and prey capture (Easter and Taylor, 1989; Burrill and Easter, 1994; Kubo et al., 2014; Semmelhack et al., 2014).”
BackgroundAn interhemispheric neural circuit allowing binocular integration in the optic tectum
Gebhardt, C., Auer, T. O., Henriques, P. M., Rajan, G., Duroure, K., Bianco, I. H., & Bene, F. D. (2019) · Nature Communications · doi:10.1038/s41467-019-13484-9 · Cited by 65
Wang, K., Hinz, J., Haikala, V., Reiff, D. F., & Arrenberg, A. B. (2019) · BMC Biology · doi:10.1186/s12915-019-0648-2 · Cited by 60
Self-citationA brainstem integrator for self-location memory and positional homeostasis in zebrafish
Yang, E., Zwart, M., James, B., Rubinov, M., Wei, Z., Narayan, S., Vladimirov, N., Mensh, B. D., Fitzgerald, J. E., & Ahrens, M. B. (2022) · Cell · doi:10.1016/j.cell.2022.11.022 · Cited by 64
Kist, A. M., & Portugues, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.024 · Cited by 55
Methods for studying the zebrafish brain: past, present and future
Wyatt, C., Bartoszek, E. M., & Yaksi, E. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12932 · Cited by 58
Feierstein, C. E., Portugues, R., & Orger, M. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.046 · Cited by 60
“…functional types in the population, and their locations, they were able to propose, based on minimal Boolean logic, the simplest connectivity pattern that could explain the observed responses, providing a straightforward circuit hypothesis which can now be tested experimentally (Kubo et al., 2014).”
BackgroundMethodResultInfluentialThe Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors
Palumbo, F., Serneels, B., Pelgrims, R., & Yaksi, E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108054 · Cited by 49
“Series of recent studies highlight the increasing popularity of zebrafish for studying diverse aspects of animal behavior [30-39], including complex behaviors such as learning [25, 26, 40-46] and social interactions”
Anatomy and function of retinorecipient arborization fields in zebrafish
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“The cell body-rich region dorsal to AF5/AF6 and ventral to AF9 responds strongly and selectively to binocular optic flow and is necessary and sufficient for optokinetic and optomotor responses (Kramer et al., 2019; Kubo et al., 2014).”
BackgroundSelf-citationCalcium Imaging and the Curse of Negativity
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“Another approach that we and others have used, the binarization of the data based on a threshold of activity to generate “bar codes” of the brain activity, also has an intrinsic non-negative assumption (Kubo et al., 2014; Naumann et al., 2016; Heap et al., 2018; Daviu et al., 2020; Etter et al., 2020).”
MethodNeural connections of the pretectum in zebrafish ( Danio rerio )
Yáñez, J., Suárez, T., Quelle‐Regaldie, A., Folgueira, M., & Anadón, R. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24388 · Cited by 45
“Functional studies suggest that pretectal centers in zebrafish larvae are involved in the generation of stereotyped movements (Fajardo, Zhu, & Friedrich, 2013; Kubo et al., 2014; Portugues, Feierstein, Engert, & Orger, 2014) and in prey detection (Semmelhack et al., 2014; Muto et al., 2017).”
BackgroundAncestral photoreceptor diversity as the basis of visual behaviour
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“This organization is perhaps particularly obvious in zebrafish, where the dendrites of retinal ganglion cells associated with widefield motion processing stratify towards the outer edges of the inner retina 57,74,77 (Fig.”
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Wibble, T., Pansell, T., Grillner, S. E., & Pérez‐Fernández, J. (2022) · Nature Communications · doi:10.1038/s41467-022-32379-w · Cited by 39
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Wu, Y., Maschio, M. D., Kubo, F., & Baier, H. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.027 · Cited by 37
Self-citationDense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish
Friedrich, R. W., & Wanner, A. A. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110220-013050 · Cited by 33
A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain
Yildizoglu, T., Riegler, C., Fitzgerald, J. E., & Portugues, R. (2020) · Current Biology · doi:10.1016/j.cub.2020.04.043 · Cited by 34
Spike Burst Coding of Translatory Optic Flow and Depth from Motion in the Fly Visual System
Longden, K. D., Wicklein, M., Hardcastle, B., Huston, S. J., & Krapp, H. G. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.044 · Cited by 34
Using a variant of the optomotor response as a visual defect detection assay in zebrafish
LeFauve, M. K., Rowe, C. J., Crowley-Perry, M., Wiegand, J. L., & Shapiro, A. (2021) · Journal of Biological Methods · doi:10.14440/jbm.2021.341 · Cited by 34
“Zebrafish OMR is generated by several separate visual and motor circuits, many of which overlap with the circuits activated by the OKR in the eyes [9].”
BackgroundThe world according to zebrafish: how neural circuits generate behavior
Sumbre, G., & de Polavieja, G. G. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00091 · Cited by 36
“Meyer, A., and Schartl, M. (1999). Gene and genome duplications in vertebrates: the one-to-four (-to-eight in fish) rule and the evolution of novel gene”
BackgroundDehmelt, F. A., Meier, R., Hinz, J., Yoshimatsu, T., Simacek, C. A., Huang, R., Wang, K., Baden, T., & Arrenberg, A. B. (2021) · eLife · doi:10.7554/elife.63355 · Cited by 37
Self-citationNeurons Responsive to Global Visual Motion Have Unique Tuning Properties in Hummingbirds
Gaede, A. H., Goller, B., Lam, J., WYLIE, D. R. W., & Altshuler, D. L. (2017) · Current Biology · doi:10.1016/j.cub.2016.11.041 · Cited by 32
Information processing in the CNS: a supramolecular chemistry?
Tozzi, A. (2015) · Cognitive Neurodynamics · doi:10.1007/s11571-015-9337-1 · Cited by 32
“We now list some recent studies linking neuronal types to specific active molecules and well-defined behaviours: • A new neuron type within the area pretectalis helps zebrafish coordinates their eye and swimming move- ments, to compensate for self-motion (Kubo et al. 2014).”
BackgroundSustained Rhythmic Brain Activity Underlies Visual Motion Perception in Zebrafish
Pérez-Schuster, V., Kulkarni, A., Nouvian, M., Romano, S. A., Lygdas, K., Jouary, A., Dipoppa, M., Pietri, T., Haudrechy, M., Candat, V., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.065 · Cited by 30
“To inhibit eye movements during OKR using optogenetics and spatially selected illumination via an optic fiber (Arrenberg et al., 2009; Schoonheim et al., 2010) we used the Tg(HuC:Gal4);Tg(UAS:eNpHR-mCherry)s1988t (E. Baier) zebrafish line, referred as to the HuC:Gal4;UAS:eNpHR-mCherry line.”
InfluentialCircuit Organization Underlying Optic Flow Processing in Zebrafish
Matsuda, K., & Kubo, F. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.709048 · Cited by 31
Self-citationEvoking and tracking zebrafish eye movement in multiple larvae with ZebEyeTrack
Dehmelt, F. A., von Daranyi, A., Leyden, C., & Arrenberg, A. B. (2018) · Nature Protocols · doi:10.1038/s41596-018-0002-0 · Cited by 30
Self-citationA robust receptive field code for optic flow detection and decomposition during self-motion
Zhang, Y., Huang, R., Nörenberg, W., & Arrenberg, A. B. (2022) · Current Biology · doi:10.1016/j.cub.2022.04.048 · Cited by 29
Self-citationThe Cellular Organization of Zebrafish Visuomotor Circuits
Orger, M. B. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.054 · Cited by 28
“For example, orientation to prey depends on sensory motor maps in the optic tectum, a homolog of the mammalian superior colliculus, while whole-field motion signals originating in direction-selective ganglion cells are processed in a set of specialized nuclei, with similarities to the accessory optic system [18].”
BackgroundResponses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish
Scalise, K., Shimizu, T., Hibi, M., & Sawtell, N. B. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00042.2016 · Cited by 27
“Direction-selective visual responses have been observed in areas of the larval zebrafish brain, including the pretectum, and have been suggested to play a role in the OMR (Kubo et al. 2014; Portugues et al. 2014).”
BackgroundFallani, F. D. V., Corazzol, M., Sternberg, J. R., Wyart, C., & Chávez, M. (2014) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2014.2341632 · Cited by 26
“resolution level [3], [4], [18], [19], [39], [40].”
Brysch, C., Leyden, C., & Arrenberg, A. B. (2019) · BMC Biology · doi:10.1186/s12915-019-0720-y · Cited by 26
“In short, stimuli were presented as vertical gratings (12 roughly equally spaced, red, vertical bars per 360°) rotating horizontally around the larvae on a custom-made LED arena (described in the supplemental information under the “Visual Stimulation” section in [1]).”
BackgroundMethodInfluentialSelf-citationGeometric framework to predict structure from function in neural networks
Tirthabir Biswas, A., & Fitzgerald, J. E. (2022) · Physical Review Research · doi:10.1103/physrevresearch.4.023255 · Cited by 22
“This description is useful because many systems neuroscience experiments measure representations directly, and it is important to build mechanistic models that explain these data in terms of neural network interactions [12, 15, 18, 77].”
BackgroundFu, R., Liu, H., Zhang, Y., Mao, L., Zhu, L., Jiang, H., Zhang, L. H., & Liu, X. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168572 · Cited by 24
Lin, X., Li, V. W. T., Chen, S., Chan, C.-Y., Cheng, S. H., & Shi, P. (2016) · Biomicrofluidics · doi:10.1063/1.4946013 · Cited by 23
Input from torus longitudinalis drives binocularity and spatial summation in zebrafish optic tectum
Tesmer, A. L., Fields, N. P., & Robles, E. (2022) · BMC Biology · doi:10.1186/s12915-021-01222-x · Cited by 20
Sequential Nonlinear Filtering of Local Motion Cues by Global Motion Circuits
Barnhart, E. L., Wang, I. E., Wei, H., Desplan, C., & Clandinin, T. R. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.022 · Cited by 21
“, 2015) and are under active investigation in vertebrates (Hedges et al., 2011; Kubo et al., 2014).”
Fornetto, C., Tiso, N., Pavone, F. S., & Vanzi, F. (2020) · BMC Biology · doi:10.1186/s12915-020-00903-3 · Cited by 19
Binocular integration of retinal motion information underlies optic flow processing by the cortex
Rasmussen, R. N., Matsumoto, A., Arvin, S., & Yonehara, K. (2021) · Current Biology · doi:10.1016/j.cub.2020.12.034 · Cited by 21
Peripheral and central sensation: multisensory orienting and recognition across species
Zhaoping, L. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.03.001 · Cited by 23
Multilevel visuomotor control of locomotion in Drosophila
Cruz, T. L., & Chiappe, M. E. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102774 · Cited by 17
A noninvasive light driven technique integrated microfluidics for zebrafish larvae transportation
Mani, K., Hsieh, Y.-C., Panigrahi, B., & Chen, C. (2018) · Biomicrofluidics · doi:10.1063/1.5027014 · Cited by 20
Zebrafishdscaml1Deficiency Impairs Retinal Patterning and Oculomotor Function
Ma, M., Ramirez, A. D., Wang, T., Roberts, R. L., Harmon, K., Schoppik, D., Sharma, A., Kuang, C., Goei, S. L., Gagnon, J. A., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1783-19.2019 · Cited by 20
“Zebrafish oculomotor behavior is robust at the larval stage; the small size and optical translucency of zebrafish larvae make it possible to use two-photon calcium imaging to record neuronal activity en masse while the animal is behaving (Kubo et al., 2014; Daie et al., 2015; Kawashima et al., 2016).”
BackgroundPositive taxis and sustained responsiveness to water motions in larval zebrafish
Groneberg, A. H., Herget, U., Ryu, S., & Marco, R. J. D. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00009 · Cited by 19
Visual Search Efficiency Evaluation Method for Potential Connected Vehicles on Sharp Curves
Peng, J., Wang, C., Shao, Y., & Xu, J. H. (2018) · IEEE Access · doi:10.1109/access.2018.2861940 · Cited by 17
“In addition, when driving along a sharp bend of a mountain road (the radius of a bend is less than 50 m), the driving horizon is seriously inadequate, the level of traffic safety facilities is low, and traffic accidents easily happen; thus, higher visual searching requirements are put forth [21], [22].”
Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior
Sylvester, S., Lee, M. M., Ramirez, A. D., Lim, S., Goldman, M. S., & Aksay, E. R. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-15938-w · Cited by 17
“Many pretectal neurons sensitive to movement in the horizontal plane fire in a reciprocal manner, increasing firing for stimulation in one direction, and decreasing firing for the other (Mustari and Fuchs, 1990; Kubo et al., 2014).”
Fouke, K. E., He, Z., Loring, M. D., & Naumann, E. A. (2024) · Current Biology · doi:10.1016/j.cub.2025.04.027 · Cited by 18
Gutiérrez‐Ibáñez, C., WYLIE, D. R. W., & Altshuler, D. L. (2023) · Journal of Comparative Physiology A · doi:10.1007/s00359-023-01663-5 · Cited by 16
Dowell, C. K., Hawkins, T. A., & Bianco, I. H. (2025) · Current Biology · doi:10.1016/j.cub.2024.12.010 · Cited by 16
“…stimulation of this region of pretectum (and electrical stimulation of its supposed mammalian equivalent) evokes slow phase eye movements, 43,81 it is possible that AF5-pretectal neurons might mediate the early direct component of the OKR in which the eye responds to the onset of visual…”
Leyden, C., Brysch, C., & Arrenberg, A. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-90315-2 · Cited by 15
Self-citationBrożko, N., Baggio, S., Lipiec, M. A., Jankowska, M., Szewczyk, Ł. M., Gabriel, M., Chakraborty, C., Ferrán, J. L., & Wisniewska, M. B. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.838567 · Cited by 15
Structural and functional organization of visual responses in the inferior olive of larval zebrafish
Félix, R., Markov, D. A., Renninger, S. L., Tomás, A. R., Laborde, A., Carey, M. R., Orger, M. B., & Portugues, R. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2352-21.2023 · Cited by 15
“…neurons are monocular but mechanisms for binocular integration of the optic fl ow have been proposed to be computed at the pretectum circuit level (Kubo et al., 2014; Naumann et al., 2016; Kramer et al., 2019; Wang et al., 2019), and a topographic organization of PD in a population of binocular…”
BackgroundWang, R., Wang, B., & Chen, A. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124473 · Cited by 16
Ali, M. A., Lischka, K., Preuß, S., Trivedi, C. A., & Bollmann, J. H. (2023) · Nature Communications · doi:10.1038/s41467-023-43255-6 · Cited by 12
Zebrafish Optokinetic Reflex: Minimal Reporting Guidelines and Recommendations
Rodwell, V., Patil, M., Kuht, H. J., Neuhauss, S. C. F., Norton, W., & Thomas, M. G. (2023) · Biology · doi:10.3390/biology13010004 · Cited by 16
“The most common time of day was between 12 and 6 pm, with 37.5% of these papers performing an OKR exclusively in the afternoon [53,101,102].”
BackgroundInfluentialMethods for Mapping Neuronal Activity to Synaptic Connectivity: Lessons From Larval Zebrafish
Wanner, A. A., & Vishwanathan, A. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00089 · Cited by 15
“, 2013) and two photon microscopy (O’Malley et al., 1996; Friedrich and Korsching, 1997; Ritter et al., 2001; Brustein et al., 2003; Niell and Smith, 2005; Yaksi and Friedrich, 2006; Orger et al., 2008; Ramdya and Engert, 2008; Sumbre et al., 2008; Naumann et al., 2010, 2016; Niessing and Friedrich, 2010; Blumhagen et…”
BackgroundRetina-derived signals control pace of neurogenesis in visual brain areas but not circuit assembly
Sherman, S., Arnold-Ammer, I., Schneider, M., Kawakami, K., & Baier, H. (2023) · Nature Communications · doi:10.1038/s41467-023-40749-1 · Cited by 14
“Similarly, OKR-like eye movements could be elicited by photo-stimulating the accessory optic system in the pretectum 47,48 .”
BackgroundSelf-citationZebrafish as a Model for Revealing the Neuronal Basis of Behavior
McArthur, K. L., Chow, D. M., & Fetcho, J. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812431-4.00046-4 · Cited by 15
Visual escape in larval zebrafish: stimuli, circuits, and behavior
Legorreta, E. M., Piber, M., & Scott, E. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817528-6.00004-8 · Cited by 13
Holman, J. G., Lai, W. W. K., Pichler, P., Saska, D., Lagnado, L., & Buckley, C. L. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010924 · Cited by 12
“There is neurobiological evidence for the first [11,12,14,35,36] and last of these [16,42] but less evidence relevant to the proposed intermediate processes.”
Genoarchitectonics of the larval zebrafish diencephalon
Wullimann, M. F., Mokayes, N., Shainer, I., Kuehn, E., & Baier, H. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25549 · Cited by 12
“These neurons were shown to drive optokinetic and optomotor responses (Kubo et al., 2014; Sherman et al., 2023; Wu et al., 2020).”
BackgroundSelf-citationBarker, A. J., Helmbrecht, T. O., Grob, A. A., & Baier, H. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25082 · Cited by 14
“2021;529:2159–2175. wileyonlinelibrary.com/journal/cne 2159 et al., 2014; Portugues & Engert, 2009; Kubo et al., 2014; Mearns et al., 2020).”
Self-citationFiber Optic-Based Photostimulation of Larval Zebrafish
Arrenberg, A. B. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3771-4_24 · Cited by 12
Self-citationIn Vivo Whole-Cell Patch-Clamp Recording in the Zebrafish Brain
Zhang, R., & Du, J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3771-4_19 · Cited by 11
Feierstein, C. E., de Goeij, M. H. M., Ostrovsky, A. D., Laborde, A., Portugues, R., Orger, M. B., & Machens, C. K. (2023) · Current Biology · doi:10.1016/j.cub.2023.08.037 · Cited by 10
Metadata
- Authors
- Kubo, F., Hablitzel, B., Dal Maschio, M., Driever, W., Baier, H., & Arrenberg, A. B.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- University of Freiburg (DE)
- Max Planck Society (DE)
- Corresponding author
- Baier, Herwig
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 81
- Issue
- 6
- Pages
- 1344-1359
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2067473018
- Cited by
- 182
- References
- 60
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 21 · 2019: 16 · 2018: 12 · 2017: 19 · 2016: 14 · 2015: 13 · 2014: 10
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (EXC‐294‐BIOSS, SFB780, (EXC 294))
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- optical flow, horizontal eye movements, optokinetic response, optomotor response, zebrafish, direction selectivity, binocular vision, neural circuit organization, optogenetic manipulation, in vivo calcium imaging
- MeSH terms
- Animals, Eye Movements, Motion Perception, Neurons, Photic Stimulation, Visual Fields, Visual Pathways, Zebrafish, Nystagmus, Optokinetic, Optic Flow
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