The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
HTR7 Mediates Serotonergic Acute and Chronic Itch
Open accessAbstract
SUMMARY Chronic itch is a prevalent and debilitating condition for which few effective therapies are available. We harnessed the natural variation across genetically distinct mouse strains to identify transcripts co-regulated with itch behavior. This survey led to the discovery of the serotonin receptor, HTR7, as a key mediator of serotonergic itch. Activation of HTR7 promoted opening of the ion channel TRPA1, which in turn triggered itch behaviors. In addition, acute itch triggered by serotonin or a selective serotonin reuptake inhibitor required both HTR7 and TRPA1. Aberrant serotonin signaling has long been linked to a variety of human chronic itch conditions, including atopic dermatitis. In a mouse model of atopic dermatitis, mice lacking HTR7 or TRPA1 displayed reduced scratching and skin lesion severity. These data highlight a role for HTR7 in acute and chronic itch, and suggest that HTR7 antagonists may be useful for treating a variety of pathological itch conditions.
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Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
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The gut-skin axis in health and disease: A paradigm with therapeutic implications
O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R. (2016) · BioEssays · doi:10.1002/bies.201600008 · Cited by 449
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Meixiong, J., Anderson, M., Limjunyawong, N., Sabbagh, M. F., Hu, E., Mack, M. R., Oetjen, L. K., Wang, F., Kim, B. S., & Dong, X. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.013 · Cited by 369
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Metadata
- Authors
- Morita, T., McClain, S. P., Batia, L. M., Pellegrino, M., Wilson, S. R., Kienzler, M. A., Lyman, K., Olsen, A. S. B., Wong, J. F., Stucky, C. L., Brem, R. B., & Bautista, D. M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 87
- Issue
- 1
- Pages
- 124-138
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1951576969
- Cited by
- 188
- References
- 8
- FWCI
- 15.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Morita, T., McClain, S. P., Batia, L. M., Pellegrino, M., Wilson, S. R., Kienzler, M. A., Lyman, K., Olsen, A. S. B., Wong, J. F., Stucky, C. L., Brem, R. B., & Bautista, D. M. (2015). HTR7 Mediates Serotonergic Acute and Chronic Itch. Neuron. https://doi.org/10.1016/j.neuron.2015.05.044
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