Sensory inputs control the integration of neurogliaform interneurons into cortical circuits
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Neuronal microcircuits in the superficial layers of the mammalian cortex provide the substrate for associative cortical computation. Inhibitory interneurons constitute an essential component of the circuitry and are fundamental to the integration of local and long-range information. Here we report that, during early development, superficially positioned Reelin-expressing neurogliaform interneurons in the mouse somatosensory cortex receive afferent innervation from both cortical and thalamic excitatory sources. Attenuation of ascending sensory, but not intracortical, excitation leads to axo-dendritic morphological defects in these interneurons. Moreover, abrogation of the NMDA receptors through which the thalamic inputs signal results in a similar phenotype, as well as in the selective loss of thalamic and a concomitant increase in intracortical connectivity. These results suggest that thalamic inputs are critical in determining the balance between local and long-range connectivity and are fundamental to the proper integration of Reelin-expressing interneurons into nascent cortical circuits.
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Functional maturation of some interneuron types, such as neurogliaform cells, is particularly dependent on excitatory inputs from the thalamus.
“Interestingly, the functional maturation of some types of cortical interneurons such as neurogliaform cells seems to be particularly dependent on excitatory inputs from the thalamus (De Marco García et al., 2015).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as De Marco García et al., 2015
Elimination of GluN1 and GluN2B, but not GluN2A, in cortical CGE derived interneurons produces cell type specific (reelin-positive, but not VIP-containing cells) stunting of dendritic and axonal morphology.
“Elimination of GluN1 and GluN2B, but not GluN2A, in cortical CGE derived interneurons produces cell type specific (reelin-positive, but not VIP-containing cells) stunting of dendritic and axonal morphology (261).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [261]
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- Authors
- De Marco García, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Fishell, Gord
- Venue
- Nature Neuroscience
- Published
- 2015-02-09
- Volume
- 18
- Issue
- 3
- Pages
- 393-401
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4624196
- OpenAlex
- W2128346152
- Cited by
- 117
- References
- 45
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 11 · 2019: 13 · 2018: 15 · 2017: 15 · 2016: 6 · 2015: 6
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institute of Mental Health (R00MH095825, K99MH095825, R01MH071679, R37MH071679)
- National Institute of Neurological Disorders and Stroke (P01NS074972, R01NS032993, R01NS039007)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- thalamic afferents, NMDA receptor, NR2B, reelin, somatosensory barrel cortex, cortical circuit development, intracortical connectivity, inhibitory interneurons, sensory input
- MeSH terms
- Reelin Protein, Empty Spiracles Homeobox Proteins, Afferent Pathways, Animals, Bicuculline, Cerebral Cortex, Female, Interneurons, Mice, Transgenic, Nerve Net, Pregnancy, Transcription Factors, Vibrissae, Receptors, N-Methyl-D-Aspartate, Electroporation, Homeodomain Proteins, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Excitatory Postsynaptic Potentials, RNA, Untranslated, Receptors, Serotonin, 5-HT3, Vesicular Glutamate Transport Protein 2, Mice, In Vitro Techniques
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