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Cited by 327Pain Mechanisms and TreatmentsPain Management and TreatmentIon Channels and Receptors

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Dorsal Horn Circuits for Persistent Mechanical Pain

Open access
Peirs, Cedric, Williams, Sean-Paul G., Zhao, Xinyi, Walsh, Claire E., Gedeon, Jeremy Y., Cagle, Natalie E., Goldring, Adam C., Hioki, Hiroyuki, Liu, Zheng, Marell, Paulina S., Seal, Rebecca P.·2015·Neuron
DOI 10.1016/j.neuron.2015.07.029PMC PMC4562334
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Abstract

Persistent mechanical hypersensitivity that occurs in the setting of injury or disease remains a major clinical problem largely because the underlying neural circuitry is still not known. Here we report the functional identification of key components of the elusive dorsal horn circuit for mechanical allodynia. We show that the transient expression of VGLUT3 by a discrete population of neurons in the deep dorsal horn is required for mechanical pain and that activation of the cells in the adult conveys mechanical hypersensitivity. The cells, which receive direct low threshold input, point to a novel location for circuit initiation. Subsequent analysis of c-Fos reveals the circuit extends dorsally to nociceptive lamina I projection neurons, and includes lamina II calretinin neurons, which we show also convey mechanical allodynia. Lastly, using inflammatory and neuropathic pain models, we show that multiple microcircuits in the dorsal horn encode this form of pain.

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Metadata

Authors
Peirs, C., Williams, S.-P. G., Zhao, X., Walsh, C. E., Gedeon, J. Y., Cagle, N. E., Goldring, A. C., Hioki, H., Liu, Z., Marell, P. S., & Seal, R. P.
Affiliations
  • University of Pittsburgh (US)
  • Kyoto University (JP)
Corresponding author
Seal, Rebecca P.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2015-08
Volume
87
Issue
4
Pages
797-812
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2015.07.029
PMC
PMC4562334
OpenAlex
W2169382112
Cited by
327
References
51
Citations by year
2026: 19 · 2025: 17 · 2024: 21 · 2023: 30 · 2022: 34 · 2021: 34 · 2020: 40 · 2019: 36 · 2018: 36 · 2017: 34 · 2016: 22 · 2015: 3
FWCI
23.33
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion, cc-by)
Funders
  • National Institutes of Health (UL1TR000005)
  • Japan Society for the Promotion of Science (15K14333, 15H01430)
  • National Institute of Neurological Disorders and Stroke (NS084191, T32NS007433, R21NS084191)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
dorsal horn, mechanical allodynia, mechanical hypersensitivity, VGLUT3, glutamate uptake, lamina II, nociceptive circuits, neuropathic pain, inflammatory pain, chronic pain
MeSH terms
Animals, Hyperalgesia, Nerve Net, Organ Culture Techniques, Pain, Touch, Mice, Knockout, Amino Acid Transport Systems, Acidic, Mice, Spinal Cord Dorsal Horn

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