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Cited by 35Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex

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Babij, Rachel, Ferrer, Camilo, Donatelle, Alexander, Wacks, Sam, Buch, Amanda M., Niemeyer, James E., Ma, Hongtao, Duan, Zhe Ran S. +7 more·2023·Neuron
DOI 10.1016/j.neuron.2022.10.037PMC PMC9852093
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Abstract

Dysfunction of gamma-aminobutyric acid (GABA)ergic circuits is strongly associated with neurodevelopmental disorders. However, it is unclear how genetic predispositions impact circuit assembly. Using in vivo two-photon and widefield calcium imaging in developing mice, we show that Gabrb3, a gene strongly associated with autism spectrum disorder (ASD) and Angelman syndrome (AS), is enriched in contralaterally projecting pyramidal neurons and is required for inhibitory function. We report that Gabrb3 ablation leads to a developmental decrease in GABAergic synapses, increased local network synchrony, and long-lasting enhancement in functional connectivity of contralateral-but not ipsilateral-pyramidal neuron subtypes. In addition, Gabrb3 deletion leads to increased cortical response to tactile stimulation at neonatal stages. Using human transcriptomics and neuroimaging datasets from ASD subjects, we show that the spatial distribution of GABRB3 expression correlates with atypical connectivity in these subjects. Our studies reveal a requirement for Gabrb3 during the emergence of interhemispheric circuits for sensory processing.

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  • Altered function of GABRB2 and GABRB3 receptors disrupts functional integration of pyramidal neuron subtypes in cortical circuits and has been linked to an imbalance between excitation and inhibition in cortical and subcortical circuits, a widely proposed mechanism in ASD pathophysiology.

    “Altered function of these receptors disrupts the functional integration of pyramidal neuron subtypes in cortical circuits (Babij et al., 2023) and has been linked to an imbalance between excitation and inhibition in cortical and subcortical circuits, a widely proposed mechanism in ASD pathophysiology (Babij et al., 2023; Coskunpinar et al., 2023).”

    From Biological hierarchy from genotype to phenotype in syndromic and non-syndromic autism spectrum disorder (2026) · cites this paper as Babij et al., 2023

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Cited by

Sorted by citations

Authors
Babij, R., Ferrer, C., Donatelle, A., Wacks, S., Buch, A. M., Niemeyer, J. E., Ma, H., Duan, Z. R. S., Fetcho, R. N., Che, A., Otsuka, T., Schwartz, T. H., Huang, B. S., Liston, C., & De Marco García, N. V.
Affiliations
  • Weill Cornell Medicine (US)
  • NewYork–Presbyterian Hospital (US)
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2023-01
Volume
111
Issue
2
Pages
256-274.e10
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2022.10.037
PMC
PMC9852093
OpenAlex
W4310141934
Cited by
35
References
12
Citations by year
2026: 8 · 2025: 6 · 2024: 15 · 2023: 4 · 2022: 2
FWCI
2.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (F30MH117939, F30MH115622, R01MH109685, R01MH110553, R01MH118451)
  • National Institute of General Medical Sciences (T32GM007739)
  • National Institute of Neurological Disorders and Stroke (K99NS114166, R01NS116137)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
GABRB3, GABAB receptors, somatosensory cortex, pyramidal neurons, interhemispheric connectivity, GABAergic synapses, autism spectrum disorder, Angelman syndrome, tactile processing, neurodevelopmental disorders, GABAergic circuits
MeSH terms
Autism Spectrum Disorder, Animals, Humans, Receptors, GABA-A, Somatosensory Cortex, Synapses, Touch, Pyramidal Cells, Mice

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