Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · cited 1×

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426

The link between microglia and the severity of COVID‐19: The “two‐hit” hypothesis

Bouayed, J., & Bohn, T. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26984 · Cited by 23

Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS

Leem, Y., Park, J., Park, J., Kim, D., & Kim, H.-S. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.039 · Cited by 23

Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?

Ba, L., Huang, L., He, Z., Deng, S., Xie, Y., Zhang, M., Jacob, C., Antonecchia, E., Liu, Y., Xiao, W., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.759983 · Cited by 27

N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer's disease

Layé, S., Madore, C., St‐Amour, I., Delpech, J.-C., Joffre, C., Nadjar, A., & Calon, F. (2015) · Nutrition and Aging · doi:10.3233/nua-150049 · Cited by 24

A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes

Perkins, A. E., Doremus‐Fitzwater, T. L., Spencer, R. L., Varlinskaya, E. I., Conti, M. M., Bishop, C., & Deak, T. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.01.012 · Cited by 24

The metabolic and neuroinflammatory changes induced by consuming a cafeteria diet are age-dependent

Teixeira, D., Cecconello, A. L., Partata, W. A., de Fraga, L. S., Ribeiro, M. F. M., & Guedes, R. P. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1380892 · Cited by 25

Neuroimmune dynamics and brain aging: mechanisms and consequences

Müller, L., Benedetto, S. D., & Müller, V. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1715045 · Cited by 24

A Neurometabolic Pattern of Elevated Myo-Inositol in Children Who Are HIV-Exposed and Uninfected: A South African Birth Cohort Study

Bertran-Cobo, C., Wedderburn, C. J., Robertson, F. C., Subramoney, S., Narr, K. L., Joshi, S. H., Roos, A., Rehman, A. M., Hoffman, N., Zar, H. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.800273 · Cited by 21

Exploring microglia and their phenomenal concatenation of stress responses in neurodegenerative disorders

Asveda, T., Talwar, P., & Ravanan, P. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121920 · Cited by 23

The Importance of Inter-Species Variation in Traumatic Brain Injury-Induced Alterations of Microglial-Axonal Interactions

Gorse, K. M., & Lafrenaye, A. D. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00778 · Cited by 22

Subliminal (latent) processing of pain and its evolution to conscious awareness

Borsook, D., Youssef, A. M., Barakat, N., Sieberg, C. B., & Elman, I. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.015 · Cited by 21

Developmental functions of microglia: Impact of psychosocial and physiological early life stress

Smail, M. A., & Lenz, K. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110084 · Cited by 24

The Complementary Role of Morphology in Understanding Microglial Functional Heterogeneity

Godeanu, S., & Cătălin, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083811 · Cited by 22

Immunomodulators as Therapeutic Agents in Mitigating the Progression of Parkinson’s Disease

Grimmig, B., Morganti, J., Nash, K., & Bickford, P. (2016) · Brain Sciences · doi:10.3390/brainsci6040041 · Cited by 17

Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage

Wang, H., Faw, T. D., Lin, Y., Huang, S., Venkatraman, T. N., Cantillana, V., Lascola, C. D., James, M. L., & Laskowitz, D. T. (2021) · Neurocritical Care · doi:10.1007/s12028-020-01184-y · Cited by 22

Treelet transform analysis to identify clusters of systemic inflammatory variance in a population with moderate-to-severe traumatic brain injury

Vijapur, S. M., Vaughan, L. E., Awan, N., DiSanto, D., McKernan, G., & Wagner, A. K. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.026 · Cited by 21

The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation

Ullah, F., Gamage, R. V., Sen, M. K., & Gyengési, E. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03499-4 · Cited by 21

Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury

Donat, C. K., Gaber, K., Meixensberger, J., Brust, P., Pinborg, L. H., Hansen, H. H., & Mikkelsen, J. D. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8385-y · Cited by 25

Inflammation Effects on Glutamate as a Pathway to Neuroprogression in Mood Disorders

Haroon, E., & Miller, A. H. (2017) · Modern trends in psychiatry · doi:10.1159/000470805 · Cited by 22

A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking

Grifasi, I. R., Evans, W. A., Rexha, A. D., Sako, L. W., & Marshall, S. A. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.10.018 · Cited by 21

Influence of aging on deterioration of patients with COVID-19

Pang, L., Liu, Y., Shen, M., Ye, J., Chen, R., Lan, Z., Wu, Z., Guo, Y., & Zhang, P. (2020) · Aging · doi:10.18632/aging.202136 · Cited by 20

Age and sex differences in primary microglia culture: A comparative study

Ngwa, C., Qi, S., Mamun, A. A., Xu, Y., Sharmeen, R., & Liu, F. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109359 · Cited by 22

A Levee to the Flood: Pre-injury Neuroinflammation and Immune Stress Influence Traumatic Brain Injury Outcome

Houle, S., & Kokiko‐Cochran, O. N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.788055 · Cited by 22

Systemic inflammation moderates the association of prior concussion with hippocampal volume and episodic memory in high school and collegiate athletes

Brett, B. L., Savitz, J. B., Nitta, M. E., España, L. Y., Teague, T. K., Nelson, L. D., McCrea, M., & Meier, T. B. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.024 · Cited by 21

Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response

Huntula, S., Saegusa, H., Wang, X., Zong, S., & Tanabe, T. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.102059 · Cited by 19

Obesity Impacts Fever and Sickness Behavior During Acute Systemic Inflammation

Rummel, C. D., Bredehöft, J., Damm, J., Schweighöfer, H., Peek, V., & Harden, L. M. (2016) · Physiology · doi:10.1152/physiol.00049.2015 · Cited by 19

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

Navarro, E., Norden, D. M., Trojanowski, P. J., Godbout, J. P., & López, M. G. (2021) · Molecules · doi:10.3390/molecules26082107 · Cited by 20

Epigenetic and 3D genome reprogramming during the aging of the human hippocampus

Zemke, N. R., Lee, S. Y., Mamde, S., Yang, B., Berchtold, N. C., Garduño, B. M., Indralingam, H. S., Bartosik, W. M., Lau, P. K., Dong, K., et al. (2026) · Science · doi:10.1126/science.adt8307 · Cited by 32

Early‐Life Adversity Predicts Markers of Aging‐Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women

Fleck, L., Buß, C., Bauer, M., Stein, M., Ralf Mekle, A., Kock, L., Klawitter, H., Godara, M., Ramler, J., Entringer, S., et al. (2025) · Annals of Neurology · doi:10.1002/ana.27161 · Cited by 20

Tau and Amyloid beta causes microglial activation in Alzheimer’s disease

Chinnathambi, S., Adithyan, A., Chandrashekar, M., & Rangappa, N. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.06.002 · Cited by 19

CpG methylation differences between neurons and glia are highly conserved from mouse to human

Kessler, N. J., Baak, T. E. V., Baker, M. S., Laritsky, E., Coarfa, C., & Waterland, R. A. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv459 · Cited by 18

Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits

Wang, T.-F., Wu, S.-Y., Pan, B., Tsai, S., & Kuo, Y. (2022) · Cells · doi:10.3390/cells11030481 · Cited by 18

Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1

Finneran, D. J., Li, Q., Subbarayan, M. S., Joly‐Amado, A., Kamath, S. G., Dengler, D. G., Gordon, M. N., Jackson, M. R., Morgan, D., Bickford, P. C., et al. (2022) · Glia · doi:10.1002/glia.24269 · Cited by 18

Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish

Bollaerts, I., houcke, J. V., Beckers, A., Lemmens, K., Vanhunsel, S., Groef, L. D., & Moons, L. (2019) · Mediators of Inflammation · doi:10.1155/2019/6135795 · Cited by 18

Late aging–associated increases in L-DOPA–induced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat

Lanza, K., Perkins, A. E., Deak, T., & Bishop, C. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.05.019 · Cited by 18

Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming

Hashimoto, O., Kuniishi, H., Nakatake, Y., Yamada, M., Wada, K., & Sekiguchi, M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.013 · Cited by 17

Huangqin flavonoid extraction for spinal cord injury in a rat model

Zhang, Q., Zhang, L.-X., An, J., An, J., Liu, C., Zhao, J., & Yang, H. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.241472 · Cited by 17

Stroke-Induced Neurological Dysfunction in Aged Mice Is Attenuated by Preconditioning with Young Sca-1+ Stem Cells

Wlodarek, L., Alibhai, F. J., Wu, J., Li, S., & Li, R. (2022) · Stem Cells · doi:10.1093/stmcls/sxac019 · Cited by 17

Intermittent hypoxia treatments cause cellular priming in human microglia

Felice, M. D., Germelli, L., Piccarducci, R., Pozzo, E. D., Giacomelli, C., Baccaglini‐Frank, A., & Martini, C. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17682 · Cited by 16

SIRPα deficiency accelerates the pathologic process in models of Parkinson disease

Wang, J., Ding, X., Wu, X., Liu, J., Zhou, R., Wei, P., Zhang, Q., Zhang, C., Zen, K., & Li, L. (2019) · Glia · doi:10.1002/glia.23689 · Cited by 20

Enduring and Sex-specific Changes in Hippocampal Gene Expression after a Subchronic Immune Challenge

Tchessalova, D., & Tronson, N. C. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.019 · Cited by 18

Aging and neuropathic pain: Mitochondria-to-glia cascade, system mechanisms, and therapeutic strategies

Majumdar, S., Samaiya, P. K., Gupta, S. K., Krishnamurthy, S., & Prajapati, S. K. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103042 · Cited by 18

Plasma cytokines profile in patients with Alzheimer’s and Parkinson’s Disease: a comparative study in terms of inflammation

Shateri, S., Khatami, S. H., Toutounchi, A. H., Rajaei, S., Mahdavi, M., Baram, S. M., Shahidi, G. A., Habibi, A. H., Aghamollaii, V., Ghlichnia, B., et al. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2023.2292951 · Cited by 16

TGF-β1/SMADs signaling involved in alleviating inflammation induced by nanoparticulate titanium dioxide in BV2 cells

Huang, W., Tao, Y., Zhang, X., & Zhang, X. (2022) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105303 · Cited by 15

CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells—As a Potential Therapeutic Target for Neurodegenerative Dementia

Lin, M.-S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00260 · Cited by 17

Lipopolysaccharide Induces Mitochondrial Fragmentation and Energetic Shift in Reactive Microglia: Evidence for a Cell-Autonomous Program of Metabolic Plasticity

dos Santos, M. P., Leocadio, V. E., Hayashide, L. D. S., Marques, M., Carvalho, C. F., Galina, A., & Diniz, L. P. (2025) · Toxins · doi:10.3390/toxins17060293 · Cited by 14

Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice

Walrath, T., McMahan, R. H., Idrovo, J., Quillinan, N., & Kovacs, E. J. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111975 · Cited by 15

Possible Implications of Obesity-Primed Microglia that Could Contribute to Stroke-Associated Damage

Carreto, R. J. R., Rodríguez-Cortés, Y. M., Guerrero, H. T., & Chavarría, A. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01329-5 · Cited by 15

Biological activities of astaxanthin in the treatment of neurodegenerative diseases

Lotfi, A., Abroodi, Z., & Khazaei, M. (2024) · Neurodegenerative Disease Management · doi:10.1080/17582024.2024.2433932 · Cited by 14

Recurrent binge ethanol is associated with significant loss of dentate gyrus granule neurons in female rats despite concomitant increase in neurogenesis

West, R. K., Wooden, J. I., Barton, E. A., & Leasure, J. L. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.016 · Cited by 15

Molecular changes in glaucomatous trabecular meshwork. Correlations with retinal ganglion cell death and novel strategies for neuroprotection

Saccà, S. C., Vernazza, S., Iorio, E. L., Tirendi, S., Bassi, A. M., Gandolfi, S., & Izzotti, A. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.06.003 · Cited by 14

The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases

Kung, W., & Lin, M.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020934 · Cited by 14

Aspects of the immune system that impact brain function

Bondy, S. C. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577167 · Cited by 14

Potential Role for Herpesviruses in Alzheimer’s Disease

Duggan, M. R., Torkzaban, B., Ahooyi, T. M., & Khalili, K. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200814 · Cited by 13

Network Rewiring in the Aging Immune System: From Chronic Inflammation to Age-Related Pathologies

Müller, L., & Benedetto, S. D. (2026) · Cells · doi:10.3390/cells15050414 · Cited by 14

The Role of Aging in Intracerebral Hemorrhage

Huang, B., Chen, A., Sun, Y., & He, Q. (2024) · Brain Sciences · doi:10.3390/brainsci14060613 · Cited by 15

Partial microglial depletion through inhibition of colony-stimulating factor 1 receptor improves synaptic plasticity and cognitive performance in aged mice

Strackeljan, L., Baidoe‐Ansah, D., Mirzapourdelavar, H., Jia, S., Kaushik, R., Cangalaya, C., & Dityatev, A. E. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115186 · Cited by 14

Social influences on microglial reactivity and neuronal damage after cardiac arrest/cardiopulmonary resuscitation

Gaudier‐Diaz, M. M., Haines, A. H., Zhang, N., & DeVries, A. C. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.06.012 · Cited by 13

Traumatic Brain Injury and Chronic Traumatic Encephalopathy: Not Only Trigger for Neurodegeneration but Also for Cerebral Amyloid Angiopathy?

Zedde, M., Piazza, F., & Pascarella, R. (2025) · Biomedicines · doi:10.3390/biomedicines13040881 · Cited by 12

A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury

Patil, V., O'Connell, E., Quinlan, L., Fearnhead, H., McMahon, S., & Pandit, A. (2020) · iScience · doi:10.1016/j.isci.2021.102182 · Cited by 11

Priming of microglia by type II interferon is lasting and resistant to modulation by interleukin-10 in situ

Hemmerich, M., Malorny, N., Lewen, A., Hollnagel, J., Chausse, B., & Kann, O. (2022) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2022.577881 · Cited by 11

Panax quinquefolium saponins attenuates microglia activation following acute cerebral ischemia‐reperfusion injury via Nrf2/miR‐103‐3p/TANK pathway

Bai, X., Qiu, Y., Wang, J., Dong, Y., Zhang, T., & Jin, H. (2023) · Cell Biology International · doi:10.1002/cbin.12100 · Cited by 11

Long‐term reprogramming of primed microglia after moderate inhibition of CSF1R signaling

León‐Rodríguez, A., Grondona, J. M., Marín‐Wong, S., López‐Aranda, M. F., & López-Ávalos, M. D. (2024) · Glia · doi:10.1002/glia.24627 · Cited by 13

Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition

Benedetto, S. D., & Müller, L. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_14 · Cited by 12

Acute Time-Course Changes in CCL11, CCL2, and IL-10 Levels After Controlled Subconcussive Head Impacts: A Pilot Randomized Clinical Trial

Huibregtse, M. E., Ejima, K., Chen, Z.-X., Kalbfell, R., Koppineni, A., & Kawata, K. (2020) · The journal of head trauma rehabilitation · doi:10.1097/htr.0000000000000597 · Cited by 9

Restoration of Proresolution Pathway with Exogenous Resolvin D1 Prevents Sevoflurane-Induced Cognitive Decline by Attenuating Neuroinflammation in the Hippocampus in Rats with Type 2 Diabetes Mellitus

Sun, Q., Yan, H., Chen, F., Jiang, F., Chen, W., Li, D., & Guo, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.720249 · Cited by 13

Microglia-Induced Maladaptive Plasticity Can Be Modulated by NeuropeptidesIn Vivo

Morara, S., Colangelo, A. M., & Provini, L. (2015) · Neural Plasticity · doi:10.1155/2015/135342 · Cited by 12

Increased Risk of Dementia in Patients with Craniofacial Trauma: A Nationwide Population-Based Cohort Study

Yang, J.-R., Kuo, C., Chung, T., & Liao, H.-T. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.01.133 · Cited by 11

Neurogenesis and Neuroinflammation in Dialogue: Mapping Gaps, Modulating Microglia, Rewiring Aging

Tanaka, M. (2026) · Cells · doi:10.3390/cells15010078 · Cited by 11

BV2-derived extracellular vesicles modulate microglia inflammatory profile, neuronal plasticity, and behavioural performances in late adult mice.

Rinaldi, A., Balietti, M., Principi, E., Luca, M. D., Felice, E. D., Narcisi, F. M., Vilardo, L., Rosito, M., Piacentini, R., D'Alessandro, G., et al. (2024) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2024.08.012 · Cited by 8

Multiple synergistic anti-aging effects of vascular cell adhesion molecule 1 functionalized nanoplatform to improve age-related neurodegenerative diseases

Zhu, S., Zhang, Y., Li, C., Deng, Z., Yin, Y., Dong, Z., Kuang, L., Li, C., Hu, X., Yin, T., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.01.022 · Cited by 11

Jak kinase 3 signaling in microgliogenesis from the spinal nestin+ progenitors in both development and response to injury

Barua, S., Chung, J.-I., Kim, A. Y., Lee, S., Lee, S., & Baik, E. J. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000854 · Cited by 10

Sex‐specific incident dementia in patients with central nervous system trauma

Mollayeva, T., Hurst, M., Escobar, M. D., & Colantonio, A. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.03.003 · Cited by 10

Microglia: Rheostats of space radiation effects in the CNS microenvironment

Kerry O'Banion, M. (2022) · Life Sciences in Space Research · doi:10.1016/j.lssr.2022.08.002 · Cited by 10

Age-related changes in microglial physiology: the role for healthy brain ageing and neurodegenerative disorders

Garaschuk, O. (2017) · e-Neuroforum · doi:10.1515/nf-2016-a057 · Cited by 10

Aging alters glucose uptake in the naïve and injured rodent spinal cord

von Leden, R. E., Moritz, K. E., Bermudez, S., Jaiswal, S., Wilson, C. M., Dardzinski, B. J., & Byrnes, K. R. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.004 · Cited by 10

Exercise-driven restoration of the alcohol-damaged brain

West, R. K., Najjar, L. Z., & Leasure, J. L. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.07.003 · Cited by 12

Effects of NADPH Oxidase Isoform-2 (NOX2) Inhibition on Behavioral Responses and Neuroinflammation in a Mouse Model of Neuropathic Pain

Teixeira-Santos, L., Veríssimo, E., Martins, S., Sousa, T., Albino‐Teixeira, A., & Pinho, D. (2023) · Biomedicines · doi:10.3390/biomedicines11020416 · Cited by 10

Bidirectional Interplay Between Microglia and Mast Cells

Lakatos, S., & Rosta, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157556 · Cited by 13

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

Bertoni, G., Ristori, S., & Monti, D. (2026) · Cells · doi:10.3390/cells15080657 · Cited by 10

Short term exposure to ethyl pyruvate has long term anti-inflammatory effects on microglial cells

Stanisavljević, S., Jevtić, B., Djedović, N., & Miljković, D. M. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.03.006 · Cited by 9

Repeated social defeat stress exacerbates lipopolysaccharide-induced behavioural deficits in mice: ameliorative role of Chrysophyllum albidum fruit extract through anti-neuroinflammation, antioxidant and neurochemical balance

Ajayi, A. M., Ben‐Azu, B., Ogunkolade, G. E., Melete, J., Oyedele, A. T., & Umukoro, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01053-x · Cited by 10

Microglia Demonstrate Local Mixed Inflammation and a Defined Morphological Shift in an APP/PS1 Mouse Model

Holloway, O. G., King, A. E., & Ziebell, J. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200098 · Cited by 10

Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin primes cortical microglia to tissue injury

Lowery, R. L., Latchney, S. E., Peer, R. P., Lamantia, C. E., Lordy, K. A., Opanashuk, L. A., McCall, M. N., & Majewska, A. K. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.01.013 · Cited by 9

The pathologic outcomes and efficacy of epothilone treatment following traumatic brain injury is determined by age

Zhu, Z., Chuckowree, J. A., Musgrove, R. E., Dickson, T. C., & Blizzard, C. A. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.03.023 · Cited by 9

Redefining the timeline: a three-phase framework of hypothalamic microinflammation in metabolic disease

Zagmutt, S., Rodriguez-Garcia, M., Bolaños-Hurtado, M., Reguera, A. C., Casals, N., & Rodríguez‐Rodríguez, R. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09992-3 · Cited by 12

Neural interfacing biomaterials coated with the firmly tethered neuro-specific lipid bilayer

Hasan, M. L., Kim, G. E., Elnaggar, M. A., Yang, D. H., & Joung, Y. K. (2023) · Applied Surface Science · doi:10.1016/j.apsusc.2023.156424 · Cited by 8

Daily supplementation with GrandFusion® improves memory and learning in aged rats

Yu, J., Zhu, H., Perry, S. J., Taheri, S., & Kindy, M. S. (2017) · Aging · doi:10.18632/aging.101209 · Cited by 8

Regulation of aging and cancer by enhanced environmental activation of a hypothalamic-sympathoneural-adipocyte axis

Hassan, Q. N., Queen, N. J., & Cao, L. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.02.39 · Cited by 7

Aged xCT-Deficient Mice Are Less Susceptible for Lactacystin-, but Not 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine-, Induced Degeneration of the Nigrostriatal Pathway

Bentea, E., Pauw, L. D., Verbruggen, L., Winfrey, L. C., Deneyer, L., Moore, C., Albertini, G., Sato, H., Eeckhaut, A. V., Meshul, C. K., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.796635 · Cited by 8

Intravenous Transplantation of Adipose-Derived Mesenchymal Stem Cells Promoted The Production of Dopaminergic Neurons and Improved Spatial Memory in A Rat Model of Parkinson's Disease.

Hamedi, H., Ghorbanian, S. H., Mirzaeian, L., Abrari, K., Mozdziak, P. E., & Ghorbanian, M. T. (2023) · PubMed Central · doi:10.22074/cellj.2023.1972266.1161 · Cited by 8

Circulating T‐cell subsets discrepancy between bipolar disorder and major depressive disorder during mood episodes: A naturalistic, retrospective study of 1015 cases

Li, S., Lv, D., Qian, C., Jiang, J., Zhang, P., Xi, C., Wu, L., Gao, X., Fu, Y., Zhang, D., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14361 · Cited by 10

Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord

Galbavy, W., Lu, Y., Kaczocha, M., Puopolo, M., Liu, L., & Rebecchi, M. J. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0091-6 · Cited by 8

Brain glucose metabolism in patients with traumatic brain injury undergoing rehabilitation: a longitudinal 18F-FDG PET study

Pingue, V., Bossert, I., D’Ambrosio, D., Nardone, A., Trifirò, G., Canessa, N., & Franciotta, D. M. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1556427 · Cited by 8

The critical role of matrix metalloproteinase 9-mediated microglial polarization in perioperative neurocognitive disorders of aged rats

Xin, X., Zhang, H., Yang, C., Wang, X., Zhang, L., Ma, J., & Wang, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1650254 · Cited by 7

Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction

Yang, S., Zhang, S., Tang, W., Fang, S., Zhang, H., Zheng, J., Liu, X., Zhang, Y., Zhao, L., Huang, L., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.744719 · Cited by 7

NLRP3 Inflammasome Is Involved in Cocaine-Mediated Potentiation on Behavioral Changes in CX3CR1-Deficient Mice

Guo, M., Chivero, E. T., Callen, S. E., & Buch, S. J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11100963 · Cited by 7

Exacerbated immune response of the brain to peripheral immune challenge in post-septic mice

Salmani, H., Hosseini, M., Nabi, M. M., Noshahr, Z. S., Baghcheghi, Y., & Sadeghi, M. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.013 · Cited by 6

Anandamide Reuptake Inhibitor (VDM11) as a Possible Candidate for COVID-19 Associated Depression; a Combination of Network Pharmacology, Molecular Docking and In Vivo Experimental Analysis

Alzarea, S. I., Qasim, S., Afzal, M., Alsaidan, O. A., Alhassan, H. H., Alharbi, M., Alqinyah, M., & Alenazi, F. (2023) · Processes · doi:10.3390/pr11010143 · Cited by 7

Impact of gut–brain interaction in emerging neurological disorders

Lin, M.-S., Wang, Y., Chen, W., & Kung, W. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i1.1 · Cited by 7

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

Perry, V. H., & Teeling, J. L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0382-8 · Cited by 634

Cognitive Deficits after TBI are Exaggerated by Microglia-Associated Reactivity to Immune Challenge

Muccigrosso, M. M. (2015) · OhioLink ETD Center (Ohio Library and Information Network)

Microglial Cells and Inflammatory Cytokines in the Aged Brain

Richwine, A. F., & Johnson, R. W. (2008) · Springer eBooks · doi:10.1007/978-0-387-84851-8_19

Microglial priming in neurodegenerative disease

Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127