Cited by 144Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

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NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear

Dalton, Gemma L., Wu, Dong Chuan, Wang, Yu Tian, Floresco, Stan B., Phillips, Anthony G.·2012·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.09.001

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Abstract

Synaptic plasticity mediated by NMDA glutamate receptors is thought to be a primary mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor subunits may induce long-term potentiation (LTP), whereas low-frequency stimulation of GluN2B receptors induces long-term depression (LTD). In the present study, we show that blockade of GluN2A, but not GluN2B receptors with NVP-AAM077 and Ro25-6981 respectively, prevented LTP of auditory thalamic inputs to the lateral amygdala. Conversely, LTD induction in this pathway was prevented by blockade of GluN2B, but not GluN2A receptors. As this pathway plays a critical role in the acquisition, retrieval and extinction of a learned auditory-cue fear association, we next examined the effects of blockade of GluN2A and GluN2B receptors on the development and retention of a conditioned fear response. Administration of NVP-AAM077, but not Ro25-6981, prior to conditioning disrupted the expression of conditioned fear 24h later. Conversely, Ro25-6981 but not NVP-AAM077 impaired extinction of the conditioned fear response. These data expand on previous work showing that LTP/D in the thalamic-lateral amygdala pathway is dependent on NMDA receptors, by demonstrating selective roles for GluN2A and GluN2B NMDA receptor subunits in LTP and LTD respectively. Furthermore, GluN2A receptor activation and associated LTP may be involved specifically in the initial formation and/or stabilization of a learned fear response, whereas GluN2B receptor activation and associated LTD may facilitate the suppression of Pavlovian fear responses during extinction. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

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A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913
Synaptic plasticity: LTP and LTD
Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355
Cognitive Neuroscience and the Study of Memory
Milner, B. A., Squire, L. R., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80987-3 · Cited by 1,335
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004) · Science · doi:10.1126/science.1096615 · Cited by 1,131
Self-citation
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092
NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms
Malenka, R. C., & Nicoll, R. A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90197-t · Cited by 904
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
Sakimura, K., Kutsuwada, T., Ito, I., Manabe, T., Takayama, C., Kushiya, E., Yagi, T., Aizawa, S., Inoue, Y., Sugiyama, H., et al. (1995) · Nature · doi:10.1038/373151a0 · Cited by 865
Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · cited 1×
“Treatments that block LTP, such as NMDA receptor antagonists and protein synthesis inhibitors, disrupt the acquisition of a conditioned fear response (Bailey et al., 1999; Fanselow and Kim, 1994; Frey et al., 1996; Kim et al., 1991; Miserendino et al., 1990; Schafe and LeDoux, 2000).”
Background
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815
Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808
Fear conditioning induces a lasting potentiation of synaptic currents in vitro
McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771
Strengthening of horizontal cortical connections following skill learning
Rioult-Pedotti, M. S., Friedman, D. J., Hess, G., & Donoghue, J. P. (1998) · Nature Neuroscience · doi:10.1038/678 · Cited by 713
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression
Massey, P. V., Johnson, B. E., Moult, P. R., Auberson, Y. P., Brown, M. W., Molnár, E., Collingridge, G. L., & Bashir, Z. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1697-04.2004 · Cited by 712
Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning
Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08177.2000 · Cited by 678
Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala
Schafe, G. E., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0003.2000 · Cited by 611
Ro 25–6981, a Highly Potent and Selective Blocker of N-Methyl-d-aspartate Receptors Containing the NR2B Subunit. Characterization in Vitro
Fischer, G., Mutel, V., Trube, G., Malherbe, P., Kew, J. N. C., MOHACSI, E., Heitz, M., & Kemp, J. A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37138-1 · Cited by 480
Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo
Sprengel, R., Suchanek, B., Amico, C., Brusa, R., Burnashev, N., Rozov, A. V., Hvalby, Ø., Jensen, V., Paulsen, O., Andersen, P. N., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80921-6 · Cited by 460
NMDA Receptors and L-Type Voltage-Gated Calcium Channels Contribute to Long-Term Potentiation and Different Components of Fear Memory Formation in the Lateral Amygdala
Bauer, E. P., Schafe, G. E., & LeDoux, J. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05239.2002 · Cited by 438
Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala.
Fanselow, M. S., & Kim, J. J. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.210 · Cited by 360
Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory
Santini, E., Muller, R. U., & Quirk, G. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-22-09009.2001 · Cited by 358
Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning
Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06889.2001 · Cited by 350
Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning
Brigman, J. L., Wright, T., Talani, G., Prasad-Mulcare, S., Jinde, S., Seabold, G. K., Mathur, P., Davis, M. I., Bock, R., Gustin, R. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0640-10.2010 · Cited by 339
Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation
Berberich, S., Punnakkal, P., Jensen, V., Pawlak, V., Seeburg, P. H., Hvalby, Ø., & Köhr, G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1905-05.2005 · Cited by 304
N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.
Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 301
LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit
Rogan, M. T., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90070-5 · Cited by 300
Hippocampal long-term depression is required for the consolidation of spatial memory
Ge, Y., Dong, Z., Bagot, R. C., Howland, J. G., Phillips, A. G., Wong, T. P., & Wang, Y. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008200107 · Cited by 298
Self-citation
Acquisition of Fear Extinction Requires Activation of NR2B-Containing NMDA Receptors in the Lateral Amygdala
Sotres-Bayón, F., Bush, D. E. A., & LeDoux, J. E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301316 · Cited by 298
Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization
Brebner, K., Wong, T. P., Liu, L., Liu, Y., Campsall, P. A., Gray, S. L., Phelps, L., Phillips, A. G., & Wang, Y. T. (2005) · Science · doi:10.1126/science.1116894 · Cited by 296
Self-citation
Influence of actinomycin D, a RNA synthesis inhibitor, on long‐term potentiation in rat hippocampal neurons in vivo and in vitro.
Frey, U., Frey, S., Schollmeier, F., & Krug, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021179 · Cited by 274
Amygdala depotentiation and fear extinction
Kim, J., Lee, S., Park, K., Hong, I., Song, B., Son, G. H., Park, H., Kim, W. R., Park, E. J., Choe, H. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710548105 · Cited by 261
L-Type Voltage-Gated Calcium Channels Mediate NMDA-Independent Associative Long-Term Potentiation at Thalamic Input Synapses to the Amygdala
Weisskopf, M. G., Bauer, E. P., & LeDoux, J. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10512.1999 · Cited by 253
Increased Thresholds for Long-Term Potentiation and Contextual Learning in Mice Lacking the NMDA-type Glutamate Receptor ε1 Subunit
Kiyama, Y., Manabe, T., Sakimura, K., Kawakami, F., Mori, H., & Mishina, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06704.1998 · Cited by 236
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression
Morishita, W., Lü, W., Smith, G. B., Nicoll, R. A., Bear, M. F., & Malenka, R. C. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.005 · Cited by 235
Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment
Wong, T. P., Howland, J. G., Robillard, J. M., Ge, Y., Yu, W. K., Titterness, A. K., Brebner, K., Liu, L., Weinberg, J., Christie, B. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702308104 · Cited by 228
Self-citation
NMDA Receptor Subunit NR2A Is Required for Rapidly Acquired Spatial Working Memory But Not Incremental Spatial Reference Memory
Bannerman, D. M., Niewoehner, B., Lyon, L., Romberg, C., Schmitt, W. B., Taylor, A. M., Sanderson, D. J., Cottam, J. C. H., Sprengel, R., Seeburg, P. H., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3639-07.2008 · Cited by 206
Overtraining Does Not Mitigate Contextual Fear Conditioning Deficits Produced by Neurotoxic Lesions of the Basolateral Amygdala
Maren, S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-03088.1998 · Cited by 196
Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction
Köhr, G., Jensen, V., Koester, H. J., Mihaljević, A. L., Utvik, J. K., Kvello, A., Ottersen, O. P., Seeburg, P. H., Sprengel, R., & Hvalby, Ø. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10791.2003 · Cited by 183
Behavioral Stress Enhances Hippocampal CA1 Long-Term Depression through the Blockade of the Glutamate Uptake
Yang, C., Huang, C., & Hsu, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0406-05.2005 · Cited by 181
Glutamate Receptors in Extinction and Extinction-Based Therapies for Psychiatric Illness
Myers, K. M., Carlezon, W. A., & Davis, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.88 · Cited by 177
d-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning
Duffy, S., Labrie, V., & Roder, J. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301486 · Cited by 173
Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo
Fox, C. J., Russell, K., Wang, Y. T., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20230 · Cited by 172
Self-citation
In Vitro Binding Properties in Rat Brain of [3H]Ro 25‐6981, a Potent and Selective Antagonist of NMDA Receptors Containing NR2B Subunits
Mutel, V., Buchy, D., Klingelschmidt, A., Messer, J., Bleuel, Z., Kemp, J. A., & Richards, J. G. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052147.x · Cited by 171
Acquisition of fear conditioning in rats requires the synthesis of mRNA in the amygdala.
Bailey, D. J., Kim, J. J., Sun, W. Y., Thompson, R. F., & Helmstetter, F. J. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.276 · Cited by 169
Using Pavlovian Higher-Order Conditioning Paradigms to Investigate the Neural Substrates of Emotional Learning and MemoryPreprint
Gewirtz, J. C., & Davis, M. E. (2000) · Learning & Memory · doi:10.1101/lm.35200 · Cited by 168
Involvement of a Calcineurin Cascade in Amygdala Depotentiation and Quenching of Fear Memory
Lin, C.-H., Lee, C.-C., & Gean, P. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.44 · Cited by 158
Disruption of AMPA Receptor Endocytosis Impairs the Extinction, but not Acquisition of Learned Fear
Dalton, G. L., Wang, Y. T., Floresco, S., & Phillips, A. G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301642 · Cited by 154
Self-citation
Zinc Modulates Bidirectional Hippocampal Plasticity by Effects on NMDA Receptors
Izumi, Y., Auberson, Y. P., & Zorumski, C. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1258-06.2006 · Cited by 152
Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition
Higgins, G. A., Ballard, T. M., Huwyler, J., Kemp, J. A., & Gill, R. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00402-1 · Cited by 108
NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala
Goosens, K. A., & Maren, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03513.x · Cited by 108
Ifenprodil and Ethanol Enhance NMDA Receptor-Dependent Long-Term Depression
Hendricson, A. W., Miao, C. L. A., Lippmann, M. J., & Morrisett, R. A. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.938 · Cited by 95
Conditioned fear-induced tachycardia in the rat; vagal involvement
Nijsen, M. J. M. A., Croiset, G., Diamant, M., Stam, R., Delsing, D., de Wied, D., & Wiegant, V. M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00261-1 · Cited by 92
Role of AMPA receptor trafficking in NMDA receptor‐dependent synaptic plasticity in the rat lateral amygdala
Yu, S. Y., Wu, D., Liu, L., Ge, Y., & Wang, Y. T. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05461.x · Cited by 75
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Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning
Dalton, G. L., Ma, L., Phillips, A. G., & Floresco, S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2246-z · Cited by 74
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Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle testPreprint
Walker, D. L., & Davis, M. E. (2008) · Learning & Memory · doi:10.1101/lm.798908 · Cited by 67
Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult micePreprint
Müller, T., Albrecht, D., & Gebhardt, C. (2009) · Learning & Memory · doi:10.1101/lm.1398709 · Cited by 65
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Lynch, D. R., Shim, S. S., Seifert, K. M., Kurapathi, S., Mutel, V., Gallagher, M. J., & Guttmann, R. P. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00868-8 · Cited by 40
Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory
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Mathur, P., Graybeal, C., Feyder, M. J., Davis, M. I., & Holmes, A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.08.028 · Cited by 32
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Iijima, M., Kurosu, S., & Chaki, S. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.048 · Cited by 28
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Wu, L., Xu, H., Ren, M., Cao, X., & Zhuo, M. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-11 · Cited by 27
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GluN2B subunits of the NMDA receptor contribute to the AMPA receptor internalization during long-term depression in the lateral amygdala of juvenile rats
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Authors: Dalton, G. L., Wu, D. C., Wang, Y. T., Floresco, S. B., & Phillips, A. G.
Affiliations: University of British Columbia (CA)
Corresponding author: Floresco, Stan B.
Phillips, Anthony G.
ORCID: Wu, Dong Chuan
Wang, Yu Tian
Floresco, Stan B.
Phillips, Anthony G.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2012-02
Volume: 62
Issue: 2
Pages: 797-806
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.09.001
OpenAlex: W2089923284
Cited by: 144
References: 70
Citations by year: 2026: 5 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 16 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 13 · 2015: 9 · 2014: 18 · 2013: 13 · 2012: 7
FWCI: 5.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Michael Smith Health Research BC
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: NMDA receptor subunits, GluN2A, GluN2B, long-term potentiation, long-term depression, lateral amygdala, auditory fear conditioning, fear extinction, NVP-AAM077, Ro 25-6981, synaptic plasticity
MeSH terms: Amygdala, Animals, Association Learning, Conditioning, Classical, Extinction, Psychological, Fear, Male, Quinoxalines, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Long-Term Potentiation, Excitatory Amino Acid Antagonists, Long-Term Synaptic Depression, Rats

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NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear

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