The state of the orbitofrontal cortex
Open accessAbstract
State representation is fundamental to behavior. However, identifying the true state of the world is challenging when explicit cues are ambiguous. Here, Bradfield and colleagues show that the medial OFC is critical for using associative information to discriminate ambiguous states.
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Cites
Cognitive maps in rats and men
Tolman, E. C. (1948) · Psychological Review · doi:10.1037/h0061626 · Cited by 6,641 · see citing works
Orbitofrontal Cortex as a Cognitive Map of Task Space
Wilson, R. C., Takahashi, Y. K., Schoenbaum, G., & Niv, Y. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.005 · Cited by 885 · see citing works
Self-citationContext, learning, and extinction
Gershman, S. J., Blei, D. M., & Niv, Y. (2010) · Psychological Review · doi:10.1037/a0017808 · Cited by 386 · cited 1× · see citing works
“Yet an appreciation of the contribution of prediction errors to segregating learning between different inferred states (Gershman et al., 2010) indicates that for extinction to be effective it must be conducted under circumstances—a state—similar to the original learning, otherwise the relevant…”
BackgroundSelf-citationOrbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning
Ostlund, S. B., & Balleine, B. W. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5443-06.2007 · Cited by 379 · cited 1× · see citing works
“While this deficit differs from the effects of medial OFC damage reported here, it is remarkably similar to the effects of damage to the lateral OFC, which are often not evident until contingencies change (Ostlund and Balleine, 2007; Riceberg and Shapiro, 2012; Schoenbaum et al., 2002).”
ResultOrbitofrontal lesions in rats impair reversal but not acquisition of go, no-go odor discriminations
Schoenbaum, G. M., Nugent, S. L., Saddoris, M. P., & Setlow, B. (2002) · Neuroreport · doi:10.1097/00001756-200205070-00030 · Cited by 320 · see citing works
Self-citationBradfield, L. A., Bertran‐Gonzalez, J., Chieng, B. C. H., & Balleine, B. W. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.039 · Cited by 307 · see citing works
Model-based choices involve prospective neural activity
Doll, B. B., Duncan, K., Simon, D. A., Shohamy, D., & Daw, N. (2015) · Nature Neuroscience · doi:10.1038/nn.3981 · Cited by 284 · see citing works
Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex
Takahashi, Y. K., Roesch, M. R., Wilson, R. C., Toreson, K., O'Donnell, P., Niv, Y., & Schoenbaum, G. (2011) · Nature Neuroscience · doi:10.1038/nn.2957 · Cited by 280 · see citing works
Self-citationMedial Orbitofrontal Cortex Mediates Outcome Retrieval in Partially Observable Task Situations
Bradfield, L. A., Dezfouli, A., van Holstein, M., Chieng, B. C. H., & Balleine, B. W. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.044 · Cited by 206 · see citing works
Effect of reinforcer devaluation on discriminative control of instrumental behavior.
Colwill, R. M., & Rescorla, R. A. (1990) · PubMed · Cited by 163 · see citing works
Gradual extinction prevents the return of fear: implications for the discovery of state
Gershman, S. J., Jones, C. E., Norman, K. A., Monfils, M.-H., & Niv, Y. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00164 · Cited by 160 · see citing works
Self-citationKlein-Flügge, M. C., Barron, H. C., Brodersen, K. H., Dolan, R. J., & Behrens, T. E. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2532-12.2013 · Cited by 128 · see citing works
Effect of reinforcer devaluation on discriminative control of instrumental behavior.
Colwill, R. M., & Rescorla, R. A. (1990) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.16.1.40 · Cited by 94 · see citing works
Reward Stability Determines the Contribution of Orbitofrontal Cortex to Adaptive Behavior
Riceberg, J. S., & Shapiro, M. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0776-12.2012 · Cited by 68 · see citing works
How Did the Chicken Cross the Road? With Her Striatal Cholinergic Interneurons, Of Course
Schoenbaum, G. M., Stalnaker, T. A., & Niv, Y. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.033 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Colwill RM Rescorla RA 1990 J Exp Psychol Anim Behav Process 16 40 47 2303793
Cited by
Sorted by citations
The orbitofrontal cortex: reward, emotion and depression
Rolls, E. T., Cheng, W., & Feng, J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa196 · Cited by 474 · see citing works
- Authors
- Sharpe, M. J., Wikenheiser, A. M., Niv, Y., & Schoenbaum, G.
- Affiliations
- National Institute on Drug Abuse (US)
- Princeton University (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Sharpe, Melissa J.
- Schoenbaum, Geoffrey
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 88
- Issue
- 6
- Pages
- 1075-1077
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5541257
- OpenAlex
- W2198032813
- Cited by
- 21
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 3 · 2017: 2 · 2016: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 DA999999)
- National Institute on Drug Abuse (ZIADA000587)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- orbitofrontal cortex, state representation, ambiguity, associative learning, decision-making, state discrimination
- MeSH terms
- Animals, Choice Behavior, Male, Psychomotor Performance, Reward, Prefrontal Cortex
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