The DOI matches its Crossref record; 132 of the 133 references it cites were found in a registry or an index.
The Outer Subventricular Zone and Primate-Specific Cortical Complexification
Open accessAbstract
Evolutionary expansion and complexification of the primate cerebral cortex are largely linked to the emergence of the outer subventricular zone (OSVZ), a uniquely structured germinal zone that generates the expanded primate supragranular layers. The primate OSVZ departs from rodent germinal zones in that it includes a higher diversity of precursor types, inter-related in bidirectional non-hierarchical lineages. In addition, primate-specific regulatory mechanisms are operating in primate cortical precursors via the occurrence of novel miRNAs. Here, we propose that the origin and evolutionary importance of the OSVZ is related to genetic changes in multiple regulatory loops and that cell-cycle regulation is a favored target for evolutionary adaptation of the cortex.
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“the developing human CNS possesses certain divergent and highly derived features, such as expanded proliferative zones and diverse subtypes of neural stem and progenitor cells with enhanced proliferative capacities that facilitate brain expansion, especially of the neocortex (Bae et al., 2015; Bystron et al., 2006; Dehay et al., 2015; Gulden and Sestan, 2014; Howard et al., 2008; Lui et al., 2011;”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Dehay et al., 2015
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Metadata
- Authors
- Dehay, C., Kennedy, H., & Kosik, K. S.
- Affiliations
- Lyon 1 Université (FR)
- University of California, Santa Barbara (US)
- Corresponding author
- Dehay, Colette
- Kennedy, Henry
- Kosik, Kenneth S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 85
- Issue
- 4
- Pages
- 683-694
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1980117419
- Cited by
- 314
- References
- 133
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 26 · 2023: 22 · 2022: 33 · 2021: 39 · 2020: 35 · 2019: 25 · 2018: 29 · 2017: 24 · 2016: 32 · 2015: 11
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-IDEX-0007, ANR-14-CE13-0036, ANR-11-LABX-0042, ANR-10-IBHU-0003)
- LabEx DEvweCAN
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- outer subventricular zone, germinal zone, microRNA, cell cycle regulation, supragranular layers, neurogenesis
- MeSH terms
- Animals, Cell Cycle, Cerebral Cortex, Biological Evolution, Humans, Primates, Lateral Ventricles
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