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Cited by 142Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

The role of astrocyte structural plasticity in regulating neural circuit function and behavior

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Lawal, Oluwadamilola, Ulloa Severino, Francesco Paolo, Eroglu, Cagla·2022·Glia
DOI 10.1002/glia.24191PMC PMC9233050
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Abstract

Brain circuits undergo substantial structural changes during development, driven by the formation, stabilization, and elimination of synapses. Synaptic connections continue to undergo experience‐dependent structural rearrangements throughout life, which are postulated to underlie learning and memory. Astrocytes, a major glial cell type in the brain, are physically in contact with synaptic circuits through their structural ensheathment of synapses. Astrocytes strongly contribute to the remodeling of synaptic structures in healthy and diseased central nervous systems by regulating synaptic connectivity and behaviors. However, whether structural plasticity of astrocytes is involved in their critical functions at the synapse is unknown. This review will discuss the emerging evidence linking astrocytic structural plasticity to synaptic circuit remodeling and regulation of behaviors. Moreover, we will survey possible molecular and cellular mechanisms regulating the structural plasticity of astrocytes and their non‐cell‐autonomous effects on neuronal plasticity. Finally, we will discuss how astrocyte morphological changes in different physiological states and disease conditions contribute to neuronal circuit function and dysfunction.

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Cited by

Sorted by citations

Authors
Lawal, O., Ulloa Severino, F. P., & Eroglu, C.
Affiliations
  • Duke Medical Center (US)
  • Department of Cell Biology Duke University Medical Center Durham North Carolina USA
ORCID
Venue
Glia
Publisher
Wiley
Published
2022-05-10
Volume
70
Issue
8
Pages
1467-1483
ISSN
  • 0894-1491 (ISSN-L)
  • 1098-1136
DOI
10.1002/glia.24191
PMC
PMC9233050
OpenAlex
W4280500951
Cited by
142
References
25
Citations by year
2026: 35 · 2025: 48 · 2024: 31 · 2023: 20 · 2022: 8
FWCI
3.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Glia (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion, other-oa)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
astrocytes, synaptic remodeling, neural circuit function, behavior, experience-dependent plasticity, learning and memory, non-cell-autonomous effects, neuroplasticity, glial morphology, brain development
MeSH terms
Astrocytes, Brain, Neuronal Plasticity, Neurons, Synapses

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