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Cited by 420Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Regulation of neuronal input transformations by tunable dendritic inhibition

Lovett-Barron, Matthew, Turi, Gergely F, Kaifosh, Patrick, Lee, Peter H, Bolze, Frédéric, Sun, Xiao-Hua, Nicoud, Jean-François, Zemelman, Boris V +2 more·2012·Nature Neuroscience
DOI 10.1038/nn.3024
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Abstract

Transforming synaptic input into action potential output is a fundamental function of neurons. The pattern of action potential output from principal cells of the mammalian hippocampus encodes spatial and nonspatial information, but the cellular and circuit mechanisms by which neurons transform their synaptic input into a given output are unknown. Using a combination of optical activation and cell type-specific pharmacogenetic silencing in vitro, we found that dendritic inhibition is the primary regulator of input-output transformations in mouse hippocampal CA1 pyramidal cells, and acts by gating the dendritic electrogenesis driving burst spiking. Dendrite-targeting interneurons are themselves modulated by interneurons targeting pyramidal cell somata, providing a synaptic substrate for tuning pyramidal cell output through interactions in the local inhibitory network. These results provide evidence for a division of labor in cortical circuits, where distinct computational functions are implemented by subtypes of local inhibitory neurons.

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Crossref · 10.1038/nn.3024

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50 of 50 references verified0 citation errors · 0 not checkable

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  • In V1, axons of L4 MCs primarily projected to L1 where they are potentially able to synapse onto the tuft of L4 PYRs.

    “In V1, axons of L4 MCs primarily projected to L1 where they are potentially able to synapse onto the tuft of L4 PYRs, similar to the pattern described in other cortical layers58,59.”

    From Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas (2019) · cites this paper as [59]

  • Functional GABAAR-mediated inhibitory inputs are observed onto BiCs and O-LM interneurons with a higher synaptic strength onto the former.

    “Functional GABAAR-mediated inhibitory inputs are observed onto BiCs and O-LM interneurons with a higher synaptic strength onto the former (703).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [703]

  • Inhibiting PV interneuron activity increases the firing rate of BiCs, resulting in a switch from perisomatic to dendritic inhibition of CA1 PCs.

    “Inhibiting PV interneuron activity increases the firing rate of BiCs, resulting in a switch from perisomatic to dendritic inhibition of CA1 PCs (703).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [703]

  • This interaction paces O-LM interneuron output, modulating their firing rate and timing with implications for dendritic electrogenesis, burst firing in PCs, and the generation of oscillatory activity.

    “This interaction paces O-LM interneuron output, modulating their firing rate and timing with implications for dendritic electrogenesis, burst firing in PCs, and the generation of oscillatory activity (703, 1145).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [703]

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Authors
Lovett-Barron, M., Turi, G. F., Kaifosh, P., Lee, P. H., Bolze, F., Sun, X.-H., Nicoud, J.-F., Zemelman, B. V., Sternson, S. M., & Losonczy, A.
Affiliations
  • Columbia University (US)
  • Howard Hughes Medical Institute (US)
  • Centre National de la Recherche Scientifique (FR)
  • The University of Texas at Austin (US)
Corresponding author
Losonczy, Attila
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2012-01-15
Volume
15
Issue
3
Pages
423-430
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.3024
OpenAlex
W2156222687
Cited by
417
References
50
Citations by year
2026: 21 · 2025: 27 · 2024: 16 · 2023: 30 · 2022: 20 · 2021: 28 · 2020: 25 · 2019: 34 · 2018: 28 · 2017: 27 · 2016: 26 · 2015: 32 · 2014: 41 · 2013: 31 · 2012: 31
FWCI
17.79
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dendritic inhibition, CA1 pyramidal neurons, input-output transformation, optical activation
MeSH terms
Channelrhodopsins, Dependovirus, Animals, Biophysics, Cerebral Cortex, DNA-Binding Proteins, Electric Stimulation, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Interneurons, Luminescent Proteins, Membrane Potentials, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Mutation, Neural Inhibition, Synaptic Transmission, Parvalbumins, Photic Stimulation, Pyridazines, Synapses, Transcription Factors, Transduction, Genetic, Valine, Pyramidal Cells, Receptors, Glycine, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Glutamic Acid, GABA Antagonists, RNA, Small Interfering, Mice, Ligand-Gated Ion Channels, In Vitro Techniques

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