Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress
Abstract
Chronic stress occurs in everyday life and induces impaired spatial cognition, neuroendocrine and plasticity abnormalities. A potential therapeutic for these stress related disturbances is curcumin, derived from the curry spice turmeric. Previously we demonstrated that curcumin reversed the chronic stress-induced behavioral deficits in escape from an aversive stimulus, however the mechanism behind its beneficial effects on stress-induced learning defects and associated pathologies are unknown. This study investigated the effects of curcumin on restraint stress-induced spatial learning and memory dysfunction in a water maze task and on measures related neuroendocrine and plasticity changes. The results showed that memory deficits were reversed with curcumin in a dose dependent manner, as were stress-induced increases in serum corticosterone levels. These effects were similar to positive antidepressant imipramine. Additionally, curcumin prevented adverse changes in the dendritic morphology of CA3 pyramidal neurons in the hippocampus, as assessed by the changes in branch points and dendritic length. In primary hippocampal neurons it was shown that curcumin or imipramine protected hippocampal neurons against corticosterone-induced toxicity. Furthermore, the portion of calcium/calmodulin kinase II (CaMKII) that is activated (phosphorylated CaMKII, pCaMKII), and the glutamate receptor sub-type (NMDA(2B)) expressions were increased in the presence of corticosterone. These effects were also blocked by curcumin or imipramine treatment. Thus, curcumin may be an effective therapeutic for learning and memory disturbances as was seen within these stress models, and its neuroprotective effect was mediated in part by normalizing the corticosterone response, resulting in down-regulating of the pCaMKII and glutamate receptor levels.
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Curcumin exerts its neuroprotective effect by normalizing the corticosterone response, resulting in downregulating of calcium/calmodulin kinase II and glutamate receptor (NMDA-2B) levels.
“Curcumin exerts its neuroprotective effect by normalizing the corticosterone response, resulting in downregulating of calcium/calmodulin kinase II and glutamate receptor (NMDA-2B) levels [131].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [131]
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- Authors
- Xu, Y., Lin, D., Li, S., Li, G., Shyamala, S. G., Barish, P. A., Vernon, M. M., Pan, J., & Ogle, W. O.
- Affiliations
- University of Florida (US)
- Wenzhou Medical University (CN)
- Corresponding author
- Pan, Jianchun
- Ogle, William O.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 57
- Issue
- 4
- Pages
- 463-471
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2020788145
- Cited by
- 119
- References
- 41
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 10 · 2013: 5 · 2012: 15
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ellison Medical Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
- Keywords
- curcumin, chronic restraint stress, spatial learning and memory, corticosterone, hippocampal CA3 pyramidal neurons, dendritic morphology, CaMKII phosphorylation, NMDA receptor subunit 2B, imipramine, neuroprotection, neuroendocrine stress response
- MeSH terms
- Animals, Antidepressive Agents, Tricyclic, Cells, Cultured, Cognition Disorders, Corticosterone, Curcumin, Hippocampus, Imipramine, Learning Disabilities, Male, Memory Disorders, Neuronal Plasticity, Random Allocation, Space Perception, Stress, Psychological, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Pyramidal Cells, Neuroprotective Agents, Maze Learning, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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