Functional mapping of single spines in cortical neurons in vivo.

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859 · see citing works

Two-photon laser scanning fluorescence microscopy

Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488 · see citing works

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Wong, E. H. F., Kemp, J. A., Priestley, T., Knight, A. R., Woodruff, G. N., & Iversen, L. L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.7104 · Cited by 1,820 · see citing works

In vivo two-photon calcium imaging of neuronal networks

Stosiek, C., Garaschuk, O., Holthoff, K., & Konnerth, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232232100 · Cited by 1,313 · see citing works

DENDRITIC COMPUTATION

London, M., & Häusser, M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135703 · Cited by 1,149 · see citing works

Transient and persistent dendritic spines in the neocortex in vivo

Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease

Busche, M. A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., & Garaschuk, O. (2008) · Science · doi:10.1126/science.1162844 · Cited by 1,125 · see citing works

Dendritic spines as basic functional units of neuronal integration

Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950 · see citing works

Computational subunits in thin dendrites of pyramidal cells

Polsky, A., Mel, B. W., & Schiller, J. (2004) · Nature Neuroscience · doi:10.1038/nn1253 · Cited by 817 · see citing works

NMDA spikes in basal dendrites of cortical pyramidal neurons

Schiller, J., Major, G., Koester, H., & Schiller, Y. (2000) · Nature · doi:10.1038/35005094 · Cited by 735 · see citing works

Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex

Kerlin, A. M., Andermann, M. L., Berezovskii, V. K., & Reid, R. C. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.002 · Cited by 613 · see citing works

Dendritic organization of sensory input to cortical neurons in vivo

Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature · doi:10.1038/nature08947 · Cited by 508 · see citing works

Spine-Neck Geometry Determines NMDA Receptor-Dependent Ca2+ Signaling in Dendrites

Noguchi, J., Matsuzaki, M., Ellis-Davies, G. C. R., & Kasai, H. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.015 · Cited by 419 · see citing works

Functional organization and population dynamics in the mouse primary auditory cortex

Rothschild, G., Nelken, I., & Mizrahi, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2484 · Cited by 390 · see citing works

From form to function: calcium compartmentalization in dendritic spines

Yuste, R., Majewska, A. K., & Holthoff, K. (2000) · Nature Neuroscience · doi:10.1038/76609 · Cited by 370 · see citing works

The single dendritic branch as a fundamental functional unit in the nervous system

Branco, T., & Häusser, M. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.07.009 · Cited by 355 · see citing works

Ca(2+) signaling in dendritic spines.

Sabatini, B., Maravall, M., & Svoboda, K. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00218-x · Cited by 340 · see citing works

Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo

Kitamura, K., Judkewitz, B., Kano, M., Denk, W. T., & Häusser, M. (2007) · Nature Methods · doi:10.1038/nmeth1150 · Cited by 331 · see citing works

Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated

Mainen, Z. F., Malinow, R., & Svoboda, K. (1999) · Nature · doi:10.1038/20187 · Cited by 314 · see citing works

Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons

Cash, S. S., & Yuste, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)81098-3 · Cited by 308 · see citing works

Major signal increase in fluorescence microscopy through dark-state relaxation

Donnert, G., Eggeling, C., & Hell, S. W. (2006) · Nature Methods · doi:10.1038/nmeth986 · Cited by 292 · see citing works

NMDA Receptor-Mediated Subthreshold Ca2+Signals in Spines of Hippocampal Neurons

Kovalchuk, Y., Eilers, J., Lisman, J. E., & Konnerth, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01791.2000 · Cited by 270 · see citing works

Tonic facilitation of glutamate release by presynaptic N-methyl-D-aspartate autoreceptors in the entorhinal cortex.

Berretta, N., & Jones, R. S. G. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00301-6 · Cited by 264 · see citing works

Dichotomy of functional organization in the mouse auditory cortex

Bandyopadhyay, S., Shamma, S., & Kanold, P. O. (2010) · Nature Neuroscience · doi:10.1038/nn.2490 · Cited by 263 · see citing works

Synaptic clustering by dendritic signalling mechanisms

Larkum, M. E., & Nevian, T. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.08.013 · Cited by 262 · see citing works

Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo

Svoboda, K., Helmchen, F., Denk, W. T., & Tank, D. W. (1999) · Nature Neuroscience · doi:10.1038/4569 · Cited by 259 · see citing works

Spectrotemporal Structure of Receptive Fields in Areas AI and AAF of Mouse Auditory Cortex

Linden, J. F., Liu, R. C., Sahani, M., Schreiner, C. E., & Merzenich, M. M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00751.2002 · Cited by 255 · see citing works

High-speed, low-photodamage nonlinear imaging using passive pulse splitters

Ji, N., Magee, J. C., & Betzig, E. (2008) · Nature Methods · doi:10.1038/nmeth.1175 · Cited by 247 · see citing works

Supralinear Ca 2+ Influx into Dendritic Tufts of Layer 2/3 Neocortical Pyramidal Neurons In Vitro and In Vivo

Waters, J., Larkum, M. E., Sakmann, B. J., & Helmchen, F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08558.2003 · Cited by 227 · see citing works

GABAergic Neurons Are Less Selective to Stimulus Orientation than Excitatory Neurons in Layer II/III of Visual Cortex, as Revealed byIn VivoFunctional Ca2+Imaging in Transgenic Mice

Sohya, K., Kameyama, K., Yanagawa, Y., Obata, K., & Tsumoto, T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4641-06.2007 · Cited by 227 · see citing works

In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons

Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature Protocols · doi:10.1038/nprot.2010.169 · Cited by 199 · see citing works

Problems of the Keimbahn. New work on mammalian germ cell lineage.

Sturrock, R. R. (1983) · PubMed · Cited by 182 · see citing works

Nonoverlapping Sets of Synapses Drive On Responses and Off Responses in Auditory Cortex

Scholl, B., Gao, X., & Wehr, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.020 · Cited by 156 · see citing works

Nonmonotonic Synaptic Excitation and Imbalanced Inhibition Underlying Cortical Intensity Tuning

Wu, G. K., Li, P., Tao, H. W., & Zhang, L. I. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.009 · Cited by 147 · see citing works

Dendritic Branch Typing and Spine Expression Patterns in Cortical Nonpyramidal Cells

Kawaguchi, Y., Karube, F., & Kubota, Y. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj015 · Cited by 125 · see citing works

Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines

Bloodgood, B. L., Giessel, A. J., & Sabatini, B. L. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000190 · Cited by 119 · see citing works

High frequency action potential bursts (≥ 100 Hz) in L2/3 and L5B thick tufted neurons in anaesthetized and awake rat primary somatosensory cortex

de Kock, C. P. J., & Sakmann, B. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.155580 · Cited by 107 · see citing works

Multi-Photon Laser Scanning Microscopy Using an Acoustic Optical Deflector

Lechleiter, J. D., Lin, D., & Sieneart, I. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)73989-1 · Cited by 99 · see citing works

Single‐shock LTD by local dendritic spikes in pyramidal neurons of mouse visual cortex

Holthoff, K., Kovalchuk, Y., Yuste, R., & Konnerth, A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072678 · Cited by 83 · see citing works

Video-Rate Nonlinear Microscopy of Neuronal Membrane Dynamics With Genetically Encoded Probes

Roorda, R. D., Hohl, T. M., Toledo‐Crow, R., & Miesenböck, G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00087.2004 · Cited by 72 · see citing works

A spatio-temporally compensated acousto-optic scanner for two-photon microscopy providing large field of view

Kremer, Y., Léger, J., Lapole, R., Honnorat, N., Candela, Y., Dieudonné, S., & Bourdieu, L. (2008) · Optics Express · doi:10.1364/oe.16.010066 · Cited by 47 · see citing works

The Synaptic Representation of Sound Source Location in Auditory Cortex

Chadderton, P. T., Agapiou, J., McAlpine, D., & Margrie, T. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2061-09.2009 · Cited by 38 · see citing works

A simple optical filter for chirp radar

Gerig, J., & Montague, H. (1964) · Proceedings of the IEEE · doi:10.1109/proc.1964.3500 · Cited by 36 · see citing works

Ultrasensitive fluorescent proteins for imaging neuronal activity

Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works

Imaging Calcium in Neurons

Grienberger, C., & Konnerth, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.011 · Cited by 1,344 · see citing works

Nonlinear dendritic integration of sensory and motor input during an active sensing task

Xu, N.-L., Harnett, M. T., Williams, S. R., Huber, D., O’Connor, D. H., Svoboda, K., & Magee, J. C. (2012) · Nature · doi:10.1038/nature11601 · Cited by 548 · see citing works

Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice

Zong, W., Wu, R., Li, M., Hu, Y., Li, Y., Li, J., Rong, H., Wu, H., Xu, Y., Lu, Y. M., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4305 · Cited by 506 · see citing works

Structural plasticity upon learning: regulation and functions

Caroni, P., Donato, F., & Muller, D. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3258 · Cited by 491 · see citing works

Dendritic integration: 60 years of progress

Stuart, G. J., & Spruston, N. (2015) · Nature Neuroscience · doi:10.1038/nn.4157 · Cited by 489 · see citing works

Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo

Fu, M., Yu, X., Lu, J., & Zuo, Y. (2012) · Nature · doi:10.1038/nature10844 · Cited by 478 · see citing works

Active properties of neocortical pyramidal neuron dendrites

Major, G., Larkum, M. E., & Schiller, J. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150343 · Cited by 443 · see citing works

Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning

Zhang, J., He, Y., Liang, S., Liao, X., Li, T., Qiao, Z., Chang, C., Jia, H., & Chen, X. (2021) · Nature Communications · doi:10.1038/s41467-021-23025-y · Cited by 373 · see citing works

Auditory dysfunction in schizophrenia: integrating clinical and basic features

Javitt, D. C., & Sweet, R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4002 · Cited by 363 · see citing works

Locally synchronized synaptic inputs

Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N., & Ikegaya, Y. (2012) · Science · doi:10.1126/science.1210362 · Cited by 352 · see citing works

Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence

Zhang, K., Förster, R., He, W., Liao, X., Li, J., Yang, C., Qin, H., Wang, M., Ding, R., Li, R., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00949-8 · Cited by 325 · see citing works

NMDA spikes enhance action potential generation during sensory input

Palmer, L. M., Shai, A. S., Reeve, J. E., Anderson, H. L., Paulsen, O., & Larkum, M. E. (2014) · Nature Neuroscience · doi:10.1038/nn.3646 · Cited by 321 · see citing works

The effects of aerobic activity on brain structure.

Thomas, A. G., Dennis, A., Bandettini, P. A., & Johansen-Berg, H. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00086 · Cited by 303 · see citing works

Dendritic spines: from structure to in vivo function

Rochefort, N. L., & Konnerth, A. (2012) · The EMBO Reports · doi:10.1038/embor.2012.102 · Cited by 299 · see citing works

Dendritic spines and distributed circuits

Yuste, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.024 · Cited by 298 · see citing works

Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation

Chambers, A. R., Resnik, J., Yuan, Y.-S., Whitton, J. P., Edge, A. S. B., Liberman, M. C., & Polley, D. B. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.041 · Cited by 297 · see citing works

Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex

Mohan, H., Verhoog, M. B., Doreswamy, K. K., Eyal, G., Aardse, R., Lodder, B. N., Goriounova, N. A., Asamoah, B., B. Brakspear, A. B. C., Groot, C., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv188 · Cited by 280 · see citing works

Video-rate volumetric functional imaging of the brain at synaptic resolution

Lu, R., Sun, W., Liang, Y., Kerlin, A., Bierfeld, J., Seelig, J. D., Wilson, D. E., Scholl, B., Mohar, B., Tanimoto, M., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4516 · Cited by 272 · see citing works

Technologies for imaging neural activity in large volumes

Ji, N., Freeman, J., & Smith, S. L. (2016) · Nature Neuroscience · doi:10.1038/nn.4358 · Cited by 271 · see citing works

Genetically Encoded Green Fluorescent Ca2+ Indicators with Improved Detectability for Neuronal Ca2+ Signals

Ohkura, M., Sasaki, T., Sadakari, J., Gengyo‐Ando, K., Kagawa‐Nagamura, Y., Kobayashi, C., Ikegaya, Y., & Nakai, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051286 · Cited by 267 · see citing works

Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex

Wilson, D. E., Whitney, D. E., Scholl, B., & Fitzpatrick, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4323 · Cited by 261 · see citing works

Calcium transient prevalence across the dendritic arbour predicts place field properties

Sheffield, M. E. J., & Dombeck, D. A. (2014) · Nature · doi:10.1038/nature13871 · Cited by 250 · see citing works

Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites

Kleindienst, T., Winnubst, J., Roth-Alpermann, C., Bonhoeffer, T., & Löhmann, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.015 · Cited by 247 · see citing works

Synaptic organization of visual space in primary visual cortex

Iacaruso, M. F., Gasler, I. T., & Hofer, S. B. (2017) · Nature · doi:10.1038/nature23019 · Cited by 241 · see citing works

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

Petersen, C. C. H., & Crochet, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.020 · Cited by 239 · see citing works

Robustness of Cortical Topography across Fields, Laminae, Anesthetic States, and Neurophysiological Signal Types

Guo, W., Chambers, A. R., Darrow, K. N., Hancock, K. E., Shinn‐Cunningham, B. G., & Polley, D. B. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0065-12.2012 · Cited by 226 · see citing works

Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

Makino, H., & Malinow, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.036 · Cited by 219 · see citing works

Imaging Neural Activity Using Thy1-GCaMP Transgenic Mice

Chen, Q., Cichon, J., Wang, W., Qiu, L., Lee, S.-J. R., Campbell, N. R., DeStefino, N. R., Goard, M. J., Fu, Z., Yasuda, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.011 · Cited by 213 · see citing works

Local translation in neuronal compartments: how local is local?

Rangaraju, V., Dieck, S. T., & Schuman, E. M. (2017) · EMBO Reports · doi:10.15252/embr.201744045 · Cited by 193 · see citing works

Synaptic clustering within dendrites: An emerging theory of memory formation

Kastellakis, G., Cai, D. J., Mednick, S. C., Silva, A. J., & Poirazi, P. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.12.002 · Cited by 190 · see citing works

Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons

Chabrol, F. P., Arenz, A., Wiechert, M. T., Margrie, T. W., & DiGregorio, D. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3974 · Cited by 189 · see citing works

Multiscale optical Ca2+ imaging of tonal organization in mouse auditory cortex

Issa, J. B., Haeffele, B. D., Agarwal, A., Bergles, D. E., Young, E. D., & Yue, D. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.009 · Cited by 188 · see citing works

NMDA Receptor-Dependent Multidendrite Ca 2+ Spikes Required for Hippocampal Burst Firing In Vivo

Grienberger, C., Chen, X., & Konnerth, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.014 · Cited by 185 · see citing works

Functional clustering of dendritic activity during decision-making

Kerlin, A., Mohar, B., Flickinger, D., MacLennan, B. J., Dean, M. B., Davis, C., Spruston, N., & Svoboda, K. (2019) · eLife · doi:10.7554/elife.46966 · Cited by 181 · see citing works

Spontaneous Activity Drives Local Synaptic Plasticity In Vivo

Winnubst, J., Cheyne, J. E., Niculescu, D., & Lohmann, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.029 · Cited by 180 · see citing works

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

Frank, A. C., Huang, S., Zhou, M., Gdalyahu, A., Kastellakis, G., Silva, T. K., Lu, E. D., Wen, X., Poirazi, P., Trachtenberg, J. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02751-2 · Cited by 178 · see citing works

Synaptic Mechanisms Underlying Strong Reciprocal Connectivity between the Medial Prefrontal Cortex and Basolateral Amygdala

Little, J. P., & Carter, A. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2385-13.2013 · Cited by 173 · see citing works

Multiphoton fluorescence microscopy for in vivo imaging

Xu, C., Nedergaard, M., Fowell, D. J., Friedl, P., & Ji, N. (2024) · Cell · doi:10.1016/j.cell.2024.07.036 · Cited by 172 · see citing works

Contribution of sublinear and supralinear dendritic integration to neuronal computations

Tran-Van-Minh, A., Cazé, R. D., Abrahamsson, T., Cathala, L., Gutkin, B. S., & DiGregorio, D. A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00067 · Cited by 166 · see citing works

Kilohertz frame-rate two-photon tomography

Kazemipour, A., Novák, O., Flickinger, D., Marvin, J. S., Abdelfattah, A. S., King, J., Borden, P. M., Kim, J. J., Al-Abdullatif, S. H., Deal, P. E., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0493-9 · Cited by 162 · see citing works

The next generation of approaches to investigate the link between synaptic plasticity and learning

Humeau, Y., & Choquet, D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0480-6 · Cited by 154 · see citing works

Two-photon calcium imaging of neuronal activity

Grienberger, C., Giovannucci, A., Zeiger, W., & Portera‐Cailliau, C. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00147-1 · Cited by 148 · see citing works

The Mechanism of Orientation Selectivity in Primary Visual Cortex without a Functional Map

Hansel, D., & van Vreeswijk, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6284-11.2012 · Cited by 147 · see citing works

Modern Laser Scanning Confocal Microscopy

Bayguinov, P. O., Oakley, D. M., Shih, C., Geanon, D. J., Joens, M. S., & Fitzpatrick, J. A. J. (2018) · Current Protocols in Cytometry · doi:10.1002/cpcy.39 · Cited by 145 · see citing works

Dendritic coding of multiple sensory inputs in single cortical neurons in vivo

Varga, Z., Jia, H., Sakmann, B. J., & Konnerth, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112355108 · Cited by 144 · see citing works

Interpreting in vivo calcium signals from neuronal cell bodies, axons, and dendrites: a review

Ali, F., & Kwan, A. C. (2019) · Neurophotonics · doi:10.1117/1.nph.7.1.011402 · Cited by 141 · see citing works

A highly sensitive fluorescent indicator dye for calcium imaging of neural activity in vitro and in vivo

Tada, M., Takeuchi, A., Hashizume, M., Kitamura, K., & Kano, M. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12476 · Cited by 139 · see citing works

Microscopy in 3D: a biologist's toolbox

Fischer, R. S., Wu, Y., Kanchanawong, P., Shroff, H., & Waterman, C. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.008 · Cited by 135 · see citing works

Selective Loss of Smaller Spines in Schizophrenia

MacDonald, M. L., Alhassan, J., Newman, J. T., Richard, M. D., Gu, H., Kelly, R. M., Sampson, A. R., Fish, K. N., Penzes, P., Wills, Z. P., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16070814 · Cited by 131 · see citing works

Laminar Transformation of Frequency Organization in Auditory Cortex

Winkowski, D. E., & Kanold, P. O. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3101-12.2013 · Cited by 129 · see citing works

Subcellular Synaptic Connectivity of Layer 2 Pyramidal Neurons in the Medial Prefrontal Cortex

Little, J. P., & Carter, A. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1616-12.2012 · Cited by 128 · see citing works

Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites

Bloss, E. B., Cembrowski, M. S., Karsh, B., Colonell, J. I., Fetter, R. D., & Spruston, N. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0084-6 · Cited by 125 · see citing works

Compartment-specific tuning of dendritic feature selectivity by intracellular Ca 2+ release

O’Hare, J. K., Gonzalez, K. C., Herrlinger, S. A., Hirabayashi, Y., Hewitt, V. L., Blockus, H., Szoboszlay, M., Rolotti, S. V., Geiller, T. C., Negrean, A., et al. (2022) · Science · doi:10.1126/science.abm1670 · Cited by 125 · see citing works

Local versus global scales of organization in auditory cortex

Kanold, P. O., Nelken, I., & Polley, D. B. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.06.003 · Cited by 121 · see citing works

Voltage compartmentalization in dendritic spines in vivo

Cornejo, V. H., Ofer, N., & Yuste, R. (2021) · Science · doi:10.1126/science.abg0501 · Cited by 120 · see citing works

Advanced Fiber Soliton Sources for Nonlinear Deep Tissue Imaging in Biophotonics

Wang, K., Horton, N. G., Charan, K., & Xu, C. (2013) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2013.2276860 · Cited by 119 · see citing works

Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex

Deitcher, Y., Eyal, G., Kanari, L., Verhoog, M. B., Kahou, G. A. A., Mansvelder, H. D., de Kock, C. P. J., & Segev, I. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx226 · Cited by 114 · see citing works

Local Order within Global Disorder: Synaptic Architecture of Visual Space

Scholl, B., Wilson, D. E., & Fitzpatrick, D. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.017 · Cited by 113 · see citing works

Plasticity in the auditory system

Irvine, D. R. F. (2017) · Hearing Research · doi:10.1016/j.heares.2017.10.011 · Cited by 111 · see citing works

Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics

Schneider, J., Zahn, J. T., Maglione, M., Sigrist, S. J., Marquard, J., Chojnacki, J., Kräusslich, H., Sahl, S. J., Engelhardt, J., & Hell, S. W. (2015) · Nature Methods · doi:10.1038/nmeth.3481 · Cited by 109 · see citing works

Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level

Bono, J., & Clopath, C. (2017) · Nature Communications · doi:10.1038/s41467-017-00740-z · Cited by 108 · see citing works

A corticopontine circuit for initiation of urination

Yao, J., Zhang, Q., Liao, X., Li, Q., Liang, S., Li, X., Zhang, Y., Li, X., Wang, H., Qin, H., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0256-4 · Cited by 105 · see citing works

Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals

Szalay, G., Judák, L., Katona, G., Ócsai, K., Juhász, G., Veress, M., Szadai, Z., Fehér, A., Tompa, T., Chiovini, B., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.002 · Cited by 104 · see citing works

Cellular and Widefield Imaging of Sound Frequency Organization in Primary and Higher Order Fields of the Mouse Auditory Cortex

Pinto, S. R., Hight, A. E., Clayton, K. K., Resnik, J., Williamson, R. S., Hancock, K. E., & Polley, D. B. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz190 · Cited by 103 · see citing works

Whole-Cell Recording of Neuronal Membrane Potential during Behavior

Petersen, C. C. H. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.049 · Cited by 100 · see citing works

Dendritic function in vivo

Grienberger, C., Chen, X., & Konnerth, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.002 · Cited by 97 · see citing works

Multibranch activity in basal and tuft dendrites during firing of layer 5 cortical neurons in vivo

Hill, D. N., Varga, Z., Jia, H., Sakmann, B. J., & Konnerth, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312599110 · Cited by 96 · see citing works

Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates

Karpf, S., Riche, C. T., Carlo, D. D., Goel, A., Zeiger, W., Suresh, A., Portera‐Cailliau, C., & Jalali, B. (2020) · Nature Communications · doi:10.1038/s41467-020-15618-w · Cited by 93 · see citing works

Synaptic Clustering and Memory Formation

Kastellakis, G., & Poirazi, P. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00300 · Cited by 89 · see citing works

Spatiotemporal dynamics of dendritic spines in the living brain

Chen, C.-C., Lu, J., & Zuo, Y. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00028 · Cited by 88 · see citing works

Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography

Zheng, T., Yang, Z., Li, A., Lv, X., Zhou, Z., Wang, X., Qi, X., Li, S., Luo, Q., Gong, H., et al. (2013) · Optics Express · doi:10.1364/oe.21.009839 · Cited by 87 · see citing works

Examining Form and Function of Dendritic Spines

Lee, K. F. H., Soares, C., & Béïque, J.-C. (2012) · Neural Plasticity · doi:10.1155/2012/704103 · Cited by 82 · see citing works

Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex

Lai, C. S. W., Adler, A., & Gan, W. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801504115 · Cited by 82 · see citing works

Inhibitory Regulation of Dendritic Activity in vivo

Palmer, L. M., Murayama, M., & Larkum, M. E. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00026 · Cited by 82 · see citing works

Mitigating Phototoxicity during Multiphoton Microscopy of Live Drosophila Embryos in the 1.0–1.2 µm Wavelength Range

Débarre, D., Olivier, N., Supatto, W., & Beaurepaire, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104250 · Cited by 80 · see citing works

Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo

Wilms, C. D., & Häusser, M. (2015) · Nature Communications · doi:10.1038/ncomms7464 · Cited by 80 · see citing works

Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens

MacAskill, A. F., Little, J. P., Cassel, J. M., & Carter, A. G. (2012) · Nature Neuroscience · doi:10.1038/nn.3254 · Cited by 80 · see citing works

From Functional Architecture to Functional Connectomics

Reid, R. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.031 · Cited by 79 · see citing works

Methods of dendritic spine detection: From Golgi to high-resolution optical imaging

Mancuso, J. J., Chen, Y., Li, X., Xue, Z., & Wong, S. T. C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.010 · Cited by 76 · see citing works

Auditory perceptual learning and changes in the conceptualization of auditory cortex

Irvine, D. R. F. (2018) · Hearing Research · doi:10.1016/j.heares.2018.03.011 · Cited by 75 · see citing works

Emergence of local and global synaptic organization on cortical dendrites

Kirchner, J. H., & Gjorgjieva, J. (2021) · Nature Communications · doi:10.1038/s41467-021-23557-3 · Cited by 74 · see citing works

Primary Auditory Cortex is Required for Anticipatory Motor Response

Li, J., Liao, X., Zhang, J., Wang, M., Yang, N., Zhang, J., Lv, G., Li, H., Lu, J., Ding, R., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx079 · Cited by 73 · see citing works

Single-neuron representation of learned complex sounds in the auditory cortex

Wang, M., Liao, X., Li, R., Liang, S., Ding, R., Li, J., Zhang, J., He, W., Liu, K., Pan, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18142-z · Cited by 71 · see citing works

Linear integration of spine Ca 2+ signals in layer 4 cortical neurons in vivo

Jia, H., Varga, Z., Sakmann, B. J., & Konnerth, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408525111 · Cited by 67 · see citing works

Grid Cells and Neural Coding in High-End Cortices

Moser, E. I., & Moser, M. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.043 · Cited by 65 · see citing works

The fiber-optic imaging and manipulation of neural activity during animal behavior

Miyamoto, D., & Murayama, M. (2015) · Neuroscience Research · doi:10.1016/j.neures.2015.09.004 · Cited by 65 · see citing works

Pushing the Boundaries of Neuroimaging with Optoacoustics

Ovsepian, S. V., Olefir, I., Westmeyer, G. G., Razansky, D., & Ntziachristos, V. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.022 · Cited by 64 · see citing works

Synaptic modifications in learning and memory – A dendritic spine story

Ma, S., & Zuo, Y. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.015 · Cited by 64 · see citing works

Lineage-dependent circuit assembly in the neocortex

Gao, P., Sultan, K. T., Zhang, X., & Shi, S. (2013) · Development · doi:10.1242/dev.087668 · Cited by 64 · see citing works

Altered Glutamate Protein Co-Expression Network Topology Linked to Spine Loss in the Auditory Cortex of Schizophrenia

MacDonald, M. L., Ding, Y., Newman, J. T., Hemby, S. E., Penzes, P., Lewis, D. A., Yates, N. A., & Sweet, R. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.006 · Cited by 64 · see citing works

Functional maps within a single neuron

Narayanan, R., & Johnston, D. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00530.2012 · Cited by 64 · see citing works

Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons

Ju, N., Li, Y., Liu, F., Jiang, H., Macknik, S. L., Martínez‐Conde, S., & Tang, S. (2020) · Nature Communications · doi:10.1038/s41467-020-14501-y · Cited by 63 · see citing works

Sublinear integration underlies binocular processing in primary visual cortex

Longordo, F., To, M., Ikeda, K., & Stuart, G. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3394 · Cited by 63 · see citing works

LOTOS-based two-photon calcium imaging of dendritic spines in vivo

Chen, X., Leischner, U., Varga, Z., Jia, H., Deca, D., Rochefort, N. L., & Konnerth, A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.106 · Cited by 62 · see citing works

Sound‐evoked network calcium transients in mouse auditory cortex in vivo

Grienberger, C., Adelsberger, H., Stroh, A., Milos, R., Garaschuk, O., Schierloh, A., Nelken, I., & Konnerth, A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.222513 · Cited by 62 · see citing works

Freeze-frame imaging of synaptic activity using SynTagMA

Pérez‐Alvarez, A., Fearey, B. C., O’Toole, R. J., Yang, W., Arganda‐Carreras, I., Lamothe‐Molina, P. J., Moeyaert, B., Mohr, M. A., Panzera, L. C., Schulze, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16315-4 · Cited by 60 · see citing works

Acousto-optic systems for advanced microscopy

Duocastella, M., Surdo, S., Zunino, A., Diaspro, A., & Saggau, P. (2020) · Journal of Physics Photonics · doi:10.1088/2515-7647/abc23c · Cited by 60 · see citing works

Imaging Neuronal Populations in Behaving Rodents: Paradigms for Studying Neural Circuits Underlying Behavior in the Mammalian Cortex

Chen, J. L., Andermann, M. L., Keck, T., Xu, N.-L., & Ziv, Y. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3255-13.2013 · Cited by 58 · see citing works

Input transformation by dendritic spines of pyramidal neurons

Araya, R. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00141 · Cited by 58 · see citing works

In brief

(2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3081

Analysis of cortical processing of sound-evoked inputs: from single spines to cortical populations

Deca, D. (2015) · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Dendritic organization of sensory input to cortical neurons in vivo

Jia, H., Rochefort, N. L., Chen, X., & Konnerth, A. (2010) · Nature · doi:10.1038/nature08947 · Cited by 508 · see citing works

In Vivo Dendritic Mapping of Sensory Inputs in Cortical Neurons

Jia, H., & Konnerth, A. (2013) · Neuromethods · doi:10.1007/978-1-62703-785-3_6 · Cited by 1 · see citing works

Synaptic input architecture of visual cortical neurons revealed by large-scale synapse imaging without backpropagating action potentialsPreprint

Kondo, S., Kikuta, K., & Ohki, K. (2025) · eLife · doi:10.7554/elife.104334