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Cited by 10Neuroinflammation and Neurodegeneration MechanismsSpaceflight effects on biologyEffects of Radiation Exposure

Microglia: Rheostats of space radiation effects in the CNS microenvironment

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Kerry O'Banion, M.·2022·Life Sciences in Space Research
DOI 10.1016/j.lssr.2022.08.002
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Abstract

Microglia are innate immune cells within the brain that arise from a distinct myeloid lineage. Like other tissue resident macrophages, microglia respond to injury or immune challenges and participate in reparative processes such as phagocytosis to preserve normal function. Importantly, they also participate in normal homeostatic processes including maintenance of neurogenic niches and synaptic plasticity associated with development. This review highlights aspects of microglial biology and how repeated insults that occur with age, neurodegenerative disease and possibly radiation exposure may heighten microglial responses and contribute to their dysfunction, creating a situation where their normal reparative mechanisms are no longer sufficient to maintain brain health. These ideas are discussed in the context of an evolving literature focused on microglial responses as possible targets for mitigation of late CNS radiation effects that represent potential risks for future exploration of deep space environments.

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Cited by

Sorted by citations

Authors
Kerry O'Banion, M.
ORCID
Kerry O'Banion, M.
Venue
Life Sciences in Space Research
Publisher
Elsevier BV
Published
2022-11
Volume
35
Pages
180-186
ISSN
2214-5524 (ISSN-L)
DOI
10.1016/j.lssr.2022.08.002
OpenAlex
W4291097451
Cited by
10
References
26
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2022: 1
FWCI
0.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Life Sciences in Space Research (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (R56 AG066397)
  • National Aeronautics and Space Administration (80NSSC21K0542)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
microglia, space radiation, late radiation effects, central nervous system, microglial dysfunction, neuroinflammation, neurodegenerative diseases, aging, neurogenesis, synaptic plasticity, phagocytosis, radiation mitigation, deep space exploration
MeSH terms
Brain, Humans, Radiation Injuries, Microglia, Neurodegenerative Diseases

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