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Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age
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Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age.
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“Nonetheless, we did observe the previously reported aging-related decline of OPC 49 , NRP 35,36 and ImmN 36,50 .”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [49]
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Metadata
- Authors
- Spitzer, S. O., Sitnikov, S., Kamen, Y., Evans, K. A., Kronenberg-Versteeg, D., Dietmann, S., de Faria, O., Agathou, S., & Káradóttir, R. T.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Corresponding author
- Káradóttir, Ragnhildur Thóra
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 101
- Issue
- 3
- Pages
- 459-471.e5
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6372724
- OpenAlex
- W2909833689
- Cited by
- 364
- References
- 53
- Citations by year
- 2026: 32 · 2025: 48 · 2024: 53 · 2023: 47 · 2022: 66 · 2021: 52 · 2020: 41 · 2019: 23
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuron (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Opin vísindi (Opin vísindi) (submittedVersion, cc-by-nc-sa)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Opin vísindi (Opin vísindi) (submittedVersion, other-oa)
- Apollo (cc-by)
- Funders
- European Research Council
- European Union Horizon 2020 Research and Innovation Program (771411)
- Wellcome Trust (091543/Z/10/Z, 102160/Z/13/Z)
- Paul G. Allen Frontiers Group (12076)
- Medical Research Council
- Gates Cambridge Trust
- Biotechnology and Biological Sciences Research Council
- Homerton College Cambridge
- UK MS Society (50)
- Fonds de Recherche du Québec - Santé
- Cambridge Commonwealth, European and International Trust
- Lister Institute
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- oligodendrocyte precursor cells, functional heterogeneity, regional heterogeneity, aging, myelination, oligodendrocyte differentiation, single-cell electrophysiology, adult brain
- MeSH terms
- Action Potentials, Animals, Brain, Cells, Cultured, Female, Ion Channels, Male, Mice, Inbred C57BL, Oligodendroglia, Receptors, N-Methyl-D-Aspartate, Mice, Neural Stem Cells
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