New approaches for brain repair-from rescue to reprogramming
Open accessAbstract
The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.
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An unresolved controversy is whether the apparent generation of new neurons from astrocytes in earlier reports may actually reflect endogenous neuronal precursors or mature neurons mistakenly labeled by various fluorescent marking schemes, as opposed to transdifferentiation from glia.
“An unresolved controversy41 is whether the apparent generation of new neurons from astrocytes in earlier reports7 may actually reflect endogenous neuronal precursors or mature neurons mistakenly labeled by various fluorescent marking schemes, as opposed to transdifferentiation from glia.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [7]
The discussion accompanying Figure 3 (pp. 8–9) describes endogenous neurogenesis and reports glia-to-neuron conversion, but does not discuss a controversy over the origin of the reported neurons. Searches for fluorescent mislabeling and for neuronal precursors being mistaken for glial-derived neurons found no passage addressing that concern. (LLM, conf=0.76)
Experimental — accuracy not yet measuredThe brain parenchyma outside these niches limits the neurogenic potential of transplanted NSCs or neuroblasts.
“The brain parenchyma outside these niches (e.g., neocortex; Figure 1A) even limits the neurogenic potential of transplanted NSCs or neuroblasts”
From Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis (2020) · cites this paper as Barker et al., 2018
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- Authors
- Barker, R. A., Götz, M., & Parmar, M.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Helmholtz Munich (DE)
- Lund University (SE)
- Corresponding author
- Barker, Roger A.
- Götz, Magdalena
- Parmar, Malin
- Venue
- Nature
- Published
- 2018-05-16
- Volume
- 557
- Issue
- 7705
- Pages
- 329-334
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2799816031
- Cited by
- 214
- References
- 102
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 21 · 2023: 24 · 2022: 29 · 2021: 32 · 2020: 47 · 2019: 18 · 2018: 6
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Site cant be reached (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Wellcome Trust
- National Institute for Health and Care Research (NF-SI-0616-10011)
- Medical Research Council (MC_PC_12009)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain repair, nerve regeneration, neural circuit reconstruction, neurodegenerative diseases, growth factor delivery, cell transplantation, neuronal rescue
- MeSH terms
- Animals, Brain, Humans, Nerve Regeneration, Fetal Tissue Transplantation, Neurodegenerative Diseases, Stem Cell Transplantation, Regenerative Medicine, Cellular Reprogramming
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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