Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area
Abstract
Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment and were abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum. Oxytocin-induced penile erection occurred 15 min after the increase of the concentration of extracellular dopamine in the dialysate obtained from either the nucleus accumbens or the prelimbic medial prefrontal cortex, which was also abolished by d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin. An increase in extracellular glutamic acid concentration was also observed in the same dialysate obtained from the ventral tegmental area, but not from the prelimbic medial prefrontal cortex or the nucleus accumbens in which dopamine concentration was measured, 15 min after the injection of oxytocin into the ventral subiculum. This effect was also abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin into the ventral subiculum. These results confirm previous findings showing that ventral subiculum oxytocin-induced penile erection is mediated by an increase of glutamic acid neurotransmission in the ventral tegmental area. This in turn increases mesolimbic and mesocortical dopaminergic activity, releasing dopamine in the nucleus accumbens and in the prelimbic medial prefrontal cortex. These results are in line with previous studies supporting the hypothesis that the ventral subiculum participates in a complex neural circuit controlling not only penile erection and copulation, but also sexual motivation, arousal and rewarding.
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Activation of oxytocin neurons thought to target the VTA stimulates mesocorticolimbic dopaminergic neurons.
“Recent studies show activation of oxytocin neurons thought to target the VTA stimulates mesocorticolimbic dopaminergic neurons (Melis et al., 2007, Melis et al., 2009, Succu et al., 2011, Succu et al., 2008).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Succu et al., 2011
The effect of oxytocin stimulation of the amygdala and hippocampus on penile erection and accumbal dopamine is suggested to occur due to activation of glutamatergic projections from the amygdala and hippocampus that act to stimulate mesolimbic dopamine neurons within the VTA.
“This is suggested to occur due to activation of glutamatergic projections from the amygdala and hippocampus that act to stimulate mesolimbic dopamine neurons within the VTA (Melis et al., 2009, Succu et al., 2011).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Succu et al., 2011
Dopamine release in the nucleus accumbens stimulates dopamine neurons within the PVN that can ultimately activate oxytocinergic neurons and induce penile erection.
“dopamine release in the nucleus accumbens has been demonstrated to produce stimulation of dopamine neurons within the PVN that can ultimately activate oxytocinergic neurons and induce penile erection (Melis et al., 2007, Melis et al., 2009, Succu et al., 2011, Succu et al., 2007).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Succu et al., 2011
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“Direct OT injection into the ventral subiculum induces penile erection episodes in male rats (Succu et al., 2011), confirming the important role of this hormone for sexual behavior.”
BackgroundBratzu, J., Bharatiya, R., Manca, E., Cocco, C., Argiolas, A., Melis, M. R., & Sanna, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112147 · Cited by 12 · see citing works
Hu, B., Boyle, C. A., & Lei, S. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa363 · Cited by 12 · see citing works
“Paradoxically, the physiological functions of OXTR activation in the subiculum have not been determined, except that injection of OXT into the ventral subiculum induces penile erection (Melis et al. 2009; Melis et al. 2010; Melis and Argiolas 2011; Succu et al. 2011).”
BackgroundMelis, M. R., Sanna, F., & Argiolas, A. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0058 · Cited by 9 · see citing works
Potential role of oxytocin in the regulation of memories and treatment of memory disorders
Walia, V., Wal, P., Mishra, S., Agrawal, A., Kosey, S., & Patil, A. D. (2024) · Peptides · doi:10.1016/j.peptides.2024.171222 · Cited by 8 · see citing works
Sanna, F., Serra, M. P., Boi, M., Bratzu, J., Poddighe, L., Sanna, F., Carta, A., Corda, M. G., Giorgi, O., Melis, M. R., et al. (2022) · Hippocampus · doi:10.1002/hipo.23448 · Cited by 7 · see citing works
“…as oxytocin contribute to mediate the interaction between motivational and consummatory aspects of male sexual behavior (Bratzu et al., 2019; Melis et al., 2007, 2009, 2010; Melis & Argiolas, 2011, 2021a, 2021b; Sanna et al., 2020; Sanna, Bratzu, Argiolas, & Melis, 2017; Succu et al., 2008, 2011).”
BackgroundThe role of intraamygdaloid oxytocin in spatial learning and avoidance learning
Vörös, D., Kiss, O., Taigiszer, M., László, B. R., Ollmann, T., Péczely, L., Zagorácz, O., Kertes, E., Kállai, V., Berta, B., et al. (2024) · Peptides · doi:10.1016/j.peptides.2024.171169 · Cited by 5 · see citing works
“This leads to an increase in extracellular Dopamine levels in the nucleus accumbens or an increase in the firing rate of dopaminergic neurons, which are projected towards the nucleus accumbens from the ventral tegmental area [73 , 75].”
Central nucleus of the amygdala is involved in induction of yawning response in rats
Kubota, N., Amemiya, S., Yanagita, S., Nishijima, T., & Kita, I. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111974 · Cited by 4 · see citing works
Oxytocin in the Developing Brain
Chini, B., Leonzino, M., & Gigliucci, V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00016-9 · Cited by 2 · see citing works
Hull, E. M., & Dominguez, J. M. (2012) · Handbook of Psychology, Second Edition · doi:10.1002/9781118133880.hop203012
- Authors
- Succu, S., Sanna, F., Argiolas, A., & Melis, M. R.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Melis, Maria Rosaria
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 61
- Issue
- 1-2
- Pages
- 181-188
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2020991134
- Cited by
- 35
- References
- 66
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 2 · 2013: 6 · 2012: 5
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- oxytocin, penile erection, ventral subiculum, hippocampus, ventral tegmental area, glutamatergic neurotransmission, dopamine, nucleus accumbens, arginine vasotocin, oxytocin receptor, mesolimbic dopamine system, sexual behavior, sexual motivation
- MeSH terms
- Animals, Hippocampus, Injections, Intraventricular, Male, Neural Pathways, Synaptic Transmission, Oxytocin, Penile Erection, Rats, Sprague-Dawley, Ventral Tegmental Area, Glutamic Acid, Rats
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