An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000412 · Cited by 7,300 · see citing works

Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research

Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.72351 · Cited by 6,277 · see citing works

A Simple Practice Guide for Dose Conversion between Animals and Human

Nair, A., & Jacob, S. (2016) · Journal of Basic and Clinical Pharmacy · doi:10.4103/0976-0105.177703 · Cited by 6,174 · see citing works

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

Usoskin, D., Furlan, A., Islam, S., Abdo, H., Lönnerberg, P., Lou, D., Hjerling-Leffler, J., Haeggström, J., Kharchenko, O., Kharchenko, P. V., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3881 · Cited by 2,136 · see citing works

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., de Laureto, P. P., DasGupta, B. R., & Montecucco, C. (1992) · Nature · doi:10.1038/359832a0 · Cited by 1,803 · see citing works

DREADDs for neuroscientists

Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742 · see citing works

DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION

Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532 · see citing works

Calcium regulation of neuronal gene expression

West, A. E., Chen, W. G., Dalva, M., Dolmetsch, R., Kornhauser, J., Shaywitz, A. J., Takasu, M., Tao, X., & Greenberg, M. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191352298 · Cited by 1,115 · see citing works

The Presynaptic Active Zone

Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062 · cited 3× · see citing works

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Liu, K., Lü, Y., Lee, J. K., Samara, R. F., Willenberg, R., Sears‐Kraxberger, I., Tedeschi, A., Park, K. K., Jin, D., Cai, B., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2603 · Cited by 987 · see citing works

Simple Neurite Tracer: open source software for reconstruction, visualization and analysis of neuronal processes

Longair, M., Baker, D. A., & Armstrong, J. D. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr390 · Cited by 939 · see citing works

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.002 · Cited by 938 · see citing works

Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

Feldmann, J., Callebaut, I., Raposo, G., Dogniaux, S., Bacq, D., Dumont, C., Lambert, N., Ouachée-Chardin, M., Chédeville, G., Tamary, H., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00855-9 · Cited by 935 · see citing works

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

Lu, P., Wang, Y., Graham, L., McHale, K., Gao, M., Wu, D., Brock, J., Blesch, A., Rosenzweig, E. S., Havton, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.020 · Cited by 897 · see citing works

The Biology of Regeneration Failure and Success After Spinal Cord Injury

Tran, A. P., Warren, P. M., & Silver, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00017.2017 · Cited by 883 · see citing works

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787 · see citing works

Moving beyond the glial scar for spinal cord repair

Bradbury, E. J., & Burnside, E. R. (2019) · Nature Communications · doi:10.1038/s41467-019-11707-7 · Cited by 748 · see citing works

Towards an Understanding of Synapse Formation

Südhof, T. C. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.040 · Cited by 698 · see citing works

Functional regeneration beyond the glial scar

Cregg, J. M., DePaul, M. A., Filous, A. R., Lang, B. T., Tran, A. P., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.024 · Cited by 664 · see citing works

Regeneration of Dorsal Column Fibers into and beyond the Lesion Site following Adult Spinal Cord Injury

Neumann, S., & Woolf, C. J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80755-2 · Cited by 659 · see citing works

Intrinsic Control of Axon Regeneration

He, Z., & Jin, Y. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.022 · Cited by 652 · see citing works

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

Varoqueaux, F., Sigler, A., Rhee, J.-S., Brose, N., Enk, C., Reim, K., & Rosenmund, C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122623799 · Cited by 619 · see citing works

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction

Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo, J., & Südhof, T. C. (2011) · Cell · doi:10.1016/j.cell.2010.12.029 · Cited by 607 · see citing works

Intrinsic mechanisms of neuronal axon regeneration

Mahar, M., & Cavalli, V. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0001-8 · Cited by 599 · see citing works

Cell biology of spinal cord injury and repair

O’Shea, T. M., Burda, J. E., & Sofroniew, M. V. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90608 · Cited by 590 · see citing works

Calcium regulation of the neuronal growth cone

Kater, S. B., Mattson, M. P., Cohan, C. S., & Connor, J. A. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90094-x · Cited by 579 · see citing works

Serotonin Selectively Inhibits Growth Cone Motility and Synaptogenesis of Specific Identified Neurons

Haydon, P. G., McCobb, D. P., & Kater, S. B. (1984) · Science · doi:10.1126/science.6093252 · Cited by 545 · see citing works

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

Renthal, W. R., Tochitsky, I., Yang, L., Cheng, Y., Li, E., Kawaguchi, R., Geschwind, D. H., & Woolf, C. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.026 · Cited by 544 · see citing works

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

McMahon, H. T., Ushkaryov, Y. A., Edelmann, L., Link, E., Binz, T., Niemann, H., Jahn, R., & Südhof, T. C. (1993) · Nature · doi:10.1038/364346a0 · Cited by 509 · see citing works

Spinal cord repair: advances in biology and technology

Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508 · see citing works

A Transcription-Dependent Switch Controls Competence of Adult Neurons for Distinct Modes of Axon Growth

Smith, D. S., & Skene, J. H. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00646.1997 · Cited by 498 · see citing works

The emergence of transcriptional identity in somatosensory neurons

Sharma, N., Flaherty, K., Lezgiyeva, K., Wagner, D. E., Klein, A. M., & Ginty, D. D. (2020) · Nature · doi:10.1038/s41586-019-1900-1 · Cited by 498 · see citing works

Peripheral injury enhances central regeneration of primary sensory neurones

Richardson, P. M., & Issa, V. M. K. (1984) · Nature · doi:10.1038/309791a0 · Cited by 494 · see citing works

The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration

Raivich, G., Bohatschek, M., Costa, C. D., Iwata, O., Galiano, M., Hristova, M., Nateri, A. S., Makwana, M., Riera-Sans, L., Wolfer, D. P., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.005 · Cited by 489 · see citing works

Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells

Goldberg, J. L., Klassen, M. P., Hua, Y., & Barres, B. A. (2002) · Science · doi:10.1126/science.1068428 · Cited by 488 · see citing works

Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures

Plaisier, S. B., Taschereau, R., Wong, J. A., & Graeber, T. G. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq636 · Cited by 468 · see citing works

How botulinum and tetanus neurotoxins block neurotransmitter release**This paper is dedicated to the memory of Heiner Niemann.

Humeau, Y., Doussau, F., Grant, N. J., & Poulain, B. (2000) · Biochimie · doi:10.1016/s0300-9084(00)00216-9 · Cited by 466 · see citing works

Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity

Malin, S. A., Davis, B. M., & Molliver, D. C. (2007) · Nature Protocols · doi:10.1038/nprot.2006.461 · Cited by 464 · see citing works

Microglia-organized scar-free spinal cord repair in neonatal mice

Li, Y., He, X., Kawaguchi, R., Zhang, Y., Wang, Q., Monavarfeshani, A., Yang, Z., Chen, B., Shi, Z., Meng, H., et al. (2020) · Nature · doi:10.1038/s41586-020-2795-6 · Cited by 434 · see citing works

ATF3 Increases the Intrinsic Growth State of DRG Neurons to Enhance Peripheral Nerve Regeneration

Seijffers, R., Mills, C. D., & Woolf, C. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5313-06.2007 · Cited by 425 · see citing works

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J.-S., Scheuss, V., Rosenmund, C., Rettig, J., & Brose, N. (2001) · Neuron · doi:10.1016/s0896-6273(01)00272-0 · Cited by 425 · see citing works

Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release

Betz, A., Ashery, U., Rickmann, M., Augustin, I., Neher, E., Südhof, T. C., Rettig, J., & Brose, N. (1998) · Neuron · doi:10.1016/s0896-6273(00)80520-6 · Cited by 425 · see citing works

Calcium regulation of neurite elongation and growth cone motility

Mattson, M., & Kater, S. B. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-12-04034.1987 · Cited by 423 · see citing works

Protein-Protein Interactions Contributing to the Specificity of Intracellular Vesicular Trafficking

Calakos, N., Bennett, M. K., Peterson, K. E., & Scheller, R. H. (1994) · Science · doi:10.1126/science.8108733 · Cited by 399 · see citing works

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.009 · Cited by 389 · see citing works

Nogo limits neural plasticity and recovery from injury

Schwab, M. E., & Strittmatter, S. M. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.02.011 · Cited by 379 · see citing works

RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone

Han, Y., Kaeser, P. S., Südhof, T. C., & Schneggenburger, R. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.014 · Cited by 354 · see citing works

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

Chandran, V., Coppola, G., Nawabi, H., Omura, T., Versano, R., Huebner, E. A., Zhang, A., Costigan, M., Yekkirala, A. S., Barrett, L. B., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.034 · Cited by 351 · see citing works

Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits

Sanes, J. R., & Zipursky, S. L. (2020) · Cell · doi:10.1016/j.cell.2020.04.008 · Cited by 327 · see citing works

Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., et al. (2014) · Science · doi:10.1126/science.1253050 · Cited by 322 · see citing works

Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?

Harel, N. Y., & Strittmatter, S. M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1957 · Cited by 297 · see citing works

Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach

Cahill, K. M., Huo, Z., Tseng, G. C., Logan, R. W., & Seney, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-27903-2 · Cited by 294 · see citing works

Intrathecal Baclofen for Spasticity in Cerebral Palsy

Albright, A. L. (1991) · JAMA · doi:10.1001/jama.1991.03460110084029 · Cited by 293 · see citing works

Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity

Junge, H. J., Rhee, J.-S., Jahn, O., Varoqueaux, F., Spiess, J., Waxham, M. N., Rosenmund, C., & Brose, N. (2004) · Cell · doi:10.1016/j.cell.2004.06.029 · Cited by 290 · see citing works

Ca2+-Dependent Exocytosis in the Somata of Dorsal Root Ganglion Neurons

Huang, L., & Neher, E. (1996) · Neuron · doi:10.1016/s0896-6273(00)80287-1 · Cited by 289 · see citing works

Evidence from In Vivo Imaging That Synaptogenesis Guides the Growth and Branching of Axonal Arbors by Two Distinct Mechanisms

Meyer, M. P., & Smith, S. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0223-06.2006 · Cited by 283 · see citing works

Restoring function after spinal cord injury: towards clinical translation of experimental strategies.

Ramer, L., Ramer, M., & Bradbury, E. (2014) · Lancet Neurology · doi:10.1016/s1474-4422(14)70144-9 · Cited by 280 · see citing works

Suppression of Neurite Elongation and Growth Cone Motility by Electrical Activity

Cohan, C. S., & Kater, S. B. (1986) · Science · doi:10.1126/science.3715470 · Cited by 278 · see citing works

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

Zhou, X., Wahane, S., Friedl, M.-S., Kluge, M., Friedel, C. C., Avrampou, K., Zachariou, V., Guo, L., Zhang, B., He, X., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0597-7 · Cited by 275 · see citing works

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

Blackmore, M. G., Wang, Z., Lerch, J. K., Motti, D., Zhang, Y. P., Shields, C. B., Lee, J. K., Goldberg, J. L., Lemmon, V., & Bixby, J. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120684109 · Cited by 272 · see citing works

RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels

Kiyonaka, S., Wakamori, M., Miki, T., Uriu, Y., Nonaka, M., Bito, H., Beedle, A., Mori, E., Hara, Y., Waard, M. D., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1904 · Cited by 262 · see citing works

Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts

Wictorin, K., Brundin, P., Gustavii, B., Lindvall, O., & Björklund, A. (1990) · Nature · doi:10.1038/347556a0 · Cited by 258 · see citing works

The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS

Tedeschi, A., Dupraz, S., Laskowski, C. J., Xue, J., Ulas, T., Beyer, M., Schultze, J. L., & Bradke, F. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.026 · Cited by 251 · see citing works

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

Shin, O.-H., Lu, J., Rhee, J.-S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., Machius, M., Rizo, J., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1758 · Cited by 243 · see citing works

In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration

Bareyre, F. M., Garzorz, N., Lang, C. C. V., Misgeld, T., Büning, H., & Kerschensteiner, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015239108 · Cited by 235 · see citing works

Munc13-4 Is an Effector of Rab27a and Controls Secretion of Lysosomes in Hematopoietic Cells

Neeft, M., Wieffer, M., de Jong, A. S., Negroiu, G., Metz, C. H. G., van Loon, A., Griffith, J. M., Krijgsveld, J., Wulffraat, N. M., Koch, H., et al. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0923 · Cited by 215 · see citing works

A minimal domain responsible for Munc13 activity

Basu, J., Shen, N., Dulubova, I., Lu, J., Guan, R., Guryev, O., Grishin, N. V., Rosenmund, C., & Rizo, J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1001 · Cited by 213 · see citing works

ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain

Flynn, K. C., Hellal, F., Neukirchen, D., Jacob, S., Tahirović, S., Dupraz, S., Stern, S., Garvalov, B. K., Gurniak, C. B., Shaw, A. E., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.038 · Cited by 202 · see citing works

Action of baclofen on mammalian synaptic transmission

Fox, S., Krnjević, K., Morris, M. E., Puil, E., & Werman, R. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90016-7 · Cited by 199 · see citing works

CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.

Dorrier, C. E., Aran, D., Haenelt, E. A., Sheehy, R. N., Hoi, K. K., Pintarić, L., Chen, Y., Lizama, C. O., Cautivo, K. M., Weiner, G. A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00770-9 · Cited by 199 · see citing works

Analyzing Somatosensory Axon Projections with the Sensory Neuron-SpecificAdvillinGene

Hasegawa, H., Abbott, S. E., Han, B.-X., Qi, Y., & Wang, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4908-07.2007 · Cited by 173 · see citing works

Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca2+-Calmodulin-Munc13-1 Signaling

Lipstein, N., Sakaba, T., Cooper, B. H., Lin, K.-H., Strenzke, N., Ashery, U., Rhee, J.-S., Taschenberger, H., Neher, E., & Brose, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.011 · Cited by 165 · see citing works

A common molecular basis for membrane docking and functional priming of synaptic vesicles

Siksou, L., Varoqueaux, F., Pascual, O., Triller, A., Brose, N., & Marty, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06811.x · Cited by 160 · see citing works

Rehabilitative training and plasticity following spinal cord injury

Fouad, K., & Tetzlaff, W. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.009 · Cited by 158 · see citing works

Structure and flexibility in cortical representations of odour space

Pashkovski, S. L., Iurilli, G., Brann, D. H., Chicharro, D., Drummey, K., Franks, K. M., Panzeri, S., & Datta, S. R. (2020) · Nature · doi:10.1038/s41586-020-2451-1 · Cited by 156 · see citing works

Continuous infusion of intrathecal baclofen: long-term effects on spasticity in spinal cord injury

Loubser, P. G., Narayan, R. K., Sandin, K. J., Donovan, W. H., & Russell, K. D. (1991) · Spinal Cord · doi:10.1038/sc.1991.7 · Cited by 146 · see citing works

Chronically CNS-Injured Adult Sensory Neurons Gain Regenerative Competence upon a Lesion of Their Peripheral Axon

Ylera, B., Ertürk, A., Hellal, F., Nadrigny, F., Hurtado, A., Tahirović, S., Oudega, M., Kirchhoff, F., & Bradke, F. (2009) · Current Biology · doi:10.1016/j.cub.2009.04.017 · Cited by 140 · see citing works

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

Fawcett, J. W. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02844-y · Cited by 137 · see citing works

Inhibition of calcium currents in cultured rat dorsal root ganglion neurones by (−)‐baclofen

DOLPHIN, A. C., & Scott, R. H. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb09489.x · Cited by 135 · see citing works

Can injured adult CNS axons regenerate by recapitulating development?

Hilton, B. J., & Bradke, F. (2017) · Development · doi:10.1242/dev.148312 · Cited by 134 · see citing works

Brief Electrical Stimulation Accelerates Axon Regeneration in the Peripheral Nervous System and Promotes Sensory Axon Regeneration in the Central Nervous System

Gordon, T., Udina, E., Verge, V. M. K., & de Chaves, E. I. P. (2009) · Motor Control · doi:10.1123/mcj.13.4.412 · Cited by 131 · see citing works

Entrapment via Synaptic-Like Connections between NG2 Proteoglycan+ Cells and Dystrophic Axons in the Lesion Plays a Role in Regeneration Failure after Spinal Cord Injury

Filous, A. R., Tran, A. P., Howell, C., Busch, S. A., Evans, T. A., Stallcup, W. B., Kang, S. H., Bergles, D. E., Lee, S.-I., Levine, J. M., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1309-14.2014 · Cited by 129 · see citing works

The Cerebellum-Specific Munc13 Isoform Munc13-3 Regulates Cerebellar Synaptic Transmission and Motor Learning in Mice

Augustin, I., Korte, S., Rickmann, M., Kretzschmar, H. A., Südhof, T. C., Herms, J. W., & Brose, N. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00010.2001 · Cited by 125 · see citing works

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Hutson, T. H., Kathe, C., Palmisano, I., Bartholdi, K., Hervera, A., Virgiliis, F. D., McLachlan, E., Zhou, L., Kong, G., Barraud, Q., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw2064 · Cited by 124 · see citing works

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

Sigler, A., Oh, W. C., Imig, C., Altas, B., Kawabe, H., Cooper, B. H., Kwon, H., Rhee, J., & Brose, N. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.029 · Cited by 123 · see citing works

Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons

Yan, Z., Chi, P., Bibb, J. A., Ryan, T. A., & Greengard, P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013376 · Cited by 110 · see citing works

ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS

Tedeschi, A., Dupraz, S., Curcio, M., Laskowski, C. J., Schaffran, B., Flynn, K. C., Santos, T. E., Stern, S., Hilton, B. J., Larson, M. J. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.007 · Cited by 102 · see citing works

In VivoImaging of Dorsal Root Regeneration: Rapid Immobilization and Presynaptic Differentiation at the CNS/PNS Border

Maio, A. D., Skuba, A., Himes, B. T., Bhagat, S. L., Hyun, J. K., Tessler, A. R., Bishop, D. L., & Son, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4638-10.2011 · Cited by 99 · see citing works

RIM1α and RIM1β are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions

Kaeser, P. S., Kwon, H.-B., Chiu, C.-Y. Q., Deng, L., Castillo, P., & Südhof, T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3235-08.2008 · Cited by 97 · see citing works

Munc13 controls the location and efficiency of dense-core vesicle release in neurons

van de Bospoort, R., Farina, M., Schmitz, S. K., de Jong, A. P. H., de Wit, H., Verhage, M., & Toonen, R. F. G. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201208024 · Cited by 96 · see citing works

Electrical Activity Suppresses Axon Growth through Cav1.2 Channels in Adult Primary Sensory Neurons

Enes, J., Langwieser, N. N., Ruschel, J., Carballosa-Gonzalez, M. M., Klug, A., Traut, M. H., Ylera, B., Tahirović, S., Hofmann, F. B., Stein, V., et al. (2010) · Current Biology · doi:10.1016/j.cub.2010.05.055 · Cited by 93 · see citing works

Epigenomic signatures underpin the axonal regenerative ability of dorsal root ganglia sensory neurons

Palmisano, I., Danzi, M., Hutson, T., Zhou, L.-M., Mclachlan, E., Serger, E., Shkura, K., Srivastava, P., Hervera, A., Neill, N. O., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0490-4 · Cited by 91 · see citing works

A Surviving Intact Branch Stabilizes Remaining Axon Architecture after Injury as Revealed by In Vivo Imaging in the Mouse Spinal Cord

Lorenzana, A. O., Lee, J. K., Mui, M. K.-H., Chang, A., & Zheng, B. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.061 · Cited by 88 · see citing works

Human fetal hippocampal development: II. The neuronal cytoskeleton

Arnold, S. E., & Trojanowski, J. Q. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960401)367:2 · Cited by 87 · see citing works

Relevance of Exocytotic Glutamate Release from Retinal Glia

Ślęzak, M., Grosche, A., Niemiec, A., Tanimoto, N., Pannicke, T., Münch, T. A., Crocker, B., Isope, P., Härtig, W., Beck, S. C., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.027 · Cited by 81 · see citing works

The RAB3-RIM pathway is essential for the release of neuromodulators

Persoon, C. M., Hoogstraaten, R. I., Nassal, J., van Weering, J. V., Kaeser, P. S., Toonen, R., & Verhage, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.015 · Cited by 73 · see citing works

A C1–C2 Module in Munc13 Inhibits Calcium-Dependent Neurotransmitter Release

Michelassi, F., Liu, H.-W., Hu, Z.-T., & Dittman, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.015 · Cited by 72 · see citing works

Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

Faure, L., Wang, Y., Kastriti, M. E., Fontanet, P., Cheung, K. K. Y., Petitpré, C., Wu, H., Sun, L. L., Runge, K., Croci, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17929-4 · Cited by 72 · see citing works

Intrinsic Determinants of Axon Regeneration

Fawcett, J. W., & Verhaagen, J. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22637 · Cited by 69 · see citing works

Membrane trafficking events underlying axon repair, growth, and regeneration

Bloom, O., & Morgan, J. R. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.04.003 · Cited by 66 · see citing works

Regulation of Growth Cone Extension by SNARE Proteins

Kimura, K., Mizoguchi, A., & Idé, C. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305100404 · Cited by 64 · see citing works

Molecular and functional architecture of striatal dopamine release sites

Banerjee, A., Imig, C., Balakrishnan, K., Kershberg, L., Lipstein, N., Uronen, R.-L., Wang, J., Cai, X., Benseler, F., Rhee, J. S., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.10.028 · Cited by 58 · see citing works

The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels

Calloway, N. T., Gouzer, G., Xue, M., & Ryan, T. A. (2015) · eLife · doi:10.7554/elife.07728 · Cited by 57 · see citing works

Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution

Paredes, R. G., & Ågmo, A. (1989) · Psychopharmacology · doi:10.1007/bf00439451 · Cited by 57 · see citing works

Identification of motor areas of the cat cerebral cortex based on studies of cortical stimulation and corticospinal connections

Ghosh, S. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970407)380:2 · Cited by 53 · see citing works

Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

Wu, D., Jin, Y., Shapiro, T. M., Hinduja, A., Baas, P. W., & Tom, V. J. (2020) · Nature Communications · doi:10.1038/s41467-020-19914-3 · Cited by 44 · see citing works

A pharmacokinetic–pharmacodynamic model for intrathecal baclofen in patients with severe spasticity

Heetla, H. W., Proost, J. H., Molmans, B. H., Staal, M. J., & van Laar, T. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12781 · Cited by 43 · see citing works

Munc18 and Munc13 regulate early neurite outgrowth

Broeke, J. H. P., Roelandse, M., Luteijn, M. J., Boiko, T., Matus, A. I., Toonen, R. F. G., & Verhage, M. (2010) · Biology of the Cell · doi:10.1042/bc20100036 · Cited by 42 · see citing works

Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons

Hoogstraaten, R. I., van Keimpema, L., Toonen, R. F. G., & Verhage, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-67988-2 · Cited by 41 · see citing works

A Presynaptic Phosphosignaling Hub for Lasting Homeostatic Plasticity

Müller, J. A., Betzin, J., Santos-Tejedor, J., Mayer, A., Oprişoreanu, A.-M., Engholm-Keller, K., Paulußen, I., Gulakova, P., McGovern, T. D., Gschossman, L. J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110696 · Cited by 36 · see citing works

Fusogenic Pairings of Vesicle-Associated Membrane Proteins (VAMPs) and Plasma Membrane t-SNAREs – VAMP5 as the Exception

Hasan, N., Corbin, D. R., & Hu, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014238 · Cited by 32 · see citing works

High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing

Hilton, B. J., Blanquie, O., Tedeschi, A., & Bradke, F. (2019) · Nature Protocols · doi:10.1038/s41596-019-0140-z · Cited by 32 · see citing works

Red fluorescent Xenopus laevis: a new tool for grafting analysis

Waldner, C., Roose, M., & Ryffel, G. U. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-37 · Cited by 27 · see citing works

Synthesis and Biological Evaluation of a Selective N- and P/Q-Type Calcium Channel Agonist

Liang, M., Tarr, T. B., Bravo‐Altamirano, K., Valdomir, G., Rensch, G., Swanson, L., DeStefino, N. R., Mazzarisi, C. M., Olszewski, R. A., Wilson, G. M., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml3002083 · Cited by 27 · see citing works

A Longitudinal Study of the Neurologic Safety of Acute Baclofen Use After Spinal Cord Injury

Cragg, J. J., Tong, B., Jutzeler, C. R., Warner, F. M., Cashman, N. R., Geisler, F. H., & Kramer, J. L. K. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00713-8 · Cited by 23 · see citing works

Axonal branch patterning and neuronal shape diversity: roles in developmental circuit assembly

Hoersting, A.-K., & Schmucker, D. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.019 · Cited by 22 · see citing works

SEQUIN: An imaging and analysis platform for quantification and characterization of synaptic structures in mouse

Reitz, S. J., Sauerbeck, A. D., & Kummer, T. T. (2021) · STAR Protocols · doi:10.1016/j.xpro.2020.100268 · Cited by 19 · see citing works

Functional Parameters of Voltage-Activated Ca2+Currents From Olfactory Interneurons in the Antennal Lobe ofPeriplaneta americana

Husch, A., Heß, S., & Kloppenburg, P. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00719.2007 · Cited by 16 · see citing works

Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys

Carmichael, S. T., & Price, J. L. (1996) · Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960722)371:2

Spinal cord injury: molecular mechanisms and therapeutic interventions

Hu, X., Xu, W., Ren, Y., Wang, Z., He, X., Huang, R., Ma, B., Zhao, J., Zhu, R., & Cheng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01477-6 · Cited by 823 · see citing works

Regulation of axonal regeneration after mammalian spinal cord injury

Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328 · see citing works

Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

Jacobi, A., Tran, N. M., Yan, W., Benhar, I., Tian, F., Schaffer, R., He, Z., & Sanes, J. R. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.002 · Cited by 154 · see citing works

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Squair, J. W., Milano, M., de Coucy, A., Gautier, M., Skinnider, M. A., James, N. D., Cho, N., Lasne, A., Kathe, C., Hutson, T. H., et al. (2023) · Science · doi:10.1126/science.adi6412 · Cited by 144 · see citing works

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Wang, X., Yang, C., Wang, X., Miao, J., Chen, W., Zhou, Y., Xu, Y., An, Y., Cheng, A., Ye, W., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.028 · Cited by 84 · see citing works

Neuronal maturation and axon regeneration: unfixing circuitry to enable repair

Hilton, B. J., Griffin, J. M., Fawcett, J. W., & Bradke, F. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00849-3 · Cited by 77 · see citing works

UNC13A in amyotrophic lateral sclerosis: from genetic association to therapeutic target

Willemse, S. W., Harley, P., van Eijk, R. P. A., Demaegd, K. C., Zelina, P., Pasterkamp, R. J., Damme, P. V., Ingre, C., van Rheenen, W., Veldink, J. H., et al. (2023) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-330504 · Cited by 67 · see citing works

Mechanisms of Axon Growth and Regeneration: Moving between Development and Disease

Bradke, F. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1131-22.2022 · Cited by 58 · see citing works

Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair

Saraswathy, V. M., Zhou, L., & Mokalled, M. H. (2024) · Nature Communications · doi:10.1038/s41467-024-50628-y · Cited by 49 · see citing works

The injured axon: intrinsic mechanisms driving axonal regeneration

Tomé, D., & Almeida, R. D. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.09.009 · Cited by 38 · see citing works

Molecular approaches for spinal cord injury treatment

Martinez, A. B., de Almeida, F. M., Marques, S. A., dos Santos, A. R., Prins, C. A., Cardoso, F. S. D. S., Heringer, L. D. S., & Mendonça, H. R. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.344830 · Cited by 36 · see citing works

Role of Sirtuin 3 in Degenerative Diseases of the Central Nervous System

Zhang, H., Dai, S., Yang, Y., Wei, J., Li, X., Luo, P., & Jiang, X. (2023) · Biomolecules · doi:10.3390/biom13050735 · Cited by 33 · see citing works

Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS

Ruan, Y., Cheng, J., Dai, J., Ma, Z., Luo, S., Yan, R., Wang, L., Zhou, J., Yu, B., Tong, X., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh0183 · Cited by 33 · see citing works

Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways

Wang, X., Yang, S., Hu, M., Wang, R., Zhang, C., Kosanam, A. R., Ochuba, A., Jiang, J., Luo, X., Guan, Y., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci163145 · Cited by 30 · see citing works

The 2021 yearbook of Neurorestoratology

Sharma, H. S., Chopp, M., Chen, L., Sarnowska, A., Xue, M., Ao, Q., Siniscalco, D., Chen, L., Hawamdeh, Z. M., & Huang, H. (2022) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2022.100008 · Cited by 31 · see citing works

CRISPR and Artificial Intelligence in Neuroregeneration: Closed-Loop Strategies for Precision Medicine, Spinal Cord Repair, and Adaptive Neuro-Oncology

Șerban, M., Toader, C., & Covache-Busuioc, R.-A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199409 · Cited by 30 · see citing works

Advances in molecular therapies for targeting pathophysiology in spinal cord injury

Kim, H. N., McCrea, M. R., & Li, S. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2194532 · Cited by 30 · see citing works

Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species

Peng, C., Luo, J., Wang, K., Li, J., Ma, Y., Li, J., Yang, H., Chen, T., Zhang, G., Ji, X., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102913 · Cited by 24 · see citing works

Moving through the crowd. Where are we at understanding physiological axon growth?

Alfadil, E., & Bradke, F. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.07.001 · Cited by 23 · see citing works

Neuronal regeneration after injury: a new perspective on gene therapy

Zeng, C., & Zhang, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1181816 · Cited by 23 · see citing works

Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

da Costa, G., Ribeiro, F. F., Sebastião, A. M., Muir, E. M., & Vaz, S. H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1003145 · Cited by 22 · see citing works

Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells

Shan, F., Zhang, N., Yao, X., Li, Y., Wang, Z., Zhang, C., & Wang, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01497-x · Cited by 20 · see citing works

Piezo1 Regulates Stiffness‐Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics

Lei, M., Wang, W., Zhang, H., Gong, J., Cai, H., Wang, Z., Zhu, L., Yang, X., Wang, S., & Ma, C. (2024) · Advanced Science · doi:10.1002/advs.202405705 · Cited by 20 · see citing works

Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review

Li, M., Zhou, J., Ning, Y., & Xiong, Y. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00017 · Cited by 20 · see citing works

Intrinsic regulation of axon regeneration after spinal cord injury: Recent advances and remaining challenges

Noristani, H. N. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114198 · Cited by 18 · see citing works

Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury

Guo, Q., Liu, Q., Zhou, S., Lin, Y., Lv, A., Zhang, L., Li, L., & Huang, F. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105885 · Cited by 16 · see citing works

Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons

Kim, O., Okamoto, Y., Kaufmann, W. A., Brose, N., Shigemoto, R., & Jonas, P. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002879 · Cited by 15 · see citing works

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody

Fabris, F., Šoštarić, P., Matak, I., Binz, T., Toffan, A., Simonato, M., Montecucco, C., Pirazzini, M., & Rossetto, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084355 · Cited by 14 · see citing works

Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury

Steenbergen, V. V., Burattini, L., Trumpp, M., Fourneau, J., Aljović, A., Chahin, M., Oh, H., D’Ambra, M., & Bareyre, F. M. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220615 · Cited by 15 · see citing works

Multichannel 3D-Printed Bioactive Scaffold Combined with Small Interfering RNA Delivery to Promote Neurological Recovery after Spinal Cord Injury

Ye, J., Li, F., Wen, Z., He, J., Pan, G., Zhai, X., Song, L., Zhang, X., Zhou, X., Yao, X., et al. (2025) · Research · doi:10.34133/research.0951 · Cited by 13 · see citing works

14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

Liu, Q., Yang, H., Luo, J., Peng, C. Y., Wang, K., Zhang, G., Lin, H., & Ji, Z. (2023) · eLife · doi:10.7554/elife.90184 · Cited by 12 · see citing works

Unleashing metabolic power for axonal regeneration

Yang, X.-Y., & Zhou, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.001 · Cited by 12 · see citing works

Oligodendrocyte precursor cells stop sensory axons regenerating into the spinal cord

Kim, H., Skuba, A., Xia, J., Han, S. B., Zhai, J., Hu, H., Kang, S. H., & Son, Y. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113068 · Cited by 11 · see citing works

Single-Nuclei Sequencing Reveals a Robust Corticospinal Response to Nearby Axotomy But Overall Insensitivity to Spinal Injury

Wang, Z., Kumaran, M., Batsel, E., Testor-Cabrera, S., Beine, Z., Ribelles, A. A., Tsoulfas, P., Venkatesh, I., & Blackmore, M. G. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1508-24.2024 · Cited by 20 · see citing works

Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice

Cellini, B. R., Edachola, S. V., Faw, T. D., & Cigliola, V. (2025) · BMC Biology · doi:10.1186/s12915-025-02203-0 · Cited by 11 · see citing works

Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution

Rempel, S. K., Welch, M. J., Ludwig, A. L., Phillips, M. J., Kancherla, Y., Zack, D. J., Gamm, D. M., & Gómez, T. M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110827 · Cited by 10 · see citing works

Spinal cord injury repair based on drug and cell delivery: From remodeling microenvironment to relay connection formation

Ma, W., & Li, X. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101556 · Cited by 10 · see citing works

Mechanisms underpinning spontaneous spinal cord regeneration

Tendolkar, A., & Mokalled, M. H. (2025) · Development · doi:10.1242/dev.204790 · Cited by 8 · see citing works

Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila

Trombley, S., Powell, J. R., Guttipatti, P., Matamoros, A. J., Lin, X., O’Harrow, T. C. D. G., Steinschaden, T., Miles, L., Wang, Q., Wang, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42306-2 · Cited by 8 · see citing works

Rapid presynaptic maturation in naturally regenerating axons of the adult mouse olfactory nerve

Browne, L., Crespo, A., & Grubb, M. S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111750 · Cited by 8 · see citing works

GsMTx4 Combined with Exercise Exerts Neuroprotective Effects by Regulating Neuronal Autophagy in Rats with Spinal Cord Injury

Li, Q., Li, C., Li, X., Liu, X., Qian, J., Li, J., Li, X., & Zhang, X. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04304-8 · Cited by 7 · see citing works

A pre-trained large generative model for translating single-cell transcriptomes to proteomes

Liu, L., Li, W., Wang, F., Li, Y., Huang, L.-K., Wong, K., Yang, F., & Yao, J. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01528-z · Cited by 19 · see citing works

MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2

Liu, F.-Y., Cho, Y., Fridayana, F. R., Niloofar, L., Vo, M. N., Huang, Y., Limanjaya, A., Kwon, M., Ock, J., Lee, S., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01373-1 · Cited by 7 · see citing works

Injury distance limits the transcriptional response to spinal injuryPreprint

Wang, Z., Kumaran, M., Batsel, E., Testor-Cabrera, S., Beine, Z., Ribelles, A. A., Tsoulfas, P., Venkatesh, I., & Blackmore, M. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.27.596075 · Cited by 7 · see citing works

The roles of circular RNAs in nerve injury and repair

Zong, Y., Dai, Y., Yan, J., Yu, B., Wang, D., & Mao, S. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1419520 · Cited by 6 · see citing works

Neuronal HDAC3 knockdown promotes propriospinal detour pathway formation and locomotor recovery in a mouse model of spinal cord injury

Gao, Z., Xing, H., Shen, Y., Ding, X., Xu, S., Li, R., Zhang, Y., Mao, S., Liu, C., Jin, J., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adp1873 · Cited by 6 · see citing works

MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6/ calcium activity pathway

Shen, Y., Chen, X., Song, Z., Yao, H., Han, A., Zhang, Y., Cai, Y., & Hu, B. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05117-2 · Cited by 6 · see citing works

Multimodal rehabilitation promotes axonal sprouting and functional recovery in a murine model of spinal cord injury (SCI)

Wang, Y., Luo, H., Liu, Y., Yang, C., Yin, Y., & Tan, B. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.137029 · Cited by 6 · see citing works

Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway

Li, Q., Hong, H., Xu, G., Xia, M., Wang, T., Zhou, Z., Huang, J., Fu, Q., & Cui, Z. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin43900 · Cited by 4 · see citing works

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

Cui, J., Shen, Y., Song, Z., Fan, D., & Hu, B. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-00529 · Cited by 4 · see citing works

Remaking a connection: molecular players involved in post-injury synapse formation

Tomé, D., & Almeida, R. D. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00265 · Cited by 4 · see citing works

Engineering nanomedicines for neuroprotection and neuroregeneration in spinal cord injury

Jiang, Y., Chen, Z., Zhang, J., Xu, Z., Zhou, X., Yuan, X., Yao, X. X., & Guo, S. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102643 · Cited by 4 · see citing works

Phosphoproteomics Profiling Reveals Key Proteins Involved in Neuroinflammation and Impaired Axon Guidance Induced by Bilirubin Deficiency

Chen, M., Wu, C., Cui, Y., Ke, B., Mao, L., Wang, H., Shen, J., Yin, S., Hu, M., & Li, C. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00117 · Cited by 3 · see citing works

Identification and Validation of Synapse-related Hub Genes after Spinal Cord Injury by Bioinformatics Analysis

Shi, M., Xu, H., Hu, R., Chen, Y., Wu, X., Chen, B., & Ma, R. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207326666230426151114 · Cited by 3 · see citing works

Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity

Friedman, T. N., Lamothe, S. M., Maguire, A. D., Hammond, T., Tenorio, G., Hilton, B. J., Plemel, J. R., Kurata, H. T., & Kerr, B. J. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16292 · Cited by 3 · see citing works

Biological engineering approaches for modulating the pathological microenvironment and promoting axonal regeneration after spinal cord injury

Chen, X., Rong, H., Yang, Z., Zhang, J., Yang, Y., Gao, F., Liu, M., & Zhang, S. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1574763 · Cited by 3 · see citing works

Advances in the study of axon–associated vesicles

Liu, Y., Shuai, K., Sun, Y., Zhu, L., & Wu, X. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1045778 · Cited by 3 · see citing works

Axonal Regeneration in the Central Nervous System

Klimaschewski, L. P. (2024) · Springer eBooks · doi:10.1007/978-3-662-68053-7_2 · Cited by 3 · see citing works

The applications of spinal cord stimulation in diseases with motor disorders, pain, and cognitive disturbance

Shang, P., Wen, L., Zheng, R., Cheng, R., Gao, Y., Wen, M., & Lin, M. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00001 · Cited by 3 · see citing works

Context Specificity of MAP3K DLK Signaling in the Nervous System: Insights from Genetics and Genomics

Ritchie, E. M., & Jin, Y. (2025) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102103 · Cited by 2 · see citing works

Sox11 overexpression restores embryonic pro-growth transcription in mature corticospinal tract neurons

Batsel, E., Wang, Z., Otten, E., Roshan, S., Mohammad, R., Pascual, P., O’Shea, D., Rosas, J., Tsoulfas, P., & Blackmore, M. G. (2025) · Scientific Reports · doi:10.1038/s41598-025-33479-5 · Cited by 2 · see citing works

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

Powell, J. R., Steinschaden, T., Horowitz, R., & Song, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-02049 · Cited by 2 · see citing works

Chronic activation of corticospinal tract neurons after pyramidotomy injury enhances neither behavioral recovery nor axonal sprouting

Wang, Z., Brannigan, M., Friedrich, L., & Blackmore, M. G. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115810 · Cited by 2 · see citing works

Plasticity meets regeneration during innate spinal cord repair

Tendolkar, A., & Mokalled, M. H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01197 · Cited by 2 · see citing works

Pathway-specific maturation of presynaptic functions of the somatosensory thalamus

Midorikawa, M. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.04.008 · Cited by 2 · see citing works

Cell adhesion and actin dynamics factors promote axonal extension and synapse formation in transplanted Drosophila photoreceptor cells

Iwanaga, R., Yahagi, N., Hakeda‐Suzuki, S., & Suzuki, T. (2024) · Development Growth & Differentiation · doi:10.1111/dgd.12916 · Cited by 2 · see citing works

Amyotrophic lateral sclerosis

Lin, Z., Ibrahim, A. N., Brown, R. H., & Sreedharan, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19176-3.00034-0 · Cited by 2 · see citing works

Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutonsPreprint

Kim, O., Okamoto, Y., Brose, N., Shigemoto, R., & Jónás, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.04.569907 · Cited by 2 · see citing works

Transforming growth factor beta–related proteins promote axonal regeneration of injured dorsal root ganglion neurons

Shen, Y., Yang, P., Dai, W., Gu, X., & Yi, S. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01427 · Cited by 1 · see citing works

Biomaterial-assisted neuralization strategies for tissue engineering applications

Ye, J., Ji, L., Liu, L., Zhou, K., Zhu, R., Sun, C., Lei, L., & Dai, M. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102713 · Cited by 3 · see citing works

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

Beard, E., El‐Bushra, S., Kader, Z., Sun, Y. J., & Au, N. P. B. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70800 · Cited by 1 · see citing works

Targeting VAMPs in Aging-Related Diseases: From Mechanisms to Pharmacotherapy

Jia, B., Dong, H., Liu, Y., Liu, X., Zhu, X., Sun, C., Zhang, Q., & Kang, N. (2026) · Pharmaceutical Research · doi:10.1007/s11095-026-04123-2 · Cited by 1 · see citing works

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

Jang, E.-H., Yang, E. M., Gil, S., Park, S. M., Choi, H., Kim, J., Kim, C. I., Gim, Y., Jeon, H., Cho, Y., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70602 · Cited by 1 · see citing works

microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

Chen, X., Shen, Y., Song, Z., Wang, X.-L., Yao, H., Cai, Y., Zhao, Z.-A., & Hu, B. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.03.016 · Cited by 1 · see citing works

Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43

Li, K., Fan, D., Zhou, J., Zhao, Z.-A., Han, A., Song, Z., Tang, X., & Hu, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010950 · Cited by 1 · see citing works

Axonal injury signaling is restrained by a spared synaptic branch

Smithson, L. J., Zang, J. L., Junginger, L. M., Waller, T. J., Jankowiak, R., Khan, S. A., Li, Y., Cai, D., & Collins, C. A. (2025) · eLife · doi:10.7554/elife.104896.3 · Cited by 1 · see citing works

Comparative developmental transcriptomics of Drosophila mushroom body neurons highlights the mevalonate pathway as a regulator of axon growthPreprint

Fahdan, L., Meltzer, H., Wigoda, N., Rotkopf, R., & Schuldiner, O. (2026) · eLife · doi:10.7554/elife.109630 · Cited by 1 · see citing works

Rapid presynaptic maturation in naturally regenerating axonsPreprint

Browne, L., Crespo, A., & Grubb, M. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.09.493421

The role of novel genes in axon regeneration after CNS injury– A Systematic review and Meta-analysis

Alhajlah, S. H., Alrouji, M., Albugami, R. R., Almutairi, F. N., & Ahmed, Z. (2023) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.47750/jptcp.2023.30.14.037

14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist interventionPreprint

Liu, Q., Yang, H., Luo, J., Peng, C. Y., Wang, K., Zhang, G., Ji, Z., & Lin, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.25.550600

eLife Assessment: The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamics

Unsain, N. (2023) · eLife · doi:10.7554/elife.90184.1.sa3

Reviewer #3 (Public Review): The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamics

(2023) · eLife · doi:10.7554/elife.90184.1.sa0

Reviewer #2 (Public Review): The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamics

(2023) · eLife · doi:10.7554/elife.90184.1.sa1

The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamicsPreprint

Liu, Q., Yang, H., Luo, J., Peng, C. Y., Wang, K., Zhang, G., Ji, Z., & Lin, H. (2023) · eLife · doi:10.7554/elife.90184.1

Axonale Regeneration im zentralen Nervensystem

Klimaschewski, L. P. (2023) · Springer eBooks · doi:10.1007/978-3-662-66330-1_2

The 14-3-3/spastin pathway coordinates neurite regeneration and recovery of spinal cord injury by targeting microtubule dynamicsPreprint

Liu, Q., Yang, H., Luo, J., Peng, C. Y., Wang, K., Zhang, G., Ji, Z., & Lin, H. (2023) · eLife · doi:10.7554/elife.90184.2

Author Response: 14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

Liu, Q., Yang, H., Luo, J., Peng, C. Y., Wang, K., Zhang, G., Ji, Z., & Lin, H. (2023) · eLife · doi:10.7554/elife.90184.3.sa2

14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist interventionPreprint

Liu, Q., Yang, H., Luo, J., Peng, C. Y., Wang, K., Zhang, G., Ji, Z., & Lin, H. (2023) · eLife · doi:10.7554/elife.90184.3

14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

Liu, Q., Yang, H., Luo, J., Peng, C. Y., Wang, K., Zhang, G., Lin, H., & Ji, Z. (2024) · eLife · doi:10.7554/elife.90184.4

Axonal injury signaling is restrained by a spared synaptic branchPreprint

Smithson, L. J., Zang, J. L., Junginger, L. M., Waller, T. J., Reilly-Jankowiak, L., Khan, S. A., Li, Y., Cai, D., & Collins, C. A. (2024) · eLife · doi:10.7554/elife.104896.1 · Cited by 1 · see citing works

Axonal injury signaling is restrained by a spared synaptic branchPreprint

Smithson, L. J., Zang, J. L., Junginger, L. M., Waller, T. J., Reilly-Jankowiak, L., Khan, S. A., Li, Y., Cai, D., & Collins, C. A. (2024) · eLife · doi:10.7554/elife.104896 · Cited by 1 · see citing works

Axon regeneration after spinal cord and brain injuries

McCrea, M. R., & Li, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15580-2.00023-0

Axonal injury signaling is restrained by a spared synaptic branchPreprint

Smithson, L. J., Zang, J. L., Junginger, L. M., Waller, T. J., Jankowiak, R., Khan, S. A., Li, Y., Cai, D., & Collins, C. A. (2025) · eLife · doi:10.7554/elife.104896.2

ACUPUNCTURE TREATMENT FOR SPINAL CORD INJURY: A RESEARCH BASED ON BIBLIOMETRICS AND DATA MINING

Xue, E., Wang, J., Gu, J., Xia, S., Luo, S., & HUANG, Z. (2025) · Journal of Pharmaceutical and Medical Research · doi:10.61784/jpmr3031

Comparative developmental transcriptomics of Drosophila mushroom body neurons highlights the mevalonate pathway as a regulator of axon growthPreprint

Fahdan, L., Meltzer, H., Wigoda, N., Rotkopf, R., & Schuldiner, O. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676757

Microfluidic Chip for Axonal Injury Models Construction and Enabling Multi-Omics Analysis

Zhou, B., Liu, R., Sun, J., Lu, M., & Zhang, Q. (2025) · Journal of Visualized Experiments · doi:10.3791/68915

Additional file 8 of Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells

Shan, F., Zhang, N., Yao, X., Li, Y., Wang, Z., Zhang, C., & Wang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26675651

Additional file 1 of Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells

Shan, F., Zhang, N., Yao, X., Li, Y., Wang, Z., Zhang, C., & Wang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25132072

Additional file 9 of Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells

Shan, F., Zhang, N., Yao, X., Li, Y., Wang, Z., Zhang, C., & Wang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26675654

Additional file 7 of Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells

Shan, F., Zhang, N., Yao, X., Li, Y., Wang, Z., Zhang, C., & Wang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26675648

Electrical activity suppresses intrinsic growth competence in adult primary sensory neurons implications for spinal cord regeneration

Enes, J. (2009)

Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration

Neumann, S., Skinner, K., & Basbaum, A. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508538102 · Cited by 60 · see citing works

Neuronal intrinsic barriers for axon regeneration in the adult CNS

Sun, F., & He, Z. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.03.013 · Cited by 199 · see citing works

Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons

Bomze, H. M., Bulsara, K. R., Iskandar, B. J., Caroni, P., & Skene, J. H. P. (2001) · Nature Neuroscience · doi:10.1038/82881 · Cited by 375 · see citing works

Electrical activity suppresses intrinsic growth competence in adult primary sensory neurons

Enes, J. (2009) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.10070