Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches
Open accessAbstract
Although modern techniques such as two-photon microscopy can now provide cellular-level three-dimensional imaging of the intact living brain, the speed and fields of view of these techniques remain limited. Conversely, two-dimensional wide-field optical mapping (WFOM), a simpler technique that uses a camera to observe large areas of the exposed cortex under visible light, can detect changes in both neural activity and haemodynamics at very high speeds. Although WFOM may not provide single-neuron or capillary-level resolution, it is an attractive and accessible approach to imaging large areas of the brain in awake, behaving mammals at speeds fast enough to observe widespread neural firing events, as well as their dynamic coupling to haemodynamics. Although such wide-field optical imaging techniques have a long history, the advent of genetically encoded fluorophores that can report neural activity with high sensitivity, as well as modern technologies such as light emitting diodes and sensitive and high-speed digital cameras have driven renewed interest in WFOM. To facilitate the wider adoption and standardization of WFOM approaches for neuroscience and neurovascular coupling research, we provide here an overview of the basic principles of WFOM, considerations for implementation of wide-field fluorescence imaging of neural activity, spectroscopic analysis and interpretation of results. This article is part of the themed issue ‘Interpreting BOLD: a dialogue between cognitive and cellular neuroscience’.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Violet to yellow excitation and emission light are well absorbed by blood within the vasculature, so blood vessels lacking fluorescent proteins appear as dark shadows when fluorescent proteins are diffusely expressed in brain cells.
“Violet to yellow excitation and emission light are well absorbed by the blood within the vasculature. Therefore, when fluorescent proteins are diffusely expressed in brain cells, blood vessels that lack these proteins appear as dark shadows36,37.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [37]
In “The need for haemodynamic correction of wide-field fluorescence data” (page unavailable), the paper says GCaMP excitation and emission overlap strong haemoglobin absorption bands, attenuating fluorescence. In “Methods of correcting for haemodynamic cross-talk” (page unavailable), it reports strong vessel artefacts in uncorrected GCaMP images. It does not specify the full violet-to-yellow range or explain the dark appearance as vessels lacking fluorescent proteins. (LLM, conf=0.82)
Experimental — accuracy not yet measuredVessel dilation reduces detectable parenchymal fluorescence.
“Vessel dilation consequently reduces the detectable parenchymal fluorescence.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works
MCML—Monte Carlo modeling of light transport in multi-layered tissues
Wang, L. V., Jacques, S. L., & Zheng, L. (1995) · Computer Methods and Programs in Biomedicine · doi:10.1016/0169-2607(95)01640-f · Cited by 3,330 · see citing works
Capillary pericytes regulate cerebral blood flow in health and disease
Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O’Farrell, F. M., Buchan, A. M., Lauritzen, M., & Attwell, D. (2014) · Nature · doi:10.1038/nature13165 · Cited by 1,870 · see citing works
Functional architecture of cortex revealed by optical imaging of intrinsic signals
Grinvald, A., Lieke, E. E., Frostig, R. D., Gilbert, C. D., & Wiesel, T. N. (1986) · Nature · doi:10.1038/324361a0 · Cited by 1,243 · see citing works
Diversity of astrocyte functions and phenotypes in neural circuits
Khakh, B. S., & Sofroniew, M. V. (2015) · Nature Neuroscience · doi:10.1038/nn.4043 · Cited by 1,239 · see citing works
Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
Ohki, K., Chung, S., Ch'ng, Y. H., Kara, P., & Reid, R. C. (2005) · Nature · doi:10.1038/nature03274 · Cited by 1,191 · see citing works
Miniaturized integration of a fluorescence microscope
Ghosh, K. K., Burns, L. D., Cocker, E. D., Nimmerjahn, A., Ziv, Y., Gamal, A. E., & Schnitzer, M. J. (2011) · Nature Methods · doi:10.1038/nmeth.1694 · Cited by 1,130 · see citing works
Malonek, D., & Grinvald, A. (1996) · Science · doi:10.1126/science.272.5261.551 · Cited by 1,095 · see citing works
Akerboom, J., Calderón, N. C., Tian, L., Wabnig, S., Prigge, M., Tolö, J., Gordus, A. G., Orger, M. B., Severi, K. E., Macklin, J. J., et al. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00002 · Cited by 710 · see citing works
Coupling Mechanism and Significance of the BOLD Signal: A Status Report
Hillman, E. M. C. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014111 · Cited by 615 · see citing works
Self-citationRetinal waves coordinate patterned activity throughout the developing visual system
Ackman, J. B., Burbridge, T. J., & Crair, M. C. (2012) · Nature · doi:10.1038/nature11529 · Cited by 525 · see citing works
High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor
Gong, Y., Huang, C., Li, J. Z., Grewe, B. F., Zhang, Y., Eismann, S., & Schnitzer, M. J. (2015) · Science · doi:10.1126/science.aab0810 · Cited by 462 · see citing works
Optical brain imaging in vivo: techniques and applications from animal to man
Hillman, E. M. C. (2007) · Journal of Biomedical Optics · doi:10.1117/1.2789693 · Cited by 436 · see citing works
Self-citationChronic optical access through a polished and reinforced thinned skull
Drew, P. J., Shih, A. Y., Driscoll, J. D., Knutsen, P. M., Blinder, P., Davalos, D., Akassoglou, K., Tsai, P. S., & Kleinfeld, D. (2010) · Nature Methods · doi:10.1038/nmeth.1530 · Cited by 406 · see citing works
St-Pierre, F., Marshall, J. D., Yang, Y., Gong, Y., Schnitzer, M. J., & Lin, M. Z. (2014) · Nature Neuroscience · doi:10.1038/nn.3709 · Cited by 402 · see citing works
Devor, A., Dunn, A. K., Andermann, M. L., Ulbert, I., Boas, D. A., & Dale, A. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00403-3 · Cited by 387 · see citing works
Shoham, D., Glaser, D. E., Arieli, A., Kenet, T., Wijnbergen, C., Toledo, Y., Hildesheim, R., & Grinvald, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81027-2 · Cited by 350 · see citing works
A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain
Chen, B. R., Kozberg, M. G., Bouchard, M. B., Shaik, M. A., & Hillman, E. M. C. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000787 · Cited by 346 · see citing works
Self-citationNonuniqueness in diffusion-based optical tomography
Arridge, S., & Lionheart, W. R. B. (1998) · Optics Letters · doi:10.1364/ol.23.000882 · Cited by 337 · see citing works
Dunn, A. K., Devor, A., Bolay, H., Andermann, M. L., Moskowitz, M. A., Dale, A. M., & Boas, D. A. (2003) · Optics Letters · doi:10.1364/ol.28.000028 · Cited by 333 · see citing works
Vanzetta, I., & Grinvald, A. (1999) · Science · doi:10.1126/science.286.5444.1555 · Cited by 319 · see citing works
Tian, P., Teng, I. C., May, L. D., Kurz, R., Lu, K., Scadeng, M., Hillman, E. M. C., de Crespigny, A. J., D'Arceuil, H. E., Mandeville, J. B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006735107 · Cited by 294 · see citing works
Self-citationHillman, E. M. C., Devor, A., Bouchard, M. B., Dunn, A. K., Krauss, G. W., Skoch, J. M., Bacskai, B. J., Dale, A. M., & Boas, D. A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.11.032 · Cited by 290 · see citing works
Self-citationBevilacqua, F. P., Berger, A. J., Cerussi, A. E., Jakubowski, D. B., & Tromberg, B. J. (2000) · Applied Optics · doi:10.1364/ao.39.006498 · Cited by 284 · see citing works
Optical mapping of electrical activity in rat somatosensory and visual cortex
Orbach, H., Cohen, L., & Grinvald, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-07-01886.1985 · Cited by 282 · see citing works
Investigating neural–hemodynamic coupling and the hemodynamic response function in the awake rat
Martin, C. J., Martindale, J., Berwick, J., & Mayhew, J. E. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.021 · Cited by 255 · see citing works
Mohajerani, M. H., McVea, D. A., Fingas, M., & Murphy, T. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6437-09.2010 · Cited by 246 · see citing works
Shibuki, K., Hishida, R., Murakami, H., Kudoh, M., Kawaguchi, T., Watanabe, M., Watanabe, S., Kouuchi, T., & Tanaka, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040709 · Cited by 240 · see citing works
Jones, M., Berwick, J., Johnston, D., & Mayhew, J. E. (2001) · NeuroImage · doi:10.1006/nimg.2001.0808 · Cited by 239 · see citing works
Mayevsky, A., & Chance, B. (1982) · Science · doi:10.1126/science.7201167 · Cited by 232 · see citing works
Bouchard, M. B., Chen, B. R., Burgess, S. A., & Hillman, E. M. C. (2009) · Optics Express · doi:10.1364/oe.17.015670 · Cited by 221 · see citing works
Self-citationImaging Neural Activity Using Thy1-GCaMP Transgenic Mice
Chen, Q., Cichon, J., Wang, W., Qiu, L., Lee, S.-J. R., Campbell, N. R., DeStefino, N. R., Goard, M. J., Fu, Z., Yasuda, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.011 · Cited by 213 · see citing works
Brain NADH redox state monitored in vivo by fiber optic surface fluorometry
Mayevsky, A. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90029-8 · Cited by 202 · see citing works
All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast
Hillman, E. M. C., & Moore, A. V. (2007) · Nature Photonics · doi:10.1038/nphoton.2007.146 · Cited by 188 · see citing works
Self-citationImproved calcium imaging in transgenic mice expressing a troponin C–based biosensor
Heim, N., Garaschuk, O., Friedrich, M. W., Mank, M., Milos, R., Kovalchuk, Y., Konnerth, A., & Griesbeck, O. (2007) · Nature Methods · doi:10.1038/nmeth1009 · Cited by 186 · see citing works
Physical model for the spectroscopic analysis of cortical intrinsic optical signals
Kohl‐Bareis, M., Lindauer, U., Royl, G., Kühl, M., Gold, L., Villringer, A., & Dirnagl, U. (2000) · Physics in Medicine and Biology · doi:10.1088/0031-9155/45/12/317 · Cited by 177 · see citing works
Vanni, M. P., & Murphy, T. H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1818-14.2014 · Cited by 168 · see citing works
Lindauer, U., Royl, G., Leithner, C., Kühl, M., Gold, L., Gethmann, J. M., Kohl‐Bareis, M., Villringer, A., & Dirnagl, U. (2001) · NeuroImage · doi:10.1006/nimg.2000.0709 · Cited by 154 · see citing works
Sheth, S. A., Nemoto, M., Guiou, M., Walker, M. A., Pouratian, N., Hageman, N. S., & Toga, A. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4526-03.2004 · Cited by 137 · see citing works
Distortions of visuotopic map match orientation singularities in primary visual cortex
Das, A., & Gilbert, C. D. (1997) · Nature · doi:10.1038/42461 · Cited by 135 · see citing works
Mayhew, J. E., Zheng, Y., Hou, Y., Vuksanovic, B., Berwick, J., Askew, S., & Coffey, P. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0460 · Cited by 134 · see citing works
Imaging local neuronal activity by monitoring PO2 transients in capillaries
Parpaleix, A., Houssen, Y. G., & Charpak, S. (2013) · Nature Medicine · doi:10.1038/nm.3059 · Cited by 131 · see citing works
Berwick, J., Johnston, D., Jones, M., Martindale, J., Martin, C. J., Kennerley, A. J., Redgrave, P., & Mayhew, J. E. W. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00658.2007 · Cited by 131 · see citing works
Spatiotemporal precision and hemodynamic mechanism of optical point spreads in alert primates
Sirotin, Y. B., Hillman, E. M. C., Bordier, C., & Das, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905509106 · Cited by 121 · see citing works
Self-citationHigh-speed vascular dynamics of the hemodynamic response
Chen, B. R., Bouchard, M. B., McCaslin, A. F. H., Burgess, S. A., & Hillman, E. M. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.036 · Cited by 120 · see citing works
Self-citationKozberg, M. G., Chen, B. R., DeLeo, S. E., Bouchard, M. B., & Hillman, E. M. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212785110 · Cited by 117 · see citing works
Self-citationImaging the awake visual cortex with a genetically encoded voltage indicator
Carandini, M., Shimaoka, D., Rossi, L. F., Sato, T. K., Benucci, A., & Knöpfel, T. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0594-14.2015 · Cited by 115 · see citing works
Mason, M. G., Nicholls, P. J., & Cooper, C. E. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.08.005 · Cited by 110 · see citing works
In vivo optical imaging and dynamic contrast methods for biomedical research
Hillman, E. M. C., Amoozegar, C., Wang, T. S., McCaslin, A. F. H., Bouchard, M. B., Mansfield, J. R., & Levenson, R. M. (2011) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2011.0264 · Cited by 110 · see citing works
Self-citationNonlinear coupling of neural activity and CBF in rodent barrel cortex
Jones, M., Hewson-Stoate, N., Martindale, J., Redgrave, P., & Mayhew, J. E. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.02.007 · Cited by 104 · see citing works
The story of the initial dip in fMRI
Hu, X. P., & Yacoub, E. S. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.005 · Cited by 102 · see citing works
Berwick, J., Johnston, D. K., Jones, M., Martindale, J., Redgrave, P., McLoughlin, N. P., Schießl, I., & Mayhew, J. E. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04347.x · Cited by 100 · see citing works
Cohen, L. B., Keynes, R. D., & Landowne, D. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009919 · Cited by 97 · see citing works
Sheth, S. A., Nemoto, M., Guiou, M., Walker, M. A., & Toga, A. W. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600091 · Cited by 93 · see citing works
Rayshubskiy, A., Wojtasiewicz, T. J., Mikell, C. B., Bouchard, M. B., Timerman, D., Youngerman, B. E., McGovern, R. A., Otten, M. L., Canoll, P., McKhann, G. M., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.10.044 · Cited by 92 · see citing works
Self-citationThe Triphasic Intrinsic Signal: Implications for Functional Imaging
Chen‐Bee, C. H., Agoncillo, T., Xiong, Y., & Frostig, R. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0326-07.2007 · Cited by 91 · see citing works
Optical Imaging of SI Topography in Anesthetized and Awake Squirrel Monkeys
Chen, L. M., Friedman, R. M., & Roe, A. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1990-05.2005 · Cited by 90 · see citing works
Coupling between neuronal activity and microcirculation: Implications for functional brain imaging
Vanzetta, I., & Grinvald, A. (2008) · HFSP journal · doi:10.2976/1.2889618 · Cited by 84 · see citing works
Vanzetta, I., & Grinvald, A. (2001) · NeuroImage · doi:10.1006/nimg.2001.0843 · Cited by 78 · see citing works
Further nonlinearities in neurovascular coupling in rodent barrel cortex
Hewson-Stoate, N., Jones, M., Martindale, J., Berwick, J., & Mayhew, J. E. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.040 · Cited by 78 · see citing works
Spatio-temporal mapping of rat whisker barrels with fast scattered light signals
Rector, D. M., Carter, K. M., Volegov, P. L., & GEORGE, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.030 · Cited by 77 · see citing works
Measurement and modelling of the optical properties of human tissue in the near infrared.
van der Zee, P. (1993) · Cited by 71 · see citing works
Kozberg, M. G., Ma, Y., Shaik, M. A., Kim, S. H., & Hillman, E. M. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2363-15.2016 · Cited by 71 · see citing works
Self-citationFlavoprotein autofluorescence imaging in the cerebellar cortex in vivo
Reinert, K. C., Gao, W., Chen, G., & Ebner, T. J. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21348 · Cited by 69 · see citing works
Scott, N. A., & Murphy, T. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029859 · Cited by 59 · see citing works
Harrison, T. C., Sigler, A., & Murphy, T. H. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.06.021 · Cited by 58 · see citing works
Kennerley, A. J., Harris, S., Bruyns‐Haylett, M., Boorman, L. W., Zheng, Y., Jones, M., & Berwick, J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.163 · Cited by 54 · see citing works
A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast
Yuan, B., Burgess, S. A., Iranmahboob, A. K., Bouchard, M. B., Lehrer, N., Bordier, C., & Hillman, E. M. C. (2009) · Review of Scientific Instruments · doi:10.1063/1.3117204 · Cited by 48 · see citing works
Self-citationA structured matrix factorization framework for large scale calcium imaging data analysisPreprint
Pnevmatikakis, E. A., Gao, Y., Soudry, D., Pfau, D., Lacefield, C., Poskanzer, K. E., Bruno, R. M., Yuste, R., & Paninski, L. (2014) · arXiv (Cornell University) · doi:10.48550/arxiv.1409.2903 · Cited by 42 · see citing works
Ma, H., Harris, S., Rahmani, R., Lacefield, C., Zhao, M., Daniel, A. G. S., Zhou, Z., Bruno, R. M., Berwick, J., & Schwartz, T. H. (2014) · Neurophotonics · doi:10.1117/1.nph.1.1.015003 · Cited by 31 · see citing works
Vincis, R., Lagier, S., Ville, D. V. D., Rodríguez, I., & Carleton, A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.016 · Cited by 28 · see citing works
Sun, R. R., Bouchard, M. B., & Hillman, E. M. C. (2010) · Biomedical Optics Express · doi:10.1364/boe.1.000385 · Cited by 24 · see citing works
Self-citationRefinement of optical imaging spectroscopy algorithms using concurrent BOLD and CBV fMRI
Kennerley, A. J., Berwick, J., Martindale, J., Johnston, D. K., Zheng, Y., & Mayhew, J. E. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.092 · Cited by 24 · see citing works
Sirotin, Y. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00006 · Cited by 20 · see citing works
Shibuki, K., Ono, K., Hishida, R., & Kudoh, M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.004 · Cited by 18 · see citing works
L’Heureux, B., Gurden, H., & Pain, F. (2009) · Optics Express · doi:10.1364/oe.17.009477 · Cited by 18 · see citing works
Daniel, A. G. S., Laffont, P., Zhao, M., Ma, H., & Schwartz, T. H. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.04.036 · Cited by 17 · see citing works
A rapid topographic mapping and eye alignment method using optical imaging in Macaque visual cortex
Lu, H. D., Chen, G., Ts’o, D. Y., & Roe, A. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.007 · Cited by 16 · see citing works
Sakota, D., & Takatani, S. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.5.057007 · Cited by 16 · see citing works
Sakaguchi, K., Tachibana, T., Furukawa, S., Katsura, T., Yamazaki, K., Kawaguchi, H., Maki, A., & Okada, E. (2007) · Applied Optics · doi:10.1364/ao.46.002769 · Cited by 14 · see citing works
The Early Days of the Indifferent Gas Method for Measuring Cerebral Blood Flow
Schmidt, C. F. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.1 · Cited by 14 · see citing works
Ranji, M., Jaggard, D. L., Apreleva, S. V., Vinogradov, S. A., & Chance, B. (2006) · Optics Letters · doi:10.1364/ol.31.002995 · Cited by 13 · see citing works
Renaud, R., Martin, C., Gurden, H., & Pain, F. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.1.016012 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 85 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ma, Y., Shaik, M. A., Kozberg, M. G., Kim, S. H., Portes, J., Timerman, D., & Hillman, E. M. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525369113 · Cited by 308 · see citing works
Self-citationGlymphatic influx and clearance are accelerated by neurovascular coupling
von Holstein‐Rathlou, S., Gan, Y., Giannetto, M. J., Rasmussen, M. K., Sigurdsson, B., Beinlich, F. R. M., Rose, L., Untiet, V., Hablitz, L. M., Kelley, D. H., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01327-2 · Cited by 244 · see citing works
Task-Dependent Changes in the Large-Scale Dynamics and Necessity of Cortical Regions
Pinto, L., Rajan, K., DePasquale, B., Thiberge, S. Y., Tank, D. W., & Brody, C. D. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.025 · Cited by 235 · see citing works
Renaudin, N., Demené, C., Dizeux, A., Ialy-Radio, N., Pezet, S., & Tanter, M. (2022) · Nature Methods · doi:10.1038/s41592-022-01549-5 · Cited by 185 · see citing works
Linking brain vascular physiology to hemodynamic response in ultra-high field MRI
Uludaǧ, K., & Blinder, P. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.063 · Cited by 170 · see citing works
Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Lake, E. M. R., Ge, X., Shen, X., Hermán, P., Hyder, F., Cardin, J. A., Higley, M. J., Scheinost, D., Papademetris, X., Crair, M. C., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-00984-6 · Cited by 168 · see citing works
Imaging cortical dynamics in GCaMP transgenic rats with a head-mounted widefield macroscope
Scott, B. B., Thiberge, S., Guo, C.-Y., Tervo, D. G., Brody, C. D., Karpova, A., & Tank, D. W. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.050 · Cited by 153 · see citing works
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task
Salkoff, D. B., Zagha, E., McCarthy, E., & McCormick, D. A. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz206 · Cited by 153 · see citing works
Clancy, N. T., Jones, G., Maier‐Hein, L., Elson, D. S., & Stoyanov, D. V. (2020) · Medical Image Analysis · doi:10.1016/j.media.2020.101699 · Cited by 158 · see citing works
Inhibition stabilization is a widespread property of cortical networks
Sanzeni, A., Akitake, B., Goldbach, H. C., Leedy, C. E., Brunel, N., & Histed, M. H. (2020) · eLife · doi:10.7554/elife.54875 · Cited by 157 · see citing works
Lights, fiber, action! A primer on in vivo fiber photometry
Simpson, E. H., Akam, T. E., Patriarchi, T., Blanco-Pozo, M., Burgeno, L. M., Mohebi, A., Cragg, S. J., & Walton, M. E. (2023) · Neuron · doi:10.1016/j.neuron.2023.11.016 · Cited by 150 · see citing works
Mesoscopic Imaging: Shining a Wide Light on Large-Scale Neural Dynamics
Cardin, J. A., Crair, M. C., & Higley, M. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.031 · Cited by 135 · see citing works
Vanni, M. P., Chan, A. W., Balbi, M., Silasi, G., & Murphy, T. H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3560-16.2017 · Cited by 149 · see citing works
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani, S., Moberly, A. H., Benisty, H., Landa, B., Jing, M., Li, Y., Higley, M. J., & Cardin, J. A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01202-6 · Cited by 146 · see citing works
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson, D. G., Hamodi, A. S., Shen, X., Lür, G., Constable, R. T., Cardin, J. A., Crair, M. C., & Higley, M. J. (2019) · Nature Methods · doi:10.1038/s41592-019-0625-2 · Cited by 140 · see citing works
Behavioral Strategy Determines Frontal or Posterior Location of Short-Term Memory in Neocortex
Gilad, A., Gallero-Salas, Y., Groos, D., & Helmchen, F. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.029 · Cited by 133 · see citing works
Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons
Xiao, D., Vanni, M. P., Mitelut, C., Chan, A. W., LeDue, J. M., Xie, Y., Chen, A. C. N., Swindale, N. V., & Murphy, T. H. (2017) · eLife · doi:10.7554/elife.19976 · Cited by 127 · see citing works
Norepinephrine links astrocytic activity to regulation of cortical state
Reitman, M. E., Tse, V., Mi, X., Willoughby, D. D., Peinado, A., Aivazidis, A., Myagmar, B., Simpson, P. C., Bayraktar, O. A., Yu, G., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01284-w · Cited by 128 · see citing works
Sensory coding and the causal impact of mouse cortex in a visual decision
Zatka-Haas, P., Steinmetz, N. A., Carandini, M., & Harris, K. D. (2021) · eLife · doi:10.7554/elife.63163 · Cited by 119 · see citing works
Functional connectivity structure of cortical calcium dynamics in anesthetized and awake mice
Wright, P. W., Brier, L. M., Bauer, A. Q., Baxter, G. A., Kraft, A. W., Reisman, M. D., Bice, A. R., Snyder, A. Z., Lee, J., & Culver, J. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185759 · Cited by 114 · see citing works
Monitoring norepinephrine release in vivo using next-generation GRABNE sensors
Feng, J., Dong, H., Lischinsky, J. E., Zhou, J., Deng, F., Zhuang, C., Miao, X., Wang, H., Li, G., Cai, R., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.001 · Cited by 121 · see citing works
Cerebral oxygenation during locomotion is modulated by respiration
Zhang, Q., Roche, M., Gheres, K. W., Chaigneau, E. M., Kedarasetti, R. T., Haselden, W. D., Charpak, S., & Drew, P. J. (2019) · Nature Communications · doi:10.1038/s41467-019-13523-5 · Cited by 121 · see citing works
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
Bennett, H. C., Zhang, Q., Wu, Y.-T., Manjila, S. B., Chon, U., Shin, D., Vanselow, D. J., Pi, H.-J., Drew, P. J., & Kim, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-50559-8 · Cited by 109 · see citing works
Montgomery, M. K., Kim, S. H., Dovas, A., Zhao, H., Goldberg, A., Xu, W., Yagielski, A. J., Cambareri, M. K., Patel, K., Mela, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.064 · Cited by 104 · see citing works
Self-citationChronic, cortex-wide imaging of specific cell populations during behavior
Couto, J., Musall, S., Sun, X. R., Khanal, A., Gluf, S., Saxena, S., Kinsella, I., Abe, T., Cunningham, J. P., Paninski, L., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00527-z · Cited by 103 · see citing works
Advances in Monte Carlo Simulation for Light Propagation in Tissue
Periyasamy, V., & Pramanik, M. (2017) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2017.2739801 · Cited by 99 · see citing works
Separation of hemodynamic signals from GCaMP fluorescence measured with wide-field imaging
Valley, M. T., Moore, M. G., Zhuang, J., Mesa, N., Castelli, D., Sullivan, D., Reimers, M., & Waters, J. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00304.2019 · Cited by 99 · see citing works
Low-Dimensional Spatiotemporal Dynamics Underlie Cortex-wide Neural Activity
MacDowell, C. J., & Buschman, T. J. (2020) · Current Biology · doi:10.1016/j.cub.2020.04.090 · Cited by 94 · see citing works
Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data
Saxena, S., Kinsella, I., Musall, S., Kim, S. H., Mészáros, J., Thibodeaux, D. N., Kim, C. Y., Cunningham, J. P., Hillman, E. M. C., Churchland, A. K., et al. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007791 · Cited by 90 · see citing works
Self-citationCharacterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging
Ren, C., & Komiyama, T. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3003-20.2021 · Cited by 86 · see citing works
Spreading depression as an innate antiseizure mechanism
Tamim, I., Chung, D. Y., Morais, A., Loonen, I. C. M., Qin, T., Misra, A., Schlunk, F., Endres, M., Schiff, S. J., & Ayata, C. (2021) · Nature Communications · doi:10.1038/s41467-021-22464-x · Cited by 83 · see citing works
Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo
Deng, F., Wan, J., Li, G., Dong, H., Xia, X., Wang, Y., Li, X., Zhuang, C., Zheng, Y. R., Liu, L. D., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02188-8 · Cited by 93 · see citing works
A human-specific modifier of cortical connectivity and circuit function
Schmidt, E. R. E., Zhao, H. T., Park, J. M., Dipoppa, M., Monsalve-Mercado, M. M., Dahan, J. B., Rodgers, C. C., Lejeune, A., Hillman, E. M. C., Miller, K. D., et al. (2021) · Nature · doi:10.1038/s41586-021-04039-4 · Cited by 82 · see citing works
Self-citationDesigning a large field-of-view two-photon microscope using optical invariant analysis
Bumstead, J., Park, J. J., Rosen, I. A., Kraft, A. W., Wright, P. W., Reisman, M. D., Côté, D. C., & Culver, J. P. (2018) · Neurophotonics · doi:10.1117/1.nph.5.2.025001 · Cited by 75 · see citing works
Cramer, J. V., Gesierich, B. G., Roth, S., Dichgans, M., Duering, M., & Liesz, A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.014 · Cited by 75 · see citing works
Mascaro, A. L. A., Conti, E., Lai, S., Giovanna, A. P. D., Spalletti, C., Alia, C., Panarese, A., Scaglione, A., Sacconi, L., Micera, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.062 · Cited by 72 · see citing works
Neuronal Origin of the Temporal Dynamics of Spontaneous BOLD Activity Correlation
Matsui, T., Murakami, T., & Ohki, K. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy045 · Cited by 75 · see citing works
Cortical State Fluctuations during Sensory Decision Making
Jacobs, E. A. K., Steinmetz, N. A., Peters, A. J., Carandini, M., & Harris, K. D. (2020) · Current Biology · doi:10.1016/j.cub.2020.09.067 · Cited by 69 · see citing works
Interpreting BOLD: towards a dialogue between cognitive and cellular neuroscience
Hall, C. N., Howarth, C., Kurth-Nelson, Z. L., & Mishra, A. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0348 · Cited by 72 · see citing works
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty, H., Barson, D., Moberly, A. H., Lohani, S., Tang, L., Coifman, R. R., Crair, M. C., Mishne, G., Cardin, J. A., & Higley, M. J. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01498-y · Cited by 65 · see citing works
Arousal as a universal embedding for spatiotemporal brain dynamics
Raut, R. V., Rosenthal, Z. P., Wang, X., Miao, H., Zhang, Z., Lee, J., Raichle, M. E., Bauer, A. Q., Brunton, S. L., Brunton, B. W., et al. (2025) · Nature · doi:10.1038/s41586-025-09544-4 · Cited by 67 · see citing works
Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion
West, S. L., Aronson, J. D., Popa, L. S., Feller, K. D., Carter, R. E., Chiesl, W. M., Gerhart, M. L., Shekhar, A. C., Ghanbari, L., Kodandaramaiah, S. B., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab373 · Cited by 61 · see citing works
Oršolić, I., Rio, M., Mrsic‐Flogel, T. D., & Znamenskiy, P. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.031 · Cited by 63 · see citing works
McGirr, A., LeDue, J. M., Chan, A. W., Xie, Y., & Murphy, T. H. (2017) · Brain · doi:10.1093/brain/awx142 · Cited by 58 · see citing works
Borden, P. Y., Wright, N. C., Morrissette, A. E., Jaeger, D., Haider, B., & Stanley, G. B. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.008 · Cited by 58 · see citing works
Zhang, W., Chao, T.-H. H., Yang, Y., Wang, T., Lee, S.-H., Oyarzabal, E. A., Zhou, J., Nonneman, R., Pégard, N. C., Hongtu Zhu, B., et al. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100243 · Cited by 58 · see citing works
The impact of bilateral ongoing activity on evoked responses in mouse cortex
Shimaoka, D., Steinmetz, N. A., Harris, K. D., & Carandini, M. (2019) · eLife · doi:10.7554/elife.43533 · Cited by 54 · see citing works
Differential effects of anesthetics on resting state functional connectivity in the mouse
Xie, H., Chung, D. Y., Kura, S., Sugimoto, K., Aykan, S. A., Wu, Y., Sakadžić, S., Yaseen, M. A., Boas, D. A., & Ayata, C. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19847123 · Cited by 56 · see citing works
Emerging imaging methods to study whole-brain function in rodent models
Markicevic, M., Savvateev, I., Grimm, C., & Zerbi, V. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01575-5 · Cited by 54 · see citing works
Kim, E., Anguluan, E., & Kim, J. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-13572-0 · Cited by 52 · see citing works
Kisler, K., Lazić, D., Sweeney, M. D., Plunkett, S., Khatib, M. E., Vinogradov, S. A., Boas, D. A., Sakadžić, S., & Zloković, B. V. (2018) · Nature Protocols · doi:10.1038/nprot.2018.034 · Cited by 52 · see citing works
Müllenbroich, M. C., Turrini, L., Silvestri, L., Alterini, T., Gheisari, A., Tiso, N., Vanzi, F., Sacconi, L., & Pavone, F. S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00315 · Cited by 50 · see citing works
Wide-Field Calcium Imaging of Neuronal Network Dynamics In Vivo
Nietz, A. K., Popa, L. S., Streng, M. L., Carter, R. E., Kodandaramaiah, S. B., & Ebner, T. J. (2022) · Biology · doi:10.3390/biology11111601 · Cited by 52 · see citing works
Chao, T.-H. H., Lee, B., Hsu, L.-M., Cerri, D. H., Zhang, W.-T., Wang, T.-W. W., Ryali, S., Menon, V., & Shih, Y.-Y. I. (2023) · Science Advances · doi:10.1126/sciadv.ade5732 · Cited by 49 · see citing works
Shahsavarani, S., Thibodeaux, D. N., Xu, W., Kim, S. H., Lodgher, F., Nwokeabia, C., Cambareri, M. K., Yagielski, A. J., Zhao, H., Handwerker, D. A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112527 · Cited by 50 · see citing works
Self-citationCortical signatures of wakeful somatosensory processing
Song, C., Piscopo, D. M., Niell, C. M., & Knöpfel, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-30422-9 · Cited by 49 · see citing works
Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury
Zhao, H., Tuohy, M. C., Chow, D. S., Kozberg, M. G., Kim, S. H., Shaik, M. A., & Hillman, E. M. C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109794 · Cited by 47 · see citing works
Self-citationRelating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States
Turner, K. L., Gheres, K. W., & Drew, P. J. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1244-22.2022 · Cited by 41 · see citing works
Zhong, X., Liang, Y., Wang, X., Lan, H., Bai, X., Jin, L., & Guan, B. (2024) · Light Science & Applications · doi:10.1038/s41377-023-01348-3 · Cited by 47 · see citing works
Urban, A., Golgher, L., Brunner, C., Gdalyahu, A., Har-Gil, H., Kain, D., Montaldo, G., Sironi, L., & Blinder, P. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.018 · Cited by 45 · see citing works
Buchanan, E. K., Kinsella, I., Zhou, D. X., Zhu, R., Zhou, P., Gerhard, F., Ferrante, J., Ma, Y., Kim, S. H., Shaik, M., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/334706 · Cited by 47 · see citing works
Self-citationLong-wavelength traveling waves of vasomotion modulate the perfusion of cortex
Broggini, T., Duckworth, J. C., Ji, X., Liu, R., Xia, X., Mächler, P., Shaked, I., Munting, L. P., Iyengar, S., Kotlikoff, M. I., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.034 · Cited by 44 · see citing works
Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice
Chung, D. Y., Sugimoto, K., Fischer, P., Böhm, M., Takizawa, T., Sadeghian, H., Morais, A., Harriott, A. M., Oka, F., Qin, T., et al. (2018) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.09.001 · Cited by 44 · see citing works
Separability of calcium slow waves and functional connectivity during wake, sleep, and anesthesia
Brier, L. M., Landsness, E. C., Snyder, A. Z., Wright, P. W., Baxter, G. A., Bauer, A. Q., Lee, J., & Culver, J. P. (2019) · Neurophotonics · doi:10.1117/1.nph.6.3.035002 · Cited by 45 · see citing works
Bethge, P., Carta, S., Lorenzo, D. A., Egolf, L., Goniotaki, D., Madisen, L., Voigt, F. F., Chen, J. L., Schneider, B. L., Ohkura, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179460 · Cited by 42 · see citing works
Lu, X., Wang, Y., Liu, Z., Gou, Y., Jaeger, D., & St-Pierre, F. (2023) · Nature Communications · doi:10.1038/s41467-023-41975-3 · Cited by 41 · see citing works
Krolak, T., Kaplan, L., Navas, K., Chen, L., Birmingham, A., Ryvkin, D., Izsa, V., Powell, M., Wu, Z., Deverman, B. E., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.030 · Cited by 43 · see citing works
Kura, S., Xie, H., Fu, B., Ayata, C., Boas, D. A., & Sakadžić, S. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaafe4 · Cited by 38 · see citing works
Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain‐Wide Sensory Responses
Chen, Z., Zhou, Q., Deán‐Ben, X. L., Gezginer, I., Ni, R., Reiss, M., Shoham, S., & Razansky, D. (2022) · Advanced Science · doi:10.1002/advs.202105588 · Cited by 37 · see citing works
A human-specific enhancer fine-tunes radial glia potency and corticogenesis
Liu, J., Mosti, F., Zhao, H., Lollis, D., Sotelo-Fonseca, J. E., Escobar-Tomlienovich, C. F., Musso, C. M., Mao, Y., Massri, A. J., Doll, H. M., et al. (2025) · Nature · doi:10.1038/s41586-025-09002-1 · Cited by 37 · see citing works
Self-citationAntipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers
Heindorf, M., & Keller, G. B. (2023) · eLife · doi:10.1101/2022.01.31.478462 · Cited by 63 · see citing works
He, Y., Shi, J., Maslov, K., Cao, R., & Wang, L. V. (2020) · Journal of Biomedical Optics · doi:10.1117/1.jbo.25.6.066501 · Cited by 36 · see citing works
Chung, D. Y., Oka, F., Jin, G., Harriott, A. M., Kura, S., Aykan, S. A., Qin, T., Edmiston, W. J., Lee, H., Yaseen, M. A., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20940152 · Cited by 36 · see citing works
Babij, R., Ferrer, C., Donatelle, A., Wacks, S., Buch, A. M., Niemeyer, J. E., Ma, H., Duan, Z. R. S., Fetcho, R. N., Che, A., et al. (2023) · Neuron · doi:10.1016/j.neuron.2022.10.037 · Cited by 35 · see citing works
Zhang, X., Landsness, E. C., Chen, W., Miao, H., Tang, M., Brier, L. M., Culver, J. P., Lee, J., & Anastasio, M. A. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109421 · Cited by 36 · see citing works
Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks
Mohan, H., An, X., Xu, X. H., Kondo, H., Zhao, S., Matho, K. S., Wang, B., Musall, S., Mitra, P. P., & Huang, Z. J. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01244-w · Cited by 37 · see citing works
Spatiotemporal patterns of spontaneous brain activity: a mini-review
Meyer-Baese, L., Watters, H. N., & Keilholz, S. D. (2022) · Neurophotonics · doi:10.1117/1.nph.9.3.032209 · Cited by 34 · see citing works
Wide-field calcium imaging of cortex-wide activity in awake, head-fixed mice
Ren, C., & Komiyama, T. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100973 · Cited by 33 · see citing works
Любашина, О. А., Mamontov, O. V., Volynsky, M. A., Zaytsev, V. V., & Kamshilin, A. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01235 · Cited by 31 · see citing works
Decoding cortical brain states from widefield calcium imaging data using visibility graph
Zhu, L., Lee, C. R., Margolis, D. J., & Najafizadeh, L. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.003017 · Cited by 32 · see citing works
Jones-Tabah, J., Mohammad, H., Hadj-Youssef, S., Kim, L., Martin, R., Benaliouad, F., Tanny, J. C., Clarke, P. B. S., & Hébert, T. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-71121-8 · Cited by 30 · see citing works
Шумкова, В. В., Sitdikova, V., Rechapov, I., Leukhin, A., & Minlebaev, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-88461-8 · Cited by 30 · see citing works
Nakajima, R., & Baker, B. J. (2018) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/aae2e3 · Cited by 29 · see citing works
Matsui, T., & Yamashita, K.-I. (2022) · Brain Connectivity · doi:10.1089/brain.2022.0044 · Cited by 27 · see citing works
Swanson, R. A., Chinigò, E., Levenstein, D., Vöröslakos, M., Mousavi, N., Wang, X., Basu, J., & Buzsáki, G. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.019 · Cited by 29 · see citing works
Distributed and Localized Dynamics Emerge in the Mouse Neocortex during Reach-to-Grasp Behavior
Quarta, E., Scaglione, A., Lucchesi, J., Sacconi, L., Mascaro, A. L. A., & Pavone, F. S. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0762-20.2021 · Cited by 27 · see citing works
Song, X., Guo, Y., Li, H., Chen, C., Lee, J. H., Zhang, Y., Schmidt, Z., & Wang, X. (2022) · Nature Communications · doi:10.1038/s41467-022-29864-7 · Cited by 26 · see citing works
Padawer-Curry, J. A., Krentzman, O. J., Kuo, C., Wang, X., Bice, A. R., Nicol, G. E., Snyder, A. Z., Siegel, J. S., McCall, J. G., & Bauer, A. Q. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02069-z · Cited by 28 · see citing works
Munting, L. P., Bonnar, O., Kozberg, M. G., Auger, C. A., Hirschler, L., Hou, S. S., Greenberg, S. M., Bacskai, B. J., & van Veluw, S. J. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231152550 · Cited by 28 · see citing works
Self-citationDCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans
da Silva, R. V., Johannssen, H. C., Wyss, M. T., Roome, R. B., Bourojeni, F. B., Stifani, N., Marsh, A. P. L., Ryan, M. M., Lockhart, P. J., Leventer, R. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.004 · Cited by 26 · see citing works
Rehani, R., Atamna, Y., Tiroshi, L., Chiu, W., Buendia, J. D. J. A., Martins, G. J., Jacobson, G. A., & Goldberg, J. A. (2019) · eNeuro · doi:10.1523/eneuro.0351-18.2018 · Cited by 25 · see citing works
Computing hemodynamic response functions from concurrent spectral fiber-photometry and fMRI data
Chao, T.-H. H., Zhang, W., Hsu, L.-M., Cerri, D. H., Wang, T.-W. W., & Shih, Y.-Y. I. (2022) · Neurophotonics · doi:10.1117/1.nph.9.3.032205 · Cited by 21 · see citing works
Chen, W., Park, K., Pan, Y., Koretsky, A. P., & Du, C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116554 · Cited by 23 · see citing works
De-scattering with Excitation Patterning enables rapid wide-field imaging through scattering media
Zheng, C., Park, J. K., Yıldırım, M., Boivin, J. R., Xue, Y., Sur, M., So, P. T. C., & Wadduwage, D. N. (2021) · Science Advances · doi:10.1126/sciadv.aay5496 · Cited by 23 · see citing works
Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells
Zhou, Q., Glück, C., Tang, L., Glandorf, L., Droux, J., Amki, M. E., Wegener, S., Weber, B., Razansky, D., & Chen, Z. (2024) · Nature Communications · doi:10.1038/s41467-024-47892-3 · Cited by 22 · see citing works
Giannoni, L., Lange, F., Sajic, M., Smith, K. J., & Tachtsidis, I. (2021) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2021.3053634 · Cited by 22 · see citing works
Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope
Wu, J., Chen, Y., Veeraraghavan, A., Seidemann, E., & Robinson, J. T. (2024) · Nature Communications · doi:10.1038/s41467-024-45417-6 · Cited by 22 · see citing works
Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome
Sugimoto, K., Yang, J. C., Fischer, P., Takizawa, T., Mulder, I. A., Qin, T., Erdogan, T. D., Yaseen, M. A., Sakadžić, S., Chung, D. Y., et al. (2023) · Stroke · doi:10.1161/strokeaha.122.041351 · Cited by 21 · see citing works
Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks
Hady, A. E., Takahashi, D. Y., Sun, R., Akinwale, O., Boyd-Meredith, T., Zhang, Y. S., Charles, A. S., & Brody, C. D. (2023) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2023.110033 · Cited by 20 · see citing works
Mesoscale brain explorer, a flexible python-based image analysis and visualization tool
Haupt, D., Vanni, M. P., Bolaños, F., Mitelut, C., LeDue, J. M., & Murphy, T. H. (2017) · Neurophotonics · doi:10.1117/1.nph.4.3.031210 · Cited by 21 · see citing works
- Authors
- Ma, Y., Shaik, M. A., Kim, S. H., Kozberg, M. G., Thibodeaux, D. N., Zhao, H. T., Yu, H., & Hillman, E. M. C.
- Affiliations
- Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
- Corresponding author
- Hillman, Elizabeth M. C.
- ORCID
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2016-10-05
- Volume
- 371
- Issue
- 1705
- Pages
- 20150360
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC5003860
- OpenAlex
- W2513047215
- Cited by
- 335
- References
- 85
- Citations by year
- 2026: 24 · 2025: 54 · 2024: 52 · 2023: 47 · 2022: 40 · 2021: 31 · 2020: 24 · 2019: 21 · 2018: 24 · 2017: 15 · 2016: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Update notices
- correction (2017-02-19)
- Open access
- hybrid
- doi.org
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0954796)
- U.S. Department of Defense (MURI W911NF-12-1-0594)
- National Institute of Neurological Disorders and Stroke (1R01NS063226, 5U01NS094296, 1R21NS053684, 1R01NS076628)
- National Eye Institute (1R01EY019500)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neuronal activity imaging, neurovascular coupling, genetically encoded fluorescent indicators, wide-field fluorescence imaging, spectroscopic analysis, cortical imaging, BOLD signal
- MeSH terms
- Animals, Brain, Brain Mapping, Hemodynamics, Humans, Neurons, Mice, Rats, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
