Cited by 195Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 41 of the 43 references it cites were found in a registry or an index.

Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats

Slattery, D.A., Neumann, I.D.·2010·Neuropharmacology

DOI 10.1016/j.neuropharm.2009.06.038

Open this paper in CoChat — free account

Abstract

Central oxytocin (OXT) has been shown to promote numerous social behaviours, to attenuate hormonal stress responsiveness of the HPA axis and to decrease anxiety. Wistar rats selectively bred for high (HAB) and low (LAB) anxiety-related behaviour, respectively, have been shown to represent a suitable animal model to study the underlying aetiology of psychopathologies like anxiety- and depression-related disorders. The goal of the present studies was to assess the effects of central OXT on anxiety- and depression-related behaviour in male and female HAB and LAB rats. Acute icv OXT (1 microg) or OXT receptor antagonist (OXT-A; 0.75 microg) administration did not affect anxiety-related behaviour in male or female HAB and LAB rats as assessed in the light-dark box. In contrast, chronic icv OXT infusion (10 ng/h; 6 d) attenuated the high level of anxiety-related behaviour in female, but not male, HAB rats, whereas chronic OXT-A infusion (7.5 ng/h; 6 d) increased anxiety-related behaviour in female, but not male, LAB rats. Neither acute nor chronic manipulation of the OXT system altered depression-related behaviour as assessed by the forced swim test. Combined, these results suggest that pharmacological manipulation of the brain OXT system is effective to attenuate extremes in trait anxiety in an animal model of psychopathological anxiety. Moreover, the data indicate that differences in the activity of the brain OXT systems between HAB and LAB rats may, at least partially, contribute to the opposing anxiety but not depression-related behaviour.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2009.06.038

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Self-citation
Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict
Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 805 · cited 2×
“, 2003) and to mediate the positive and buffering effects of social support (Ditzen et al., 2009).”
Animal models of anxiety: an ethological perspective
Rodgers, R. J., Cao, B.-J., Dalvi, A., & Holmes, A. (1997) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1997000300002 · Cited by 642
Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice
Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., & Nishimori, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5593-08.2009 · Cited by 608
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439
Self-citation

Show all 43 references

Sorted by citations

The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Self-citation
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
Self-citation
The Social Salience Hypothesis of Oxytocin
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.020 · Cited by 904
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573
Postpartum depression: Etiology, treatment and consequences for maternal care
Brummelte, S., & Galea, L. A. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.008 · Cited by 567
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511
Self-citation
Maternal and paternal plasma, salivary, and urinary oxytocin and parent–infant synchrony: considering stress and affiliation components of human bonding
Feldman, R., Gordon, I., & Zagoory‐Sharon, O. (2011) · Developmental Science · doi:10.1111/j.1467-7687.2010.01021.x · Cited by 486
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
Self-citation
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423
The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403
Self-citation
Sex differences in anxiety and emotional behavior
Donner, N. C., & Lowry, C. A. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1271-7 · Cited by 379
Role of neuropeptides in anxiety, stress, and depression: From animals to humans
Kormos, V., & Gaszner, B. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.014 · Cited by 333
Breaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268
REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
Viéro, C., Shibuya, I., Kitamura, N., Verkhratsky, A., Fujihara, H., Katoh, A., Ueta, Y., Zingg, H. H., Chvátal, A., Syková, E., et al. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00185.x · Cited by 259
Aggression and anxiety: social context and neurobiological links
Neumann, I. D. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00012 · Cited by 252
Self-citation
Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety
Lovick, T. A., & Zangrossi, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.711065 · Cited by 234
Behavioral effects of neuropeptides in rodent models of depression and anxiety
Rotzinger, S., Lovejoy, D. A., & Tan, L. A. (2010) · Peptides · doi:10.1016/j.peptides.2009.12.015 · Cited by 211
Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children
Carson, D. S., Berquist, S. W., Trujillo, T. H., Garner, J. P., Hannah, S. L., Hyde, S. A., Sumiyoshi, R. D., Jackson, L. P., Moss, J. K., Strehlow, M. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.132 · Cited by 196
Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence
Bosch, O. J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0085 · Cited by 194
Brain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
Zoicas, I., Slattery, D. A., & Neumann, I. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.156 · Cited by 189
Self-citation
Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice
Peters, S., Slattery, D. A., Uschold‐Schmidt, N., Reber, S. O., & Neumann, I. D. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.021 · Cited by 189
Self-citation
Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
Kalkman, H. O., & Feuerbach, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2175-4 · Cited by 191
Making room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 175
Animal models of depression and anxiety: What do they tell us about human condition?
Neumann, I. D., Wegener, G., Homberg, J. R., Cohen, H., Slattery, D. A., Zohar, J., Olivier, J. D. A., & Mathé, A. A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.028 · Cited by 164
Self-citation
Roles of Oxytocin in Stress Responses, Allostasis and Resilience
Takayanagi, Y., & Onaka, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010150 · Cited by 173
Maternal nurturing is dependent on her innate anxiety: The behavioral roles of brain oxytocin and vasopressin
Bosch, O. J. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.11.012 · Cited by 163
Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149
Forced swim test: What about females?
Kokras, N., Antoniou, K., Mikail, H. G., Kafetzopoulos, V., Papadopoulou‐Daifoti, Z., & Dalla, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.016 · Cited by 149
Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143
Oxytocin and psychotherapy: a pilot study of its physiological, behavioral and subjective effects in males with depression
MacDonald, K., MacDonald, T. M., Brüne, M., Lamb, K., Wilson, M. P., Golshan, S., & Feifel, D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.014 · Cited by 140
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor
Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128
Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment
Wong, R. Y., Oxendine, S. E., & Godwin, J. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-348 · Cited by 132
Oxytocin Regulates Stress-InducedCrfGene Transcription through CREB-Regulated Transcription Coactivator 3
Jurek, B., Slattery, D. A., Hiraoka, Y., Liu, Y., Nishimori, K., Aguilera, G., Neumann, I. D., & van den Burg, E. H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1345-14.2015 · Cited by 124
Self-citation
Oxytocin and Estrogen Receptor β in the Brain: An Overview
Acevedo-Rodriguez, A., Mani, S. K., & Handa, R. J. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00160 · Cited by 124
Exposure to Chronic Pregnancy Stress Reverses Peripartum-Associated Adaptations: Implications for Postpartum Anxiety and Mood Disorders
Hillerer, K. M., Reber, S. O., Neumann, I. D., & Slattery, D. A. (2011) · Endocrinology · doi:10.1210/en.2011-1091 · Cited by 122
Self-citation
Oxytocin and postpartum depression: Delivering on what's known and what's not
Kim, S., Soeken, T. A., CROMER, S. J., Martinez, S. R., Hardy, L. R., & Strathearn, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.11.009 · Cited by 121
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108
Oxytocin and same-sex social behavior in female meadow voles
Beery, A. K., & Zucker, I. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.023 · Cited by 108
Oxytocin in the prelimbic medial prefrontal cortex reduces anxiety-like behavior in female and male rats
Sabihi, S., Durosko, N. E., Dong, S. M., & Leuner, B. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.009 · Cited by 106
The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention
Holt-Lunstad, J., Birmingham, W., & Light, K. C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.007 · Cited by 103
Long-term effects of early life stress exposure: Role of epigenetic mechanisms
Silberman, D. M., Acosta, G. B., & Zubilete, M. A. Z. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.033 · Cited by 114
Early life stress modulates oxytocin effects on limbic system during acute psychosocial stress
Grimm, S., Pestke, K., Feeser, M., Aust, S., Weigand, A., Wang, J., Wingenfeld, K., Pruessner, J. C., Marca, R. L., Böker, H., et al. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu020 · Cited by 106
Oxytocin inhibits ethanol consumption and ethanol‐induced dopamine release in the nucleus accumbens
Peters, S., Bowen, M. T., Bohrer, K., McGregor, I. S., & Neumann, I. D. (2016) · Addiction Biology · doi:10.1111/adb.12362 · Cited by 101
Self-citation
Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat
Mak, P., Broussard, C., Vacy, K., & Broadbear, J. H. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111416687 · Cited by 95
Oxytocin and Major Depressive Disorder: Experimental and Clinical Evidence for Links to Aetiology and Possible Treatment
Slattery, D. A., & Neumann, I. D. (2010) · Pharmaceuticals · doi:10.3390/ph3030702 · Cited by 94
Self-citation
Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala
Han, R. T., Kim, Y., Park, E. H., Kim, J. Y., Ryu, C., Kim, H. Y., Lee, J., Pahk, K., Cui, S., Kim, H., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00246 · Cited by 92
Social interaction prevents the development of depressive-like behavior post nerve injury in mice: a potential role for oxytocin
Norman, G. J., Karelina, K., Morris, J. S., Zhang, N., Cochran, M., & Courtney DeVries, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181de8678 · Cited by 88
Oxytocinergic manipulations in corticolimbic circuit differentially affect fear acquisition and extinction
Lahoud, N., & Maroun, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.006 · Cited by 87
Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm: Peripheral vs Central Administration
Ayers, L. W., Missig, G., Schulkin, J. A., & Rosen, J. B. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.138 · Cited by 87
Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals
Frijling, J. L. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1302652 · Cited by 94
Emotion and Mood Adaptations in the Peripartum Female: Complementary Contributions of GABA and Oxytocin
Lonstein, J. S., Maguire, J. L., Meinlschmidt, G., & Neumann, I. D. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12188 · Cited by 89
Self-citation
Social stress buffering by friends in childhood and adolescence: Effects on HPA and oxytocin activity
Doom, J. R., Doyle, C., & Gunnar, M. R. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1149095 · Cited by 92
Oxytocin in the medial prefrontal cortex attenuates anxiety: Anatomical and receptor specificity and mechanism of action
Sabihi, S., Dong, S. M., Maurer, S., Goodpaster, C. M., & Leuner, B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.024 · Cited by 87
Differential Contribution of Hypothalamic MAPK Activity to Anxiety-Like Behaviour in Virgin and Lactating Rats
Jurek, B., Slattery, D. A., Maloumby, R., Hillerer, K. M., Koszinowski, S., Neumann, I. D., & van den Burg, E. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037060 · Cited by 83
Self-citation
Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat
Slattery, D. A., Neumann, I. D., & Cryan, J. F. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110368873 · Cited by 77
Self-citation
Oxytocin-augmented labor and risk for autism in males
Weisman, O., Agerbo, E., Carter, C. S., Harris, J. C., Uldbjerg, N., Henriksen, T. B., Thygesen, M., Mortensen, P. B., Leckman, J. F., & Dalsgaard, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.028 · Cited by 78
Peripheral oxytocin administration buffers autonomic but not behavioral responses to environmental stressors in isolated prairie voles
Grippo, A. J., Pournajafi-Nazarloo, H., Sanzenbacher, L., Trahanas, D. M., McNeal, N., Clarke, D. A., Porges, S. W., & Sue Carter, C. (2012) · Stress · doi:10.3109/10253890.2011.605486 · Cited by 74
The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73
Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.018 · Cited by 71
Intracerebroventricular oxytocin administration in rats enhances object recognition and increases expression of neurotrophins, microtubule‐associated protein 2, and synapsin I
Havránek, T., Zatkova, M., Lestanova, Z., Bačová, Z., Mravec, B., Hodosy, J., Štrbák, V., & Bakoš, J. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23559 · Cited by 71
Chronic Subordinate Colony Housing Paradigm: A Mouse Model to Characterize the Consequences of Insufficient Glucocorticoid Signaling
Langgartner, D., Füchsl, A. M., Uschold‐Schmidt, N., Slattery, D. A., & Reber, S. O. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00018 · Cited by 73
Self-citation
Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior
Sánchez-Vidaña, D. I., Chan, N.-M. J., Chan, A. H. L., Hui, K. K. Y., Lee, S. Y., Chan, H.-Y., Law, Y. S., Sze, M. Y., Tsui, W.-C. S., Fung, T. K. H., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.005 · Cited by 71
Oxytocin and Rodent Models of Addiction
Leong, K.-C., Cox, S. S., King, C. E., Becker, H. C., & Reichel, C. M. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.007 · Cited by 72
The role of oxytocin in alcohol and drug abuse
King, C. E., Gano, A., & Becker, H. C. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146761 · Cited by 69
Different patterns of respiration in rat lines selectively bred for high or low anxiety.
Carnevali, L., Sgoifo, A., Trombini, M., Landgraf, R., Neumann, I. D., & Nalivaiko, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064519 · Cited by 65
Self-citation
Selectively Bred Rodents as Models of Depression and Anxiety
Wegener, G., Mathé, A. A., & Neumann, I. D. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_192 · Cited by 65
Self-citation
Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin‐3/RXFP3 system in neuropsychiatric disorders
Kumar, J. R., Rajkumar, R., Jayakody, T., Marwari, S., Hóng, J., Ma, S., Gundlach, A. L., Lai, M. K. P., & Dawe, G. S. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13564 · Cited by 63
Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 63
Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
de la Mora, M. P., Pérez-Carrera, D., Crespo-Ramírez, M., Tarakanov, A., Fuxe, K., & Borroto-Escuela, D. O. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.004 · Cited by 63
Hypoactivation of CRF Receptors, Predominantly Type 2, in the Medial-Posterior BNST Is Vital for Adequate Maternal Behavior in Lactating Rats
Klampfl, S. M., Brunton, P. J., Bayerl, D. S., & Bosch, O. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4220-13.2014 · Cited by 63
Using animal models to study post‐partum psychiatric disorders
Perani, C. V., & Slattery, D. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12640 · Cited by 62
Self-citation
Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62
Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies—potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST)
Janeček, M., & Dabrowska, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2889-8 · Cited by 63
Effects of a 10-day oxytocin trial in older adults on health and well-being
Barraza, J. A., Grewal, N. S., Ropacki, S., Perez, P., Gonzalez, A., & Zak, P. J. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0031581 · Cited by 61
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107602 · Cited by 61
Intranasal oxytocin affects amygdala functional connectivity after trauma script-driven imagery in distressed recently trauma-exposed individuals
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.278 · Cited by 60
Distinct BOLD Activation Profiles Following Central and Peripheral Oxytocin Administration in Awake Rats
Ferris, C. F., Yee, J. R., Kenkel, W. M., Dumais, K. M., Moore, K., Veenema, A. H., Kulkarni, P. P., Perkybile, A. M., & Carter, C. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00245 · Cited by 60
Selective Breeding for High Anxiety Introduces a Synonymous SNP That Increases Neuropeptide S Receptor Activity
Slattery, D. A., Naik, R. R., Grund, T., Yen, Y.-C., Sartori, S. B., Füchsl, A. M., Finger, B. C., Elfving, B., Nordemann, U., Guerrini, R., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4764-13.2015 · Cited by 56
Self-citation
Chronic Subordinate Colony Housing (CSC) as a Model of Chronic Psychosocial Stress in Male Rats
Nyuyki, K. D., Beiderbeck, D. I., Lukas, M., Neumann, I. D., & Reber, S. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052371 · Cited by 58
Self-citation
Oxytocin and Anorexia Nervosa: A Review of the Emerging Literature
Maguire, S., O’Dell, A., Touyz, L. M., & Russell, J. D. (2013) · European Eating Disorders Review · doi:10.1002/erv.2252 · Cited by 61
Long-term exercise from adolescence to adulthood reduces anxiety- and depression-like behaviors following maternal immune activation in offspring
Rahimi, S., Peeri, M., Azarbayjani, M. A., Anoosheh, L., Ghasemzadeh, E., Khalifeh, N., Noroozi-Mahyari, S., Deravi, S., Saffari-Anaraki, S., Zangeneh, F. H., et al. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113130 · Cited by 56
Anxiolytic Effects of Chronic Intranasal Oxytocin on Neural Responses to Threat Are Dose-Frequency Dependent
Kou, J., Zhang, Y., Zhou, F., Gao, Z., Yao, S., Zhao, W., Li, H., Lei, Y., Gao, S., Kendrick, K. M., et al. (2022) · Psychotherapy and Psychosomatics · doi:10.1159/000521348 · Cited by 54
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53
Oxytocin attenuates stress-induced reinstatement of alcohol seeking behavior in male and female mice
King, C. E., & Becker, H. C. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05233-z · Cited by 53
Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models
Renoir, T., Pang, T. Y., & Lanfumey, L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.003 · Cited by 56
Oxytocin Induces a Conditioned Social Preference in Female Mice
Kent, K., Arientyl, V., Khachatryan, M. M., & Wood, R. I. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12075 · Cited by 48
Chronic enhancement of brain oxytocin levels causes enduring anti-aggressive and pro-social explorative behavioral effects in male rats
Calcagnoli, F., Meyer, N., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.008 · Cited by 53
Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats
Bayerl, D. S., & Bosch, O. J. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12517 · Cited by 46
Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety
Winter, J. J., Meyer, M., Berger, I., Royer, M., Bianchi, M., Kuffner, K., Peters, S., Stang, S., Langgartner, D., Hartmann, F., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01141-x · Cited by 46
Self-citation
The two fold role of oxytocin in social developmental disorders: A cause and a remedy?
Lefèvre, A., & Sirigu, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.011 · Cited by 48
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 42
Oxytocin treatment alleviates stress-aggravated colitis by a receptor-dependent mechanism
Çetınel, Ş., Hancıoğlu, S., Şener, T. E., Üner, C., Çil, M. K., Şener, G., & Yeğen, B. Ç. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.11.011 · Cited by 42
Role of the oxytocin system in amygdala subregions in the regulation of social interest in male and female rats
Dumais, K. M., Alonso, A. G., Bredewold, R., & Veenema, A. H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.036 · Cited by 42
Oxytocin prevents the increase of cocaine-related responses produced by social defeat
Perez, C. F., Castro‐Zavala, A., Luján, M. Á., Filarowska, J., Ballestín, R., Miñarro, J., Valverde, O., & Rodríguez‐Arias, M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.011 · Cited by 40
Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
Cid-Jofré, V., Moreno, M., Reyes-Parada, M. I., & Renard, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112077 · Cited by 40
Oxytocin Affects the Connectivity of the Precuneus and the Amygdala: A Randomized, Double-Blinded, Placebo-Controlled Neuroimaging Trial
Kumar, J., Vӧllm, B., & Palaniyappan, L. K. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu051 · Cited by 40
Autism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36
Trauma, Mothering, and Intergenerational Transmission: A Synthesis of Behavioral and Oxytocin Research
Kim, S., & Strathearn, L. (2017) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2016.1277897 · Cited by 38
Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats
Ferland‐Beckham, C., Reichel, C. M., & McGinty, J. F. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4184-7 · Cited by 34

Authors: Slattery, D. A., & Neumann, I. D.
Affiliations: University of Regensburg (DE)
Corresponding author: Neumann, I.D.
ORCID: Slattery, D.A.
Neumann, I.D.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2010-01
Volume: 58
Issue: 1
Pages: 56-61
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2009.06.038
OpenAlex: W1998893802
Cited by: 195
References: 43
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 17 · 2015: 23 · 2014: 19 · 2013: 26 · 2012: 15
FWCI: 19.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
National Institutes of Health
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: intracerebroventricular infusion, anxiety-like behavior, oxytocin receptor antagonist, sex differences, animal models of anxiety, Wistar rats
MeSH terms: Analysis of Variance, Animals, Anti-Arrhythmia Agents, Anxiety, Behavior, Animal, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Injections, Intraventricular, Male, Oxytocin, Sex Factors, Swimming, Drug Delivery Systems, Rats, Wistar, Maze Learning, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks