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Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age
Open accessAbstract
Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age.
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“Nonetheless, we did observe the previously reported aging-related decline of OPC 49 , NRP 35,36 and ImmN 36,50 .”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [49]
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Single-cell transcriptomic profiling of the aging mouse brain
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Brain aging mechanisms with mechanical manifestations
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Metadata
- Authors
- Spitzer, S. O., Sitnikov, S., Kamen, Y., Evans, K. A., Kronenberg-Versteeg, D., Dietmann, S., de Faria, O., Agathou, S., & Káradóttir, R. T.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Corresponding author
- Káradóttir, Ragnhildur Thóra
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 101
- Issue
- 3
- Pages
- 459-471.e5
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6372724
- OpenAlex
- W2909833689
- Cited by
- 364
- References
- 53
- Citations by year
- 2026: 32 · 2025: 48 · 2024: 53 · 2023: 47 · 2022: 66 · 2021: 52 · 2020: 41 · 2019: 23
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuron (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Opin vísindi (Opin vísindi) (submittedVersion, cc-by-nc-sa)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Opin vísindi (Opin vísindi) (submittedVersion, other-oa)
- Apollo (cc-by)
- Funders
- European Research Council
- European Union Horizon 2020 Research and Innovation Program (771411)
- Wellcome Trust (091543/Z/10/Z, 102160/Z/13/Z)
- Paul G. Allen Frontiers Group (12076)
- Medical Research Council
- Gates Cambridge Trust
- Biotechnology and Biological Sciences Research Council
- Homerton College Cambridge
- UK MS Society (50)
- Fonds de Recherche du Québec - Santé
- Cambridge Commonwealth, European and International Trust
- Lister Institute
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- oligodendrocyte precursor cells, functional heterogeneity, regional heterogeneity, aging, myelination, oligodendrocyte differentiation, single-cell electrophysiology, adult brain
- MeSH terms
- Action Potentials, Animals, Brain, Cells, Cultured, Female, Ion Channels, Male, Mice, Inbred C57BL, Oligodendroglia, Receptors, N-Methyl-D-Aspartate, Mice, Neural Stem Cells
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