Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming
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Abstract
Region-specific gene expression shared with neurons imparts to astrocytes competence for region-specific neuronal reprogramming.
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These observations are consistent with the notion that astrocytes and neurons are derived from common regionally distinct progenitors and share common transcription factors for spatial patterning.
“These observations are consistent with the notion that astrocytes and neurons are derived from common regionally distinct progenitors and share common transcription factors for spatial patterning66,67.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [67]
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Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths
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Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus
Guillamón-Vivancos, T., Aníbal-Martínez, M., Puche-Aroca, L., Moreno‐Bravo, J. A., Valdeolmillos, M., Martini, F. J., & López‐Bendito, G. (2022) · Science · doi:10.1126/science.abq2960 · Cited by 38 · see citing works
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The secreted neuronal signal Spock1 promotes blood-brain barrier development
O’Brown, N. M., Patel, N. B., Hartmann, U., Klein, A. M., Gu, C., & Megason, S. G. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.06.005 · Cited by 33 · see citing works
Yang, R., Chai, R., Pan, J.-Y., Pan, J., Xia, P.-H., Wang, Y.-K., Chen, Y., Li, Y., Wu, J., & Chen, G. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346463 · Cited by 30 · see citing works
Neuronal replacement: Concepts, achievements, and call for caution
Götz, M., & Bocchi, R. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.03.014 · Cited by 29 · see citing works
Schweingruber, C., & Hedlund, E. (2022) · Biology · doi:10.3390/biology11081191 · Cited by 29 · see citing works
“that neurons and glial cells show shared region-specificity [151].”
BackgroundReprogramming cellular identity in vivo
Leaman, S., Marichal, N., & Berninger, B. (2022) · Development · doi:10.1242/dev.200433 · Cited by 22 · see citing works
Self-citationMultifarious astrocyte–neuron dialog in shaping neural circuit architecture
Ngoc, K. H., Jeon, Y., Ko, J., & Um, J. W. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.05.002 · Cited by 23 · see citing works
Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex
Xiang, Z., He, S., Chen, R., Liu, S., Liu, M., Xu, L., Zheng, J., Jiang, Z., Ma, L., Sun, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386401 · Cited by 19 · see citing works
“…processes into neuronal processes suggests that local neurons and astrocytes may share certain commonalities, which is supported by a recent study reporting that astrocytes are more likely to be converted into local neuron types during in vivo reprogramming (Herrero-Navarro et al., 2021).”
ResultDual lineage origins contribute to neocortical astrocyte diversity
Zhou, J., Vitali, I., Roig‐Puiggros, S., Javed, A., Cantando, I., Puglisi, M., Bezzi, P., Jabaudon, D., Mayer, C., & Bocchi, R. (2025) · Nature Communications · doi:10.1038/s41467-025-61829-4 · Cited by 31 · see citing works
Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice
Rosa, J. S., Hamel, K. A., Sheeler, C. A., Borgenheimer, E., Gilliat, S., Soles, A., Ghannoum, F. J., Sbrocco, K., Handler, H. P., Rainwater, O., et al. (2022) · Cells · doi:10.3390/cells11203323 · Cited by 19 · see citing works
“Differences in the activity and metabolic needs of neurons across and within brain regions indicate the heterogeneous and region-specific activity of astrocytes [8][9][10][11][12][13][14].”
BackgroundSensory modality-specific wiring of thalamocortical circuits
Guillamón-Vivancos, T., Aníbal-Martínez, M., Puche-Aroca, L., Martini, F. J., & López‐Bendito, G. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00945-y · Cited by 18 · see citing works
“Recent work by Herrero-Navarro and colleagues 35 highlighted that both thalamic neurons and astrocytes share a common transcriptional identity rooted in their progenitors.”
Self-citationTherapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain
Fu, X.-D., & Mobley, W. C. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-083022-113120 · Cited by 16 · see citing works
β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice
Rosenberg, M. F., Godoy, M. I., Wade, S. D., Paredes, M. F., Zhang, Y., & Molofsky, A. V. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0357-23.2023 · Cited by 16 · see citing works
Sculpting Astrocyte Diversity through Circuits and Transcription
Cheng, Y.-T., Woo, J., & Deneen, B. (2022) · The Neuroscientist · doi:10.1177/10738584221082620 · Cited by 15 · see citing works
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Zhao, Y., Li, X., Tang, Y.-X., Talukder, M., Zhao, Y. P., & Li, J. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02963 · Cited by 15 · see citing works
Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment
Yang, R., Pan, J., Wang, Y., Xia, P.-H., Tai, M., Jiang, Z., & Chen, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1005399 · Cited by 15 · see citing works
Direct In Vitro Reprogramming of Astrocytes into Induced Neurons
Sharif, N., Calzolari, F., & Berninger, B. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1601-7_2 · Cited by 14 · see citing works
Self-citationGalante, C., Marichal, N., Scarante, F. F., Ghayad, L. M., Shi, Y., Schuurmans, C. J., Berninger, B., & Péron, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.919462 · Cited by 13 · see citing works
Self-citationMcDowall, S., Bagda, V., Hodgetts, S. I., Mastaglia, F. L., & Li, D. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00450-9 · Cited by 14 · see citing works
Francistiová, L., Vörös, K., Lovász, Z., Dinnyés, A., & Kobolák, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.793769 · Cited by 14 · see citing works
Astrocytes as essential time‐keepers of the central pacemaker
Astiz, M., Delgado‐García, L. M., & López‐Mascaraque, L. (2021) · Glia · doi:10.1002/glia.24121 · Cited by 12 · see citing works
Self-citationAstrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction
Zhang, Y., Li, D., Cai, Y., Zou, R., Zhang, Y., Deng, X., Wang, Y., Tang, T., Ma, Y., Wu, F., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00218-x · Cited by 11 · see citing works
Felske, T., Tocco, C., Péron, S., Harb, K., Alfano, C., Galante, C., Berninger, B., & Studer, M. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002237 · Cited by 11 · see citing works
Self-citationSingle-Cell RNA-seq reveals transcriptomic modulation of Alzheimer’s disease by activated protein C
Fatmi, M. K., Wang, H., Slotabec, L. A., Wen, C., Seale, B. C., Zhao, B., & Li, J. (2024) · Aging · doi:10.18632/aging.205624 · Cited by 10 · see citing works
Milne, S. M., Lahiri, A., Sanchez, C. L., Marshall, M. J., Jahan, I., & Meares, G. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-63877-0 · Cited by 10 · see citing works
“While astrocytes have been analyzed by FACS and flow cytometry in many previous studies 72,82–86 , this could represent a limitation in our study.”
ResultBrain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease
Wu, Z., Xu, L., Xie, Y., Sambangi, A., Swaminathan, S., Pei, Z., Ji, W., Li, Z., Guo, Y., Li, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202410080 · Cited by 10 · see citing works
ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration
Dringen, R., Karger, G., Winkler, U., & Hirrlinger, J. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04604-7 · Cited by 10 · see citing works
Dennison, R., Usuga, E., Chen, H., Paul, J. Z., Arbelaez, C. A., & Teng, Y. D. (2023) · Cells · doi:10.3390/cells12040618 · Cited by 11 · see citing works
Update for astrocytomas: medical and surgical management considerations
Willman, M., Willman, J., Figg, J., Dioso, E., Sriram, S., Olowofela, B. O., Chacko, K. M., Hernandez, J. S., & Lucke-Wold, B. P. (2023) · Exploration of neuroscience · doi:10.37349/en.2023.00009 · Cited by 11 · see citing works
“The exact function and morphology of the astrocyte may be primarily determined by the spatial domain the cell occupies within the brain and the surrounding population of astrocytes [6, 7].”
BackgroundPatterning the cerebral cortex into distinct functional domains during development
Appan, D., Hsu, S.-M., Hsu, W.-H., & Chou, S. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102698 · Cited by 14 · see citing works
Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes
Imrie, G., Gray, M. B., Raghuraman, V., & Farhy-Tselnicker, I. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_5 · Cited by 9 · see citing works
A prenatal window for enhancing spatial resolution of cortical barrel maps
Aníbal-Martínez, M., Puche-Aroca, L., Pérez-Montoyo, E., Pumo, G., Madrigal, M. P., Rodríguez-Malmierca, L. M., Martini, F. J., Rijli, F. M., & López-Bendito, G. (2025) · Nature Communications · doi:10.1038/s41467-025-57052-w · Cited by 3 · see citing works
Self-citationReactive astrocytes generated from human iPSC are pro-inflammatory and display altered metabolism
McComish, S. F., O’Sullivan, J., Copas, A. N. M., Imiolek, M., Boyle, N. T., Crompton, L., Lane, J. D., & Caldwell, M. A. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114979 · Cited by 8 · see citing works
Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1
Lundie-Brown, J., Puletti, F., Philpott, A., & Azzarelli, R. (2025) · Open Biology · doi:10.1098/rsob.250018 · Cited by 8 · see citing works
“Region-specific differences in the glial cells of origin were also preserved in neuronal reprogramming experiments with NEUROG2 [144].”
Yamamoto, M., & Takano, T. (2025) · Cells · doi:10.3390/cells14241936 · Cited by 11 · see citing works
Livingston, J. M., Lee, T. T., Enbar, T., Daniele, E., Phillips, C., Krassikova, A., Bang, K. W. A., Kortebi, I., Donville, B., Ibragimov, O. S., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12030663 · Cited by 8 · see citing works
Identification and validation of novel engineered AAV capsid variants targeting human glia
Giacomoni, J., Åkerblom, M., Habekost, M., Fiorenzano, A., Kajtez, J., Davidsson, M., Parmar, M., & Björklund, T. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1435212 · Cited by 7 · see citing works
Dual lineage origins of neocortical astrocytesPreprint
Zhou, J., Vitali, I., Roig‐Puiggros, S., Javed, A., Jabaudon, D., Mayer, C., & Bocchi, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.12.557313 · Cited by 7 · see citing works
Sartoretti, M. M., Campetella, C. A., & Lanuza, G. M. (2022) · Development · doi:10.1242/dev.200750 · Cited by 6 · see citing works
Maddhesiya, P., Lepko, T., Steiner-Mezzardi, A., Schneider, J., Schwarz, V., Merl‐Pham, J., Berger, F., Hauck, S. M., Ronfani, L., Bianchi, M. E., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03556-z · Cited by 5 · see citing works
“In addition to several factors associated with chromatin, microRNAs and small molecules have been found to improve the conversion efficiency and maturation status of reprogrammed neurons despite being unable to induce conversion on their own [12, 15, 32, 33].”
Kang, H., Liu, Q., Seim, I., Zhang, W., Li, H., Gao, H., Lin, W., Lin, M., Zhang, P., Zhang, Y., et al. (2023) · Molecular Ecology Resources · doi:10.1111/1755-0998.13775 · Cited by 5 · see citing works
“MEIS2 has roles in embryonic and adult neurogenesis and its high expression in astrocytes agrees with recent transcriptome studies on rats (Zhou et al., 2022) and mice (Herrero-Navarro et al., 2021).”
BackgroundCellular identity through the lens of direct lineage reprogramming
Falk, S., Han, D., & Karow, M. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.06.015 · Cited by 5 · see citing works
Self-citationRe-Activation of Neurogenic Niches in Aging BrainPreprint
Maimon, R., Chillón-Marinas, C., Vazquez‐Sanchez, S., Kern, C., Jenie, I., Malukhina, K., Moore, S. R., Cui, J., Goginashvili, A., Moghadami, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.27.575940 · Cited by 5 · see citing works
Lu, Z., Wang, C., Zhu, Y., Zhao, J., Gu, Y., Zhu, X., Liao, W., Zhu, J., Jiang, R., Feng, S., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106472 · Cited by 4 · see citing works
Curing the brain: in search for new astrocyte-specific therapies
Verkhratsky, A., Lee, C. J., Chun, H., Göritz, C., Harkany, T., Lee, J., Lee, S., Lindskog, M., Koh, W., Mulder, J., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01712-4 · Cited by 5 · see citing works
Protocol for the purification and transcriptomic analysis of mouse astrocytes using GFAT
Labarta-Bajo, L., Deng, J., Contreras, M., & Allen, N. J. (2023) · STAR Protocols · doi:10.1016/j.xpro.2023.102599 · Cited by 5 · see citing works
Vierl, F., Kaur, M., & Götz, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.698002 · Cited by 4 · see citing works
Stifani, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.707861 · Cited by 4 · see citing works
Lineage Relationships Between Subpallial Progenitors and Glial Cells in the Piriform Cortex
Sánchez‐González, R., & López‐Mascaraque, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.825969 · Cited by 4 · see citing works
“…anterior PC. Piriform cortex neurons originate at the earliest stages of mouse telencephalic development as revealed through tritiated thymidine (Hinds and Angevine, 1965; Bayer, 1986; Frontiers in Neuroscience | www.frontiersin.org 1 March 2022 | Volume 16 | Article 825969 Valverde and…”
BackgroundSelf-citationCell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis
Olmos-Carreño, C. L., Figueres‐Oñate, M., Scicolone, G. E., & López‐Mascaraque, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012388 · Cited by 4 · see citing works
Self-citationÖzkan, A., Padmanabhan, H. K., Shipman, S. L., Azim, E., Kumar, P., Sadegh, C., Başak, A. N., & Macklis, J. D. (2024) · eLife · doi:10.7554/elife.100340 · Cited by 5 · see citing works
Reisman, S. J., Halabi, D., Miller, S. E., Song, L., Geraghty, S., Sangvai, N., Rice, G., Safi, A., Crawford, G. E., & Gersbach, C. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.11.681828 · Cited by 4 · see citing works
Zhou, J., & Bocchi, R. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1787840 · Cited by 3 · see citing works
Rogic, S., Mancarci, B. O., Xu, B., Xiao, A., Yan, C., & Pavlidis, P. (2026) · Database J. Biol. Databases Curation · doi:10.1093/database/baag041 · Cited by 1 · see citing works
“However, the Methods section of the corresponding paper [ 19 ] identifies the strain more precisely as FVB/N, which our curators missed.”
Zhou, Y., Zhang, K., Wang, F., Chen, J., Chen, S., Wu, M., Lai, M., Zhang, Y., & Zhou, W. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1174341 · Cited by 3 · see citing works
“Existing experimental results suggest that in different brain regions, astrocytes have different transcriptional and proteomic environments, as well as region-specific neural transcription factors, which lead to the transdifferentiation of astrocytes into different subtype-specific neurons after reprogramming (Mattugi…”
BackgroundPortela-Lomba, M., Simón, D., Callejo-Móstoles, M., de la Fuente, G., de Sevilla, D. F., García‐Escudero, V., Moreno-Flores, M. T., & Sierra, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06862-9 · Cited by 3 · see citing works
“pCAG-Ngn2-IRES-GFP (LV-Ngn2) (Herrero-Navarro et al., 2021) was kindly supplied by Dr.”
MethodNeonatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography
Tahmasian, N., Feng, M. Y., Arbabi, K., Rusu, B., Cao, W., Kukreja, B., Lubotzky, A., Wainberg, M., Tripathy, S. J., & Kalish, B. T. (2024) · eNeuro · doi:10.1523/eneuro.0224-24.2024 · Cited by 3 · see citing works
Wang, X., Zhang, H.-Y., Wan, Z., Li, X., Ibáñez, C. F., & Xie, M. (2025) · BMC Biology · doi:10.1186/s12915-025-02230-x · Cited by 3 · see citing works
“Such phenomenon may be explained by the regional specification for astro-cyte-to-neuron reprogramming as previously described [33].”
Péron, S., Miyakoshi, L. M., Brill, M. S., Manzano-Franco, D., Serrano-López, J., Fan, W., Marichal, N., Ghanem, A., Conzelmann, K., Karow, M., et al. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.10.019 · Cited by 3 · see citing works
Self-citationEarly lineage divergence segregates sensory and non-sensory thalamic circuitsPreprint
Puche-Aroca, L., Andrés-Bayón, B., Wilson, E. S., Javed, A., Torregrosa-Mira, A., López‐Atalaya, J. P., & López‐Bendito, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.17.665342 · Cited by 3 · see citing works
“Interrogation of the dLG-specific GRN revealed that Sp9 regulates a cascade of transcriptional targets (either activating or repressing) associated with visual thalamic identity 28 , including Gbx2 , Zic1, Zic4, Pou2f2 and Lhx9 (Fig.”
Self-citationCerrato, V., Turrini, G., Vitali, I., Xiong, B., Solanelles-Farré, L., Lopes, A., Magrinelli, E., Bocchi, R., Götz, M., Fischer-Sternjak, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.17.665323 · Cited by 3 · see citing works
Direct Neural Reprogramming in situ: Existing Approaches and Their Optimization
Dokukin, N. V., Chudakova, D. A., Shkap, M. O., Kovalchuk, A. M., Kibirsky, P. D., & Baklaushev, V. P. (2025) · Biochemistry (Moscow) · doi:10.1134/s000629792460426x · Cited by 2 · see citing works
Jiang, H., Qi, H., Tang, A., Hu, S., & Lai, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102808 · Cited by 2 · see citing works
Peña-Ortiz, M. Á., Sunstrum, J. K., Ghahramani, A., McConkey, H., Dumeaux, V., Inoue, W., & Bérubé, N. G. (2025) · Glia · doi:10.1002/glia.70098 · Cited by 2 · see citing works
Brain renin–angiotensin system in the injured brain
Ramos, A. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99618-1.00016-7 · Cited by 2 · see citing works
Inducing Neural Regeneration from Glia Using Proneural bHLH Transcription Factors
Todd, L. J. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-27681-1_84 · Cited by 2 · see citing works
Dlx2 reprograms the transcriptome and laminar position of glia-derived Ascl1-induced interneuronsPreprint
Cooper, A., Garcia-Mora, A., Herrera-Oropeza, G., Beltrán-Arranz, A., Marichal, N., Shi, Y., Leaman, S., Gonzalez, K. L., Strom, M., Hamid, F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.02.697435 · Cited by 2 · see citing works
Self-citationFunctional recruitment of astrocyte-derived neurons into the mouse visual cortexPreprint
Leaman, S., Ferreira, F. M., Dong, L., Beltrán-Arranz, A., Jurado‐Arjona, J., Garcia-Mora, A., Cooper, A., Treder, N., Fakhira, S., Sreenivasan, V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.25.701593 · Cited by 2 · see citing works
Self-citationReisman, S. J., Zhu, W., Miller, S. E., Halabi, D., Sangvai, N., Crawford, G. E., Gordân, R., & Gersbach, C. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.01.703129 · Cited by 2 · see citing works
Reversal of Postnatal Brain Astrocytes and Ependymal Cells towards a Progenitor Phenotype in Culture
Kakogiannis, D., Kourla, M., Dimitrakopoulos, D., & Kazanis, I. (2024) · Cells · doi:10.3390/cells13080668 · Cited by 1 · see citing works
“Based on recent experimental work showing that astrocytes, at different anatomical positions, express genes that mark local populations of neurons [14], we looked for the expression of genes, such as Tbr1 , Pitx3 , and Gbx2 , that act to determine and specify cortical, nigral, and thalamic neurons,…”
BackgroundStarTrack: Mapping Cellular Fates with Inheritable Color Codes
Figueres‐Oñate, M., García‐Marqués, J., Ojalvo‐Sanz, A. C., & López‐Mascaraque, L. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4310-5_16 · Cited by 1 · see citing works
Self-citationNeuropeptide receptors as entry points for developmental vulnerability to drug abuse
Harkany, T., Hevesi, Z., & Hökfelt, T. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103125 · Cited by 1 · see citing works
Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma
Fogli, M., Nato, G., Peretto, P. M., Buffo, A., & Luzzati, F. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1737065 · Cited by 2 · see citing works
Astrocyte Regulation of Spinal Circuit Function
Duff, M. K., Li, M. J., & Nimmerjahn, A. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70366 · Cited by 1 · see citing works
“…can exist as heterogeneous subpopulations both between regions of the CNS—for example, astrocytes in the neo-cortex versus in the thalamus (Herrero-Navarro et al. 2021)— and within the same region (Bayraktar et al. 2020; De Ceglia et al. 2023; Martín et al. 2015; Martin-Fernandez et al.…”
A 2026 perspective on neural stem cells and glial plasticity
Puletti, F., Lloret-Fernández, C., Lorenz, A., Cao, C., Poole, R. J., & Azzarelli, R. (2026) · Trends in Cell Biology · doi:10.1016/j.tcb.2026.05.001 · Cited by 1 · see citing works
Grochowska, M. M., Ferraro, F., Mascaro, A. C., Natale, D., Winkelaar, A. B., Boumeester, V., Breedveld, G. J., Bonifati, V., & Mandemakers, W. J. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049980 · Cited by 1 · see citing works
“Studies performed in various brain regions have demonstrated that astrocytes and neurons derived from a common progenitor show a shared region-specific molecular signature, which might act as a code for region-specific interactions (Herrero-Navarro et al., 2021).”
Cha, J., Zeng, P., Zong, H., Zhao, J., Chen, J., Zuo, H., Zhang, B., Shi, C., Li, J., Hua, Q., et al. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10309-5 · Cited by 1 · see citing works
“Astrocytes of distinct brain regions have region-specific transcriptional signatures that confer regional identity to neuronal reprogramming in vivo [12].”
In situ neuroregeneration: frontiers and therapeutic prospects
Wang, Q., Li, W., Lei, W., Chen, W., Zheng, J., Xiang, Z., MinHui, L. I. U., He, Q., Xu, L., Li, Z., et al. (2021) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0024 · Cited by 1 · see citing works
- Authors
- Herrero-Navarro, Á., Puche-Aroca, L., Moreno-Juan, V., Sempere-Ferràndez, A., Espinosa, A., Susín, R., Torres-Masjoan, L., Leyva-Díaz, E., Karow, M., Figueres-Oñate, M., López-Mascaraque, L., López-Atalaya, J. P., Berninger, B., & López-Bendito, G.
- Affiliations
- Universitat de Miguel Hernández d'Elx (ES)
- Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d’Alacant, Spain.
- King's College London (GB)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Instituto Cajal, CSIC, Madrid, Spain.
- ORCID
- Venue
- Science Advances
- Published
- 2021-04-09
- Volume
- 7
- Issue
- 15
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC8026135
- OpenAlex
- W3150234287
- Cited by
- 117
- References
- 56
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 19 · 2023: 22 · 2022: 21 · 2021: 14 · 2020: 1
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- H2020 European Research Council (647012)
- Generalitat Valenciana (PROMETEO/2017/149)
- Agencia Estatal de Investigación (PGC2018-096631-B-I00)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- astrocytes, neurons, regional identity, gene expression signatures, epigenetic signatures, neocortex, thalamus, thalamic nuclei, progenitor cells, clonal analysis
- MeSH terms
- Astrocytes, Neurons, Thalamus, Neocortex, Epigenomics
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