The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety
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Although it has been long believed that new neurons were only generated during development, there is now growing evidence indicating that at least two regions in the brain are capable of continuously generating functional neurons: the subventricular zone and the dentate gyrus of the hippocampus. Adult hippocampal neurogenesis (AHN) is a widely observed phenomenon verified in different adult mammalian species including humans. Factors such as environmental enrichment, voluntary exercise, and diet have been linked to increased levels of AHN. Conversely, aging, stress, anxiety and depression have been suggested to hinder it. However, the mechanisms underlying these effects are still unclear and yet to be determined. In this paper, we discuss some recent findings addressing the effects of different dietary polyphenols on hippocampal cell proliferation and differentiation, models of anxiety, and depression as well as some proposed molecular mechanisms underlying those effects with particular focus on those related to AHN. As a whole, dietary polyphenols seem to exert positive effects on anxiety and depression, possibly in part via regulation of AHN. Studies on the effects of dietary polyphenols on behaviour and AHN may play an important role in the approach to use diet as part of the therapeutic interventions for mental-health-related conditions.
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Diet and depression: Exploring the biological mechanisms of action
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- Authors
- Dias, G. P., Cavegn, N., Nix, A., do Nascimento Bevilaqua, M. C., Stangl, D., Zainuddin, M. S. A., Nardi, A. E., Gardino, P. F., & Thuret, S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- King's College London (GB)
- Program of Neurobiology, Laboratory of Neurobiology of the Retina, Institute of Biophysics, Universidade Federal do Rio de Janeiro (UFRJ), Bloco C, sala 31, Avenida Carlos Chagas Filho 373, 21941-902 Rio de Janeiro, RJ, Brazil
- Laboratory of Panic & Respiration, Institute of Psychiatry, Universidade Federal do Rio de Janeiro (UFRJ), Avenida Venceslau Brás, 71 Fundos, 22290-140 Rio de Janeiro, RJ, Brazil
- Corresponding author
- Thuret, Sandrine
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-18
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC3395274
- OpenAlex
- W2136529079
- Cited by
- 153
- References
- 126
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 9 · 2020: 16 · 2019: 10 · 2018: 18 · 2017: 3 · 2016: 18 · 2015: 12 · 2014: 12 · 2013: 6 · 2012: 2
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Greenwich Academic Literature Archive (University of Greenwich) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Psychiatry Research Trust
- Research Councils UK
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- dietary polyphenols, adult hippocampal neurogenesis, depression, anxiety, hippocampal cell proliferation, neuronal differentiation, anxiety models, depression model, mental health, molecular mechanisms
- MeSH terms
- Aging, Animals, Anxiety, Behavior, Depression, Diet, Hippocampus, Humans, Neurogenesis, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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