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Functional Architecture of an Optic Flow-Responsive Area that Drives Horizontal Eye Movements in Zebrafish
Open accessAbstract
Animals respond to whole-field visual motion with compensatory eye and body movements in order to stabilize both their gaze and position with respect to their surroundings. In zebrafish, rotational stimuli need to be distinguished from translational stimuli to drive the optokinetic and the optomotor responses, respectively. Here, we systematically characterize the neural circuits responsible for these operations using a combination of optogenetic manipulation and in vivo calcium imaging during optic flow stimulation. By recording the activity of thousands of neurons within the area pretectalis (APT), we find four bilateral pairs of clusters that process horizontal whole-field motion and functionally classify eleven prominent neuron types with highly selective response profiles. APT neurons are prevalently direction selective, either monocularly or binocularly driven, and hierarchically organized to distinguish between rotational and translational optic flow. Our data predict a wiring diagram of a neural circuit tailored to drive behavior that compensates for self-motion.
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“recently identified as involved in processing whole-field motion in zebrafish (Kubo et al., 2014; Portugues et al., 2014).”
From Neural control and modulation of swimming speed in the larval zebrafish (2014) · cites this paper as Kubo et al., 2014
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“Benefitting from detailed experimental data (25, 29–34) and recent advances in physics simulation technologies (35), our open-source simZFish faithfully reproduces the zebrafish OMR, utilizing experimentally observed neural activity (25).”
From Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors (2025) · cites this paper as [33]
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Metadata
- Authors
- Kubo, F., Hablitzel, B., Dal Maschio, M., Driever, W., Baier, H., & Arrenberg, A. B.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- University of Freiburg (DE)
- Max Planck Society (DE)
- Corresponding author
- Baier, Herwig
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 81
- Issue
- 6
- Pages
- 1344-1359
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2067473018
- Cited by
- 182
- References
- 60
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 21 · 2019: 16 · 2018: 12 · 2017: 19 · 2016: 14 · 2015: 13 · 2014: 10
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (EXC‐294‐BIOSS, SFB780, (EXC 294))
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- optical flow, horizontal eye movements, optokinetic response, optomotor response, zebrafish, direction selectivity, binocular vision, neural circuit organization, optogenetic manipulation, in vivo calcium imaging
- MeSH terms
- Animals, Eye Movements, Motion Perception, Neurons, Photic Stimulation, Visual Fields, Visual Pathways, Zebrafish, Nystagmus, Optokinetic, Optic Flow
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