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Akt Inhibits the Orphan Nuclear Receptor Nur77 and T-cell Apoptosis

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The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

Lee, S., Jin, U.-H., Kang, J. H., Kim, S. B., Guthrie, A. S., Sreevalsan, S., Lee, J., & Safe, S. H. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0567 · Cited by 109 · see citing works

A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro

Liu, J., Zeng, H.-N., Zhang, L., Zhan, Y.-Y., Chen, Y., Wang, Y., Wang, J., Xiang, S., Liu, W.-J., Wang, W.-J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3160 · Cited by 105 · see citing works

1,1-Bis(3′-indolyl)-1-( p -chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

Inamoto, T., Papineni, S., Chintharlapalli, S. R., Cho, S. D., Safe, S. H., & Kamat, A. M. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0730 · Cited by 102 · see citing works

SUMO and NF-κB ties

Mabb, A. M., & Miyamoto, S. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7005-2 · Cited by 100 · see citing works

Diindolylmethane Analogs Bind NR4A1 and Are NR4A1 Antagonists in Colon Cancer Cells

Lee, S., Li, X., Hedrick, E., Jin, U.-H., Tjalkens, R. B., Backos, D. S., Li, L., Zhang, Y., Wu, Q., & Safe, S. H. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1102 · Cited by 99 · see citing works

Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation

Lévesque, D., & Rouillard, C. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.11.006 · Cited by 98 · see citing works

Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNFα-induced PAI-1 expression

Грубер, Ф., Hufnagl, P., Hofer-Warbinek, R., Schmid, J. A., Breuss, J. M., Huber-Beckmann, R., Lucerna, M., Papac-Miličević, N., Harant, H., Lindley, I. J. D., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2331 · Cited by 93 · see citing works

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

Doi, Y., Oki, S., Ozawa, T., Hohjoh, H., Miyake, S., & Yamamura, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803454105 · Cited by 91 · see citing works

Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis

Mahajan, S., Saini, A., Chandra, V., Nanduri, R., Kalra, R., Bhagyaraj, E., Khatri, N., & Gupta, P. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638064 · Cited by 90 · see citing works

Control of IκBα proteolysis by the ubiquitin-proteasome pathway

Tanaka, K., Kawakami, T., Tateishi, K., Yashiroda, H., & Chiba, T. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01237-8 · Cited by 90 · see citing works

Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis

Zhao, Y., Howatt, D. A., Gizard, F., Nomiyama, T., Findeisen, H. M., Heywood, E. B., Jones, K. L., Conneely, O. M., Daugherty, A., & Bruemmer, D. (2010) · Circulation Research · doi:10.1161/circresaha.110.222083 · Cited by 89 · see citing works

Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling

Raveney, B. J. E., Oki, S., & Yamamura, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056595 · Cited by 88 · see citing works

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

Ipseiz, N., Uderhardt, S., Scholtysek, C., Steffen, M., Schabbauer, G., Bözec, A., Schett, G. A., & Krönke, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303377 · Cited by 87 · see citing works

Knockdown of Nurr1 in the rat hippocampus: Implications to spatial discrimination learning and memoryPreprint

Colón, W. I., Martínez, M., Morales, S., Félix, J., Cruz, J., Adorno, M., Pereira, L., Colón, N., Maldonado-Vlaar, C. S., & de Ortı́z, S. P. (2006) · Learning & Memory · doi:10.1101/lm.407706 · Cited by 81 · see citing works

Activation of Nuclear Receptor Nur77 by 6-Mercaptopurine Protects Against Neointima Formation

Pires, N. M., Pols, T. W. H., de Vries, M. R., van Tiel, C. M., Bonta, P. I., Vos, M., Arkenbout, E. K., Pannekoek, H., Jukema, J. W., Quax, P. H. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.626838 · Cited by 79 · see citing works

Prostaglandin A2 Acts as a Transactivator for NOR1 (NR4A3) within the Nuclear Receptor Superfamily

Kagaya, S., Ohkura, N., Tsukada, T., Miyagawa, M., Sugita, Y., Tsujimoto, G., Matsumoto, K., Saito, H., & Hashida, R. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1603 · Cited by 78 · see citing works

Deficiency of the NR4A Neuron-Derived Orphan Receptor-1 Attenuates Neointima Formation After Vascular Injury

Nomiyama, T., Zhao, Y., Gizard, F., Findeisen, H. M., Heywood, E. B., Jones, K. L., Conneely, O. M., & Bruemmer, D. (2009) · Circulation · doi:10.1161/circulationaha.108.822056 · Cited by 77 · see citing works

The Nurr1 Activator 1,1-Bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB

Miranda, B. R. D., Popichak, K. A., Hammond, S. L., Jorgensen, B. A., Phillips, A. T., Safe, S. H., & Tjalkens, R. B. (2015) · Molecular Pharmacology · doi:10.1124/mol.114.095398 · Cited by 76 · see citing works

Regulation of the Osteopontin Gene by the Orphan Nuclear Receptor NURR1 in Osteoblasts

Lammi, J., Huppunen, J., & Aarnisalo, P. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0247 · Cited by 76 · see citing works

Transcriptional Repression of Matrix Metalloproteinase Gene Expression by the Orphan Nuclear Receptor NURR1 in Cartilage

Mix, K. S., Attur, M. G., Al-Mussawir, H., Abramson, S. B., Brinckerhoff, C., & Murphy, E. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608327200 · Cited by 73 · see citing works

NR4A nuclear receptors in immunity and atherosclerosis

Hamers, A. A. J., Hanna, R. N., Nowyhed, H. N., Hedrick, C. C., & de Vries, C. J. M. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283643eac · Cited by 73 · see citing works

The NR4A orphan nuclear receptors: mediators in metabolism and diseases

Ranhotra, H. S. (2014) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2014.948555 · Cited by 71 · see citing works

NR4A nuclear orphan receptors: protective in vascular disease?

Pols, T. W. H., Bonta, P. I., & de Vries, C. J. M. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282ef77d1 · Cited by 70 · see citing works

Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor- B

Harant, H. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh856 · Cited by 69 · see citing works

PIASγ Represses the Transcriptional Activation Induced by the Nuclear Receptor Nurr1

Galleguillos, D., Vecchiola, A., Fuentealba, J. A., Ojeda, V., Álvarez, K., Gómez, A. V., & Andrés, M. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308113200 · Cited by 68 · see citing works

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration

Hedrick, E., Lee, S., Doddapaneni, R., Singh, M. S., & Safe, S. H. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00912-15 · Cited by 67 · see citing works

TR3 Nuclear Orphan Receptor Prevents Cyclic Stretch-Induced Proliferation of Venous Smooth Muscle Cells

de Waard, V., Arkenbout, E. K., Vos, M., Mocking, A. I. M., Niessen, H. W. M., Stooker, W., de Mol, B. A. J. M., Quax, P. H. A., Bakker, E. N. T. P., VanBavel, E., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050932 · Cited by 63 · see citing works

Identification of a Novel Co-regulator Interaction Surface on the Ligand Binding Domain of Nurr1 Using NMR Footprinting

Codina, A., Benoit, G., Gooch, J. T., Neuhaus, D., Perlmann, T., & Schwabe, J. W. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409096200 · Cited by 63 · see citing works

NOR-1 is involved in VEGF-induced endothelial cell growth

Rius, J., Martínez‐González, J., Crespo, J., & Badimón, L. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.04.008 · Cited by 62 · see citing works

Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis

Aherne, C. M., McMorrow, J. P., Kane, D. J., FitzGerald, O., Mix, K. S., & Murphy, E. P. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.07.019 · Cited by 60 · see citing works

NR4A Nuclear Receptors in Atherosclerosis and Vein-Graft Disease

Bonta, P. I., Pols, T. W. H., & de Vries, C. J. M. (2007) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.02.001 · Cited by 55 · see citing works

The Orphan Nuclear Receptors NURR1 and NGFI-B Modulate Aromatase Gene Expression in Ovarian Granulosa Cells: A Possible Mechanism for Repression of Aromatase Expression upon Luteinizing Hormone Surge

Wu, Y., Ghosh, S., Nishi, Y., Yanase, T., Nawata, H., & Hu, Y. (2004) · Endocrinology · doi:10.1210/en.2004-0889 · Cited by 54 · see citing works

Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis

Watanabe, T., Sekine, S., Naguro, I., Sekine, Y., & Ichijo, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.623280 · Cited by 53 · see citing works

Nuclear Receptor Nurr1 Is Expressed In and Is Associated With Human Restenosis and Inhibits Vascular Lesion Formation In Mice Involving Inhibition of Smooth Muscle Cell Proliferation and Inflammation

Bonta, P. I., Pols, T. W. H., van Tiel, C. M., Vos, M., Arkenbout, E. K., Rohlena, J., Koch, K. T., de Maat, M. P. M., Tanck, M. W. T., de Winter, R. J., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.885673 · Cited by 53 · see citing works

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells

Crean, D., Cummins, E. P., Bahar, B., Mohan, H. M., McMorrow, J. P., & Murphy, E. P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402039 · Cited by 52 · see citing works

NOR-1 modulates the inflammatory response of vascular smooth muscle cells by preventing NFκB activation

Calvayrac, O., Rodríguez‐Calvo, R., Martí-Pàmies, Í., Alonso, J., Ferrán, B., Aguiló, S., Crespo, J., Rodríguez‐Sinovas, A., Rodrı́guez, C., & Martínez‐González, J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.12.015 · Cited by 51 · see citing works

A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro

Hammond, S. L., Safe, S. H., & Tjalkens, R. B. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.09.015 · Cited by 51 · see citing works

Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease

Miranda, B. R. D., Popichak, K. A., Hammond, S. L., Miller, J. A., Safe, S. H., & Tjalkens, R. B. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu236 · Cited by 50 · see citing works

Nur77 Decreases Atherosclerosis Progression in apoE−/− Mice Fed a High-Fat/High-Cholesterol Diet

Hu, Y., Zhang, P., Yang, J., Huang, J.-L., Ma, X., Li, S., Zhao, J., Hu, Y.-R., Wang, Y., Gao, J.-J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087313 · Cited by 50 · see citing works

Identification of novel mediators of NF-κB through genome-wide survey of monocyte adherence-induced genes

Diatchenko, L. B., Romanov, S., Malinina, I. V., Clarke, J., Tchivilev, I., Li, X., & Makarov, S. S. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405211 · Cited by 48 · see citing works

Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL

Shao, Q., Shen, L., Hu, L., Pu, J., Qi, M., Li, W.-Q., Tian, F., Jing, Q., & He, B. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.03.023 · Cited by 48 · see citing works

NR4A receptors up-regulate the antiproteinase alpha-2 macroglobulin (A2M) and modulate MMP-2 and MMP-9 in vascular smooth muscle cells

Rodríguez‐Calvo, R., Ferrán, B., Alonso, J., Martí-Pàmies, Í., Aguiló, S., Calvayrac, O., Rodrı́guez, C., & Martínez‐González, J. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-07-0645 · Cited by 47 · see citing works

Over-expression of Neuron-derived Orphan Receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury

Rodríguez‐Calvo, R., Guadall, A., Calvayrac, O., Navarro, M. A., Alonso, J., Ferrán, B., de Diego, A., Muniesa, P., Osada, J., Rodrı́guez, C., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt042 · Cited by 47 · see citing works

Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation

Yan, G., Zhu, N., Huang, S., Yi, B., Shang, X., Chen, M., Wang, N., Zhang, G., Talarico, J. A., Tilley, D. G., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00229-15 · Cited by 46 · see citing works

α-Lipoic Acid Prevents Neointimal Hyperplasia Via Induction of p38 Mitogen-Activated Protein Kinase/Nur77-Mediated Apoptosis of Vascular Smooth Muscle Cells and Accelerates Postinjury Reendothelialization

Kim, H., Kim, J., Lee, S. J., Kim, H.-J., Oh, C. J., Choi, Y., Lee, H., Do, J.-Y., Kim, S.-Y., Kwon, T., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.212308 · Cited by 46 · see citing works

Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription

Mix, K. S., McMahon, K., McMorrow, J. P., Walkenhorst, D. E., Smyth, A. M., Petrella, B. L., Gogarty, M., Fearon, U., Veale, D. J., Attur, M. G., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34399 · Cited by 44 · see citing works

Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels

Bonta, P. I., Matlung, H. L., Vos, M., Peters, S. L. M., Pannekoek, H., Bakker, E. N. T. P., & de Vries, C. J. M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq064 · Cited by 44 · see citing works

The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3

Nowyhed, H. N., Huynh, T. R., Blatchley, A., Wu, R., Thomas, G. D., & Hedrick, C. C. (2015) · Scientific Reports · doi:10.1038/srep09059 · Cited by 42 · see citing works

Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis and Modulation following TNF-α Inhibition

O’Kane, M., Markham, T., McEvoy, A. N., Fearon, U., Veale, D. J., FitzGerald, O., Kirby, B., & Murphy, E. P. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701023 · Cited by 38 · see citing works

Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid

Mahmoudi, S., Samadi, P., Gilbert, F., Ouattara, B., Morissette, M., Grégoire, L., Rouillard, C., Paolo, T. D., & Lévesque, D. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.017 · Cited by 37 · see citing works

NR4A Gene Expression Is Dynamically Regulated in the Ventral Tegmental Area Dopamine Neurons and Is Related to Expression of Dopamine Neurotransmission Genes

Eells, J. B., Wilcots, J., Sisk, S., & Guo‐Ross, S. X. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9642-z · Cited by 36 · see citing works

Perturbation of Transcription Factor Nur77 Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Mount, M. P., Zhang, Y., Amini, M., Callaghan, S. M., Kulczycki, J., Mao, Z., Slack, R. S., Anisman, H., & Park, D. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439216 · Cited by 36 · see citing works

Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

Carbone, D. L., Popichak, K. A., Moreno, J. A., Safe, S. H., & Tjalkens, R. B. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050781 · Cited by 36 · see citing works

NR4A orphan nuclear receptors in cardiovascular biology

Zhao, Y., & Bruemmer, D. (2009) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2009.06.001 · Cited by 33 · see citing works

Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin

McCoy, J. M., Walkenhorst, D. E., McCauley, K. S., Elaasar, H., Everett, J. R., & Mix, K. S. (2015) · Journal of Inflammation · doi:10.1186/s12950-015-0059-2 · Cited by 32 · see citing works

Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats

Oita, R. C., Mazzatti, D. J., Lim, F.-L., Powell, J. R., & Merry, B. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.004 · Cited by 30 · see citing works

B-Cell Translocation Gene 2 Regulates Hepatic Glucose Homeostasis via Induction of Orphan Nuclear Receptor Nur77 in Diabetic Mouse Model

Kim, Y. D., Kim, S., Hwang, S., Choi, H.-S., Bae, J., Song, D., & Im, S. (2014) · Diabetes · doi:10.2337/db13-1368 · Cited by 30 · see citing works

Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis

Chen, P., Li, J., Huo, Y., Lu, J., Wan, L., Li, B., Gan, R., & Guo, C. (2015) · PeerJ · doi:10.7717/peerj.1518 · Cited by 30 · see citing works

Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

Li, X., Zhang, S., He, X., Guo, P.-D., Lu, X.-X., Wang, J., Li, J., & Wu, H. (2016) · Journal of Inflammation · doi:10.1186/s12950-016-0112-9 · Cited by 30 · see citing works

Alpha 1‐antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77

Zhao, Y. J., Liu, Y., & Zheng, D. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06269.x · Cited by 25 · see citing works

NR4A1 enhances neural survival following oxygen and glucose deprivation: An in vitro study

Xiao, G., Sun, T., Songming, C., & Cao, Y. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.04.010 · Cited by 25 · see citing works

Nuclear orphan receptor Nor-1 contributes to depressive behavior in the Wistar–Kyoto rat model of depression

Schaffer, D. J., Tunc‐Ozcan, E., Shukla, P. K., Volenec, A., & Redei, E. E. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.041 · Cited by 24 · see citing works

Impaired behavioural and molecular adaptations to dopamine denervation and repeated L‐DOPA treatment in Nur77‐knockout mice

St‐Hilaire, M., Bourhis, E., Lévesque, D., & Rouillard, C. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04954.x · Cited by 24 · see citing works

NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61

Zhang, X., Yan, G., Diao, Z., Sun, H., & Hu, Y. (2012) · Placenta · doi:10.1016/j.placenta.2012.04.005 · Cited by 24 · see citing works

Replicated association of the <i>NR4A3</i> gene with smoking behaviour in schizophrenia and in bipolar disorder

Novak, G., Zai, C. C., Mirkhani, M., Shaikh, S., Vincent, J. B., Meltzer, H., Lieberman, J. A., Strauss, J., Lévesque, D., Kennedy, J. L., et al. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00631.x · Cited by 23 · see citing works

The peroxisome proliferator‐activated receptor‐γ agonist 1,1‐bis(3′‐indolyl)‐1‐(p‐trifluoromethylphenyl)methane suppresses manganese‐induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells

Tjalkens, R. B., Liu, X., Mohl, B., Wright, T. T., Moreno, J. A., Carbone, D. L., & Safe, S. H. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21524 · Cited by 22 · see citing works

Differential expression of oxidored nitro domain containing protein 1 (NOR1), in mouse tissues and in normal and cancerous human tissues

Xiang, B., Wang, W., Li, W., Li, X., Li, X., & Li, G. (2011) · Gene · doi:10.1016/j.gene.2011.11.039 · Cited by 20 · see citing works

Haloperidol-induced striatalNur77expression in a non-human primate model of tardive dyskinesia

Mahmoudi, S., Blanchet, P. J., & Lévesque, D. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12198 · Cited by 15 · see citing works

El receptor nuclear NOR-1 regula la activación de las células vasculares y el remodelado vascular en respuesta a estrés hemodinámico

Rodríguez‐Calvo, R., Guadall, A., Calvayrac, O., Alonso, J., Ferrán, B., Martí-Pàmies, Í., Navarro, M. Á. M., de Diego, A., Osada, J., Rodrı́guez, C., et al. (2014) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2013.11.001 · Cited by 5 · see citing works

Expression of host defense scavenger receptors in spondylarthropathy

McBeth (2001) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200104)44:4 · Cited by 1 · see citing works

Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: Viewpoint based on a systemic pathogenetic role

Straub, R. H., & Cutolo, M. (2001) · Arthritis &amp; Rheumatism · doi:10.1002/1529-0131(200103)44:3

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

Kumar, V. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.002 · Cited by 649 · see citing works

Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

Hepler, C., Shan, B., Zhang, Q., Henry, G. H., Shao, M., Vishvanath, L., Ghaben, A. L., Mobley, A. B., Strand, D., Hon, G. C., et al. (2018) · eLife · doi:10.7554/elife.39636 · Cited by 346 · see citing works

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

Kumar, V. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107087 · Cited by 276 · see citing works

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

Mattugini, N., Bocchi, R., Scheuss, V., Russo, G. L., Torper, O., Lao, C. L., & Götz, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.009 · Cited by 159 · see citing works

Radical-Scavenging and Subchondral Bone-Regenerating Nanomedicine for Osteoarthritis Treatment

Lu, H., Wei, J., Liu, K., Li, Z., Xu, T., Yang, D., Gao, Q., Xiang, H., Li, G., & Chen, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c01789 · Cited by 148 · see citing works

Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites

Li, S., Cai, Y., Guan, T., Zhang, Y., Huang, K., Zhang, Z., Cao, W., & Guan, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2374608 · Cited by 103 · see citing works

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Peng, S., Chen, X.-H., Chen, S., Zhang, J., Wang, C.-Y., Liu, W.-R., Zhang, D., Su, Y., & Zhang, X.-K. (2021) · Nature Communications · doi:10.1038/s41467-021-26295-8 · Cited by 96 · see citing works

Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes

Chiarelli, N., Ritelli, M., Zoppi, N., & Colombi, M. (2019) · Genes · doi:10.3390/genes10080609 · Cited by 82 · see citing works

Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease

Mei, D. F., Tan, W. S. D., Tay, Y., Mukhopadhyay, A., & Wong, W. S. F. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.04.007 · Cited by 59 · see citing works

The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases

Zhang, L., Wang, Q., Liu, W., Liu, F., Ji, A., & Li, Y. (2018) · Journal of Diabetes Research · doi:10.1155/2018/9363461 · Cited by 54 · see citing works

Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases

Banno, A., Lakshmi, S. P., Reddy, A. T., Kim, S. C., & Reddy, R. C. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.10.002 · Cited by 53 · see citing works

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis

Jeon, S. G., Yoo, A., Chun, D. W., Hong, S. B., Chung, H., Kim, J.-I., & Moon, M. (2020) · Aging and Disease · doi:10.14336/ad.2019.0718 · Cited by 55 · see citing works

Reactivation of NR4A1 Restrains Chondrocyte Inflammation and Ameliorates Osteoarthritis in Rats

Xiong, Y., Ran, J., Xu, L., Tong, Z., Moqbel, S. A. A., Ma, C., Xu, K., He, Y., Wu, Z., Chen, Z., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00158 · Cited by 44 · see citing works

Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction

Pan, J., Ma, N., Zhong, J., Yu, B., Wan, J., & Zhang, W. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.08.030 · Cited by 42 · see citing works

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice

Rauch, F., Geng, Y., Lamplugh, L., Hekmatnejad, B., Gaumond, M.-H., Penney, J. E., Yamanaka, Y., & Moffatt, P. (2017) · Bone · doi:10.1016/j.bone.2017.11.013 · Cited by 43 · see citing works

MicroRNA‐638 inhibits human airway smooth muscle cell proliferation and migration through targeting cyclin D1 and NOR1

Wang, H., Yao, H., Yi, B., Kazama, K., Liu, Y., Deshpande, D. A., Zhang, J., & Sun, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26930 · Cited by 43 · see citing works

The protective role of NR4A3 in acute myocardial infarction by suppressing inflammatory responses via JAK2-STAT3/NF-κB pathway

Jiang, Y. D., Feng, Y., Tang, L., Yan, Y.-L., & Bai, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.116 · Cited by 42 · see citing works

Nur77 deficiency exacerbates cardiac fibrosis after myocardial infarction by promoting endothelial‐to‐mesenchymal transition

Chen, J., Jia, J., Ma, L., Li, B., Qin, Q., Qian, J., & Ge, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29877 · Cited by 40 · see citing works

Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration

Gao, Y., Zou, Y., Sokolowskei, D., Xing, X., Tower, R. J., Lai, Z., Shi, J., Zhu, L., Zheng, Q., James, A. W., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.034 · Cited by 36 · see citing works

Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway

Chiu, H., Chu, C.-W., Huang, C., Chia, Z., Wang, Y.-L., & Lee, Y. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.125850 · Cited by 37 · see citing works

Nuclear Receptors in Cancer Inflammation and Immunity

Zhao, L., Hu, H., Gustafsson, J.-Α., & Zhou, S. (2020) · Trends in Immunology · doi:10.1016/j.it.2019.12.006 · Cited by 36 · see citing works

Molecular, chemical, and structural characterization of prostaglandin A2 as a novel agonist for Nur77

Lakshmi, S. P., Reddy, A. T., Banno, A., & Reddy, R. C. (2019) · Biochemical Journal · doi:10.1042/bcj20190253 · Cited by 36 · see citing works

Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1‐Mediated Nur77 Deacetylation

Song, H., Wu, H., Dong, J., Huang, S., Ye, J., & Liu, R. (2021) · Mediators of Inflammation · doi:10.1155/2021/6359652 · Cited by 33 · see citing works

Transcriptomic Profiling of Intracranial Arteries in Adult Patients With Moyamoya Disease Reveals Novel Insights Into Its Pathogenesis

Xu, S., Wei, W., Zhang, F., Chen, T., Dong, L., Shi, J., Wu, X., Zhang, T., Li, Z., Zhang, J., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.881954 · Cited by 33 · see citing works

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes

Zhang, C., Zhang, B., Zhang, X., Sun, G., & Sun, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.587457 · Cited by 32 · see citing works

The E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2α

Huang, B., Pei, H. Z., Chang, H., & Baek, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-32391-5 · Cited by 32 · see citing works

Tissue-Specific Control of Tissue-Resident Memory T Cells

Liu, Y., Ma, C., & Zhang, N. (2018) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2018025653 · Cited by 29 · see citing works

NURR1 expression regulates retinal pigment epithelial–mesenchymal transition and age-related macular degeneration phenotypes

Yao, P., Parmar, V. M., Choudhary, M., & Malek, G. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202256119 · Cited by 31 · see citing works

The aryl hydrocarbon receptor instructs the immunomodulatory profile of a subset of Clec4a4 + eosinophils unique to the small intestine

Wang, W.-L., Kasamatsu, J., Joshita, S., Gilfillan, S., Luccia, B. D., Panda, S. K., Kim, D., Desai, P., Bando, J. K., Huang, S. C., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204557119 · Cited by 29 · see citing works

Nuclear receptor Nur77 protects against oxidative stress by maintaining mitochondrial homeostasis via regulating mitochondrial fission and mitophagy in smooth muscle cell

Geng, N., Chen, T., Chen, L., Zhang, H., Sun, L., Lyu, Y., Che, X., Xiao, Q., Tao, Z., & Shao, Q. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.05.007 · Cited by 27 · see citing works

The effect of NR4A1 on APP metabolism and tau phosphorylation

Zhao, L., Tang, Y., Tan, J.-Z., Wang, J., Chen, G., & Zhu, B. (2018) · Genes & Diseases · doi:10.1016/j.gendis.2018.04.008 · Cited by 24 · see citing works

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response

Phelan, D. E., Shigemura, M., Aldhafiri, S., Mota, C., Hall, T. J., Sznajder, J. I., Murphy, E. P., Crean, D., & Cummins, E. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676644 · Cited by 24 · see citing works

Oleic Acid Attenuates Ang II (Angiotensin II)-Induced Cardiac Remodeling by Inhibiting FGF23 (Fibroblast Growth Factor 23) Expression in Mice

Liu, T., Wen, H., Li, H., Xu, H., Xiao, N., Liu, R., Chen, L., Sun, Y., Song, L., Bai, C., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14167 · Cited by 24 · see citing works

Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome‐Mediated Inflammation and Accelerates Atherosclerosis

Yuan, R., Zhang, W., Nie, P., Lan, K., Yang, X., Yin, A., Xiao, Q., Shen, Y., Xu, K., Wang, X., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2017815 · Cited by 23 · see citing works

Minireview: What is Known about SUMOylation Among NR4A Family Members?

Dodat, F., Mader, S., & Lévesque, D. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167212 · Cited by 22 · see citing works

The orphan nuclear receptor NR4A1 promotes FcεRI‐stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis

Jin, F., Li, X., Deng, Y., Timilshina, M., Huang, B., Kim, D. Y., Chang, J., Ichinose, H., Baek, S., Murakami, M., et al. (2018) · Allergy · doi:10.1111/all.13702 · Cited by 21 · see citing works

Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77

Fang, H., Zhang, J., Ao, M., He, F., Chen, W., Qian, Y., Zhang, Y., Xu, Y., & Fang, M. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104456 · Cited by 20 · see citing works

Bladder Exposure to Gardnerella Activates Host Pathways Necessary for Escherichia coli Recurrent UTI

O'Brien, V. P., Lewis, A., & Gilbert, N. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.788229 · Cited by 20 · see citing works

The transcription factor Nurr1 is up-regulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice

Valsecchi, V., Boido, M., Montarolo, F., Guglielmotto, M., Perga, S., Martire, S., Cutrupi, S., Iannello, A., Gionchiglia, N., Signorino, E., et al. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.043513 · Cited by 19 · see citing works

Bioinformatic analysis and validation of microRNA‐508‐3p as a protective predictor by targeting NR4A3/MEK axis in pulmonary arterial hypertension

Ma, Y., Chen, S., Jiang, F., Ma, R., & Wang, H. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16523 · Cited by 19 · see citing works

Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β2-Adrenoceptor Agonists

Yan, D., Hamed, O., Joshi, T., Mostafa, M., Jamieson, K. C., Joshi, R., Newton, R. C., & Giembycz, M. A. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.249292 · Cited by 19 · see citing works

NR4A1-3 nuclear receptor activity and immune cell dysregulation in rheumatic diseases

Murphy, E. P., & Crean, D. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.874182 · Cited by 18 · see citing works

Anti-inflammatory Effects of Siponimod in a Mouse Model of Excitotoxicity-Induced Retinal Injury

Basavarajappa, D. K., Gupta, V., Chitranshi, N., Viswanathan, D., Gupta, V., Wall, R. V., Palanivel, V., Mirzaei, M., You, Y., Klistorner, A. I., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03535-0 · Cited by 18 · see citing works

Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo

Ao, M., Zhang, J., Qian, Y., Li, B., Wang, X., Chen, J., Zhang, Y., Cao, Y., Qiu, Y., Xu, Y., et al. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105645 · Cited by 18 · see citing works

Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma

Li, X., Chen, Q., Liu, J., Lai, S., Zhang, M., Zhen, T., Hu, H., Gao, X., Wong, A. S. T., & Zeng, J.-Z. (2022) · Cells · doi:10.3390/cells11233870 · Cited by 17 · see citing works

Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases

He, S., Jiang, W., Jiang, B., Yu, C., Zhao, G., Li, Y., Qi, L., Zhang, J., & Wang, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03945-8 · Cited by 17 · see citing works

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway

Tu, X., Chen, X., Zhang, D., Gao, M., Liang, J., Bao, G., Zhang, J., Peng, S., Zhang, X.-K., Zeng, Z., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.113020 · Cited by 17 · see citing works

Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training

Mey, J. T., Solomon, T. P. J., Kirwan, J. P., & Haus, J. M. (2019) · Physiological Reports · doi:10.14814/phy2.14042 · Cited by 17 · see citing works

The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity

Jamerson, L. E., & Bradshaw, P. C. (2024) · Antioxidants · doi:10.3390/antiox13070820 · Cited by 18 · see citing works

Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibits inflammation by regulating Nur77 stability

Pei, H. Z., Huang, B., Chang, H., & Baek, S. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.03.018 · Cited by 16 · see citing works

Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet

Men, L., Hui, W., Guan, X., Song, T., Wang, X., Zhang, S., & Chen, X. (2020) · Genes · doi:10.3390/genes11070720 · Cited by 16 · see citing works

Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish

Xu, Y. Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., & Li, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.864631 · Cited by 15 · see citing works

Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro

Yuan, R., Xin, Q., Ma, X., Yu, M., Miao, Y., Chen, K., & Cong, W. (2023) · Molecules · doi:10.3390/molecules28031271 · Cited by 15 · see citing works

Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptor

Hong, H., Su, J., Huang, C., Xu, L., & Cui, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.981490 · Cited by 14 · see citing works

The Nurr7 agonist Cytosporone B differentially regulates inflammatory responses in human polarized macrophages.

Patiño-Martínez, E., Solís-Barbosa, M. A., Santana, E., González-Domínguez, É., Segovia-gamboa, N., Meraz-Ríos, M., Córdova, E., Valdés, J., Corbí, Á., & Sánchez-Torres, C. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152299 · Cited by 12 · see citing works

Deficiency of the Transcription Factor NR4A1 Enhances Bacterial Clearance and Prevents Lung Injury During Escherichia Coli Pneumonia

Cui, P., Wu, S., Xu, X., Ye, H., Hou, J., Liu, X., Wang, H., & Fang, X. (2018) · Shock · doi:10.1097/shk.0000000000001184 · Cited by 14 · see citing works

Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)

Reddy, A. T., Lakshmi, S. P., Banno, A., Jadhav, S. K., Kadamberi, I. P., Kim, S. C., & Reddy, R. C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229256 · Cited by 14 · see citing works

Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium

Dominoni, M., Scatigno, A. L., La Verde, M., Bogliolo, S., Melito, C., Gritti, A., Pasquali, M. F., Torella, M., & Gardella, B. (2023) · Healthcare · doi:10.3390/healthcare11040525 · Cited by 13 · see citing works

Structural insights into ligand-binding pocket formation in Nurr1 by molecular dynamics simulations

Windshügel, B. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1559099 · Cited by 12 · see citing works

Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis

Lin, H.-Y., Ko, C., Lo, T.-Y., Wu, S., Lan, S.-W., Huang, C.-A., Lin, Y., Lin, H.-H., Tu, H.-F., Lee, C., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02303-z · Cited by 12 · see citing works

The endocannabinoid anandamide mediates anti‐inflammatory effects through activation of NR4A nuclear receptors

Teichmann, T., Pflüger‐Müller, B., Giménez, V. M. M., Sailer, F. K., Dirks, H., Zehr, S., Warwick, T., Brettner, F. E. B., Munoz‐Tello, P., Zimmer, A., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17366 · Cited by 11 · see citing works

Store‐operated calcium entry mediates hyperalgesic responses during neuropathy

Wang, W., Wang, Q., Huang, J., Li, H., Li, F., Li, X., Liu, R., Xu, M., Chen, J., Mao, Y., et al. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13699 · Cited by 12 · see citing works

Enrichment and purification of Torreya grandis peptides by macroporous resin and its hypoglycemic mechanism revealed by transcriptome analysis

Xue, J., Wu, S., Zhu, Q., Liu, X., He, Z., Ye, W., Wang, P., & Wu, F. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.118445 · Cited by 10 · see citing works

DNA-PKcs participated in hypoxic pulmonary hypertension

Liu, Y., Zhang, W., Zhang, M., Wang, Y.-J., Ma, X.-Y., Jiang, J.-H., Wang, R., & Zeng, D. (2022) · Respiratory Research · doi:10.1186/s12931-022-02171-x · Cited by 10 · see citing works

Transcription cofactor GRIP1 differentially affects myeloid cell–driven neuroinflammation and response to IFN-β therapy

Mimouna, S., Rollins, D. A., Shibu, G., Tharmalingam, B., Deochand, D. K., Chen, X., Oliver, D., Chinenov, Y. V., & Rogatsky, I. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192386 · Cited by 10 · see citing works

Regulation of NR4A2 Gene Expression and Its Importance in Neurodegenerative and Psychiatric Diseases

Ruiz-Sánchez, E., Rojas, C., Gómez, P. Y., Martínez‐Rodríguez, N., Ruíz-Chow, Á. A., Nava-Ruíz, C., Ibáñez-Cervantes, G., Arciniega-Martínez, I. M., Reséndiz‐Albor, A. A., & Rojas, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189162 · Cited by 9 · see citing works

Variability in Behavioral Phenotypes after Forced Swimming-Induced Stress in Rats Is Associated with Expression of the Glucocorticoid Receptor, Nurr1, and IL-1β in the Hippocampus

Ruiz-Sánchez, E., López-Ramírez, A. M., Ruíz-Chow, Á. A., Calvillo, M., Reséndiz‐Albor, A. A., Anguiano, B., & Rojas, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312700 · Cited by 9 · see citing works

The Osteogenesis Imperfecta Type V Mutant BRIL/IFITM5 Promotes Transcriptional Activation of MEF2, NFATc, and NR4A in Osteoblasts

Maranda, V., Gaumond, M.-H., & Moffatt, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042148 · Cited by 10 · see citing works

Dihydromyricetin from ampelopsis grossedentata protects against vascular neointimal formation via induction of TR3

Huang, B., Li, Y., Yao, Y., Shu, W., & Chen, M. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.09.002 · Cited by 9 · see citing works

Nuclear receptors in abdominal aortic aneurysms

Neels, J. G., Hassen‐Khodja, R., & Chinetti, G. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.02.009 · Cited by 9 · see citing works

Transcriptomic analysis reveals crucial regulatory roles of immediate-early response genes and related signaling pathways in coronavirus infectious bronchitis virus infection

Yuan, L. X., Yang, B., Fung, T. S., Chen, R., & Liu, D. X. (2022) · Virology · doi:10.1016/j.virol.2022.08.001 · Cited by 8 · see citing works

The role of nuclear receptor 4A1 (NR4A1) in drug‐induced gingival overgrowth

Hatano, S., Matsuda, S., Okanobu, A., Furutama, D., Memida, T., Kajiya, M., Ouhara, K., Fujita, T., Mizuno, N., & Kurihara, H. (2021) · The FASEB Journal · doi:10.1096/fj.202100032r · Cited by 8 · see citing works

Tetramethylpyrazine and paeoniflorin combination (TMP-PF) alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway

Yuan, R., Xin, Q., Shi, W., Yu, M., Zhu, Z., Yuan, Y., Chen, Y., Chen, X., Leng, S. X., Chen, K., et al. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250212 · Cited by 7 · see citing works

Nur77 promotes embryo adhesion by transcriptionally regulating HOXA10 expression

Shen, J., Zhu, X., Zhang, M., Jiang, Y., Yan, G., Wang, Z., Sun, L., & Zhang, Q. (2019) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2019.1671536 · Cited by 7 · see citing works

Decreased Steroid Hormone Receptor NR4A2 Expression in Kawasaki Disease Before IVIG Treatment

Huang, Y., Chen, K., Lo, M., Cai, X.-Y., & Kuo, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00007 · Cited by 7 · see citing works

Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity

Joshi, R., Hamed, O., Yan, D., Michi, A. N., Mostafa, M., Wiehler, S., Newton, R. C., & Giembycz, M. A. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000196 · Cited by 7 · see citing works

Pterocarpus santalinus Selectively Inhibits a Subset of Pro-Inflammatory Genes in Interleukin-1 Stimulated Endothelial Cells

Natalia, P., Zwirchmayr, J., Rudžionytė, I., Pulsinger, A., Breuss, J. M., Uhrín, P., Rollinger, J. M., & de Martin, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.802153 · Cited by 6 · see citing works

Role of the nuclear receptor subfamily 4a in mast cells in the development of irritable bowel syndrome

Li, R., Chen, S., Gu, X., An, S., & Wang, Z. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.02.017 · Cited by 6 · see citing works

A Novel Mechanism of Coactivator Recruitment by the Nurr1 Nuclear Receptor

Daffern, N., & Radhakrishnan, I. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167718 · Cited by 6 · see citing works

Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia

Phelan, D. E., Reddan, B., Shigemura, M., Sznajder, J. I., Crean, D., & Cummins, E. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052852 · Cited by 6 · see citing works

MSCs Contribute to the Conversion of Ly6Chigh Monocytes into Ly6Clow Subsets under AMI

Lu, W., Ma, G., Sheng, Z., Wang, Q., Chen, L., Qi, J., Shi, R. H., Ji, J., Ji, Z., & Dai, Q. (2020) · Stem Cells International · doi:10.1155/2020/2460158 · Cited by 6 · see citing works

Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol-Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: A Global Transcriptomic Analysis

Joshi, R., Yan, D., Hamed, O., Mostafa, M., Joshi, T., Newton, R. C., & Giembycz, M. A. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.115311 · Cited by 6 · see citing works

Host–parasite interactions after in vitro infection of human macrophages by Leishmania major: Dual analysis of microRNA and mRNA profiles reveals regulation of key processes through time kinetics

Atri, C., Mkannez, G., Attia, H., Sghaier, R. M., Bali, A., Ben-Cheikh, A., Rabhi, I., Regnault, B., Piquemal, D., Ghedira, K., et al. (2025) · Microbes and Infection · doi:10.1016/j.micinf.2025.105502 · Cited by 5 · see citing works

Inversely Regulated Inflammation-Related Processes Mediate Anxiety–Obesity Links in Zebrafish Larvae and Adults

Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., & Meerson, A. (2023) · Cells · doi:10.3390/cells12131794 · Cited by 5 · see citing works

Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity

Guo, Y., Lu, Q., Yang, X.-J., He, Y., Wu, Y., Qin, B., Li, T., Duan, M., Liu, N., Wu, X., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299376 · Cited by 4 · see citing works

Bruceine A protects nuclear receptor 4A1 from ubiquitin-degradation to alleviate mesangial proliferative glomerulonephritis

Hu, H., Li, R., He, K., Wu, L., Li, R., Lu, J., Tian, R., Zhang, C., He, J., Chen, Y., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02495-2 · Cited by 4 · see citing works

Comprehensive characterization of a novel small-molecule activator for the nuclear receptor Nur77: Chemical, molecular, and biological insights

Reddy, A. T., Lakshmi, S. P., Nyunoya, T., & Reddy, R. C. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176945 · Cited by 4 · see citing works

Identification of novel anti-inflammatory Nur77 modulators by virtual screening

Ding, X., Zhao, Z., Wu, Y., Zhang, H., Chen, K., Luo, C., Luo, X., & Xu, H. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104912 · Cited by 4 · see citing works

Subcellular Localization of NR4A2 Orphan Nuclear Receptor Expression in Human and Mouse Synovial Joint Tissue

Smyth, A. M., Gogarty, M., Crean, D., & Murphy, E. P. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9195-2_3 · Cited by 4 · see citing works

Mechanisms of orphan nuclear receptor Nur77 in liver health, disease, and therapeutic potential: narrative review

Alsharif, O., & Rombouts, K. (2025) · npj Gut and Liver · doi:10.1038/s44355-025-00037-9 · Cited by 3 · see citing works

γδ T cells in diabetes mellitus: dual roles and therapeutic implications

Wang, B., Li, Q., & Wang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1693466 · Cited by 3 · see citing works

Classification of colorectal cancer based on gene sequencing data with XGBoost model: An application of public health informatics

Akbulut, S., Küçükakçalı, Z., & Çolak, C. (2022) · Çukurova medical journal (Online)/Çukurova medical journal · doi:10.17826/cumj.1128653 · Cited by 3 · see citing works

NR4A1 deficiency promotes carotid plaque vulnerability by activating integrated stress response via targeting Bcat1

Chen, L., Shi, Y., Xiao, D., Huang, Y., Jiang, Y., Liang, M., Liang, F., Xue, J., Chen, H., Liu, Z., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05602-2 · Cited by 3 · see citing works

Differential mRNA Expression Profiling Reveals the Role of MiR-375 in Inflammation of Bovine Mammary Epithelial Cells

Li, Y., Hu, Q., Luoreng, Z., Yang, J., Wang, X., Ma, Y., & Wei, D. (2022) · Animals · doi:10.3390/ani12111431 · Cited by 3 · see citing works

Local Regulation of Adrenal Steroidogenesis: Subtle in vitro Effects of IL-1β on the Human Cell Line NCI-H295R Steroid Production along with Changes in MicroRNA Profile and Orphan Nuclear Receptors NR4As

Santucci, N. E., Stampone, R., da Silva, E. B. F., Villar, S. R., Spinelli, S. V., Linhares‐Lacerda, L., Alves, M. R., Bay, M. L., & Bottasso, O. A. (2020) · NeuroImmunoModulation · doi:10.1159/000512325 · Cited by 3 · see citing works

The endocannabinoid anandamide prevents TH17 programming of activated T lymphocytes while preserving TH1 responses

Kiprina, A., Teichmann, T., Giménez, V. M. M., Wen-qing, X., Sailer, F. K., Windbergs, M., Manucha, W. A., Weigert, A., & Brandes, R. P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1528759 · Cited by 2 · see citing works

Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma

Wang, K., Wang, M., Shang, Y., He, Y., Li, Q., Gao, W., & Yin, H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4565246 · Cited by 2 · see citing works

Correction: Transcription cofactor GRIP1 differentially affects myeloid cell–driven neuroinflammation and response to IFN-β therapy

Mimouna, S., Rollins, D. A., Shibu, G., Tharmalingam, B., Deochand, D. K., Chen, X., Oliver, D., Chinenov, Y. V., & Rogatsky, I. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.2019238611162020c · Cited by 3 · see citing works

NR4A1 and NR4A2 orphan nuclear receptors regulate endothelial-to-hematopoietic transition in mouse hematopoietic stem cell specification

da Bandeira, D. S., Nevitt, C. D., Dezem, F. S., Marção, M., Liu, Y., Kelley, Z., DuBose, H., Chabot, A., Hall, T., Caprio, C., et al. (2024) · Development · doi:10.1242/dev.201957 · Cited by 1 · see citing works

Nuclear receptors as therapeutic targets in metabolic and cardiovascular disorders

Li, F., Chen, Q., Dai, Y., & Lu, L. (2025) · iScience · doi:10.1016/j.isci.2025.114042 · Cited by 1 · see citing works

Inflammation: a role for NR4A orphan nuclear receptors?

McMorrow, J. P., & Murphy, E. P. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390688 · Cited by 167 · see citing works

NR4A Receptors in Immunity: Bridging Neuroendocrine and Inflammatory Pathways

Santucci, N. E., & Ferreira, S. (2025) · Receptors · doi:10.3390/receptors5010003 · Cited by 1 · see citing works

Nuclear receptors in inflammation control: Repression by GR and beyond

Chinenov, Y. V., Gupte, R., & Rogatsky, I. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.006 · Cited by 61 · see citing works

Nuclear receptor Nur77: its role in chronic inflammatory diseases

Lith, S. C., & de Vries, C. J. M. (2021) · Essays in Biochemistry · doi:10.1042/ebc20210004 · Cited by 66 · see citing works

Nuclear receptors versus inflammation: mechanisms of transrepression

Pascual, G., & Glass, C. K. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.08.005 · Cited by 225 · see citing works