Spontaneous Activity Drives Local Synaptic Plasticity In Vivo
Open accessAbstract
Spontaneous activity fine-tunes neuronal connections in the developing brain. To explore the underlying synaptic plasticity mechanisms, we monitored naturally occurring changes in spontaneous activity at individual synapses with whole-cell patch-clamp recordings and simultaneous calcium imaging in the mouse visual cortex in vivo. Analyzing activity changes across large populations of synapses revealed a simple and efficient local plasticity rule: synapses that exhibit low synchronicity with nearby neighbors (<12 μm) become depressed in their transmission frequency. Asynchronous electrical stimulation of individual synapses in hippocampal slices showed that this is due to a decrease in synaptic transmission efficiency. Accordingly, experimentally increasing local synchronicity, by stimulating synapses in response to spontaneous activity at neighboring synapses, stabilized synaptic transmission. Finally, blockade of the high-affinity proBDNF receptor p75(NTR) prevented the depression of asynchronously stimulated synapses. Thus, spontaneous activity drives local synaptic plasticity at individual synapses in an "out-of-sync, lose-your-link" fashion through proBDNF/p75(NTR) signaling to refine neuronal connectivity. VIDEO ABSTRACT.
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Pro-BDNF binding to p75NTR promotes long-term depression.
“Pro-BDNF binding to p75NTR has also been shown to induce pruning of axons and dendrites85,88–91 and promote long-term depression (LTD)92–94.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [94]
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- Authors
- Winnubst, J., Cheyne, J. E., Niculescu, D., & Lohmann, C.
- Affiliations
- Netherlands Institute for Neuroscience (NL)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 87
- Issue
- 2
- Pages
- 399-410
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1553814286
- Cited by
- 180
- References
- 57
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 23 · 2023: 25 · 2022: 18 · 2021: 23 · 2020: 20 · 2019: 13 · 2018: 10 · 2017: 19 · 2016: 16 · 2015: 2
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion, other-oa)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- spontaneous activity, synaptic depression, visual cortex development, proBDNF, p75 neurotrophin receptor, calcium imaging, whole-cell patch-clamp recording
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Calcium, Computer Simulation, Electric Stimulation, Luminescent Proteins, Mice, Inbred C57BL, Mice, Transgenic, Models, Biological, Nerve Net, Neuronal Plasticity, Neurons, Organ Culture Techniques, Quinoxalines, Visual Cortex, Signal Transduction, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Mice, In Vitro Techniques
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