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Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Abstract
Central oxytocin (OXT) has been shown to promote numerous social behaviours, to attenuate hormonal stress responsiveness of the HPA axis and to decrease anxiety. Wistar rats selectively bred for high (HAB) and low (LAB) anxiety-related behaviour, respectively, have been shown to represent a suitable animal model to study the underlying aetiology of psychopathologies like anxiety- and depression-related disorders. The goal of the present studies was to assess the effects of central OXT on anxiety- and depression-related behaviour in male and female HAB and LAB rats. Acute icv OXT (1 microg) or OXT receptor antagonist (OXT-A; 0.75 microg) administration did not affect anxiety-related behaviour in male or female HAB and LAB rats as assessed in the light-dark box. In contrast, chronic icv OXT infusion (10 ng/h; 6 d) attenuated the high level of anxiety-related behaviour in female, but not male, HAB rats, whereas chronic OXT-A infusion (7.5 ng/h; 6 d) increased anxiety-related behaviour in female, but not male, LAB rats. Neither acute nor chronic manipulation of the OXT system altered depression-related behaviour as assessed by the forced swim test. Combined, these results suggest that pharmacological manipulation of the brain OXT system is effective to attenuate extremes in trait anxiety in an animal model of psychopathological anxiety. Moreover, the data indicate that differences in the activity of the brain OXT systems between HAB and LAB rats may, at least partially, contribute to the opposing anxiety but not depression-related behaviour.
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“Moreover, the administration of oxytocin exerts an antidepressant-like effect in rodents [374-377]”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [376]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Self-citationDitzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 805 · cited 2×
“, 2003) and to mediate the positive and buffering effects of social support (Ditzen et al., 2009).”
Animal models of anxiety: an ethological perspective
Rodgers, R. J., Cao, B.-J., Dalvi, A., & Holmes, A. (1997) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1997000300002 · Cited by 642
Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., & Nishimori, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5593-08.2009 · Cited by 608
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439
Self-citationWindle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402
Self-citationNeumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387
Self-citationHeinrichs, M., Meinlschmidt, G., Neumann, I., Wagner, S., Kirschbaum, C., Ehlert, U., & Hellhammer, D. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7919 · Cited by 386
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
Tomizawa, K., Iga, N., Lü, Y.-F., Moriwaki, A., Matsushita, M., Li, S., Miyamoto, O., Itano, T., & Matsui, H. (2003) · Nature Neuroscience · doi:10.1038/nn1023 · Cited by 372
Neumann, I., Russell, J. A., & Landgraf, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90285-n · Cited by 337
Self-citationAnxiety and stress responses in female oxytocin deficient mice
Amico, J. A., Mantella, R. C., Vollmer, R. R., & Li, X. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01161.x · Cited by 327
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319
No stress please! Mechanisms of stress hyporesponsiveness of the maternal brain
Slattery, D. A., & Neumann, I. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.145896 · Cited by 293
Self-citationBrain vasopressin is an important regulator of maternal behavior independent of dams’ trait anxiety
Bosch, O. J., & Neumann, I. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807412105 · Cited by 280
Self-citationHigh vs Low Anxiety-Related Behavior Rats: An Animal Model of Extremes in Trait Anxiety
Landgraf, R., & Wigger, A. (2002) · Behavior Genetics · doi:10.1023/a:1020258104318 · Cited by 277
A conditional knockout mouse line of the oxytocin receptor
Lee, H.-J., Caldwell, H. K., Macbeth, A. H., Tolu, S. G., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1710 · Cited by 269
Wigger, A., Sánchez, M. M., Mathys, K. C., Ebner, K., Frank, E., Liu, D., Kresse, A. E., Neumann, I. D., Holsboer, F., Plotsky, P. M., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300290 · Cited by 263
Self-citationCentrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261
Self-citationBlume, A., Bosch, O. J., Miklos, S., Torner, L., Wales, L., Waldherr, M., & Neumann, I. D. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06184.x · Cited by 255
Self-citationInbred Roman High- and Low-Avoidance Rats
Escorihuela, R. M., Fernández‐Teruel, A., Gil, L., Aguilar, R., Tobeña, A., & Driscoll, P. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00064-5 · Cited by 217
Ebner, K., Bosch, O. J., Krömer, S. A., Singewald, N., & Neumann, I. D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300607 · Cited by 205
Self-citationOxytocin acts as an antidepressant in two animal models of depression
Arletti, R., & Bertolini, A. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90600-x · Cited by 203
Landgraf, R., Kessler, M. S., Bunck, M., Murgatroyd, C., Spengler, D., Zimbelmann, M., Nußbaumer, M., Czibere, L., Turck, C. W., Singewald, N., et al. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.003 · Cited by 201
Female oxytocin-deficient mice display enhanced anxiety-related behavior
Mantella, R. C., Vollmer, R. R., Li, X., & Amico, J. A. (2003) · Endocrinology · doi:10.1210/en.2002-0197 · Cited by 200
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170
Keck, M. E., Welt, T., Müller, M. B., Uhr, M., Ohl, F., Wigger, A., Toschi, N., Holsboer, F., & Landgraf, R. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300040 · Cited by 169
Keck, M. E. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00351-7 · Cited by 169
GABAB Receptor Antagonist-Mediated Antidepressant-Like Behavior Is Serotonin-Dependent
Slattery, D. A., Desrayaud, S., & Cryan, J. F. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.073536 · Cited by 132
Self-citationOxytocin as a natural antipsychotic: a study using oxytocin knockout mice
Caldwell, H. K., Stephens, S. L., & Young, W. S. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002150 · Cited by 108
Nomura, M., Saito, J., Ueta, Y., Muglia, L. J., Pfaff, D. W., & Ogawa, S. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01095.x · Cited by 69
Chapter 4 Oxytocin: who needs it?
Insel, T. R., Gingrich, B., & Young, L. J. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33005-4 · Cited by 62
Oxytocin knockout mice: a model for studying stress-related and ingestive behaviours
Amico, J. A., Miedlar, J. A., CAI, H., & Vollmer, R. R. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00405-6 · Cited by 41
Keck, M. E., Welt, T., Müller, M. B., Landgraf, R., & Holsboer, F. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-38092 · Cited by 40
Oxytocin neuron activation in NCAM‐deficient mice: anatomical and functional consequences
Theodosis, D. T., Schachner, M., & Neumann, I. D. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03779.x · Cited by 38
Self-citationBosch, O. J., Waldherr, M., Nair, H. P., Young, L. J., & Neumann, I. D. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.03.324 · Cited by 6
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Metadata
- Authors
- Slattery, D. A., & Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Neumann, I.D.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 58
- Issue
- 1
- Pages
- 56-61
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W1998893802
- Cited by
- 195
- References
- 43
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 17 · 2015: 23 · 2014: 19 · 2013: 26 · 2012: 15
- FWCI
- 19.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- intracerebroventricular infusion, anxiety-like behavior, oxytocin receptor antagonist, sex differences, animal models of anxiety, Wistar rats
- MeSH terms
- Analysis of Variance, Animals, Anti-Arrhythmia Agents, Anxiety, Behavior, Animal, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Injections, Intraventricular, Male, Oxytocin, Sex Factors, Swimming, Drug Delivery Systems, Rats, Wistar, Maze Learning, Rats
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