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Role of Medial Prefrontal Cortex Serotonin 2A Receptors in the Control of Retrieval of Recognition Memory in Rats
Open accessAbstract
Often, retrieval cues are not uniquely related to one specific memory, which could lead to memory interference. Controlling interference is particularly important during episodic memory retrieval or when remembering specific events in a spatiotemporal context. Despite a clear involvement of prefrontal cortex (PFC) in episodic memory in human studies, information regarding the mechanisms and neurotransmitter systems in PFC involved in memory is scarce. Although the serotoninergic system has been linked to PFC functionality and modulation, its role in memory processing is poorly understood. We hypothesized that the serotoninergic system in PFC, in particular the 5-HT2A receptor (5-HT2AR) could have a role in the control of memory retrieval. In this work we used different versions of the object recognition task in rats to study the role of the serotoninergic modulation in the medial PFC (mPFC) in memory retrieval. We found that blockade of 5-HT2AR in mPFC affects retrieval of an object in context memory in a spontaneous novelty preference task, while sparing single-item recognition memory. We also determined that 5-HT2ARs in mPFC are required for hippocampal-mPFC interaction during retrieval of this type of memory, suggesting that the mPFC controls the expression of memory traces stored in the hippocampus biasing retrieval to the most relevant one.
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Pre-test microinjections of MDL 11,939, a 5-HT2A-R antagonist, into the rat mPFC impaired TOM, but not NOP and OPP, all with 3 hours intervals.
“Pre-test microinjections of MDL 11,939, a 5-HT2A-R antagonist, into the rat mPFC impaired TOM, but not NOP and OPP, all with 3 hours intervals (Bekinschtein et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Bekinschtein et al., 2013
Pre-test prefrontal infusions of MDL 11,939 or 8-OH DPAT, a 5HT1A-R agonist, but not of SB 242084, a 5HT2C-R antagonist, impaired OIC memory tested 3 hours later.
“Pre-test prefrontal infusions of MDL 11,939 or 8-OH DPAT, a 5HT1A-R agonist, but not of SB 242084, a 5HT2C-R antagonist, also impaired OIC memory tested 3 hours later (Bekinschtein et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Bekinschtein et al., 2013
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Metadata
- Authors
- Bekinschtein, P., Renner, M. C., Gonzalez, M. C., & Weisstaub, N.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-10-02
- Volume
- 33
- Issue
- 40
- Pages
- 15716-15725
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618481
- OpenAlex
- W2104890863
- Cited by
- 69
- References
- 79
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 9
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- medial prefrontal cortex, 5-HT2A receptor, memory retrieval, recognition memory, object recognition memory, novelty preference, memory interference, rats
- MeSH terms
- Animals, Attention, Behavior, Animal, Cues, Discrimination, Psychological, Male, Piperidines, Mental Recall, Rats, Wistar, Prefrontal Cortex, Recognition, Psychology, Receptor, Serotonin, 5-HT2A, Rats, Serotonin 5-HT2 Receptor Antagonists
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