Axon degeneration mechanisms: Commonality amid diversity

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Axonal transection in the lesions of multiple sclerosis

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works

Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042 · see citing works

Axonal damage in acute multiple sclerosis lesions

Ferguson, B. (1997) · Brain · doi:10.1093/brain/120.3.393 · Cited by 1,532 · see citing works

Death by design: apoptosis, necrosis and autophagy

Edinger, A. L., & Thompson, C. B. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.011 · Cited by 1,364 · see citing works

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

Fischer, L. R., Culver, D. G., Tennant, P., Davis, A. A., Wang, M.-S., Castellano-Sanchez, A. A., Khan, J., Polak, M. A., & Glass, J. D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2003.10.004 · Cited by 1,338 · see citing works

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214 · see citing works

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060 · see citing works

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036 · see citing works

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

Sirén, A., Fratelli, M., Brines, M. L., Goemans, C. G., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C. H., Pasquali, C., Capobianco, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051606598 · Cited by 1,019 · see citing works

XX. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres

Waller, A. V. (1850) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1850.0021 · Cited by 889 · see citing works

Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin

Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889 · see citing works

Molecular motors and mechanisms of directional transport in neurons

Hirokawa, N., & Takemura, R. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1624 · Cited by 830 · see citing works

Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1Bβ

Zhao, C., Takita, J., Tanaka, Y., Setou, M., Nakagawa, T., Takeda, S., Yang, H. W., Terada, S., Nakata, T., Takei, Y., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00363-4 · Cited by 765 · see citing works

Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport

Hafezparast, M., Klocke, R., Ruhrberg, C., Marquardt, A., Ahmad‐Annuar, A., Bowen, S., Lalli, G., Witherden, A. S., Hummerich, H., Nicholson, S. J., et al. (2003) · Science · doi:10.1126/science.1083129 · Cited by 684 · see citing works

Axonal Self-Destruction and Neurodegeneration

Raff, M., Whitmore, A., & Finn, J. (2002) · Science · doi:10.1126/science.1068613 · Cited by 670 · see citing works

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

Lunn, E. R., Perry, V. H., Brown, M. C., Rosen, H., & Gordon, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00771.x · Cited by 646 · see citing works

Toward an understanding of the molecular mechanisms of physiological cell death.

Vaux, D. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.786 · Cited by 615 · see citing works

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

Mack, T. G. A., Reiner, M., Beirowski, B., Mi, W., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., et al. (2001) · Nature Neuroscience · doi:10.1038/nn770 · Cited by 611 · see citing works

In vivo imaging of axonal degeneration and regeneration in the injured spinal cord

Kerschensteiner, M., Schwab, M. E., Lichtman, J. W., & Misgeld, T. (2005) · Nature Medicine · doi:10.1038/nm1229 · Cited by 582 · see citing works

β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury

Gentleman, S. M., Nash, M. J., Sweeting, C. J., Graham, D. I., & Roberts, G. W. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90398-5 · Cited by 570 · see citing works

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561 · see citing works

A Kinesin Heavy Chain (KIF5A) Mutation in Hereditary Spastic Paraplegia (SPG10)

Reid, E., Kloos, M. T., Ashley‐Koch, A. E., Hughes, L., Bevan, S., Svenson, I. K., Graham, F. L., Gaskell, P. C., Dearlove, A., Pericak‐Vance, M. A., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/344210 · Cited by 540 · see citing works

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

Saigoh, K., Wang, Y., Suh, J., Yamanishi, T., Sakai, Y., Kiyosawa, H., Harada, T., Ichihara, N., Wakana, S., Kikuchi, T., et al. (1999) · Nature Genetics · doi:10.1038/12647 · Cited by 501 · see citing works

Axonal damage: a key predictor of outcome in human CNS diseases

Medana, I. M., & Esiri, M. M. (2003) · Brain · doi:10.1093/brain/awg061 · Cited by 465 · see citing works

Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Na v 1.2 and Na v 1.6 sodium channels and Na + /Ca 2 + exchanger

Craner, M. J., Newcombe, J., Black, J. A., Hartle, C., Cuzner, M. L., & Waxman, S. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402765101 · Cited by 446 · see citing works

On the degeneration of rat neuromuscular junctions after nerve section

Miledi, R., & Slater, C. R. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009076 · Cited by 425 · see citing works

Axon pathology in Parkinson’s disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein

Galvin, J. E., Uryu, K., Lee, V. M. ‐., & Trojanowski, J. Q. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13450 · Cited by 422 · see citing works

Axon pathology in neurological disease: a neglected therapeutic target

Coleman, M. P., & Perry, V. H. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02255-5 · Cited by 383 · see citing works

ULTRASTRUCTURAL STUDIES OF THE DYING-BACK PROCESS

Schaumburg, H. H., Wı́sniewski, H. M., & Spencer, P. S. (1974) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197404000-00006 · Cited by 366 · see citing works

Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice

He, L., Li, S.-H., Yu, Z.-X., Shelbourne, P., & Li, X. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08473.2001 · Cited by 359 · see citing works

Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage

Libby, R. T., Li, Y., Savinova, O. V., Barter, J. W., Smith, R. S., Nickells, R. W., & John, S. W. M. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010004 · Cited by 358 · see citing works

A local mechanism mediates NAD-dependent protection of axon degeneration

Wang, J., Zhai, Q., Chen, Y., Lin, E., Gu, W., McBurney, M. W., & He, Z. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504028 · Cited by 352 · see citing works

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia

Edgar, J. M., McLaughlin, M., Yool, D., Zhang, S.-C., Fowler, J. H., Montague, P., Barrie, J. A., McCulloch, M. C., Duncan, I. D., Garbern, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312012 · Cited by 328 · see citing works

Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian Degeneration

Zhai, Q., Wang, J., Kim, A., Liu, Q., Watts, R. J., Hoopfer, E. D., Mitchison, T. J., Luo, L., & He, Z. (2003) · Neuron · doi:10.1016/s0896-6273(03)00429-x · Cited by 322 · see citing works

General mechanisms of axonal damage and its prevention

Stys, P. K. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.031 · Cited by 314 · see citing works

Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice under TET Control

Hasan, M. T., Friedrich, R., Euler, T., Larkum, M., Giese, G., Both, M., Duebel, J., Waters, J., Bujard, H., Griesbeck, O., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020163 · Cited by 299 · see citing works

The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves

Beirowski, B., Adalbert, R., Wagner, D. A., Grumme, D., Addicks, K., Ribchester, R. R., & Coleman, M. P. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-6 · Cited by 294 · see citing works

Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics

Stys, P. K. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199801000-00002 · Cited by 286 · see citing works

Ultrastructural Studies of the Dying-Back Process

Spencer, P. S., & Schaumburg, H. H. (1977) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197703000-00005 · Cited by 272 · see citing works

Blockers of sodium and calcium entry protect axons from nitric oxide‐mediated degeneration

Kapoor, R., Davies, M., Blaker, P. A., Hall, S. M., & Smith, K. J. (2002) · Annals of Neurology · doi:10.1002/ana.10443 · Cited by 252 · see citing works

A <i>Ufd2/D4Cole1e</i> chimeric protein and overexpression of <i>Rbp7</i> in the slow Wallerian degeneration ( <i>Wld</i> ^S ) mouse

Conforti, L., Tarlton, A., Mack, T. G. A., Mi, W., Buckmaster, E. A., Wagner, D., Perry, V. H., & Coleman, M. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11377 · Cited by 251 · see citing works

TRANSIENT, FOCAL ACCUMULATION OF AXONAL MITOCHONDRIA DURING THE EARLY STAGES OF WALLERIAN DEGENERATION

Webster, H. D. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.12.2.361 · Cited by 249 · see citing works

Erythropoietin both protects from and reverses experimental diabetic neuropathy

Bianchi, R., Büyükakıllı, B., Brines, M. L., Savino, C., Cavaletti, G., Oggioni, N., Lauria, G., Borgna, M., Lombardi, R., Çimen, B., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307823100 · Cited by 247 · see citing works

Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases

Finn, J. T., Weil, M., Archer, F., Siman, R., Srinivasan, A. N., & RAFF, M. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01333.2000 · Cited by 241 · see citing works

Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE

Craner, M. (2004) · Brain · doi:10.1093/brain/awh032 · Cited by 235 · see citing works

Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage

Adle‐Biassette, Chrétien, Wingertsmann, Hery, H., Ereau, Scaravilli, Tardieu, & Gray (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00167.x · Cited by 233 · see citing works

Traumatic Axonal Injury Induces Proteolytic Cleavage of the Voltage-Gated Sodium Channels Modulated by Tetrodotoxin and Protease Inhibitors

Iwata, A., Stys, P., Wolf, J., Chen, X.-H., Taylor, A. G., Meaney, D., & Smith, D. H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0515-03.2004 · Cited by 233 · see citing works

Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease

Ferri, A., Sanes, J. R., Coleman, M. P., Cunningham, J. M., & Kato, A. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00206-9 · Cited by 221 · see citing works

Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve

Schlaepfer, W. W. (1974) · Brain Research · doi:10.1016/0006-8993(74)90002-x · Cited by 212 · see citing works

Neurofilament functions in health and disease

Julien, J. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00004-5 · Cited by 209 · see citing works

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

Sagot, Y., Dubois‐Dauphin, M., Tan, S., de Bilbao, F., Aebischer, P., Martinou, J., & Kato, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07727.1995 · Cited by 202 · see citing works

Early course of wallerian degeneration in myelinated fibres of the rat phrenic nerve

Lubińska, L. (1977) · Brain Research · doi:10.1016/0006-8993(77)90841-1 · Cited by 192 · see citing works

Axonal protection using flecainide in experimental autoimmune encephalomyelitis

Bechtold, D. A., Kapoor, R., & Smith, K. J. (2004) · Annals of Neurology · doi:10.1002/ana.20045 · Cited by 192 · see citing works

Depolarization-Induced Ca2+ Release in Ischemic Spinal Cord White Matter Involves L-type Ca2+ Channel Activation of Ryanodine Receptors

Ouardouz, M., Nikolaeva, M. A., Coderre, E., Zamponi, G. W., McRory, J. E., Trapp, B. D., Yin, X., Wang, W., Woulfe, J., & Stys, P. K. (2003) · Neuron · doi:10.1016/j.neuron.2003.08.016 · Cited by 191 · see citing works

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Brendza, R. P., Bacskai, B. J., Cirrito, J. R., Simmons, K. A., Skoch, J. M., Klunk, W. E., Mathis, C. A., Bales, K. R., Paul, S. M., Hyman, B. T., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23269 · Cited by 190 · see citing works

Microanatomy of Axon/Glial Signaling during Wallerian Degeneration

Guertin, A. D., Zhang, D. P., Mak, K. S., Alberta, J. A., & Kim, H. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3766-04.2005 · Cited by 188 · see citing works

An 85-kb tandem triplication in the slow Wallerian degeneration ( Wld s ) mouse

Coleman, M. P., Conforti, L., Buckmaster, E. A., Tarlton, A., Ewing, R. M., Brown, M. C., Lyon, M. F., & Perry, V. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9985 · Cited by 188 · see citing works

Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis

Kornek, B. (2001) · Brain · doi:10.1093/brain/124.6.1114 · Cited by 185 · see citing works

Mechanism of Calcium Entry during Axon Injury and Degeneration

LoPachin, R. M., & Lehning, E. J. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8106 · Cited by 162 · see citing works

Evidence that Very Slow Wallerian Degeneration in C57BL/Ola Mice is an Intrinsic Property of the Peripheral Nerve

Perry, V. H., Brown, M. C., Lunn, E. R., Tree, P., & Gordon, S. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00472.x · Cited by 161 · see citing works

A missense mutation in Tbce causes progressive motor neuronopathy in mice

Martín, N., Jaubert, J., Gounon, P., SALIDO, E. C., Haase, G., Szatanik, M., & Guénet, J. (2002) · Nature Genetics · doi:10.1038/ng1016 · Cited by 159 · see citing works

TheWldsMutation Delays Robust Loss of Motor and Sensory Axons in a Genetic Model for Myelin-Related Axonopathy

Samsam, M., Mi, W., Wessig, C., Zielasek, J., Toyka, K. V., Coleman, M. P., & Martini, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02833.2003 · Cited by 153 · see citing works

Neurites Can Remain Viable after Destruction of the Neuronal Soma by Programmed Cell Death (Apoptosis)

Deckwerth, T. L., & Johnson, E. M. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1234 · Cited by 152 · see citing works

The 'dying back' process. A common denominator in many naturally occurring and toxic neuropathies.

Jb, C. (1979) · PubMed · Cited by 151 · see citing works

A novel endogenous erythropoietin mediated pathway prevents axonal degeneration

Keswani, S. C., Buldanlioğlu, U., Fischer, A., Reed, N., Polley, M., Hong, L. L., Zhou, C., Jack, C., Leitz, G. J., & Höke, A. (2004) · Annals of Neurology · doi:10.1002/ana.20285 · Cited by 150 · see citing works

Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons

Burne, J. F., Staple, J., & RAFF, M. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02064.1996 · Cited by 150 · see citing works

CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS

Rasband, M. N., Tayler, J. E., Kaga, Y., Yang, Y., Lappe-Siefke, C., Nave, K., & Bansal, R. (2005) · Glia · doi:10.1002/glia.20165 · Cited by 149 · see citing works

Wlds mice are resistant to paclitaxel (taxol) neuropathy

Wang, M. S., Davis, A. A., Culver, D. G., & Glass, J. D. (2002) · Annals of Neurology · doi:10.1002/ana.10300 · Cited by 146 · see citing works

Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury

Stone, J. R., Okonkwo, D. O., Diallo, A. O., Rubin, D. G., Mutlu, L. K., Povlishock, J. T., & Helm, G. A. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.022 · Cited by 145 · see citing works

Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease

Sajadi, A., Schneider, B. L., & Aebischer, P. (2004) · Current Biology · doi:10.1016/j.cub.2004.01.053 · Cited by 142 · see citing works

Structural alterations of peripheral nerve induced by the calcium ionophore A23187

Schlaepfer, W. W. (1977) · Brain Research · doi:10.1016/0006-8993(77)90126-3 · Cited by 142 · see citing works

Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axon

Glass, J. D., Brushart, T. M. E., George, E. B., & Griffin, J. W. (1993) · Journal of Neurocytology · doi:10.1007/bf01195555 · Cited by 140 · see citing works

Drug development for stroke: importance of protecting cerebral white matter

Dewar, D., Yam, P. S., & McCulloch, J. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00280-0 · Cited by 126 · see citing works

Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice

Beirowski, B., Berek, L., Adalbert, R., Wagner, D. A., Grumme, D., Addicks, K., Ribchester, R. R., & Coleman, M. P. (2003) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.10.016 · Cited by 122 · see citing works

Focal Lesions in the Rat Central Nervous System Induced by Endothelin-1

Hughes, P., Anthony, D. C., Rudin, M., Botham, M. S., Rankine, E. L., Sablone, M., Kindler, D., Mir, A. K., & Perry, V. H. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1276 · Cited by 119 · see citing works

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.

Fern, R. F., Ransom, B. R., Stys, P. K., & Waxman, S. G. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39449-8 · Cited by 118 · see citing works

Calpain inhibition protects against Taxol-induced sensory neuropathy

Wang, M. S. (2003) · Brain · doi:10.1093/brain/awh078 · Cited by 116 · see citing works

The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice

Mi, W. (2004) · Brain · doi:10.1093/brain/awh368 · Cited by 115 · see citing works

The effect of myelinating Schwann cells on axons

Martini, R. (2001) · Muscle & Nerve · doi:10.1002/mus.1027 · Cited by 113 · see citing works

The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse

Fischer, L. R., Culver, D. G., Davis, A. A., Tennant, P., Wang, M.-S., Coleman, M. P., Asress, S., Adalbert, R., Alexander, G. M., & Glass, J. D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.008 · Cited by 111 · see citing works

The spatio-temporal pattern of Wallerian degeneration in mammalian peripheral nerves

Donat, J. R., & ́niewski, H. M. W. (1973) · Brain Research · doi:10.1016/0006-8993(73)90765-8 · Cited by 110 · see citing works

Organophosphorous neuropathy. I. A teased-fiber study of the spatio-temporal spread of axonal degeneraion.

Bouldin, T. W., & Cavanagh, J. (1979) · PubMed · Cited by 108 · see citing works

Non-apoptotic neurite degeneration in apoptotic neuronal death: pivotal role of mitochondrial function in neurites.

Ikegami, K., & Koike, T. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.057 · Cited by 105 · see citing works

Age‐Dependent Synapse Withdrawal at Axotomised Neuromuscular Junctions in Wlds Mutant and Ube4b/Nmnat Transgenic Mice

Gillingwater, T. H., Thomson, D., Mack, T. G. A., Soffin, E. M., Mattison, R. J., Coleman, M. P., & Ribchester, R. R. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022343 · Cited by 91 · see citing works

Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI

Hains, B. C., Saab, C. Y., Lo, A., & Waxman, S. G. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.04.001 · Cited by 90 · see citing works

A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses

Adalbert, R., Gillingwater, T. H., Haley, J. E., Bridge, K., Beirowski, B., Berek, L., Wagner, D. A., Grumme, D., Thomson, D., Çelik, A., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03833.x · Cited by 86 · see citing works

The proximo-distal spread of axonal degeneration in the dorsal columns of the rat

George, R., & Griffin, J. W. (1994) · Journal of Neurocytology · doi:10.1007/bf01181641 · Cited by 83 · see citing works

Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis

Lo, A., Black, J. A., & Waxman, S. G. (2002) · Neuroreport · doi:10.1097/00001756-200210280-00015 · Cited by 83 · see citing works

The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration

Whitmore, A. V., Lindsten, T., RAFF, M. C., & Thompson, C. B. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401147 · Cited by 82 · see citing works

The pattern of axonal degeneration in the peripheral nervous system varies with different types of lesion

Lunn, E. R., Brown, M. C., & Perry, V. H. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90130-v · Cited by 81 · see citing works

Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

Berliocchi, L., Fava, E., Leist, M., Horvat, V., Dinsdale, D. D., Read, D., & Nicotera, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200406126 · Cited by 81 · see citing works

Cerebral white matter damage in HIV infection demonstrated using β-amyloid precursor protein immunoreactivity

Raja, F., Sherriff, F. E., Morris, C. S., Bridges, L., & Esiri, M. M. (1997) · Acta Neuropathologica · doi:10.1007/s004010050601 · Cited by 78 · see citing works

Changes at the nodes of ranvier during wallerian degeneration: an electron microscope study

Ballin, R. H. M., & Thomas, P. K. (1969) · Acta Neuropathologica · doi:10.1007/bf00685303 · Cited by 77 · see citing works

The gene for slow Wallerian degeneration (Wld(s)) is also protective against vincristine neuropathy.

Wang, M.-S., Wu, Y., Culver, D. G., & Glass, J. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0334 · Cited by 77 · see citing works

Neurites undergoing Wallerian degeneration show an apoptotic-like process with annexin V positive staining and loss of mitochondrial membrane potential

Sievers, C., Platt, N., Perry, V. H., Coleman, M. P., & Conforti, L. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00039-7 · Cited by 73 · see citing works

Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis

Brand‐Schieber, E., & Werner, P. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.023 · Cited by 73 · see citing works

Axonal protection in experimental autoimmune neuritis by the sodium channel blocking agent flecainide

Bechtold, D. A. (2004) · Brain · doi:10.1093/brain/awh328 · Cited by 73 · see citing works

The Neuroprotective Factor Wlds Does Not Attenuate Mutant SOD1-Mediated Motor Neuron Disease

Velde, C. V., Garcia, M. L., Yin, X., Trapp, B. D., & Cleveland, D. W. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:3:193 · Cited by 73 · see citing works

Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene

Sasaki, S., Warita, H., Abe, K., & Iwata, M. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1021-9 · Cited by 72 · see citing works

Axonal degeneration promotes abnormal accumulation of amyloid β-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse

Ichihara, N., Wu, J., Hua Chui, D., Yamazaki, K., Wakabayashi, T., & Kikuchi, T. (1995) · Brain Research · doi:10.1016/0006-8993(95)00729-a · Cited by 70 · see citing works

Neuroprotection after Transient Global Cerebral Ischemia in Wld ^s Mutant Mice

Gillingwater, T. H., Haley, J. E., Ribchester, R. R., & Horsburgh, K. (2004) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1097/01.wcb.0000095798.98378.34 · Cited by 68 · see citing works

Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway

MacInnis, B. L., & Campenot, R. B. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.10.003 · Cited by 67 · see citing works

Erythropoietin is neuroprotective in models of HIV sensory neuropathy

Keswani, S. C., Leitz, G. J., & Höke, A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.080 · Cited by 67 · see citing works

Deconstructing the axon: Wallerian degeneration and the ubiquitin–proteasome system

Ehlers, M. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.10.015 · Cited by 66 · see citing works

The Rate of Wallerian Degeneration in Cultured Neurons from Wild Type and C57BL/WldS Mice Depends on Time in Culture and may be Extended in the Presence of Elevated K+ Levels

Buckmaster, E. A., Perry, V. H., & Brown, M. C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01155.x · Cited by 61 · see citing works

Neuroaxonal pathology in Creutzfeldt-Jakob disease

Liberski, P. P., & Budka, H. (1999) · Acta Neuropathologica · doi:10.1007/s004010050995 · Cited by 53 · see citing works

Axonal degeneration in multiple sclerosis: Is it time for neuroprotective strategies?

Stys, P. K. (2004) · Annals of Neurology · doi:10.1002/ana.20082 · Cited by 52 · see citing works

Wallerian Degeneration Involves Rho/Rho-kinase Signaling

Yamagishi, S., Fujitani, M., Hata, K., Kitajo, K., Mimura, F., Abe, H., & Yamashita, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501945200 · Cited by 42 · see citing works

The Effect of Traumatic Brain Injury on the Visual System: A Morphologic Characterization of Reactive Axonal Change

Cheng, C. L. Y., & Povlishock, J. T. (1988) · Journal of Neurotrauma · doi:10.1089/neu.1988.5.47 · Cited by 42 · see citing works

Evidence of axonal damage in human acute demyelinating diseases

Ghosh, N., DeLuca, G. C., & Esiri, M. M. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.03.032 · Cited by 41 · see citing works

Programmed Axon Death, Synaptic Dysfunction and the Ubiquitin Proteasome System

Coleman, M. P., & Ribchester, R. R. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337436 · Cited by 40 · see citing works

Changes in intra‐axonal calcium distribution following nerve crush

Mata, M. M., Staple, J. K., & Fink, D. J. (1986) · Journal of Neurobiology · doi:10.1002/neu.480170508 · Cited by 40 · see citing works

Sodium channel blockers and axonal protection in neuroinflammatory disease

Waxman, S. G. (2004) · Brain · doi:10.1093/brain/awh353 · Cited by 34 · see citing works

The cellular distribution of the Wlds chimeric protein and its constituent proteins in the CNS

Fang, C., Bernardes-Silva, M., Coleman, M. P., & Perry, V. H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.078 · Cited by 27 · see citing works

Neuroprotective strategies in MS: Lessons from C57BL/WldS mice

Coleman, M. P., Adalbert, R., & Beirowski, B. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.028 · Cited by 24 · see citing works

N-alpha-p-tosyl-l-lysine chloromethyl ketone (TLCK) suppresses neuritic degeneration caused by different experimental paradigms including in vitro Wallerian degeneration

Ikegami, K., Kato, S., & Koike, T. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.050 · Cited by 22 · see citing works

Use of YFP to study amyloid-β associated neurite alterations in live brain slices

Brendza, R. P. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.008 · Cited by 21 · see citing works

Dystrophic neurites are associated with early stage extracellular neurofibrillary tangles in the parkinsonism-dementia complex of Guam

Schwab, C., Steele, J. C., & McGeer, P. L. (1997) · Acta Neuropathologica · doi:10.1007/s004010050737 · Cited by 18 · see citing works

Nerve destruction by colchicine resulting in suppression of limb regeneration in adult triturus

Singer, M., Flinker, D., & Sidman, R. L. (1956) · Journal of Experimental Zoology · doi:10.1002/jez.1401310306 · Cited by 12 · see citing works

The node of ranvier in early wallerian degeneration: A freeze-fracture study

Abrahams, P., Day, A., & Allt, G. (1981) · Acta Neuropathologica · doi:10.1007/bf00689401 · Cited by 12 · see citing works

Untitled work

Nolte (2001) · doi:10.1002/1098-1136(20010101)33:1

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

NAD ⁺ /NADH and NADP ⁺ /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

Ying, W. (2008) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494 · see citing works

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047 · see citing works

Clinical progression in Parkinson disease and the neurobiology of axons

Cheng, H., Ulane, C. M., & Burke, R. E. (2010) · Annals of Neurology · doi:10.1002/ana.21995 · Cited by 1,012 · see citing works

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

Houtkooper, R. H., Cantó, C., Wanders, R. J., & Auwerx, J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0026 · Cited by 899 · see citing works

‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease

Chan, C. S., Guzmán, J. N., Ilijić, E., Mercer, J. N., Rick, C., Tkatch, T., Meredith, G. E., & Surmeier, D. J. (2007) · Nature · doi:10.1038/nature05865 · Cited by 899 · see citing works

Role of Axonal Transport in Neurodegenerative Diseases

Vos, K. J. D., Grierson, A. J., Ackerley, S., & Miller, C. C. J. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.061307.090711 · Cited by 734 · see citing works

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

Nikić, I., Merkler, D., Sorbara, C., Brinkoetter, M., Kreutzfeldt, M., Bareyre, F. M., Brück, W., Bishop, D., Misgeld, T., & Kerschensteiner, M. (2011) · Nature Medicine · doi:10.1038/nm.2324 · Cited by 713 · see citing works

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701311104 · Cited by 614 · see citing works

Wallerian degeneration: an emerging axon death pathway linking injury and disease

Conforti, L., Gilley, J., & Coleman, M. P. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3680 · Cited by 611 · see citing works

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

Howell, G. R., Libby, R. T., Jakobs, T., Smith, R. S., Phalan, F. C., Barter, J. W., Barbay, J. M., Marchant, J. K., Nagaraju, M., Porciatti, V., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706181 · Cited by 593 · see citing works

Axon Physiology

Debanne, D., Campanac, E., Bialowas, A., Carlier, E., & Alcaraz, G. (2011) · Physiological Reviews · doi:10.1152/physrev.00048.2009 · Cited by 590 · see citing works

The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons

MacDonald, J. M., Beach, M. G., Porpiglia, E., Sheehan, A. E., Watts, R. J., & Freeman, M. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.028 · Cited by 523 · see citing works

Wallerian Degeneration, Wld^S, and Nmnat

Coleman, M. P., & Freeman, M. R. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153248 · Cited by 473 · see citing works

Axonal Transport Defects in Neurodegenerative Diseases

Morfini, G. A., Burns, M. R., Binder, L. I., Kanaan, N. M., LaPointe, N. E., Bosco, D. A., Brown, R. H., Brown, H. E., Tiwari, A., Hayward, L. J., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3463-09.2009 · Cited by 464 · see citing works

Mitochondrial changes within axons in multiple sclerosis

Mahad, D. J., Ziabreva, I., Campbell, G., Lax, N., White, K., Hanson, P. S., Lassmann, H., & Turnbull, D. M. (2009) · Brain · doi:10.1093/brain/awp046 · Cited by 454 · see citing works

Axon degeneration: Molecular mechanisms of a self-destruction pathway

Wang, J. T., Medress, Z. A., & Barres, B. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108111 · Cited by 441 · see citing works

Tumor Necrosis Factor-α Mediates Oligodendrocyte Death and Delayed Retinal Ganglion Cell Loss in a Mouse Model of Glaucoma

Nakazawa, T., Nakazawa, C., Matsubara, A., Noda, K., Hisatomi, T., She, H., Michaud, N. A., Hafezi‐Moghadam, A., Miller, J. W., & Benowitz, L. I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2801-06.2006 · Cited by 432 · see citing works

A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease

Sexton, C. E., Kalu, U. G., Filippini, N., Mackay, C. E., & Ebmeier, K. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.019 · Cited by 410 · see citing works

Disorganized Microtubules Underlie the Formation of Retraction Bulbs and the Failure of Axonal Regeneration

Ertürk, A., Hellal, F., Enes, J., & Bradke, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0612-07.2007 · Cited by 409 · see citing works

Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma

Buckingham, B. P., Inman, D. M., Lambert, W. S., Oglesby, E., Calkins, D. J., Steele, M. R., Vetter, M. L., Marsh‐Armstrong, N., & Horner, P. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4443-07.2008 · Cited by 408 · see citing works

Distal axonopathy with structural persistence in glaucomatous neurodegeneration

Crish, S. D., Sappington, R. M., Inman, D. M., Horner, P. J., & Calkins, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913141107 · Cited by 350 · see citing works

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain

Andres, R. H., Horie, N., Slikker, W., Keren-Gill, H., Zhan, K., Sun, G., Manley, N. C., Pereira, M. P., Sheikh, L. A., McMillan, E. L., et al. (2011) · Brain · doi:10.1093/brain/awr094 · Cited by 329 · see citing works

Neurofilaments: neurobiological foundations for biomarker applications

Gafson, A., Barthélemy, N. R., Bomont, P., Carare, R. O., Durham, H. D., Julien, J., Kühle, J., Leppert, D., Nixon, R. A., Weller, R. O., et al. (2020) · Brain · doi:10.1093/brain/awaa098 · Cited by 327 · see citing works

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis

Siffrin, V., Radbruch, H., Glumm, R., Niesner, R., Paterka, M., Herz, J., Leuenberger, T., Lehmann, S. M., Luenstedt, S., Rinnenthal, J. L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.018 · Cited by 325 · see citing works

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment

Skrobot, O. A., Attems, J., Esiri, M. M., Hortobágyi, T., Ironside, J. W., Kalaria, R. N., King, A., Lammie, G. A., Mann, D. M. A., Neal, J., et al. (2016) · Brain · doi:10.1093/brain/aww214 · Cited by 323 · see citing works

Programmed axon degeneration: from mouse to mechanism to medicine

Coleman, M. P., & Höke, A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0269-3 · Cited by 320 · see citing works

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

Gerdts, J., Summers, D. W., Milbrandt, J., & DiAntonio, A. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.023 · Cited by 318 · see citing works

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction

Bishop, P., Rocca, D. L., & Henley, J. M. (2016) · Biochemical Journal · doi:10.1042/bcj20160082 · Cited by 310 · see citing works

Mechanisms of acute axonal degeneration in the optic nerve in vivo

Knöferle, J., Koch, J. C., Ostendorf, T., Michel, U., Planchamp, V., Vutova, P., Tönges, L., Stadelmann, C., Brück, W., Bähr, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909794107 · Cited by 310 · see citing works

Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis

Stricker, N. H., Schweinsburg, B. C., Delano‐Wood, L., Wierenga, C. E., Bangen, K. J., Haaland, K. Y., Frank, L. R., Salmon, D. P., & Bondi, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.027 · Cited by 306 · see citing works

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

Calkins, D. J. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.07.001 · Cited by 305 · see citing works

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

Miller, B. R., Press, C., Daniels, R. W., Sasaki, Y., Milbrandt, J., & DiAntonio, A. (2009) · Nature Neuroscience · doi:10.1038/nn.2290 · Cited by 301 · see citing works

Bodily selves in relation: embodied simulation as second-person perspective on intersubjectivity

Gallese, V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0177 · Cited by 300 · see citing works

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

Sterky, F. H., Lee, S., Wibom, R., Olson, L., & Larsson, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103295108 · Cited by 296 · see citing works

Calcium Signaling in Neuronal Motility

Zheng, J. Q., & Poo, M.-M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123221 · Cited by 292 · see citing works

Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model

Soto, I., Oglesby, E., Buckingham, B. P., Son, J. L., Roberson, E. D. O., Steele, M. R., Inman, D. M., Vetter, M. L., Horner, P. J., & Marsh‐Armstrong, N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3714-07.2008 · Cited by 273 · see citing works

Parietal white matter lesions in Alzheimer’s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease

McAleese, K. E., Walker, L., Graham, S., Moya, E. L. J., Johnson, M. A., Erskine, D., Colloby, S. J., Dey, M., Martin-Ruiz, C. M., Taylor, J., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1738-2 · Cited by 271 · see citing works

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2320-06.2006 · Cited by 269 · see citing works

UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein

Day, I. N. M., & Thompson, R. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.020 · Cited by 263 · see citing works

Pathology of Multiple Sclerosis: Where Do We Stand?

Popescu, B. F. G., Pirko, I., & Lucchinetti, C. F. (2013) · Continuum · doi:10.1212/01.con.0000433291.23091.65 · Cited by 261 · see citing works

Mechanisms of axon degeneration: From development to disease

Saxena, S., & Caroni, P. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.07.007 · Cited by 258 · see citing works

Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

di Penta, A., Moreno, B., Reix, S., Fernández-Díez, B., Villanueva, M., Errea, O., Escala, N., Vandenbroeck, K., Comella, J. X., & Villoslada, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054722 · Cited by 258 · see citing works

Identification of E2/E3 Ubiquitinating Enzymes and Caspase Activity Regulating Drosophila Sensory Neuron Dendrite Pruning

Kuo, C. T., Zhu, S., Younger, S. H., Jan, L. Y., & Jan, Y. N. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.014 · Cited by 256 · see citing works

New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection

Haque, A., Polcyn, R., Matzelle, D. D., & Banik, N. L. (2018) · Brain Sciences · doi:10.3390/brainsci8020033 · Cited by 249 · see citing works

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M., Nascimento-Ferreira, I., Orsomando, G., Mori, V, Gilley, J., Brown, R., Janeckova, L., Vargas, M. E., Worrell, L. A., Loreto, A., et al. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.164 · Cited by 246 · see citing works

The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions

Gornstein, E. L., & Schwarz, T. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.016 · Cited by 246 · see citing works

The Axon-Myelin Unit in Development and Degenerative Disease

Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00467 · Cited by 246 · see citing works

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

Sasaki, Y., Vohra, B. P. S., Lund, F. E., & Milbrandt, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5469-08.2009 · Cited by 243 · see citing works

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.004 · Cited by 240 · see citing works

Zebrafish models of human motor neuron diseases: Advantages and limitations

Babin, P. J., Goizet, C., & Raldúa, D. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.03.001 · Cited by 228 · see citing works

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

Pigino, G. F., Morfini, G. A., Atagi, Y., Deshpande, A., Yu, C., Jungbauer, L. M., LaDu, M. J., Busciglio, J. A., & Brady, S. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901229106 · Cited by 226 · see citing works

Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction

Dubový, P. (2011) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2011.02.011 · Cited by 225 · see citing works

Parkinson’s disease as a result of aging

Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214 · see citing works

The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans

Jindahra, P., Petrie, A., & Plant, G. T. (2012) · Brain · doi:10.1093/brain/awr324 · Cited by 212 · see citing works

Protective effects and mechanisms of sirtuins in the nervous system

Zhang, F., Wang, S., Gan, L., Vosler, P. S., Gao, Y., Zigmond, M. J., & Chen, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.09.001 · Cited by 211 · see citing works

High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

Evans, T. A., Barkauskas, D. S., Myers, J., Hare, E. G., You, J., Ransohoff, R. M., Huang, A. Y.-C., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.013 · Cited by 209 · see citing works

Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery

Gaudin, R., Knipfer, C., Henningsen, A., Smeets, R., Heiland, M., & Hadlock, T. A. (2016) · BioMed Research International · doi:10.1155/2016/3856262 · Cited by 208 · see citing works

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

Barrientos, S. A., Martínez, N. W., Yoo, S., Jara, J. S., Zamorano, S., Hetz, C. A., Twiss, J. L., Álvarez, J., & Court, F. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4065-10.2011 · Cited by 207 · see citing works

Synaptic Vulnerability in Neurodegenerative Disease

Wishart, T. M., Parson, S. H., & Gillingwater, T. H. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000228202.35163.c4 · Cited by 202 · see citing works

Mechanisms of distal axonal degeneration in peripheral neuropathies

Cashman, C. R., & Höke, A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.048 · Cited by 200 · see citing works

Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging

Sun, S., Liang, H., Cross, A. H., & Song, S. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.049 · Cited by 200 · see citing works

In vivo imaging of the diseased nervous system

Misgeld, T., & Kerschensteiner, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1905 · Cited by 197 · see citing works

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca 2+ with Exposure to Hydrostatic Pressure

Sappington, R. M., Sidorova, T. N., Long, D. J., & Calkins, D. J. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2321 · Cited by 196 · see citing works

Review: Mitochondria and disease progression in multiple sclerosis

Mahad, D., Lassmann, H., & Turnbull, D. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00987.x · Cited by 193 · see citing works

Mitochondria as a central sensor for axonal degenerative stimuli

Court, F. A., & Coleman, M. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.04.001 · Cited by 193 · see citing works

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

Sasaki, Y., Nakagawa, T., Mao, X., DiAntonio, A., & Milbrandt, J. (2016) · eLife · doi:10.7554/elife.19749 · Cited by 192 · see citing works

Mechanisms of white matter damage in multiple sclerosis

Lassmann, H. (2014) · Glia · doi:10.1002/glia.22597 · Cited by 191 · see citing works

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

Yang, J. H., Weimer, R. M., Kallop, D. Y., Olsen, O., Wu, Z., Renier, N., Uryu, K., & Tessier‐Lavigne, M. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.034 · Cited by 184 · see citing works

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182 · see citing works

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Hughes, R. O., Bosanac, T., Mao, X. R., Engber, T. M., DiAntonio, A., Milbrandt, J., Devraj, R. V., & Krauss, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108588 · Cited by 181 · see citing works

Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord

Dray, C., Rougon, G., & Debarbieux, F. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900222106 · Cited by 179 · see citing works

Autophagy and Neuronal Cell Death in Neurological DisordersPreprint

Nixon, R. A., & Yang, D.-S. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008839 · Cited by 179 · see citing works

Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies

Adalbert, R., Nogradi, A., Babetto, E., Janeckova, L., Walker, S. A., Kerschensteiner, M., Misgeld, T., & Coleman, M. P. (2009) · Brain · doi:10.1093/brain/awn312 · Cited by 177 · see citing works

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease

Tonges, L., Frank, T., Tatenhorst, L., Saal, K. A., Koch, J. C., Szego, E. M., Bahr, M., Weishaupt, J. H., & Lingor, P. (2012) · Brain · doi:10.1093/brain/aws254 · Cited by 176 · see citing works

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

Yue, Z., Friedman, L. G., Komatsu, M., & Tanaka, K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.01.016 · Cited by 173 · see citing works

Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis

Vogt, J., Paul, F., Aktaş, O., Müller-Wielsch, K., Dörr, J., Dörr, S., Bharathi, B. S., Glumm, R., Schmitz, C., Steinbusch, H. W. M., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21719 · Cited by 169 · see citing works

Diffuse Axonal Injury and Oxidative Stress: A Comprehensive Review

Frati, A., Cerretani, D., Fiaschi, A. I., Frati, P., Gatto, V., Russa, R. L., Pesce, A., Pinchi, E., Santurro, A., Fraschetti, F., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122600 · Cited by 168 · see citing works

Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

Sorbara, C. D., Wagner, N. E., Ladwig, A., Nikić, I., Merkler, D., Kleele, T., Marinković, P., Naumann, R., Godinho, L., Bareyre, F. M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.006 · Cited by 167 · see citing works

Multi-system disorders of glycosphingolipid and ganglioside metabolism

Xu, Y.-H., Barnes, S., Sun, Y., & Grabowski, G. A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r003996 · Cited by 167 · see citing works

Early ultrastructural defects of axons and axon–glia junctions in mice lacking expression of Cnp1

Edgar, J. M., McLaughlin, M., Werner, H. B., McCulloch, M. C., Barrie, J. A., Brown, A. M., Faichney, A. B., Snaidero, N., Nave, K., & Griffiths, I. R. (2009) · Glia · doi:10.1002/glia.20893 · Cited by 166 · see citing works

Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity

Zhai, R. G., Cao, Y., Hiesinger, P. R., Zhou, Y., Mehta, S. Q., Schulze, K. L., Verstreken, P., & Bellen, H. J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040416 · Cited by 166 · see citing works

Collagenosis of the Deep Medullary Veins: An Underrecognized Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction?

Keith, J. L., Gao, F., Noor, R., Kiss, A., Balasubramaniam, G., Au, K., Rogaeva, E. A., Masellis, M., & Black, S. E. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx009 · Cited by 163 · see citing works

Cortical tau load is associated with white matter hyperintensities

McAleese, K. E., Firbank, M., Dey, M., Colloby, S. J., Walker, L., Johnson, M., Beverley, J. R., Taylor, J. P., Thomas, A. J., O’Brien, J. T., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0240-0 · Cited by 161 · see citing works

Aberrant Membranes and Double-Membrane Structures Accumulate in the Axons of<i>Atg5</i>-Null Purkinje Cells before Neuronal Death

Nishiyama, J., Miura, E., Mizushima, N., Watanabe, M., & Yuzaki, M. (2007) · Autophagy · doi:10.4161/auto.4964 · Cited by 159 · see citing works

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Tsika, E., Glauser, L., Moser, R., Fiser, A., Daniel, G., Sheerin, U.-M., Lees, A., Troncoso, J. C., Lewis, P. A., Bandopadhyay, R., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu178 · Cited by 159 · see citing works

Protecting Axonal Degeneration by Increasing Nicotinamide Adenine Dinucleotide Levels in Experimental Autoimmune Encephalomyelitis Models

Kaneko, S., Wang, J., Kaneko, M., Yiu, G. C., Hurrell, J., Chitnis, T., Khoury, S. J., & He, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2116-06.2006 · Cited by 159 · see citing works

PLD3 affects axonal spheroids and network defects in Alzheimer’s disease

Yuan, P., Zhang, M., Tong, L., Morse, T. M., McDougal, R. A., Ding, H., Chan, D., Cai, Y., & Grutzendler, J. (2022) · Nature · doi:10.1038/s41586-022-05491-6 · Cited by 155 · see citing works

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration<i>In Vivo</i>

Sasaki, Y., Vohra, B. P. S., Baloh, R. H., & Milbrandt, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1429-09.2009 · Cited by 152 · see citing works

Methamphetamine Causes Degeneration of Dopamine Cell Bodies and Terminals of the Nigrostriatal Pathway Evidenced by Silver Staining

Ares‐Santos, S., Granado, N., Espadas, I., Martínez‐Murillo, R., & Moratalla, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.307 · Cited by 151 · see citing works

Tumor Necrosis Factor-α Concentrations in the Aqueous Humor of Patients with Glaucoma

Sawada, H., Fukuchi, T., Tanaka, T., & Abe, H. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4247 · Cited by 151 · see citing works

Axonal Degeneration in Motor Neuron Disease

Fischer, L. R., & Glass, J. D. (2007) · Neurodegenerative Diseases · doi:10.1159/000107704 · Cited by 150 · see citing works

In vivo correlation between axon diameter and conduction velocity in the human brain

Horowitz, A., Barazany, D., Tavor, I., Bernstein, M., Yovel, G., & Assaf, Y. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0871-0 · Cited by 149 · see citing works

Neuronal death: where does the end begin?

Conforti, L., Adalbert, R., & Coleman, M. P. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.02.004 · Cited by 148 · see citing works

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases

Ryu, K. W., Kim, D.-S., & Kraus, W. L. (2015) · Chemical Reviews · doi:10.1021/cr5004248 · Cited by 147 · see citing works

Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression

Fieremans, E., Benitez, A. M., Jensen, J. H., Falangola, M. F., Tabesh, A., Deardorff, R. L., Spampinato, M. V., Babb, J. S., Novikov, D. S., Ferris, S. H., et al. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3553 · Cited by 147 · see citing works

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

Gallardo, G., Schlüter, O. M., & Südhof, T. C. (2008) · Nature Neuroscience · doi:10.1038/nn2058 · Cited by 145 · see citing works

Mechanically-induced membrane poration causes axonal beading and localized cytoskeletal damage

Kilinc, D., Gallo, G., & Barbee, K. A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.025 · Cited by 144 · see citing works

Autophagy in axonal and dendritic degeneration

Yang, Y., Coleman, M. P., Zhang, L., Zheng, X., & Yue, Z. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.001 · Cited by 144 · see citing works

Early Neurodegeneration Progresses Independently of Microglial Activation by Heparan Sulfate in the Brain of Mucopolysaccharidosis IIIB Mice

Ausseil, J., Desmaris, N., Bigou, S., Attali, R., Corbineau, S., Vitry, S., Parent, M., Cheillan, D., Fuller, M., Maire, I., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002296 · Cited by 142 · see citing works

Acquired axonal degeneration and regeneration

Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001601 · Cited by 23 · see citing works

Axon degeneration: Molecular mechanisms of a self-destruction pathway

Wang, J. T., Medress, Z. A., & Barres, B. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108111 · Cited by 441 · see citing works

Axonal degeneration as a therapeutic target in the CNS

Lingor, P., Koch, J. C., Tönges, L., & Bähr, M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1362-3 · Cited by 119 · see citing works

Wallerian Degeneration in Injury and Diseases: Concepts and Prevention

Mietto, B. S., Rodrigo, M., de Lima, S., Sergio, T., & Martinez, A. M. B. (2011) · InTech eBooks · doi:10.5772/31927 · Cited by 5 · see citing works

Axon degeneration and rescue

Griffin, J. W., Höke, A., & Nguyen, T. T. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545061.020 · Cited by 3 · see citing works