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Cited by 134Neural dynamics and brain functionMotor Control and AdaptationNeurological disorders and treatments

A Common Structure Underlies Low-Frequency Cortical Dynamics in Movement, Sleep, and Sedation

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Hall, Thomas M., de Carvalho, Felipe, Jackson, Andrew·2014·Neuron
DOI 10.1016/j.neuron.2014.07.022PMC PMC4157580
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Abstract

Upper-limb movements are often composed of regular submovements, and neural correlates of submovement frequencies between 1 and 4 Hz have been found in the motor cortex. The temporal profile of movements is usually assumed to be determined by extrinsic factors such as limb biomechanics and feedback delays, but another possibility is that an intrinsic rhythmicity contributes to low frequencies in behavior. We used multielectrode recordings in monkeys performing an isometric movement task to reveal cyclic activity in primary motor cortex locked to submovements, and a distinct oscillation in premotor cortex. During ketamine sedation and natural sleep, cortical activity traversed similar cycles and became synchronized across areas. Because the same cortical dynamics are coupled to submovements and also observed in the absence of behavior, we conclude that the motor networks controlling the upper limb exhibit an intrinsic periodicity at submovement frequencies that is reflected in the speed profile of movements.

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  • Linear low-pass filters can filter physiological tremor but require many taps for sharp cut-offs, leading to considerable time delays.

    “Therefore physiological tremor can be filtered out readily with linear low-pass filters. However, to achieve sharp cut-o s, linear filters need a large number of taps. Consequently they lead to considerable time delays [18].”

    From A Quaternion Weighted Fourier Linear Combiner for Modeling Physiological Tremor (2016) · cites this paper as [18]

    The Experimental Procedures describe low-pass filtering of cortical signals, but do not discuss filtering physiological tremor. Searches for physiological tremor, filter taps, sharp cut-offs, and filter-induced delays found no passage addressing the claimed trade-off; the Discussion’s references to delays concern sensory feedback instead. (LLM, conf=0.75)

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Authors
Hall, T. M., de Carvalho, F., & Jackson, A.
Affiliations
Newcastle University (GB)
Corresponding author
Jackson, Andrew
ORCID
Hall, Thomas M.
Venue
Neuron
Publisher
Elsevier BV
Published
2014-09
Volume
83
Issue
5
Pages
1185-1199
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2014.07.022
PMC
PMC4157580
OpenAlex
W2024591462
Cited by
134
References
49
Citations by year
2026: 4 · 2025: 7 · 2024: 8 · 2023: 13 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 18 · 2018: 12 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 1
FWCI
6.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders
  • Wellcome Trust (086561)
  • Medical Research Council (MR/K501396/1)
  • Engineering and Physical Sciences Research Council (EP/H051570/1)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
primary motor cortex, premotor cortex, upper limb movement, ketamine sedation, sleep
MeSH terms
Animals, Biomechanical Phenomena, Electromyography, Female, Macaca mulatta, Models, Biological, Motor Cortex, Movement, Sleep, Procedural Sedation, Conscious Sedation, Nonlinear Dynamics, Upper Extremity

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