Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex

Del Arco, Alberto; Mora, Francisco

doi:10.1016/j.pbb.2008.04.011

Cited by 163Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex

Del Arco, Alberto, Mora, Francisco·2008·Pharmacology Biochemistry and Behavior

DOI 10.1016/j.pbb.2008.04.011

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Abstract

Previous experimental studies have shown that the prefrontal cortex (PFC) regulates the activity of the nucleus accumbens (NAc), and in particular the release of dopamine in this area of the brain. In the present report we review recent microinjections/microdialysis studies from our laboratory on the effects of stimulation/blockade of dopamine and glutamate receptors in the PFC that modulate dopamine, and also acetylcholine release in the NAc. Stimulation of prefrontal D2 dopamine receptors, but not group I mGlu glutamate receptors, reduces the release of dopamine and acetylcholine in the NAc and spontaneous motor activity. This inhibitory role of prefrontal D2 receptors is not changed by acute systemic injections of the NMDA antagonist phencyclidine. On the other hand, the blockade of NMDA receptors in the PFC increases the release of dopamine and acetylcholine in the NAc as well as motor activity which suggests that the hypofunction of prefrontal NMDA receptors is able to produce the neurochemical and behavioural changes associated with a dysfunction of the corticolimbic circuit. We suggest here that dopamine and glutamate receptors are, in part, segregated in specific cellular circuits in the PFC. Thus, the stimulation/blockade of these receptors would have a different net impact on PFC output projections to regulate dopamine and acetylcholine release in the NAc and in guided behaviour. Finally, it is speculated that environmental enrichment might produce plastic changes that modify the functional interaction between the PFC and the NAc in both physiological and pathological conditions.

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These changes result in dysregulation of dopaminergic signalling in distinct brain structures responsible for processing salient stimuli.
“These changes result in dysregulation of dopaminergic signalling in distinct brain structures responsible for processing salient stimuli.52”
From The effects of social deprivation on adolescent development and mental health (2020) · cites this paper as [52]

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Authors: Del Arco, A., & Mora, F.
Affiliations: Universidad Complutense de Madrid (ES)
ORCID: Mora, Francisco
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2008-08
Volume: 90
Issue: 2
Pages: 226-235
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/j.pbb.2008.04.011
OpenAlex: W2046946877
Cited by: 163
References: 140
Citations by year: 2026: 4 · 2025: 6 · 2024: 12 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 14 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 8 · 2012: 10
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: prefrontal cortex, nucleus accumbens, dopamine, glutamate, dopamine D2 receptor, NMDA receptor, group I metabotropic glutamate receptors, acetylcholine release, spontaneous motor activity, corticolimbic circuits, phencyclidine, environmental enrichment
MeSH terms: Acetylcholine, Animals, Dopamine, Humans, Nucleus Accumbens, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2, Microdialysis, Receptors, Metabotropic Glutamate, Glutamic Acid

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Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex

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