The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program
Open accessAbstract
SUMMARY The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We reasoned that coordinate regulation of gene expression in injured neurons involving multiple pathways was central to PNS regenerative capacity. To provide a framework for revealing pathways involved in PNS axon regrowth after injury, we applied a comprehensive systems biology approach, starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bioinformatic analyses and experimental validation of network predictions. We used this rubric to identify a drug that accelerates DRG neurite outgrowth in vitro and optic nerve outgrowth in vivo by inducing elements of the identified network. The work provides a functional genomics foundation for understanding neural repair and proof of the power of such approaches in tackling complex problems in nervous system biology.
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Self-citationAn active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
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Self-citationIdentification of Conserved Proteomic Networks in Neurodegenerative Dementia
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Self-citationIdentification of conserved proteomic networks in neurodegenerative dementia
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Self-citationIntegrative genomics approach identifies conserved transcriptomic networks in Alzheimer’s disease
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Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
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Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
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Metadata
- Authors
- Chandran, V., Coppola, G., Nawabi, H., Omura, T., Versano, R., Huebner, E. A., Zhang, A., Costigan, M., Yekkirala, A., Barrett, L., Blesch, A., Michaelevski, I., Davis-Turak, J., Gao, F., Langfelder, P., Horvath, S., He, Z., Benowitz, L., Fainzilber, M., Tuszynski, M., Woolf, C. J., & Geschwind, D. H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 89
- Issue
- 5
- Pages
- 956-970
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2276418388
- Cited by
- 366
- References
- 10
- FWCI
- 21.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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