Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids
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Significance: There is a vast literature linking individual neurotransmitters with specific brain function and disorders, often with significant overlap. For instance, serotonin (5-HT), glutamate, and endocannabinoids have been linked to several biological functions, such as mood regulation, reward, and decision making, as well as to pathologies, such as depressive and anxiety disorders. It is becoming axiomatic that such neurochemical-based models need to be incorporated within comprehensive and dynamic circuit-based frameworks to apprehend fully the neural basis of these functions. Here, we defined the mesoscale-level functional organization of the medial prefrontal cortex input to the dorsal raphe nucleus and how this circuit is modulated by cannabinoid (CB) signalling. This network-based functional framework may help to explain several of the mood-regulating features of both 5-HT and CBs.
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DRN serotonergic neurons are controlled by glutamatergic projections from the PFC.
“In addition, DRN serotonergic neurons are controlled by glutamatergic projections from the PFC [152, 207–209].”
From Development of prefrontal cortex (2022) · cites this paper as [208]
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- Authors
- Geddes, S. D., Assadzada, S., Lemelin, D., Sokolovski, A., Bergeron, R., Haj-Dahmane, S., & Béïque, J.-C.
- Affiliations
- University of Ottawa (CA)
- Ottawa Hospital Research Institute (CA)
- Research Institute on Addictions, University at Buffalo, Buffalo, NY 14203;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-04-25
- Volume
- 113
- Issue
- 19
- Pages
- 5429-5434
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4868450
- OpenAlex
- W2342818658
- Cited by
- 90
- References
- 41
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 15 · 2020: 12 · 2019: 10 · 2018: 5 · 2017: 8 · 2016: 1
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada (G-15-9399)
- Gouvernement du Canada | Canadian Institutes of Health Research (MOP142420 & MOP 115061)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- dorsal raphe nucleus, medial prefrontal cortex, cannabinoid receptors, serotonergic neurons, GABAergic neurons, glutamatergic input, feedforward inhibition, excitation-inhibition balance, neuronal excitability, top-down control, mood regulation, stress processing, monosynaptic connections
- MeSH terms
- Animals, Cannabinoids, Models, Neurological, Nerve Net, Neural Pathways, Rats, Sprague-Dawley, Prefrontal Cortex, Rats, Serotonergic Neurons, GABAergic Neurons, Dorsal Raphe Nucleus
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