Cited by 369Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Open access

Spitzer, Sonia Olivia, Sitnikov, Sergey, Kamen, Yasmine, Evans, Kimberley Anne, Kronenberg-Versteeg, Deborah, Dietmann, Sabine, de Faria, Omar, Agathou, Sylvia, Káradóttir, Ragnhildur Thóra·2019·Neuron

DOI 10.1016/j.neuron.2018.12.020PMC PMC6372724

Open this paper in CoChat — free account Open PDF

Abstract

Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2018.12.020

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
REVIGO summarizes and visualizes long lists of gene ontology terms
Supek, F., Bošnjak, M., Škunca, N., & Šmuc, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021800 · Cited by 6,264
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195
Motor skill learning requires active central myelination
McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques, S., Zeisel, A., Codeluppi, S., van Bruggen, D., Mendanha Falcão, A., Xiao, L., Li, H., Häring, M., Hochgerner, H., Romanov, R. A., et al. (2016) · Science · doi:10.1126/science.aaf6463 · Cited by 1,132
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062

Flagged first, then by citations

Show all 53 references

Sorted by citations

Items 301–369 of 369

Early Deprivation Impairs Perforant Pathway Connectivity and Contextual Memory in Adolescent Male MicePreprint
Islam, R., White, J. D., Arefin, T. M., Mehta, S. S., Liu, X., Polis, B., Giuliano, L., Ahmed, S., Bowers, C. A., Zhang, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.08.552517 · Cited by 1
Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular BiogeographyPreprint
Tahmasian, N., Feng, M. Y., Arbabi, K., Rusu, B., Cao, W., Kukreja, B., Lubotzky, A., Wainberg, M., Tripathy, S. J., & Kalish, B. T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.25.581974 · Cited by 1
Forelimb motor learning and memory consolidation drives distinct oligodendrocyte plasticity to fine-tune task-related neural activityPreprint
Xiao, L., Wang, S., Xu, N., Wang, W., He, Y., Yang, Y., Zhang, L., Zou, Y., He, Y., Gao, L., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4579212/v1 · Cited by 1
Constitutive DREADD signalling modulates oligodendrocyte precursor cell bioelectrical membrane properties and fatePreprint
Kamen, Y., Vagionitis, S., de Faria, O., & Káradóttir, R. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.22.695316 · Cited by 1
Self-citation
Inflammation-induced epigenetic memory restores oligodendrocyte progenitor cell regenerative capacity in the aged central nervous systemPreprint
Cabeza‐Fernández, S., Niñerola, S., Armengol-Gomis, A., Paraíso‐Luna, J., Casillas-Bajo, Á., Gomez-Sanchez, J. A., Cabedo, H., Barco, Á., & de la Fuente, A. G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.11.724385 · Cited by 1
Age and axon-specific forms of cortical remyelination by divergent populations of NG2-gliaPreprint
Chapman, T. W., Olveda, G. E., Pereira, E., & Hill, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.09.414755
Neuronal and microglial interactions with oligodendrocytes regulate myelin sheath formation and elimination
Hughes, A. (2020) · doi:10.25677/72qa-5t41
Age-Associated Induction of Senescent Transcriptional Programs in Human Glial Progenitor CellsPreprint
Mariani, J. N., Madsen, P. M., Mansky, B., Huynh, N. P. T., Kuypers, N. J., Kesel, E. R., Chandler-Militello, D., Benraiss, A., & Goldman, S. A. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3950750
Hacia una etica global
Singer, P. (2003) · Claves de razón práctica
A distinct subset of oligodendrocyte lineage cells interact with the developing dorsal root entry during its genesisPreprint
Green, L. A., Gallant, R., Brandt, J. P., Nichols, E. L., & Smith, C. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.10.483786
Reprogramming of mouse embryonic fibroblasts into induced oligodendrocyte progenitor cells via nanovector-mediated indirect lineage conversionPreprint
Xiao, X., Ling, W., Qiu, X., Wang, M., Xiong, C., Xie, D.-F., Chu, X., Li, Y.-X., Huang, Y., Li, T., et al. (2020) · doi:10.21203/rs.3.rs-35533/v1
Integrated high-confidence and high-throughput approaches for quantifying synapse engulfment by oligodendrocyte precursor cellsPreprint
Kahng, J. A., Xavier, A. M., Ferro, A., Auguste, Y. S. S., & Cheadle, L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.24.554663
Glial Phenotype Plasticity
Walz, W. (2023) · Springer eBooks · doi:10.1007/978-3-031-48105-5_19
Glial Cells During the Life Cycle
Walz, W. (2023) · Springer eBooks · doi:10.1007/978-3-031-48105-5_3
Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors
Özkan, A., Padmanabhan, H. K., Shipman, S. L., Azim, E., Kumar, P., Sadegh, C., Başak, A. N., & Macklis, J. D. (2026) · eLife · doi:10.1101/2024.04.21.590488
Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitorsPreprint
Özkan, A., Padmanabhan, H. K., Shipman, S. L., Azim, E., Kumar, P., Sadegh, C., Başak, A. N., & Macklis, J. D. (2024) · eLife · doi:10.7554/elife.100340.1
Perineuronal oligodendroglia: functional specialisation or serendipitous location?
Butt, A. M., Stevens, R., Hunter, I., Gill, A., Hookings, T., & Willis, A. (2025) · Ageing & Longevity · doi:10.47855/jal9020-2025-2-4
Orchestrating the neuroglial compartment: Ontogeny and developmental interaction of astrocytes, oligodendrocytes, and microglia
Schuurmans, I. M. E., Mordelt, A., & de Witte, L. D. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00011-5
Pathways that limit differentiation of oligodendrocyte progenitors in the aging brain
(2025) · Nature Aging · doi:10.1038/s43587-025-00848-8
Exploring neuro-glial interaction mechanisms in myelin plasticity for learning and memory enhancement
Wahid, R. M., Hassan, N. H., Samy, W. M., Talaat, A., Gobran, A. M., Abdelmohsen, S. R., & Elsayed, H. A. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10431-5
Morphology of Oligodendroglial Cells
Butt, A. M., Willis, A., Stevens, R., Hunter, I., & Nishiyama, A. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-87919-7_5
Comparative Analysis of Neonatal Hypomyelination Models Using Spatial TranscriptomicsPreprint
Fabres, R. B., da Silvia, V. R. C. T., Zhang, S., Synowiec, S., Takada, S. H., Duan, J., & Drobyshevsky, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.23.661209
Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells
Cheli, V. T., Tumuluri, S. G., McDonald, Z., Denton, T. T., Dupree, J. L., Paez, P. M., & Feinstein, D. L. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70061
Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitorsPreprint
Özkan, A., Padmanabhan, H. K., Shipman, S. L., Azim, E., Kumar, P., Sadegh, C., Başak, A. N., & Macklis, J. D. (2025) · eLife · doi:10.7554/elife.100340.2
Calcium Signaling in Oligodendrocyte Precursor Cells Mediated by Spontaneous and Evoked Responses: A Modeling InvestigationPreprint
Lardy, M., Wang, L., Guerrier, C., Cheli, V. T., Paez, P. M., & Khadra, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.14.670262
Oligodendrocyte progenitor cell responses to inflammatory demyelination with agingPreprint
Fresenko, E. E., Bahri, C. N., Ahmed, N. F., Packer, D., Tabor, B. J., Sun, W., Wedemeyer, M. A., & Harrington, C. A. (2025) · Research Square · doi:10.21203/rs.3.rs-7614774/v1
Oligodendrocyte progenitor cell responses to inflammatory demyelination with aging in mouse model of multiple sclerosisPreprint
Fresenko, E. E., Bahri, C. N., Burson, B. J., Ahmed, N. F., Packer, D., Tabor, B. J., Beirowski, B., Sun, W., Wedemeyer, M. A., & Harrington, C. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.22.677854
Early developmental neuronal activity inhibits oligodendrocyte differentiation through AMPA receptor activationPreprint
Allen, T. E., Peet, G. C., Wulschner, L. E. G., Oh, W. C., & Macklin, W. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.17.683139
P/Q-type voltage-gated calcium channels regulate calcium signaling and developmental myelination in oligodendrocyte lineage cellsPreprint
Piller, M., Doan, R. A., Call, C. L., Smith, S. M., & Monk, K. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.12.694003
Additional file 2 of Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice
Yao, M., Fang, J., Li, J., Ng, A. C. K., Liu, J., Leung, G. K. K., Song, F., Zhang, J., & Chang, C. (2022) · Figshare · doi:10.6084/m9.figshare.20514833
Additional file 4 of Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Seeker, L. A., Bestard-Cuche, N., Jäkel, S., Kazakou, N.-L., Bøstrand, S. M. K., Wagstaff, L. J., Cholewa-Waclaw, J., Kilpatrick, A. M., van Bruggen, D., Kabbe, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591057
Additional file 1 of Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Islam, R., White, J. D., Arefin, T. M., Mehta, S. S., Liu, X., Polis, B., Giuliano, L., Ahmed, S., Bowers, C., Zhang, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26716942
Additional file 2 of Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Seeker, L. A., Bestard-Cuche, N., Jäkel, S., Kazakou, N.-L., Bøstrand, S. M. K., Wagstaff, L. J., Cholewa-Waclaw, J., Kilpatrick, A. M., van Bruggen, D., Kabbe, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591051
Additional file 1 of Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Seeker, L. A., Bestard-Cuche, N., Jäkel, S., Kazakou, N.-L., Bøstrand, S. M. K., Wagstaff, L. J., Cholewa-Waclaw, J., Kilpatrick, A. M., van Bruggen, D., Kabbe, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591048
Additional file 3 of Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice
Yao, M., Fang, J., Li, J., Ng, A. C. K., Liu, J., Leung, G. K. K., Song, F., Zhang, J., & Chang, C. (2022) · Figshare · doi:10.6084/m9.figshare.20514836
Additional file 6 of Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Seeker, L. A., Bestard-Cuche, N., Jäkel, S., Kazakou, N.-L., Bøstrand, S. M. K., Wagstaff, L. J., Cholewa-Waclaw, J., Kilpatrick, A. M., van Bruggen, D., Kabbe, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591063
Additional file 4 of Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice
Yao, M., Fang, J., Li, J., Ng, A. C. K., Liu, J., Leung, G. K.-K., Song, F., Zhang, J., & Chang, C. (2022) · Figshare · doi:10.6084/m9.figshare.20514839
Additional file 1 of Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice
Yao, M., Fang, J., Li, J., Ng, A. C. K., Liu, J., Leung, G. K. K., Song, F., Zhang, J., & Chang, C. (2022) · Figshare · doi:10.6084/m9.figshare.20514830
Additional file 5 of Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Seeker, L. A., Bestard-Cuche, N., Jäkel, S., Kazakou, N.-L., Bøstrand, S. M. K., Wagstaff, L. J., Cholewa-Waclaw, J., Kilpatrick, A. M., van Bruggen, D., Kabbe, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591060
Additional file 3 of Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Seeker, L. A., Bestard-Cuche, N., Jäkel, S., Kazakou, N.-L., Bøstrand, S. M. K., Wagstaff, L. J., Cholewa-Waclaw, J., Kilpatrick, A. M., van Bruggen, D., Kabbe, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591054
Neuronal TrkB supports adult cortical oligodendrogenesis in the brains of older adult mice
Nicholson, M., Wood, R. J., Murray, S. S., & Fletcher, J. L. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.12.009
Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review
Inserra, A., Murray, C. J., Campanale, A., VanderZwaag, J., & Tremblay, M. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1690318
Advances in rodent oligodendrocyte precursor cells isolation and culture: From traditional methods to modern approaches
Akbari, H., Kashani, I. R., Yazdi, F. R., Pasbakhsh, P., & Mojaverrostami, S. (2026) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2026.110706
Glial contributions to sleep: emerging roles in expression, regulation, and function
Ingiosi, A. M. (2026) · SLEEP · doi:10.1093/sleep/zsag070
Régénération spontanée de la myéline dans le cerveau de souris adulte : interactions entre cellules souches, progéniteurs et microglie
Brousse, B. (2019) · theses.fr (ABES) · doi:10.70675/84a13ba7z3dc7z4ffazab9bz484310509294
Le cil primaire : une nouvelle cible pour la remyélinisation ?
Delfino, G. (2020) · theses.fr (ABES) · doi:10.70675/a62c179az64bfz4247zb041zc7cfc961677c
Mécanismes moléculaires et cellulaires impliqués dans la production de la myéline induite par les voies de signalisation Hedgehog et des androgènes dans le système nerveux central
Kassoussi, A. (2021) · theses.fr (ABES) · doi:10.70675/38265e1ez294bz4bcez8a40z0950f2d261f8
Fonctions de PAK1 dans la régulation du cytosquelette d’actine : implication dans la myélinisation du système nerveux central
Baudouin, L. (2021) · theses.fr (ABES) · doi:10.70675/75a319c3z246bz4800z9a27z970f7eb653f4
TCF12 roles in oligodendroglial cells and gliomas
Archontidi, S. (2021) · theses.fr (ABES) · doi:10.70675/ff2d35a7z988ez4886zbc49z95515fc3af57
Etude des conséquences des altérations de la myéline sur les fonctions cognitives à la suite d’un épisode transitoire de démyélinisation chez la souris adulte
Mercier, O. (2022) · theses.fr (ABES) · doi:10.70675/d08f6127z74b9z4df6zb55dz2fb5ac93dea2
Molecular mechanism of GluN3A containing NMDA receptors
Battista, M. D. (2022) · theses.fr (ABES) · doi:10.70675/b815d9e2zd910z4047z9eb8za49aa2a22489
Rôle inattendu de la signalisation des androgènes dans le système nerveux central démyélinisé de la souris femelle : Identification de spécificités liées au sexe de l'animal
Zahaf, A. (2022) · theses.fr (ABES) · doi:10.70675/556f2067zcd1az40b4z8d33z41a22005020e
Contribution des neuroblastes dérivés de la zone sous ventriculaire à la régénération de la myéline dans le cerveau de souris adulte : impact des propriétés mécaniques des tissus
Falque, M. (2023) · theses.fr (ABES) · doi:10.70675/f778841bz8528z4bd0z9904za8868abb942d
Rôle de la protéine de densité post-synaptique 95 (PSD-95) dans la myélinisation du système nerveux central
Masson, M. L. P. (2024) · theses.fr (ABES) · doi:10.70675/7f680c8dz2453z40c7z9047z982a66a8bfd5
Aged oligodendrocyte progenitors retain the capacity to respond to an inflammatory insult
Fresenko, E. E., Kaiser, K. E., Burson, B., Bahri, C. N., Ahmed, N., Bozik, J. B., Packer, D., Tabor, B. J., Beirowski, B., Wedemeyer, M. A., et al. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115874
Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation
Lardy, M., Wang, L., Guerrier, C., Cheli, V. T., Paez, P. M., & Khadra, A. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013430
Clusterin regulates microglial inflammation and cognitive function independent of amyloid pathology in Alzheimer’s diseasePreprint
Rawal, P., Moon, H.-J., Nguyen, V., Khatri, S., Larson, M. A., Vivian, J. C., Saido, T. C., & Zhao, L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.30.741791
Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis
Dierckx, T., Wilson, S. E., Buchanan, R., Tsarouchas, T. M., Cheng, Y.-H., Nuñez, M. S., Strickland, K., Kumsa, D., Auguste, Y. S. S., Vanherle, S., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.07.015
Human Stem Cell-Derived Models of the Alzheimer’s Disease Neuroimmune System
Summers, R., Quang, D., & Johnson, N. R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167360 · Cited by 1
Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M
Andrews, J. M., Budd, K. M., Kwon, C.-H., Larson, J. D., Shirinifard, A., Kasper, L. H., Williams, C. C., Lavado, A., King, S., Gutierrez, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76468-6
Diversity of glutamate receptors in glial cells of the mouse optic nerve
Kompier, N. F., Semtner, M., Walter, S., Steinhäuser, C., Nolte, C., & Kettenmann, H. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1911068
Harnessing Neurogenic Potential of Glial Cell Types as an Emerging Strategy for Treating Epilepsy
Chesnokova, E., Kotova, I., Reznikova, A., Balaban, P. M., & Bal, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209147
Progenitor Timing Shapes NG2 ‐Glia Fate and Oligodendrocyte Differentiation
Ojalvo‐Sanz, A. C., Pernia‐Solanilla, C., & López‐Mascaraque, L. (2026) · Glia · doi:10.1002/glia.70224
Cannabis THC:CBD Composition Affects Oligodendrocyte Progenitor Cell Characteristics Following Acute Cannabis Vapor Inhalation in Adult Male and Female MicePreprint
Murray, C. J., Thorpe, H. H. A., Kayır, H., Osborne, E., Foster, S. W., Loewen, S. M., Rogers, M., Vecchiarelli, H. A., Khokhar, J. Y., & Tremblay, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.18.752658
Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions
de la Fuente, A. G. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70676
Beyond Histamine Blockade: Clemastine Fumarate as a Promoter of Myelin Regeneration, Inflammatory Regulation, and Neuroimmune Modulation in CNS Disorders
Singh, R. K., Banerjee, C., & Mehan, S. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-026-10321-x
Altered oligodendroglial cell development and increased myelination in SCN2A gain-of-function-linked epilepsy
Baez, C. B.-R., Xin, X., Lyu, H., Kirianov, D., Sun, Y., Späte, E., Grassia, M., Engeland, B., Stockebrand, M. C., Khodosevich, K., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02437-1
Combining pharmacological and non-invasive brain stimulation strategies to promote remyelination in multiple sclerosis
Scheinok, T., Bundel, D. D., Vanmierlo, T., & Schependom, J. V. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1980126
Within-state transcriptional remodelling predominates in a 41-gene ageing programme of human prefrontal OPCs
Yamanaka, T., & Matsui, H. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107670

Authors: Spitzer, S. O., Sitnikov, S., Kamen, Y., Evans, K. A., Kronenberg-Versteeg, D., Dietmann, S., de Faria, O., Agathou, S., & Káradóttir, R. T.
Affiliations: Wellcome/MRC Cambridge Stem Cell Institute (GB)
Corresponding author: Káradóttir, Ragnhildur Thóra
ORCID: Kamen, Yasmine
Evans, Kimberley Anne
Dietmann, Sabine
Káradóttir, Ragnhildur Thóra
Venue: Neuron
Publisher: Elsevier BV
Published: 2019-02
Volume: 101
Issue: 3
Pages: 459-471.e5
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2018.12.020
PMC: PMC6372724
OpenAlex: W2909833689
Cited by: 364
References: 53
Citations by year: 2026: 32 · 2025: 48 · 2024: 53 · 2023: 47 · 2022: 66 · 2021: 52 · 2020: 41 · 2019: 23
FWCI: 17.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Neuron (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Opin vísindi (Opin vísindi) (submittedVersion, cc-by-nc-sa)
Apollo (University of Cambridge) (submittedVersion, cc-by)
Opin vísindi (Opin vísindi) (submittedVersion, other-oa)
Apollo (cc-by)
Funders: European Research Council
European Union Horizon 2020 Research and Innovation Program (771411)
Wellcome Trust (091543/Z/10/Z, 102160/Z/13/Z)
Paul G. Allen Frontiers Group (12076)
Medical Research Council
Gates Cambridge Trust
Biotechnology and Biological Sciences Research Council
Homerton College Cambridge
UK MS Society (50)
Fonds de Recherche du Québec - Santé
Cambridge Commonwealth, European and International Trust
Lister Institute
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: oligodendrocyte precursor cells, functional heterogeneity, regional heterogeneity, aging, myelination, oligodendrocyte differentiation, single-cell electrophysiology, adult brain
MeSH terms: Action Potentials, Animals, Brain, Cells, Cultured, Female, Ion Channels, Male, Mice, Inbred C57BL, Oligodendroglia, Receptors, N-Methyl-D-Aspartate, Mice, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks