Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288

REVIGO summarizes and visualizes long lists of gene ontology terms

Supek, F., Bošnjak, M., Škunca, N., & Šmuc, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021800 · Cited by 6,264

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763

Synaptic scaling mediated by glial TNF-α

Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715

Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage

Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195

Motor skill learning requires active central myelination

McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Marques, S., Zeisel, A., Codeluppi, S., van Bruggen, D., Mendanha Falcão, A., Xiao, L., Li, H., Häring, M., Hochgerner, H., Romanov, R. A., et al. (2016) · Science · doi:10.1126/science.aaf6463 · Cited by 1,132

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062

Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex

Fiore, F., Alhalaseh, K., Dereddi, R. R., Torres, F. B., Çoban, İ., Harb, A., & Agarwal, A. (2023) · Nature Communications · doi:10.1038/s41467-023-43920-w · Cited by 40

The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

Kunkel, T. J., Townsend, A., Sullivan, K. A., Merlet, J., Schuchman, E. H., Jacobson, D., & Lieberman, A. P. (2023) · Nature Communications · doi:10.1038/s41467-023-39733-6 · Cited by 37

Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System

Marangon, D., Caporale, N., Boccazzi, M., Abbracchio, M. P., Testa, G., & Lecca, D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.748849 · Cited by 34

Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?

Zhang, X., Huang, N., Xiao, L., Wang, F., & Li, T. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.760200 · Cited by 32

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain

Lemaître, P., Tareen, S. H. K., Pasciuto, E., Mascali, L. G., Martirosyan, A., Callaerts‐Vegh, Z., Poovathingal, S. K., Dooley, J., Holt, M. G., Yshii, L., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216805 · Cited by 31

Features, Fates, and Functions of Oligodendrocyte Precursor CellsPreprint

Hill, R., Nishiyama, A., & Hughes, E. G. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041425 · Cited by 34

Breaking the barriers to remyelination in multiple sclerosis

Gharagozloo, M., Bannon, R., & Calabresi, P. A. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102194 · Cited by 33

Macroglial diversity: white and grey areas and relevance to remyelination

Werkman, I. L., Lentferink, D. H., & Baron, W. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03586-9 · Cited by 33

A Matter of State: Diversity in Oligodendrocyte Lineage Cells

Kamen, Y., Pivoňková, H., Evans, K. A., & Káradóttir, R. T. (2021) · The Neuroscientist · doi:10.1177/1073858420987208 · Cited by 35

GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration

Khawaja, R. R., Agarwal, A., Fukaya, M., Jeong, H., Gross, S., González‐Fernández, E., Soboloff, J., Bergles, D. E., & Kang, S. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109147 · Cited by 31

NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by inhibiting oxidative stress in Oli-neu cells

He, Z., Zhang, Y., Zhang, H., Zhou, C., Ma, Q., Deng, P., Lu, M., Mou, Z., Lin, M., Yang, L., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112554 · Cited by 31

The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex

Pitman, K. A., Ricci, R., Gasperini, R., Beasley, S. J., Pavez, M., Charlesworth, J., Foa, L. C., & Young, K. M. (2019) · Glia · doi:10.1002/glia.23723 · Cited by 31

Oligodendrocyte lineage and myelination are compromised in the gray matter of focal cortical dysplasia type IIa

Donkels, C., Peters, M., Núñez, M. T. F., Nakagawa, J. M., Kirsch, M., Vlachos, A., Scheiwe, C. F., Schulze‐Bonhage, A., Prinz, M., Beck, J., et al. (2019) · Epilepsia · doi:10.1111/epi.16415 · Cited by 30

Functional Heterogeneity of Mouse and Human Brain OPCs: Relevance for Preclinical Studies in Multiple Sclerosis

Bribián, A., Medina-Rodriguez, E. M., Josa‐Prado, F., García‐Álvarez, I., Machín-Díaz, I., Esteban, P. F., Murcia‐Belmonte, V., Vega-Zelaya, L., Pastor, J., Garrido, L., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061681 · Cited by 30

Oligodendrocyte precursor cell maturation: role of adenosine receptors

Cherchi, F., Pugliese, A. M., & Coppi, E. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.306058 · Cited by 32

SCN2A contributes to oligodendroglia excitability and development in the mammalian brain

Gould, E., & Kim, J. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109653 · Cited by 31

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Is a Negative Regulator of Oligodendrocyte Progenitor Cell Differentiation in the Adult Mouse Brain

Auderset, L., Pitman, K. A., Cullen, C. L., Pepper, R. E., Taylor, B. V., Foa, L., & Young, K. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.564351 · Cited by 30

Navigating oligodendrocyte precursor cell aging in brain health

Leenders, F., Koole, L., Slaets, H., Tiane, A., van den Hove, D., & Vanmierlo, T. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111959 · Cited by 30

Age-Related Alterations in Immune Function and Inflammation: Focus on Ischemic Stroke

Chen, Q., Wu, M., Tang, Q., Yan, P., & Zhu, L. (2023) · Aging and Disease · doi:10.14336/ad.2023.0721-1 · Cited by 33

Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells

Prozorovski, T., Ingwersen, J., Lukas, D., Göttle, P., Koop, B. E., Graf, J., Schneider, R., Franke, K., Schumacher, S., Britsch, S., et al. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.007 · Cited by 30

Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal

Kumar, M., Rainville, J. R., Williams, K., Lile, J. A., Hodes, G. E., Vassoler, F. M., & Turner, J. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108469 · Cited by 27

Targeting microglia–oligodendrocyte crosstalk in neurodegenerative and psychiatric disorders

Rahimian, R., Perlman, K., Canonne, C., & Mechawar, N. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.06.015 · Cited by 32

Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain

Nicholson, M., Wood, R. J., Gonsalvez, D. G., Hannan, A. J., Fletcher, J. L., Xiao, J., & Murray, S. S. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15840 · Cited by 27

Neurogenesis potential of oligodendrocyte precursor cells from oligospheres and injured spinal cord

Zhao, Q. C., Zhu, Y., Ren, Y., Yin, S., Yu, L., Huang, R., Song, S., Hu, X., Zhu, R., Cheng, L., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1049562 · Cited by 27

Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain

Cherchi, F., Bulli, I., Venturini, M., Pugliese, A. M., & Coppi, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147277 · Cited by 27

Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage

Boda, E., Lorenzati, M., Parolisi, R., Harding, B. N., Pallavicini, G., Bonfanti, L., Moccia, A., Bielas, S. L., Cunto, F. D., & Buffo, A. (2022) · Nature Communications · doi:10.1038/s41467-022-30010-6 · Cited by 31

A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity

Lago‐Baldaia, I., Cooper, M., Seroka, A. Q., Trivedi, C. A., Powell, G. T., Wilson, S. W., Ackerman, S. D., & Fernandes, V. M. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002328 · Cited by 30

Identity and nature of neural stem cells in the adult human subventricular zone

Baig, S., Nadaf, J., Allache, R., Le, P. U., Luo, M., Djedid, A., Nkili-Meyong, A. A., Safisamghabadi, M., Prat, A., Antel, J. P., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109342 · Cited by 31

Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain

Gomez, P. T., Carver, C. M., Rodriguez, S. L., Wang, L., Zhang, X., & Schafer, M. J. (2024) · npj Aging · doi:10.1038/s41514-024-00176-y · Cited by 27

Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2

Boshans, L. L., Soh, H., Wood, W. M., Nolan, T. M., Măndoiu, I., Yanagawa, Y., Tzingounis, A. V., & Nishiyama, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-82931-9 · Cited by 28

Mitochondrial network reorganization and transient expansion during oligodendrocyte generation

Bame, X., & Hill, R. (2024) · Nature Communications · doi:10.1038/s41467-024-51016-2 · Cited by 28

Single-cell approaches define two groups of mammalian oligodendrocyte precursor cells and their evolution over developmental time

Dennis, D. J., Wang, B. S., Karamboulas, K., Kaplan, D. R., & Miller, F. D. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.03.002 · Cited by 25

SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation

Ghelman, J., Grewing, L., Windener, F., Albrecht, S., Zarbock, A., & Kuhlmann, T. (2021) · Glia · doi:10.1002/glia.24066 · Cited by 25

Human Oligodendrocyte Myelination Potential; Relation to Age and Differentiation

Luo, J. X. X., Cui, Q., Yaqubi, M., Hall, J. A., Dudley, R., Srour, M., Addour-Boudrahem, N., Jamann, H., Larochelle, C., Blain, M., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26288 · Cited by 26

Oligodendrocyte lineage cells: Advances in development, disease, and heterogeneity

Wang, J., Gao, M.-Y., Gao, R., Zhao, K., Zhang, Y., & Li, X. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15728 · Cited by 24

27‐hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia‐associated brain white matter changes

Alanko, V., Gaminde‐Blasco, A., Quintela‐López, T., Loera‐Valencia, R., Solomon, A., Björkhem, I., Cedazo-Mı́nguez, Á., Maioli, S., Tabacaru, G., Latorre‐Leal, M., et al. (2023) · Glia · doi:10.1002/glia.24348 · Cited by 25

ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice

Schuster, K. H., Zalon, A. J., DiFranco, D. M., Putka, A. F., Stec, N. R., Jarrah, S. I., Naeem, A., Haque, Z., Zhang, H., Guan, Y., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.033 · Cited by 25

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors

Mironova, Y. A., Dang, B., Heo, D., Xu, Y. K. T., Hsu, A. T.-W., von Bernhardi, J. E., Molina-Castro, G. C., Kim, A. A., LIN, J., Reich, D. S., et al. (2026) · Science · doi:10.1126/science.adu2896 · Cited by 28

The effects of developmental and current niches on oligodendrocyte precursor dynamics and fate

Boshans, L. L., Sherafat, A., & Nishiyama, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134593 · Cited by 24

Oligodendrocyte Progenitor Cells in the Tumor Microenvironment

Hide, T., & Komohara, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_8 · Cited by 23

A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System

Ma, Z., Zhang, W., Wang, C., Su, Y., Yi, C., & Niu, J. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01261-8 · Cited by 24

When glia meet induced pluripotent stem cells (iPSCs)

Li, L., & Shi, Y. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103565 · Cited by 24

Heterogeneity of the Endocannabinoid System Between Cerebral Cortex and Spinal Cord Oligodendrocytes

Moreno‐Luna, R., Esteban, P. F., Paniagua‐Torija, B., Arévalo‐Martín, Á., García‐Ovejero, D., & Molina‐Holgado, E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02148-1 · Cited by 22

Oligodendrocyte progenitors as environmental biosensors

Dansu, D. K., Sauma, S., & Casaccia, P. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.012 · Cited by 21

Unlocking the Potential: immune functions of oligodendrocyte precursor cells

Haroon, A., Seerapu, H., Fang, L., Weß, J. H., & Bai, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1425706 · Cited by 21

Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice

Yao, M., Fang, J., Li, J., Ng, A. C. K., Liu, J., Leung, G., Song, F., Zhang, J., & Chang, C. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02561-4 · Cited by 22

A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning

Fang, L.-P., Liu, Q., Meyer, E., Welle, A., Huang, W.-H., Scheller, A., Kirchhoff, F., & Bai, X. (2022) · Glia · doi:10.1002/glia.24284 · Cited by 19

Emerging mitochondrial‐mediated mechanisms involved in oligodendrocyte development

Gil, M., & Gama, V. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25151 · Cited by 24

Bystanders or not? Microglia and lymphocytes in aging and stroke

Chauhan, A., & Nguyen, J. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360345 · Cited by 21

Emerging concepts in oligodendrocyte and myelin formation, inputs from the zebrafish model

Masson, M. L. P., & Nait‐Oumesmar, B. (2023) · Glia · doi:10.1002/glia.24336 · Cited by 24

On Beyond Constructivism

Larison, K. D. (2021) · Science & Education · doi:10.1007/s11191-021-00237-8 · Cited by 27

Live imaging of remyelination in the adult mouse corpus callosum

Bottes, S., & Jessberger, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025795118 · Cited by 22

Endocannabinoid signaling in oligodendroglia

Molina‐Holgado, E., Esteban, P. F., Arévalo‐Martín, Á., Moreno‐Luna, R., Molina‐Holgado, F., & García‐Ovejero, D. (2022) · Glia · doi:10.1002/glia.24180 · Cited by 20

Median eminence myelin continuously turns over in adult mice

Buller, S. A., Kohnke, S., Hansford, R., Shimizu, T., Richardson, W. D., & Blouet, C. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101690 · Cited by 20

Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy

Hsiao, J.-H. T., Tanglay, O., Li, A. A., Strobbe, A. Y. G., Kim, W. S., Halliday, G. M., & Fu, Y. (2023) · Cells · doi:10.3390/cells12050739 · Cited by 20

Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet

Akinlaja, Y. O., & Nishiyama, A. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1418100 · Cited by 23

Clinical and transcriptional recovery profiles in pediatric and adult multiple sclerosis patients

Menascu, S., Khavkin, Y., Zilkha‐Falb, R., Dolev, M., Magalashvili, D., Achiron, A., & Gurevich, M. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51244 · Cited by 19

OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease

Yun, W., Choi, K., Hwang, I.-S., Zheng, J., Park, M., Hong, W., Jang, A.-Y., Kim, J. H., Choi, W., Kim, D., et al. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-021-00199-z · Cited by 21

The bright and the dark side of myelin plasticity: Neuron-glial interactions in health and disease

Monje, M., & Káradóttir, R. T. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.11.009 · Cited by 18

Transcriptomic architecture of nuclei in the marmoset CNS

Lin, J., Kelly, H. M., Song, Y., Kawaguchi, R., Geschwind, D. H., Jacobson, S., & Reich, D. S. (2022) · Nature Communications · doi:10.1038/s41467-022-33140-z · Cited by 16

Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3

Schuster, K. H., DiFranco, D. M., Putka, A. F., Mato, J. P., Jarrah, S. I., Stec, N. R., Sundararajan, V. O., & McLoughlin, H. S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1118429 · Cited by 19

CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance

Takasugi, M., Ohtani, N., Takemura, K., Emmrich, S., Zakusilo, F. T., Yoshida, Y., Kutsukake, N., Mariani, J. N., Windrem, M. S., Chandler-Militello, D., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113130 · Cited by 19

Heterogeneity in oligodendrocyte precursor cell proliferation is dynamic and driven by passive bioelectrical properties

Pivoňková, H., Sitnikov, S., Kamen, Y., Vanhaesebrouck, A. E., Matthey, M., Spitzer, S. O., Ng, Y. T., Tao, C., de Faria, O., Varga, B. V., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114873 · Cited by 22

DNA methylation in Schwann cells and in oligodendrocytes

Arthur‐Farraj, P., & Moyon, S. (2020) · Glia · doi:10.1002/glia.23784 · Cited by 17

What Are the Roles of Oligodendrocyte Precursor Cells in Normal and Pathologic Conditions?

Benarroch, E. E. (2023) · Neurology · doi:10.1212/wnl.0000000000208000 · Cited by 21

Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells

Kamen, Y., Evans, K. A., Sitnikov, S., Spitzer, S. O., de Faria, O., Yucel, M., & Káradóttir, R. T. (2024) · Scientific Reports · doi:10.1038/s41598-024-53615-x · Cited by 17

Neuroinflammation: An Oligodendrocentric View

Festa, L. K., Jordan‐Sciutto, K. L., & Grinspan, J. B. (2025) · Glia · doi:10.1002/glia.70007 · Cited by 18

Fundamental Neurochemistry Review: Incorporating a greater diversity of cell types, including microglia, in brain organoid cultures improves clinical translation

Wenzel, T. J., Le, J., He, J., Alcorn, J., & Mousseau, D. D. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15741 · Cited by 17

Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice

Islam, R., White, J. D., Arefin, T. M., Mehta, S. S., Liu, X., Polis, B., Giuliano, L., Ahmed, S., Bowers, C. A., Zhang, J., et al. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00616-0 · Cited by 18

Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells

Mariani, J. N., Mansky, B., Madsen, P. M., Salinas, D., Kesmen, D., Huynh, N. P. T., Kuypers, N. J., Kesel, E. R., Bates, J., Payne, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48118-2 · Cited by 16

Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Pruvost, M., & Moyon, S. (2021) · Life · doi:10.3390/life11010062 · Cited by 18

Novel Tools and Investigative Approaches for the Study of Oligodendrocyte Precursor Cells (NG2-Glia) in CNS Development and Disease

Galichet, C., Clayton, R. W., & Lovell-Badge, R. H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.673132 · Cited by 16

Lineage-specific control of convergent differentiation by a Forkhead repressor

Mizeracka, K., Rogers, J. M., Rumley, J. D., Shaham, S., Bulyk, M. L., Murray, J. I., & Heiman, M. G. (2021) · Development · doi:10.1242/dev.199493 · Cited by 16

High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS

Xing, Y. L., Poh, J., Chuang, B. H. A., Moradi, K., Mitew, S., Richardson, W. D., Kilpatrick, T. J., Osanai, Y., & Merson, T. D. (2023) · Cell Reports Methods · doi:10.1016/j.crmeth.2023.100414 · Cited by 15

Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley

Vasylyev, D. V., Liu, C.-J., & Waxman, S. G. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.11.009 · Cited by 15

Oligodendrogenesis in Evolution, Development and Adulthood

Hu, H., Gao, T., Zhao, J., & Li, H. (2025) · Glia · doi:10.1002/glia.70033 · Cited by 16

Potassium channel K ir 4.1 regulates oligodendrocyte differentiation via intracellular pH regulation

Wang, N., Zhou, L., Shao, C., Wang, X., Zhang, N., Ma, J., Hu, H., Wang, Y., Qiu, M. S., & Shen, Y. (2022) · Glia · doi:10.1002/glia.24240 · Cited by 15

Thirty years of BDNF study in central myelination: From biology to therapy

Xiao, J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15968 · Cited by 16

Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor

Chen, K., Park, E., & Abd‐Elrahman, K. S. (2025) · Molecular Pharmacology · doi:10.1016/j.molpha.2025.100027 · Cited by 15

Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties

Treccani, G., Yiğit, H., Lingner, T., Schleuβner, V., Mey, F., van der Kooij, M. A., Wennström, M., Herzog, D. P., Linke, M., Fricke, M., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100338 · Cited by 14

Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture

Schuster, K. H., Putka, A. F., & McLoughlin, H. S. (2022) · Cells · doi:10.3390/cells11162615 · Cited by 16

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Glial Control of Cortical Neuronal Circuit Maturation and Plasticity

Faust, T. E., Devlin, B. A., Farhy-Tselnicker, I., Ferro, A., Postolache, M., & Xin, W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1208-24.2024 · Cited by 13

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Kooistra, S. M., & Schirmer, L. (2024) · Glia · doi:10.1002/glia.24655 · Cited by 14

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Kiaie, N., Gorabi, A. M., Loveless, R., Teng, Y., Jamialahmadi, T., & Sahebkar, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104794 · Cited by 13

Changes in and asymmetry of the proteome in the human fetal frontal lobe during early development

Zhao, X., Liang, W., Wang, W., Liu, H., Zhang, X., Liu, C., Zhu, C., Cui, B., Tang, Y., & Liu, S. (2022) · Communications Biology · doi:10.1038/s42003-022-04003-6 · Cited by 12

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Putka, A. F., Mato, J. P., & McLoughlin, H. S. (2023) · Cells · doi:10.3390/cells12040601 · Cited by 12

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Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation

Raabe, F. J., Stephan, M., Waldeck, J. B., Huber, V., Demetriou, D., Kannaiyan, N. R., Galinski, S., Glaser, L. V., Wehr, M. C., Ziller, M. J., et al. (2022) · Cells · doi:10.3390/cells11020241 · Cited by 11

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Zheng, Y., Huang, R., & Pan, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178155 · Cited by 11

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Cvetanović, M., & Gray, M. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01357-5 · Cited by 12

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Antunes, A. S. L. M., & Martins‐de‐Souza, D. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.03.013 · Cited by 14

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Agathou, S., & Káradóttir, R. T. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9072-6_9 · Cited by 11

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Osório, M. J., Mariani, J. N., Zou, L., Schanz, S. J., Heffernan, K. S., Cornwell, A., & Goldman, S. A. (2022) · Glia · doi:10.1002/glia.24291 · Cited by 10

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Age-related glial cell heterogeneity

Stern, P. (2019) · Science · doi:10.1126/science.363.6430.942-e

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Kamen, Y. (2022) · Apollo (University of Cambridge) · doi:10.17863/cam.93606

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Unveiling oligodendrocyte precursor cell heterogeneity: Focus on brain´s regional differences and on the G Protein coupled receptor GPR17.

Viganò, F. (2012) · PuSH - Publication Server of Helmholtz Zentrum München

Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain

Beiter, R. M., Rivet-Noor, C. R., Merchak, A. R., Bai, R., Johanson, D. M., Slogar, E. R., Sol‐Church, K., Overall, C. C., & Gaultier, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-17081-7 · Cited by 70