Fear memory
Abstract
Fear memory is the best-studied form of memory. It was thoroughly investigated in the past 60 years mostly using two classical conditioning procedures (contextual fear conditioning and fear conditioning to a tone) and one instrumental procedure (one-trial inhibitory avoidance). Fear memory is formed in the hippocampus (contextual conditioning and inhibitory avoidance), in the basolateral amygdala (inhibitory avoidance), and in the lateral amygdala (conditioning to a tone). The circuitry involves, in addition, the pre- and infralimbic ventromedial prefrontal cortex, the central amygdala subnuclei, and the dentate gyrus. Fear learning models, notably inhibitory avoidance, have also been very useful for the analysis of the biochemical mechanisms of memory consolidation as a whole. These studies have capitalized on in vitro observations on long-term potentiation and other kinds of plasticity. The effect of a very large number of drugs on fear learning has been intensively studied, often as a prelude to the investigation of effects on anxiety. The extinction of fear learning involves to an extent a reversal of the flow of information in the mentioned structures and is used in the therapy of posttraumatic stress disorder and fear memories in general.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is still a consensus that the amygdala, hippocampus, vmPFC, and ACC are central to fear learning and, especially, fear extinction.
“there is still a consensus that the Am, Hip, vmPFC, and ACC are central to fear learning [review in Ref. (193, 194)] and, especially, fear extinction [reviews in Ref. (187, 188, 195)].”
From The Stress Acceleration Hypothesis of Nightmares (2017) · cites this paper as [194]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322 · see citing works
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256 · see citing works
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250 · see citing works
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706 · see citing works
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529 · see citing works
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296 · see citing works
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088 · see citing works
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913 · see citing works
Deisseroth, K. A. (2010) · Nature Methods · doi:10.1038/nmeth.f.324 · Cited by 1,884 · see citing works
Conditioned Reflexes: an Investigation of the Physiological Activity of the Cerebral Cortex
Denny-Brown, D. E. (1928) · Nature · doi:10.1038/121662a0 · Cited by 1,854 · see citing works
The locus coeruleus and noradrenergic modulation of cognition
Sara, S. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2573 · Cited by 1,848 · see citing works
Context and Behavioral Processes in Extinction: Table 1.
Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808 · see citing works
Neurobiology of Pavlovian Fear Conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,805 · see citing works
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786 · see citing works
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745 · see citing works
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · see citing works
The Neurobiology of Consolidations, Or, How Stable is the Engram?
Dudai, Y. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142050 · Cited by 1,671 · see citing works
Optogenetic stimulation of a hippocampal engram activates fear memory recall
Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669 · see citing works
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works
Rethinking the Emotional Brain
LeDoux, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.004 · Cited by 1,594 · see citing works
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
Mechanisms of emotional arousal and lasting declarative memory.
Cahill, L., & McGaugh, J. L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01214-9 · Cited by 1,575 · see citing works
Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550 · see citing works
The contextual brain: implications for fear conditioning, extinction and psychopathology
Maren, S., Phan, K. L., & Liberzon, I. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3492 · Cited by 1,547 · see citing works
Protein synthesis and memory: A review.
Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505 · see citing works
McGaugh, J. L. (1966) · Science · doi:10.1126/science.153.3742.1351 · Cited by 1,468 · see citing works
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466 · see citing works
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428 · see citing works
HIPPOCAMPAL ELECTRICAL ACTIVITY IN AROUSAL
Green, J. D., & Arduini, A. (1954) · Journal of Neurophysiology · doi:10.1152/jn.1954.17.6.533 · Cited by 1,392 · see citing works
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277 · see citing works
Preventing the return of fear in humans using reconsolidation update mechanisms
Schiller, D., Monfils, M.-H., Raio, C. M., Johnson, D. C., LeDoux, J. E., & Phelps, E. A. (2010) · Nature · doi:10.1038/nature08637 · Cited by 1,248 · see citing works
THE BRAIN’S RECORD OF AUDITORY AND VISUAL EXPERIENCE: A FINAL SUMMARY AND DISCUSSION
PENFIELD, W., & PEROT, P. (1963) · Brain · doi:10.1093/brain/86.4.595 · Cited by 1,230 · see citing works
Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217 · see citing works
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190 · see citing works
Stress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182 · see citing works
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
Mothet, J., Parent, A., Wolosker, H., Brady, R., Linden, D. J., Ferris, C., Rogawski, M., & Snyder, S. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.9.4926 · Cited by 1,164 · see citing works
The Molecular and Systems Biology of Memory
Kandel, E. R., Dudai, Y., & Mayford, M. R. (2014) · Cell · doi:10.1016/j.cell.2014.03.001 · Cited by 1,134 · see citing works
The MAPK cascade is required for mammalian associative learning
Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083 · see citing works
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
Vaudry, D., Falluel‐Morel, A., Bourgault, S., Basille, M., Burel, D., Wurtz, O., Fournier, A., Chow, B., Hashimoto, H., Galas, L., et al. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001370 · Cited by 1,060 · see citing works
Orienting and reorienting: the locus coeruleus mediates cognition through arousal
Sara, S. J., & Bouret, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.011 · Cited by 1,056 · see citing works
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049 · see citing works
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046 · see citing works
The Biochemistry of Memory: A New and Specific Hypothesis
LYNCH, G. S., & Baudry, M. (1984) · Science · doi:10.1126/science.6144182 · Cited by 1,045 · see citing works
BDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043 · see citing works
Neurobiology of learning and memory
Delacour, J. (1985) · Neuropsychologia · doi:10.1016/0028-3932(85)90073-9 · Cited by 1,025 · see citing works
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012 · see citing works
Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
Gradinaru, V., Zhang, F., Ramakrishnan, C., Mattis, J., Prakash, R., Diester, I., Goshen, I., Thompson, K. R., & Deisseroth, K. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.037 · Cited by 999 · see citing works
Van der Werf, Y. D., Witter, M. P., & Groenewegen, H. J. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00181-9 · Cited by 994 · see citing works
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994 · see citing works
Engineering a memory with LTD and LTP
Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. (2014) · Nature · doi:10.1038/nature13294 · Cited by 980 · see citing works
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works
Glutamate receptor function in learning and memory
Riedel, G. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00272-3 · Cited by 964 · see citing works
Izquierdo, I., & Medina, J. H. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3799 · Cited by 959 · see citing works
Self-citationInduction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959 · see citing works
Ito, M., Sakurai, M., & Tongroach, P. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014103 · Cited by 959 · see citing works
The hippocampus and contextual retrieval of information from memory: A theory
Hirsh, R. (1974) · Behavioral Biology · doi:10.1016/s0091-6773(74)92231-7 · Cited by 957 · see citing works
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924 · see citing works
The seven sins of memory: how the mind forgets and remembers
(2001) · Choice Reviews Online · doi:10.5860/choice.39-2484 · Cited by 921 · see citing works
Retrieval and reconsolidation: Toward a neurobiology of remembering
Sara, S. J. (2000) · Learning & Memory · doi:10.1101/lm.7.2.73 · Cited by 919 · see citing works
Behavioral and Neural Analysis of Extinction
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918 · see citing works
Why We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala
Fanselow, M. S., & LeDoux, J. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80775-8 · Cited by 914 · see citing works
Remembering episodes: a selective role for the hippocampus during retrieval
Eldridge, L. L., Knowlton, B. J., Furmanski, C. S., Bookheimer, S. Y., & Engel, S. A. (2000) · Nature Neuroscience · doi:10.1038/80671 · Cited by 906 · see citing works
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 904 · see citing works
NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms
Malenka, R. C., & Nicoll, R. A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90197-t · Cited by 904 · see citing works
Role of locus coeruleus in attention and behavioral flexibility
Aston-Jones, G., Rajkowski, J., & Cohen, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00140-7 · Cited by 900 · see citing works
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · see citing works
Memory Deficit Produced by Bilateral Lesions in the Hippocampal Zone
Penfield, W. G. (1958) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1958.02340050003001 · Cited by 891 · see citing works
LeDoux, J. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400335111 · Cited by 891 · see citing works
Misanin, J. R., Miller, R. R., & Lewis, D. J. (1968) · Science · doi:10.1126/science.160.3827.554 · Cited by 872 · see citing works
Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat
Hopkins, D. A., & Holstege, G. (1978) · Experimental Brain Research · doi:10.1007/bf00239551 · Cited by 866 · see citing works
Storage of spatial information by the maintenance mechanism of LTP
Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006) · Science · doi:10.1126/science.1128657 · Cited by 848 · see citing works
Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory
Kelleher, R. J., Govindarajan, A., Jung, H.-Y., Kang, H., & Tonegawa, S. (2004) · Cell · doi:10.1016/s0092-8674(04)00115-1 · Cited by 845 · see citing works
Genetic dissection of an amygdala microcircuit that gates conditioned fear
Haubensak, W., Kunwar, P. S., Cai, H., Ciocchi, S., Wall, N. R., Ponnusamy, R., Biag, J., Dong, H.-W., Deisseroth, K., Callaway, E. M., et al. (2010) · Nature · doi:10.1038/nature09553 · Cited by 840 · see citing works
Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815 · see citing works
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808 · see citing works
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., et al. (2011) · Nature · doi:10.1038/nature09856 · Cited by 800 · see citing works
Handbook of Contemporary Learning Theories
Mowrer, R. R. (2000) · Psychology Press eBooks · doi:10.4324/9781410600691 · Cited by 789 · see citing works
Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., De Martinis, B. S., Kapczinski, F., Quevedo, J., Roesler, R., Schröder, N., Nardi, A. E., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.6 · Cited by 771 · see citing works
Fear conditioning induces a lasting potentiation of synaptic currents in vitro
McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771 · see citing works
Nader, K. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00042-5 · Cited by 763 · see citing works
Amygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751 · see citing works
The Cognitive Neuroscience of Human Memory Since H.M.
Squire, L. R., & Wixted, J. T. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113720 · Cited by 749 · see citing works
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
Lu, B., Nagappan, G., Guan, X.-M., Nathan, P. J., & Wren, P. B. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3505 · Cited by 747 · see citing works
Acute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745 · see citing works
Engram cells retain memory under retrograde amnesia
Ryan, T. J., Roy, D. S., Pignatelli, M., Arons, A. L., & Tonegawa, S. (2015) · Science · doi:10.1126/science.aaa5542 · Cited by 745 · see citing works
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., Zeng, H., Fenton, A. A., & Hen, R. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.038 · Cited by 713 · see citing works
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 698 · see citing works
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692 · see citing works
Conditioned Reflexes and Neuron Organization.
(1949) · Annals of Internal Medicine · doi:10.7326/0003-4819-31-6-1133_1 · Cited by 688 · see citing works
Molecular cloning of a human cannabinoid receptor which is also expressed in testis
Gérard, C. M., Mollereau, C., Vassart, G., & Parmentier, M. (1991) · Biochemical Journal · doi:10.1042/bj2790129 · Cited by 688 · see citing works
Josselyn, S. A., Köhler, S., & Frankland, P. W. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4000 · Cited by 687 · see citing works
Aimone, J. B., Deng, W., & Gage, F. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.010 · Cited by 663 · see citing works
Neural circuits and mechanisms involved in Pavlovian fear conditioning: A critical review
Kim, J. J., & Jung, M. W. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.005 · Cited by 636 · see citing works
Brain activation in PTSD in response to trauma-related stimuli
Liberzon, I., Taylor, S. F., Amdur, R., Jung, T. D., Chamberlain, K. R., Minoshima, S., Koeppe, R. A., & Fig, L. M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00246-7 · Cited by 635 · see citing works
Prefrontal control of fear: more than just extinction
Sotres-Bayon, F., & Quirk, G. J. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.005 · Cited by 625 · see citing works
CREB required for the stability of new and reactivated fear memories
Kida, S., Josselyn, S. A., de Ortı́z, S. P., Kogan, J. H., Chévere-Torres, I., Masushige, S., & Silva, A. J. (2002) · Nature Neuroscience · doi:10.1038/nn819 · Cited by 624 · see citing works
Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation
Frey, U., & Morris, R. G. M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01189-2 · Cited by 615 · see citing works
The labile nature of consolidation theory
Nader, K., Schafe, G. E., & LeDoux, J. E. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044580 · Cited by 613 · see citing works
Schafe, G. E., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0003.2000 · Cited by 611 · see citing works
Long-Term Depression in Hippocampus
Bear, M. F., & Abraham, W. C. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002253 · Cited by 601 · see citing works
CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala
Zhou, Y., Won, J., Karlsson, M. G., Zhou, M., Rogerson, T., Balaji, J., Neve, R. L., Poirazi, P., & Silva, A. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2405 · Cited by 577 · see citing works
Ito, M., & Kano, M. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90380-9 · Cited by 574 · see citing works
Lane, R. D., Ryan, L., Nadel, L., & Greenberg, L. S. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x14000041 · Cited by 572 · see citing works
Object recognition memory and the rodent hippocampus
Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E. (2010) · Learning & Memory · doi:10.1101/lm.1650110 · Cited by 568 · see citing works
Dynamics of Retrieval Strategies for Remote Memories
Goshen, I., Brodsky, M., Prakash, R., Wallace, J. L., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.033 · Cited by 546 · see citing works
Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes
Packard, M. G., Cahill, L., & McGaugh, J. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8477 · Cited by 544 · see citing works
Huang, Y.-Y., & Kandel, E. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2446 · Cited by 544 · see citing works
Roberson, E. D., English, J. D., Adams, J. P., Selcher, J. C., Kondratick, C. M., & Sweatt, J. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04337.1999 · Cited by 542 · see citing works
Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4316-06.2006 · Cited by 533 · see citing works
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
Koob, G. F., & Heinrichs, S. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01991-5 · Cited by 530 · see citing works
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
Reul, J. M. H. M. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00117-5 · Cited by 515 · see citing works
Presence and acquired origin of reduced recall for fear extinction in PTSD: Results of a twin study
Milad, M. R., Orr, S. P., Lasko, N. B., Chang, Y., Rauch, S. L., & Pitman, R. K. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.017 · Cited by 512 · see citing works
Bidirectional switch of the valence associated with a hippocampal contextual memory engram
Redondo, R. L., Kim, J., Arons, A. L., Ramirez, S., Liu, X., & Tonegawa, S. (2014) · Nature · doi:10.1038/nature13725 · Cited by 512 · see citing works
Krug, M., Lössner, B., & Ott, T. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90005-4 · Cited by 509 · see citing works
Dendritic Inhibition in the Hippocampus Supports Fear Learning
Lovett-Barron, M., Kaifosh, P., Kheirbek, M. A., Danielson, N., Zaremba, J. D., Reardon, T. R., Turi, G. F., Hen, R., Zemelman, B. V., & Losonczy, A. (2014) · Science · doi:10.1126/science.1247485 · Cited by 509 · see citing works
The paraventricular thalamus controls a central amygdala fear circuit
Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F., Palmiter, R. D., He, M., et al. (2015) · Nature · doi:10.1038/nature13978 · Cited by 506 · see citing works
AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis
Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501 · see citing works
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo
Maren, S., & Fanselow (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07548.1995 · Cited by 499 · see citing works
Roozendaal, B., Okuda, S., van der Zee, E. A., & McGaugh, J. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601874103 · Cited by 499 · see citing works
Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology
Grillon, C. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01665-7 · Cited by 498 · see citing works
Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work
Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.084 · Cited by 498 · see citing works
Experience-dependent modification of a central amygdala fear circuit
Li, H., Penzo, M. A., Taniguchi, H., Kopec, C. D., Huang, Z. J., & Li, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3322 · Cited by 497 · see citing works
Changing Fear: The Neurocircuitry of Emotion Regulation
Hartley, C. A., & Phelps, E. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.121 · Cited by 492 · see citing works
A temporal shift in the circuits mediating retrieval of fear memory
Do-Monte, F. H., Quiñones-Laracuente, K., & Quirk, G. J. (2015) · Nature · doi:10.1038/nature14030 · Cited by 491 · see citing works
Huang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490 · see citing works
Amygdala interneuron subtypes control fear learning through disinhibition
Wolff, S. B. E., Gründemann, J., Tovote, P., Krabbe, S., Jacobson, G. A., Müller, C. R., Herry, C., Ehrlich, I., Friedrich, R. W., Letzkus, J. J., et al. (2014) · Nature · doi:10.1038/nature13258 · Cited by 489 · see citing works
Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis
Wang, Y. T., & Linden, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81066-1 · Cited by 488 · see citing works
Basomedial amygdala mediates top-down control of anxiety and fear
Adhikari, A., Lerner, T. N., Finkelstein, J., Pak, S., Jennings, J. H., Davidson, T. J., Ferenczi, E., Gunaydin, L. A., Mirzabekov, J. J., Ye, L., et al. (2015) · Nature · doi:10.1038/nature15698 · Cited by 485 · see citing works
Felder, C. C., Briley, E. M., Axelrod, J., Simpson, J. T., Mackie, K., & Devane, W. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7656 · Cited by 478 · see citing works
Amygdala intercalated neurons are required for expression of fear extinction
Likhtik, E., Popa, D., Apergis-Schoute, J., Fidacaro, G. A., & Paré, D. (2008) · Nature · doi:10.1038/nature07167 · Cited by 474 · see citing works
Berman, D. E., & Dudai, Y. (2001) · Science · doi:10.1126/science.1058165 · Cited by 472 · see citing works
Involvement of the CA3–CA1 Synapse in the Acquisition of Associative Learning in Behaving Mice
Gruart, A., Muñoz, M.-D., & Delgado-Garcia, J. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2834-05.2006 · Cited by 460 · see citing works
Endogenous Peptides and Learning and Memory Processes
(1981) · Elsevier eBooks · doi:10.1016/b978-0-12-474980-1.x5001-6 · Cited by 456 · see citing works
Long-term potentiation in the amygdala: a mechanism for emotional learning and memory
Maren, S. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01465-4 · Cited by 456 · see citing works
Temporally graded requirement for protein synthesis following memory reactivation
Milekic, M. H., & Alberini, C. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00976-5 · Cited by 455 · see citing works
Different molecular cascades in different sites of the brain control memory consolidation
Izquierdo, I., Bevilaqua, L. R., Rossato, J. I., Bonini, J. S., Medina, J. H., & Cammarota, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.005 · Cited by 452 · see citing works
Self-citationGating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs
Sotres-Bayón, F., Sierra‐Mercado, D., Pardilla‐Delgado, E., & Quirk, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.028 · Cited by 451 · see citing works
Memory‐related neural systems in Alzheimer's disease: An anatomic study
Hyman, B. T., Hoesen, G. W. V., & Damasio, A. R. (1990) · Neurology · doi:10.1212/wnl.40.11.1721 · Cited by 449 · see citing works
Somatosensory and auditory convergence in the lateral nucleus of the amygdala.
Romanski, L. M., Clugnet, M.-C., Bordi, F., & LeDoux, J. E. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.3.444 · Cited by 446 · see citing works
Roozendaal, B., & McGaugh, J. L. (2011) · Behavioral Neuroscience · doi:10.1037/a0026187 · Cited by 445 · see citing works
New life in an old idea: The synaptic plasticity and memory hypothesis revisited
Martin, S. J., & Morris, R. (2002) · Hippocampus · doi:10.1002/hipo.10107 · Cited by 440 · see citing works
The case of K.C.: contributions of a memory-impaired person to memory theory
Rosenbaum, R. S., Köhler, S., Schacter, D. L., Moscovitch, M., Westmacott, R., Black, S. E., Gao, F., & Tulving, E. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.10.007 · Cited by 433 · see citing works
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works
Maren, S., De, B. M., & Fanselow, M. S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91176-2 · Cited by 428 · see citing works
The retroactive effect of electroshock on learning.
Duncan, C. P. (1949) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058173 · Cited by 428 · see citing works
Psychopharmacology: A Generation of Progress
Abrams, A. (1978) · Psychosomatic Medicine · doi:10.1097/00006842-197810000-00010 · Cited by 423 · see citing works
Protein Synthesis Subserves Reconsolidation or Extinction Depending on Reminder Duration
Pedreira, M. E., & Maldonado, H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00352-0 · Cited by 406 · see citing works
Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval
Tanaka, K. Z., Pevzner, A., Hamidi, A., Nakazawa, Y., Graham, J. A., & Wiltgen, B. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.037 · Cited by 403 · see citing works
Trace Eyeblink Conditioning Increases CA1 Excitability in a Transient and Learning-Specific Manner
Moyer, J. R., Thompson, L. T., & Disterhoft, J. F. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05536.1996 · Cited by 403 · see citing works
An Improved One-Trial Passive Avoidance Learning Situation
Jarvik, M. E., & Kopp, R. (1967) · Psychological Reports · doi:10.2466/pr0.1967.21.1.221 · Cited by 395 · see citing works
Izquierdo, I., Cunha, C. D., Rosat, R. M., Jerusalinsky, D. A., Ferreira, M. B. C., & Medina, J. H. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90847-w · Cited by 395 · see citing works
Self-citationRosenkranz, J. A., & Grace, A. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00324.2002 · Cited by 392 · see citing works
Hippocampal Inactivation Disrupts the Acquisition and Contextual Encoding of Fear Extinction
Corcoran, K., Desmond, T., Frey, K., & Maren, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2246-05.2005 · Cited by 390 · see citing works
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · see citing works
Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics
Do-Monte, F. H., Manzano-Nieves, G., Quiñones-Laracuente, K., Ramos-Medina, L., & Quirk, G. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3137-14.2015 · Cited by 385 · see citing works
The Cholinergic Hypothesis: A Historical Overview, Current Perspective, and Future Directions
Bartus, R. T., Dean, R. L., Pontecorvo, M. J., & Flicker, C. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb37600.x · Cited by 384 · see citing works
Campeau, S., & Davis, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02312.1995 · Cited by 379 · see citing works
Facilitation of time-dependent memory processes with posttrial epinephrine injections
Gold, P. E., & Buskirk, R. B. V. (1975) · Behavioral Biology · doi:10.1016/s0091-6773(75)91784-8 · Cited by 377 · see citing works
Moncada, D., & Viola, H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1083-07.2007 · Cited by 370 · see citing works
Synaptic correlates of fear extinction in the amygdala
Amano, T., Ünal, Ç. T., & Paré, D. (2010) · Nature Neuroscience · doi:10.1038/nn.2499 · Cited by 369 · see citing works
Pedreira, M. E., Pérez-Cuesta, L. M., & Maldonado, H. (2004) · Learning & Memory · doi:10.1101/lm.76904 · Cited by 367 · see citing works
Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits
Cho, J.-H., Deisseroth, K. A., & Bolshakov, V. Y. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.025 · Cited by 367 · see citing works
Garfinkel, S. N., Abelson, J. L., King, A. P. J., Sripada, R. K., Wang, X., Gaines, L. M., & Liberzon, I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4287-13.2014 · Cited by 361 · see citing works
Direct Reactivation of a Coherent Neocortical Memory of Context
Cowansage, K. K., Shuman, T., Dillingham, B. C., Chang, A., Golshani, P., & Mayford, M. R. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.022 · Cited by 359 · see citing works
Parvalbumin-Positive Basket Cells Differentiate among Hippocampal Pyramidal Cells
Lee, S.-H., Marchionni, I., Bezaire, M., Varga, C., Danielson, N., Lovett-Barron, M., Losonczy, A., & Soltesz, I. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.034 · Cited by 358 · see citing works
Matus-Amat, P., Higgins, E. A., Barrientos, R., & Rudy, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1598-03.2004 · Cited by 358 · see citing works
Santini, E., Muller, R. U., & Quirk, G. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-22-09009.2001 · Cited by 358 · see citing works
Spaced training induces normal long-term memory in CREB mutant mice
Kogan, J. H., Frankland, P. W., Blendy, J. A., Coblentz, J., Marowitz, Z., Schütz, G., & Silva, A. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00022-4 · Cited by 350 · see citing works
Anxious Responses to Predictable and Unpredictable Aversive Events.
Grillon, C., Baas, J. P., Lissek, S., Smith, K., & Milstein, J. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.5.916 · Cited by 349 · see citing works
Stable hippocampal long-term potentiation elicited by ‘theta’ pattern stimulation
Staubli, U. V., & LYNCH, G. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)91605-2 · Cited by 345 · see citing works
Takehara‐Nishiuchi, K., Kawahara, S., & Kirino, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09897.2003 · Cited by 343 · see citing works
Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD
Sajikumar, S. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.003 · Cited by 341 · see citing works
Alonso, M., Vianna, M. R. M., Depino, A. M., Mello e Souza, T., Pereira, P., Szapiro, G., Viola, H., Pitossi, F., Izquierdo, I., & Medina, J. H. (2002) · Hippocampus · doi:10.1002/hipo.10035 · Cited by 339 · see citing works
Self-citationConsolidation and Reconsolidation: Two Lives of Memories?
McKenzie, S., & Eichenbaum, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.037 · Cited by 338 · see citing works
Effectiveness of national implementation of prolonged exposure therapy in Veterans affairs care
Eftekhari, A., Ruzek, J. I., Crowley, J. J., Rosen, C. S., Greenbaum, M. A., & Karlin, B. E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.36 · Cited by 338 · see citing works
Emotional learning selectively and retroactively strengthens memories for related events
Dunsmoor, J. E., Murty, V. P., Davachi, L., & Phelps, E. A. (2015) · Nature · doi:10.1038/nature14106 · Cited by 332 · see citing works
Penfield, W. G. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490390027001 · Cited by 330 · see citing works
Sullivan, G. M., Apergis, J., Bush, D. E. A., Johnson, L. R., Hou, M., & Ledoux, J. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.015 · Cited by 327 · see citing works
Renewal of extinguished responding in a second context
Bouton, M. E., & Ricker, S. T. (1994) · Animal Learning & Behavior · doi:10.3758/bf03209840 · Cited by 327 · see citing works
Wessa, M., & Flor, H. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030525 · Cited by 323 · see citing works
Green, J. D. (1964) · Physiological Reviews · doi:10.1152/physrev.1964.44.4.561 · Cited by 321 · see citing works
Bozon, B., Davis, S., & Laroche, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00674-3 · Cited by 317 · see citing works
Izquierdo, I., Quillfeldt, J. A., Zanatta, M. S., Quevedo, J., Schaeffer, E. L., Schmitz, P. K., & Medina, J. H. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01427.x · Cited by 314 · see citing works
Self-citationThompson, R. F. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070239 · Cited by 314 · see citing works
Cammarota, M., Bevilaqua, L. R., Ardenghi, P. G., Paratcha, G., de Stein, M. L., Izquierdo, I., & Medina, J. H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00329-0 · Cited by 310 · see citing works
Self-citationSynaptic tagging during memory allocation
Rogerson, T., Cai, D. J., Frank, A. C., Sano, Y., Shobe, J. L., López‐Aranda, M. F., & Silva, A. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3667 · Cited by 305 · see citing works
Igaz, L. M., Vianna, M. R. M. R., Medina, J. H., & Izquierdo, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06781.2002 · Cited by 305 · see citing works
Self-citationVianna, M., Szapiro, G., McGaugh, J. D., Medina, J., & Izquierdo, I. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.211433298 · Cited by 301 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Hippocampal awake replay in fear memory retrieval
Wu, C.-T., Haggerty, D., Kemere, C., & Ji, D. (2017) · Nature Neuroscience · doi:10.1038/nn.4507 · Cited by 210 · see citing works
Preventing adolescent stress-induced cognitive and microbiome changes by diet
Provensi, G., Schmidt, S. D., Boehme, M., Bastiaanssen, T. F. S., Rani, B., Costa, A., Busca, K., Fouhy, F., Strain, C., Stanton, C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820832116 · Cited by 110 · see citing works
Self-citationThe Stress Acceleration Hypothesis of Nightmares
Nielsen, T. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00201 · Cited by 63 · see citing works
Lisboa, S. F., Vila-Verde, C., Rosa, J., Uliana, D. L., Stern, C. A. J., Bertoglio, L. J., Resstel, L. B., & Guimaraes, F. S. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5127-x · Cited by 54 · see citing works
Kotler, S., Mannino, M., Kelso, S., & Huskey, R. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104956 · Cited by 52 · see citing works
Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior
McCool, B. A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108750 · Cited by 7 · see citing works
- Authors
- Izquierdo, I., Furini, C. R. G., & Myskiw, J. C.
- Affiliations
- National Institute of Translational Neuroscience, National Research Council of Brazil, and Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
- Instituto do Cérebro (BR)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2016-04
- Volume
- 96
- Issue
- 2
- Pages
- 695-750
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W4211021876
- Cited by
- 453
- References
- 655
- Citations by year
- 2026: 27 · 2025: 51 · 2024: 56 · 2023: 45 · 2022: 59 · 2021: 49 · 2020: 40 · 2019: 33 · 2018: 39 · 2017: 39 · 2016: 15
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- fear memory, fear conditioning, contextual fear conditioning, passive avoidance, hippocampus, basolateral amygdala, lateral amygdala, ventromedial prefrontal cortex, central amygdala, dentate gyrus, memory consolidation, long-term potentiation, synaptic plasticity, drugs of abuse, anxiety, fear extinction, post-traumatic stress disorder
- MeSH terms
- Memory Consolidation, Amygdala, Animals, Conditioning, Psychological, Extinction, Psychological, Fear, Hippocampus, Hormones, Humans, Limbic System, Neuronal Plasticity, Stress Disorders, Post-Traumatic, Synapses, Prefrontal Cortex, Neurotransmitter Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review