The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia
Open accessAbstract
Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits.Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic glutamate actions is poorly understood.Here, we used advanced imaging methods, in situ and in vivo, to find that a classical synaptic memory mechanism, long-term potentiation (LTP), triggers withdrawal of PAPs from potentiated synapses.Optical glutamate sensors combined with patch-clamp and 3D molecular localization reveal that LTP induction thus prompts spatial retreat of astroglial glutamate transporters, boosting glutamate spillover and NMDA-receptor-mediated inter-synaptic cross-talk.The LTP-triggered PAP withdrawal involves NKCC1 transporters and the actin-controlling protein cofilin but does not depend on major Ca 2+ -dependent cascades in astrocytes.We have therefore uncovered a mechanism by which a memory trace at one synapse could alter signal handling by multiple neighboring connections.
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Cites
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
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Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains
Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 1×
“Although ‘‘thin’’ and ‘‘mushroom’’ spines have distinct identities (Matsuzaki et al., 2001), we found that LTP induction reduced local PAP VF for both types (Figure 2H).”
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Long-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389
Self-citationGliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Self-citationAstrocytic Purinergic Signaling Coordinates Synaptic Networks
Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280
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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686
The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197
The role of astrocyte structural plasticity in regulating neural circuit function and behavior
Lawal, O., Ulloa Severino, F. P., & Eroglu, C. (2022) · Glia · doi:10.1002/glia.24191 · Cited by 142
Electroacupuncture prevents astrocyte atrophy to alleviate depression
Lin, S.-S., Zhou, B., Chen, B.-J., Jiang, R.-T., Li, B., Illes, P., Semyanov, A., Tang, Y., & Verkhratsky, A. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05839-4 · Cited by 102
Cytokine Signalling at the Microglial Penta-Partite Synapse
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Metadata
- Authors
- Henneberger, C., Bard, L., Panatier, A., Reynolds, J. P., Kopach, O., Medvedev, N. I., Minge, D., Herde, M. K., Anders, S., Kraev, I., Heller, J. P., Rama, S., Zheng, K., Jensen, T. P., Sanchez-Romero, I., Jackson, C. J., Janovjak, H., Ottersen, O. P., Nagelhus, E. A., Oliet, S. H. R., Stewart, M. G., Nägerl, U. V., & Rusakov, D. A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 108
- Issue
- 5
- Pages
- 919-936.e11
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W3087901293
- Cited by
- 267
- References
- 144
- FWCI
- 15.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia. https://app.cochat.ai/papers/10.1016/j.neuron.2020.08.030
- The paper
- Henneberger, C., Bard, L., Panatier, A., Reynolds, J. P., Kopach, O., Medvedev, N. I., Minge, D., Herde, M. K., Anders, S., Kraev, I., Heller, J. P., Rama, S., Zheng, K., Jensen, T. P., Sanchez-Romero, I., Jackson, C. J., Janovjak, H., Ottersen, O. P., Nagelhus, E. A., . . . Rusakov, D. A. (2020). LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia. Neuron. https://doi.org/10.1016/j.neuron.2020.08.030
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
