Cited by 167Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Serotonergic regulation of neuronal excitability in the prefrontal cortex

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Andrade, Rodrigo·2011·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.01.015PMC PMC3110517

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Abstract

The cerebral cortex receives a dense serotonergic innervation originating predominantly from the dorsal raphe nucleus. This innervation regulates cortical functioning by activating multiple serotonin receptors that are differentially expressed by pyramidal cells and interneurons. Electrophysiological studies in the prefrontal cortex indicate that receptors of the 5-HT(1A) and 5-HT(2A) subtypes are the main serotonin receptors regulating membrane excitability in pyramidal cells. Most pyramidal cells in layer V coexpress 5-HT(1A) and 5-HT(2A) receptors that together regulate how these neurons encode excitatory input into neuronal firing. In contrast, a subset of large pyramidal cells of deep layer V appears to express exclusively 5-HT(2A) receptors that depolarize and excite these cells. Serotonin also depolarizes and excites at least two classes of GABAergic interneurons by acting on 5-HT(3) and 5-HT(2A) receptors. The differential expression of serotonin receptors in different pyramidal cells and interneurons is consistent with a growing appreciation of the anatomical, molecular and functional heterogeneity of pyramidal cells and interneurons of the cerebral cortex. These findings begin to lay the ground for a cellular-level understanding of the serotonergic regulation of the prefrontal cortex.

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Authors: Andrade, R.
Affiliations: Wayne State University (US)
Corresponding author: Andrade, Rodrigo
ORCID: Andrade, Rodrigo
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2011-09
Volume: 61
Issue: 3
Pages: 382-386
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.01.015
PMC: PMC3110517
OpenAlex: W1990926259
Cited by: 167
References: 48
Citations by year: 2026: 9 · 2025: 18 · 2024: 17 · 2023: 9 · 2022: 14 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 12
FWCI: 1.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Intellectum (Universidad de La Sabana) (submittedVersion, other-oa)
Funders: NIH grant (MH43987)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: serotonin, prefrontal cortex, neuronal excitability, dorsal raphe nucleus, 5-HT1A receptor, 5-HT2A receptor, 5-HT3 receptor, pyramidal neurons, GABAergic interneurons, cortical layer V, receptor heterogeneity, cortical excitability
MeSH terms: Animals, gamma-Aminobutyric Acid, Humans, Interneurons, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Receptors, Serotonin, Serotonin, Prefrontal Cortex, Pyramidal Cells, Glutamic Acid

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Serotonergic regulation of neuronal excitability in the prefrontal cortex

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