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Cited by 47Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

Dynorphin and its role in alcohol use disorder

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Karkhanis, Anushree N., Al-Hasani, Ream·2020·Brain Research
DOI 10.1016/j.brainres.2020.146742PMC PMC7111141
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Abstract

The dynorphin / kappa opioid receptor (KOR) system has been implicated in many aspects that influence neuropsychiatric disorders. Namely, this system modulates neural circuits that primarily regulate reward seeking, motivation processing, stress responsivity, and pain sensitivity, thus affecting the development of substance and alcohol use disorder (AUD). The effects of this system are often bidirectional and depend on projection targets. To date, a majority of the studies focusing on this system have examined the KOR function using agonists and antagonists. Indeed, there are studies that have examined prodynorphin and dynorphin levels by measuring mRNA and tissue content levels; however, static levels of the neuropeptide and its precursor do not explain complete and online function of the peptide as would be explained by measuring dynorphin transmission in real time. New and exciting methods using optogenetics, chemogenetics, genetic sensors, fast scan cyclic voltammetry are now being developed to detect various neuropeptides with a focus on opioid peptides, including dynorphin. In this review we discuss studies that examine dynorphin projections in areas involved in AUD, its functional involvement in AUD and vulnerability to develop AUD at various ages. Moreover, we discuss dynorphin's role in promoting AUD by dysregulation motivation circuits and how advancements in opioid peptide detection will further our understanding.

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  • Dynorphin has long been known to be activated by chronic psychostimulant and opioid administration and self-administration and alcohol self-administration.

    “It has long been known to be activated by chronic psychostimulant and opioid administration and self-administration (Nestler, 2004;Koob, 2008) and alcohol self-administration (Karkhanis and Al-Hasani, 2020).”

    From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Karkhanis and Al-Hasani, 2020

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Sorted by citations

Authors
Karkhanis, A. N., & Al-Hasani, R.
Affiliations
Binghamton University (US)
Corresponding author
Karkhanis, Anushree N.
ORCID
Karkhanis, Anushree N.
Venue
Brain Research
Publisher
Elsevier BV
Published
2020-05
Volume
1735
Pages
146742
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2020.146742
PMC
PMC7111141
OpenAlex
W3007183115
Cited by
47
References
14
Citations by year
2026: 3 · 2025: 5 · 2024: 13 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 1
FWCI
0.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse
  • National Institute on Alcohol Abuse and Alcoholism
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
dynorphin, kappa opioid receptor, alcoholism, prodynorphin, opioid peptides, motivation, reward seeking, stress responsivity, pain sensitivity, fast-scan cyclic voltammetry, chemogenetics, optogenetics, addiction vulnerability
MeSH terms
Alcoholism, Animals, Dynorphins, Humans, Motivation, Neuropeptides, Reward, Receptors, Opioid, kappa

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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