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RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1

Choi, W., Choe, M. S., Kim, S. M., Kim, S. J., Lee, J., Lee, Y., Lee, S.-M., Dho, S. H., Lee, M. Y., & Kim, L. K. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05129-y · Cited by 26 · see citing works

Near-Infrared-II Imaging Revealed Hypothermia Regulates Neuroinflammation Following Brain Injury by Increasing the Glymphatic Influx

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Reprogramming cellular identity in vivo

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The bHLH Transcription Factors in Neural Development and Therapeutic Applications for Neurodegenerative Diseases

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Commonly Overlooked Factors in Biocompatibility Studies of Neural Implants

Kumosa, L. S. (2023) · Advanced Science · doi:10.1002/advs.202205095 · Cited by 21 · see citing works

Radial stem astrocytes (aka neural stem cells): Identity, development, physio‐pathology, and therapeutic potential

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Origin, molecular specification, and stemness of astrocytes

Zheng, K., Huang, H., Yang, J., & Qiu, M. S. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22863 · Cited by 19 · see citing works

Cell reprogramming therapy for Parkinson’s disease

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Cell Reprogramming for Regeneration and Repair of the Nervous System

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A promise for neuronal repair: reprogramming astrocytes into neurons in vivo

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IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation

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Notch-mediated re-specification of neuronal identity during central nervous system development

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Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies

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New role of astrocytes in neuroprotective mechanisms after ischemic stroke

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Unexpected BrdU inhibition on astrocyte-to-neuron conversion

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Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Yang, R., Pan, J., Wang, Y., Xia, P.-H., Tai, M., Jiang, Z., & Chen, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1005399 · Cited by 15 · see citing works

Direct In Vitro Reprogramming of Astrocytes into Induced Neurons

Sharif, N., Calzolari, F., & Berninger, B. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1601-7_2 · Cited by 14 · see citing works

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno‐Associated Viral Vector rAAV9P1

Bauer, A., Puglisi, M., Nagl, D., Schick, J., Werner, T. A., Klingl, A., Andari, J. E., Hornung, V., Kessler, H., Götz, M., et al. (2022) · Advanced Science · doi:10.1002/advs.202104979 · Cited by 12 · see citing works

How Widespread Are the “Young” Neurons of the Mammalian Brain?

Ghibaudi, M., & Bonfanti, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.918616 · Cited by 13 · see citing works

Enhancing NeuroD1 Expression to Convert Lineage-Traced Astrocytes into NeuronsPreprint

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Synergistic Enhancement of Adeno‐Associated Virus‐Mediated In Vivo Direct Neuronal Reprogramming by Spatially Aligned Fibrous Matrices in Spinal Cord Injury Models

Kim, J., Son, Y.-W., Hwang, K., Park, H., Kim, Y., Kim, M., Shin, J. E., Park, K. I., Lee, S., & Jang, J. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300040 · Cited by 13 · see citing works

Neuronal repair after spinal cord injury by in vivo astrocyte reprogramming mediated by the overexpression of NeuroD1 and Neurogenin-2

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Suppression of PTBP1 in hippocampal astrocytes promotes neurogenesis and ameliorates recognition memory in mice with cerebral ischemia

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Astrocyte Reprogramming in Stroke: Opportunities and Challenges

Peng, Z., Lu, H., Yang, Q., & Xie, Q. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.885707 · Cited by 13 · see citing works

Comparing Viral Vectors and Fate Mapping Approaches for Astrocyte-to-Neuron Reprogramming in the Injured Mouse Cerebral Cortex

Puglisi, M., Lao, C. L., Wani, G. A., Masserdotti, G., Bocchi, R., & Götz, M. (2024) · Cells · doi:10.3390/cells13171408 · Cited by 12 · see citing works

Brain Repair by Cell Replacement via In Situ Neuronal Reprogramming

Qian, H., & Fu, X. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-071719-023616 · Cited by 14 · see citing works

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Spreng, A., Brüll, M., Leisner, H., Suciu, I., & Leist, M. (2022) · Cells · doi:10.3390/cells11172644 · Cited by 14 · see citing works

Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro?

Salmina, A. B., Alexandrova, O. P., Сергеевич, А. А., Korsakova, S. A., Saridis, M. R., Illarioshkin, S. N., & Yurchenko, S. O. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241235527 · Cited by 11 · see citing works

Reprogramming of astrocytes and glioma cells into neurons for central nervous system repair and glioblastoma therapy

Wei, J., Wang, M., Li, S., Han, R. F., Xu, W., Zhao, A., Yu, Q., Li, H., Li, M., & Chi, G. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116806 · Cited by 11 · see citing works

Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming

Stricker, S. H., & Götz, M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105174 · Cited by 10 · see citing works

Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges

Chen, J., Huang, L., Yang, Y., Xu, W., Qin, Q., Qin, R., Liang, X., Lai, X., Huang, X., Xie, M., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13030524 · Cited by 11 · see citing works

cAAVe phaenomena: Beware of appearances!

Calzolari, F., & Berninger, B. (2021) · Cell · doi:10.1016/j.cell.2021.09.027 · Cited by 11 · see citing works

Natural and forced neurogenesis in the adult brain: Mechanisms and their possible application to treat neurological disorders

Matsuda, T., & Nakashima, K. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.05.011 · Cited by 11 · see citing works

Nanoparticle-Mediated Nose-to-Brain Delivery for Ischemic Stroke Therapy: Preclinical Insights

Park, J., & Riew, T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111447 · Cited by 10 · see citing works

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

Wu, Z., Xu, L., Xie, Y., Sambangi, A., Swaminathan, S., Pei, Z., Ji, W., Li, Z., Guo, Y., Li, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202410080 · Cited by 10 · see citing works

Direct Cell Reprogramming and Phenotypic Conversion: An Analysis of Experimental Attempts to Transform Astrocytes into Neurons in Adult Animals

Dennison, R., Usuga, E., Chen, H., Paul, J. Z., Arbelaez, C. A., & Teng, Y. D. (2023) · Cells · doi:10.3390/cells12040618 · Cited by 11 · see citing works

Strategies and mechanisms of neuronal reprogramming

Wan, Y., & Ding, Y. P. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110661 · Cited by 10 · see citing works

Efficient Dlx2‐mediated astrocyte‐to‐neuron conversion and inhibition of neuroinflammation by NeuroD1

Liu, M., Xu, Y., Bai, X., Lin, J.-H., Xiang, Z., Wang, T., Xu, L., Li, W., & Chen, G. (2024) · Developmental Neurobiology · doi:10.1002/dneu.22951 · Cited by 9 · see citing works

Ice coating –A new method of brain device insertion to mitigate acute injuries

Mohammed, M., Thelin, J., Gällentoft, L., Thorbergsson, P. T., Kumosa, L. S., Schouenborg, J., & Pettersson, L. M. E. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108842 · Cited by 9 · see citing works

Neuronal Reprogramming for Brain Repair: Challenges and Perspectives

Bocchi, R., & Götz, M. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.08.006 · Cited by 9 · see citing works

In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?

Parmar, M., Björklund, A., & Björklund, T. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.06.002 · Cited by 9 · see citing works

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Flitsch, L. J., Börner, K., Stüllein, C., Ziegler, S., Sonntag-Buck, V., Wiedtke, E., Semkova, V., Yeung, S. W. C. A., Schlee, J., Hajo, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12404-0 · Cited by 9 · see citing works

Progress of reprogramming astrocytes into neuron

Liu, S., Xu, X., Omari‐Siaw, E., Yu, J., & Deng, W. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103947 · Cited by 8 · see citing works

Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex

Natarajan, P., Koupourtidou, C., de Resseguier, T., Thorwirth, M., Bocchi, R., Fischer‐Sternjak, J., Gleiss, S. A., Rodrigues, D., Myoga, M. H., Ninkovic, J., et al. (2024) · Glia · doi:10.1002/glia.24645 · Cited by 8 · see citing works

Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1

Lundie-Brown, J., Puletti, F., Philpott, A., & Azzarelli, R. (2025) · Open Biology · doi:10.1098/rsob.250018 · Cited by 8 · see citing works

The Art of Reprogramming for Regenerative Medicine

Kuang, J., Huang, T., & Pei, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.927555 · Cited by 8 · see citing works

In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review

Cho, H. E., Lee, S., Seo, J. H., Kang, S., Choi, W. A., & Cho, S. (2024) · Cells · doi:10.3390/cells13040343 · Cited by 8 · see citing works

Ectopic Expression of Neurod1 Is Sufficient for Functional Recovery following a Sensory–Motor Cortical Stroke

Livingston, J. M., Lee, T. T., Enbar, T., Daniele, E., Phillips, C., Krassikova, A., Bang, K. W. A., Kortebi, I., Donville, B., Ibragimov, O. S., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12030663 · Cited by 8 · see citing works

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

Li, Y., Hao, P., Duan, H., Hao, F., Zhao, W., Gao, Y., Yang, Z., So, K., & Li, X. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01706 · Cited by 8 · see citing works

TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons

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Partial Reprogramming as a Method for Regenerating Neural Tissues in Aged Organisms

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Identification and validation of novel engineered AAV capsid variants targeting human glia

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Direct reprogramming of astrocytes to neurons leads to functional recovery after strokePreprint

Livingston, J. M., Lee, T., Daniele, E., Phillips, C., Krassikova, A., Enbar, T., Kortebi, I., Bang, K. W. A., Donville, B., Ibragimov, O. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.02.929091 · Cited by 7 · see citing works

Co-administration of extracellular matrix-based biomaterials with neural stem cell transplantation for treatment of central nervous system injury

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Negative regulation by proBDNF signaling of peripheral neurogenesis in the sensory ganglia of adult rats

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Induced Dopaminergic Neurons for Parkinson’s Disease Therapy: Targeting the Striatum or Midbrain/Substantia Nigra Pars Compacta?

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Rewiring Brain Recovery: Astrocyte–Neuron Metabolic Cooperation in Stroke

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Reprogramming of distinct astroglial populations into specific neuronal subtypes in vitro and in vivo

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Reprogramming astrocytes for repair

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Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming

Hu, X., Qin, S., Huang, X., Yuan, Y., Tan, Z., Gu, Y., Cheng, X.-Y., Wang, D., Lian, X.-F., He, C., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.017 · Cited by 50 · see citing works

In Vitro Direct Reprogramming of Mouse and Human Astrocytes to Induced Neurons

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