BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents
Open accessAbstract
This work describes the characterization of BNC210 (6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1H)-one), a selective, small molecule, negative allosteric modulator (NAM) of α7 nicotinic acetylcholine receptors (α7 nAChR). With the aim to discover a non-sedating, anxiolytic compound BNC210 was identified during phenotypic screening of a focused medicinal chemistry library using the mouse Light Dark (LD) box to evaluate anxiolytic-like activity and the mouse Open Field (OF) (dark) test to detect sedative and/or motor effects. BNC210 exhibited anxiolytic-like activity with no measurable sedative or motor effects. Electrophysiology showed that BNC210 did not induce α7 nAChR currents by itself but inhibited EC80 agonist-evoked currents in recombinant GH4C1 cell lines stably expressing the rat or human α7 nAChR. BNC210 was not active when tested on cell lines expressing other members of the cys-loop ligand-gated ion channel family. Screening over 400 other targets did not reveal any activity for BNC210 confirming its selectivity for α7 nAChR. Oral administration of BNC210 to male mice and rats in several tests of behavior related to anxiety- and stress-related disorders, demonstrated significant reduction of these behaviors over a broad therapeutic range up to 500 times the minimum effective dose. Further testing for potential adverse effects in suitable rat and mouse tests showed that BNC210 did not produce sedation, memory and motor impairment or physical dependence, symptoms associated with current anxiolytic therapeutics. These data suggest that allosteric inhibition of α7 nAChR function may represent a differentiated approach to treating anxiety and stress-related disorders with an improved safety profile compared to current treatments.
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Preclinical pharmacology studies with BNC210 demonstrated that it was effective in several mouse and rat behavioral models of anxiety and stress-related disorders over a broad therapeutic dosage range.
“Preclinical pharmacology studies with BNC210 demonstrated that it was effective in several mouse and rat behavioral models of anxiety and stress‐related disorders over a broad therapeutic dosage range.”
In preclinical studies, BNC210 showed no signs of cognitive impairment.
“and it showed no signs of cognitive impairment”
In preclinical pharmacology and toxicology studies, BNC210 did not elicit sedation, memory or motor impairment, or physical dependence in rodent models.
“In preclinical pharmacology and toxicology studies BNC210 did not elicit sedation, memory or motor impairment, or physical dependence when evaluated in a number of rodent models”
Cites
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190 · see citing works
Bourin, M., & Hascoët, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01274-3 · Cited by 1,440 · see citing works
A cholinergic-adrenergic hypothesis of mania and depression
Janowsky, D., Davis, J., El-Yousef, M. K., & Sekerke, H. J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)93021-8 · Cited by 1,134 · see citing works
Antidepressants and the Risk of Suicidal Behaviors
Jick, H. (2004) · JAMA · doi:10.1001/jama.292.3.338 · Cited by 587 · see citing works
Jensen, A. A., Frølund, B., Liljefors, T., & Krogsgaard‐Larsen, P. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040219e · Cited by 541 · see citing works
Digging and marble burying in mice: simple methods for in vivo identification of biological impacts
Deacon, R. M. J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.20 · Cited by 508 · see citing works
Effect of nicotine and nicotinic receptors on anxiety and depression
Picciotto, M. R., Brunzell, D. H., & Caldarone, B. J. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00006 · Cited by 483 · see citing works
Maren, S., & Holmes, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.180 · Cited by 412 · see citing works
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · cited 1× · see citing works
“This effect of diazepam has been reported in humans, where attempts to combine exposure-based therapy for PTSD patients with benzodiazepines dampened anxiety but also reduced extinction learning (Singewald et al., 2015) (Fig.”
Mineur, Y. S., Obayemi, A., Wigestrand, M. B., Fote, G. M., Calarco, C. A., Li, A. M., & Picciotto, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219731110 · Cited by 375 · see citing works
Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: A systematic review
Berger, W., Mendlowicz, M. V., Marques-Portella, C., Kinrys, G., Fontenelle, L. F., Marmar, C. R., & Figueira, I. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.004 · Cited by 347 · see citing works
Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models
Markou, A., Chiamulera, C., Geyer, M. A., Tricklebank, M., & Steckler, T. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.173 · Cited by 328 · see citing works
Zhang, K., Förster, R., He, W., Liao, X., Li, J., Yang, C., Qin, H., Wang, M., Ding, R., Li, R., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00949-8 · Cited by 325 · see citing works
Treatment-resistant anxiety disorders
Bystritsky, A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001852 · Cited by 289 · cited 1× · see citing works
“These newer generation antidepressants offer an improved therapeutic option and around 25% of responders achieve recovery or remission (Bystritsky, 2006; Berger et al., 2009).”
Alkondon, M., Pereira, E. F. R., & Albuquerque, E. X. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00880-4 · Cited by 263 · see citing works
Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Young, G. T., Zwart, R., Walker, A., Sher, E., & Millar, N. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804372105 · Cited by 262 · see citing works
Alkondon, M., & Albuquerque, E. X. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.3043 · Cited by 240 · see citing works
Prickaerts, J., van Goethem, N. V., Chesworth, R., Shapiro, G., Boess, F., Methfessel, C., Reneerkens, O., Flood, D., Hilt, D., Gawryl, M., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.10.024 · Cited by 223 · see citing works
The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function
Connolly, C. N., & Wafford, K. A. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320529 · Cited by 204 · see citing works
A new continuous alternation task in T-maze detects hippocampal dysfunction in mice
Gerlai, R. T. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00214-3 · Cited by 195 · see citing works
THE EFFECTS OF DIISOPROPYLFLUOROPHOSPHONATE IN SCHIZOPHRENIA AND MANIC DEPRESSIVE PSYCHOSIS
Rowntree, D. W., Nevin, S., & Wilson, A. (1950) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.13.1.47 · Cited by 185 · see citing works
File, S. E., Kenny, P. J., & Ouagazzal, A. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1423 · Cited by 181 · see citing works
Nootropic α7 nicotinic receptor allosteric modulator derived from GABA A receptor modulators
Ng, H. J., Whittemore, E. R., Tran, M. B., Hogenkamp, D. J., Broide, R. S., Johnstone, T. B. C., Zheng, L., Stevens, K. E., & Gee, K. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701321104 · Cited by 171 · see citing works
File, S. E., Kenny, P. J., & Ouagazzal, A. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1423 · Cited by 166 · see citing works
Ketamine Treatment for Depression: A Review
Yavi, M., Lee, H., Henter, I. D., Park, L. T., & Zarate, C. A. (2022) · Discover Mental Health · doi:10.1007/s44192-022-00012-3 · Cited by 161 · see citing works
Dickinson, J. A., Kew, J. N. C., & Wonnacott, S. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046623 · Cited by 159 · see citing works
Nicotinic–serotonergic interactions in brain and behaviour
Seth, P., Cheeta, S., Tucci, S., & File, S. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00715-8 · Cited by 145 · see citing works
Response of the hypothalamo-pituitary-adrenal axis to nicotine
Matta, S. G., Fu, Y., Valentine, J. D., & Sharp, B. M. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00079-6 · Cited by 139 · see citing works
Livingstone, P. D., Srinivasan, J., Kew, J. N. C., Dawson, L. A., Gotti, C., Moretti, M., Shoaib, M., & Wonnacott, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06613.x · Cited by 133 · see citing works
GABAA Receptor Subtype-Selective Modulators. I. α2/α3-Selective Agonists as Non-Sedating Anxiolytics
Atack, J. R. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611795371350 · Cited by 132 · see citing works
Rabenstein, R. L., Caldarone, B. J., & Picciotto, M. R. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0568-z · Cited by 129 · see citing works
Wallace, T., Callahan, P., Tehim, A., Bertrand, D., Tombaugh, G., Wang, S.-J., Xie, W., Rowe, W., Ong, V., Graham, E., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.171892 · Cited by 129 · see citing works
Khiroug, L. S., Giniatullin, R. A., Klein, R. C., Fayuk, D. A., & Yakel, J. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09024.2003 · Cited by 124 · see citing works
Spurný, R., Debaveye, S., Farinha, A., Veys, K., Vos, A. M., Gossas, T., Atack, J. R., Bertrand, S., Bertrand, D., Danielson, U. H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418289112 · Cited by 109 · see citing works
Molecular and Cellular Mechanisms of Action of Nicotine in the CNS
Barik, J., & Wonnacott, S. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-69248-5_7 · Cited by 108 · see citing works
Alkondon, M., Braga, M. F. M., Pereira, E. F. R., Maelicke, A., & Albuquerque, E. X. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00006-6 · Cited by 102 · see citing works
Kenny, P. J., File, S. E., & Neal, M. J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752409.x · Cited by 100 · see citing works
Major biological actions of CCK - a critical evaluation of research findings
Fink, H., Rex, A., Voits, M., & Voigt, J. (1998) · Experimental Brain Research · doi:10.1007/s002210050546 · Cited by 88 · see citing works
Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat
Harro, J., & Vasar, E. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90156-k · Cited by 86 · see citing works
TC‐5214 (S‐(+)‐Mecamylamine): A Neuronal Nicotinic Receptor Modulator with Antidepressant Activity
Lippiello, P. M., Beaver, J. S., Gatto, G. J., James, J. W., Green-Jordan, K., Traina, V. M., Xie, J., & Bencherif, M. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00054.x · Cited by 83 · see citing works
Mineur, Y. S., Mose, T. N., Blakeman, S., & Picciotto, M. R. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13769 · Cited by 71 · see citing works
Arnáiz‐Cot, J. J., Gonzalez, J., Sobrado, M., Baldelli, P., Carbone, E., Gandı́a, L., Garcı́a, A. G., & Hernández-Guijo, J. M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06077.x · Cited by 69 · see citing works
Rex, A., Barth, T., Voigt, J., Domeney, A. M., & Fink, H. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90681-5 · Cited by 68 · see citing works
Fear conditioning and extinction in anxiety- and depression-prone persons
Dibbets, P., van den Broek, A., & Evers, E. A. T. (2014) · Memory · doi:10.1080/09658211.2014.886704 · Cited by 65 · see citing works
Tucci, S. A., Genn, R. F., & File, S. E. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00391-x · Cited by 59 · see citing works
Klein, R. C., & Yakel, J. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.118232 · Cited by 51 · see citing works
Modifying quinolone antibiotics yields new anxiolytics
Johnstone, T. B. C., Hogenkamp, D. J., Coyne, L., Su, J., Halliwell, R. F., Tran, M. B., Yoshimura, R. F., Li, W.-Y., Wang, J., & Gee, K. W. (2003) · Nature Medicine · doi:10.1038/nm967 · Cited by 50 · see citing works
Witkin, J. M., Lippa, A., Smith, J. L., Jin, X., Ping, X., Biggerstaff, A., Kivell, B. M., Knutson, D. E., Sharmin, D., Pandey, K. P., et al. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173321 · Cited by 48 · see citing works
Neurobiological investigations into the role of cholecystokinin in panic disorder.
Bradwejn, J. (1993) · PubMed Central · Cited by 47 · see citing works
Quarta, D., Naylor, C. G., Barik, J., Fernandes, C., Wonnacott, S., & Stolerman, I. P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1281-x · Cited by 39 · see citing works
Micale, V., Tamburella, A., Leggio, G. M., Mazzola, C., Volsi, V. L., & Drago, F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.04.003 · Cited by 38 · see citing works
Perkins, A. M., Patrick, F., Wise, T., Meyer, N., Mazibuko, N., Oates, A. E., van der Bijl, A. H. M., Danjou, P., O'Connor, S. M., Doolin, E. E., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01141-5 · Cited by 36 · see citing works
Self-citationNeuronal nicotinic receptor antagonist reduces anxiety-like behavior in mice
Roni, M. A., & Rahman, S. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.09.035 · Cited by 35 · see citing works
Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalized Anxiety Disorder
Wise, T., Patrick, F., Meyer, N., Mazibuko, N., Oates, A. E., van der Bijl, A. H. M., Danjou, P., O'Connor, S. M., Doolin, E. E., Wooldridge, C., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.013 · Cited by 31 · see citing works
Self-citationGriebel, G., Perrault, G., & Sanger, D. J. (1997) · Psychopharmacology · doi:10.1007/s002130050282 · Cited by 30 · see citing works
Zhang, Y., Wang, K., & Yu, Z. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01304 · Cited by 29 · see citing works
Anxiolytic effects of mecamylamine in two animal models of anxiety.
Newman, M. B., Manresa, J. J., Sanberg, P. R., & Shytle, R. D. (2002) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.10.1.18 · Cited by 24 · see citing works
Evidence for a dissociation between benzodiazepine withdrawal signs
Goudie, A. J., Harrison, A. A., & Leathley, M. J. (1993) · Neuroreport · doi:10.1097/00001756-199303000-00017 · Cited by 22 · see citing works
Anxiolytic effects of mecamylamine in two animal models of anxiety.
Newman, M. B., Manresa, J. J., Sanberg, P. R., et al. (2002) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.10.1.18 · Cited by 22 · see citing works
Fernández, A. M. M. M., Molla, H. M., Thomases, D. R., & Tseng, K. Y. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1941-20.2020 · Cited by 20 · see citing works
Wang, X., Daley, C., Gakhar, V., Lange, H. S., Vardigan, J. D., Pearson, M. S., Zhou, X., Warren, L., Miller, C. O., Belden, M., et al. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.263483 · Cited by 19 · see citing works
Self-citationRole of noradrenergic arousal for fear extinction processes in rodents and humans
Bierwirth, P., & Stockhorst, U. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107660 · Cited by 19 · see citing works
Kutlu, M. G., Holliday, E. D., & Gould, T. J. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.021 · Cited by 18 · see citing works
Terry, A. V., & Decker, M. W. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.010 · Cited by 7 · see citing works
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ANXIOLYTICS: Origins, drug discovery, and mechanisms
Witkin, J. M., & Barrett, J. E. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173858 · Cited by 12 · see citing works
α7 nicotinic acetylcholine receptor and depression: Mechanistic insights and therapeutic prospects
Wang, C., Gan, D., Hong, Z., Feng, H., Wu, Y., Xu, G., Xun, T., & Yang, X. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107122 · Cited by 8 · see citing works
Papapetropoulos, S., Doolin, E. E., Odontiadis, M., Paul, D., Jaros, M. J., Rolan, P. E., Taylor, C. T., & Stein, M. B. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116387 · Cited by 7 · see citing works
Self-citationBNC210, an α7 Nicotinic Receptor Modulator, in Post-Traumatic Stress Disorder
Papapetropoulos, S., Doolin, E., O’Connor, S., Paul, D., Odontiadis, M., Jaros, M., Rolan, P., & Stein, M. B. (2025) · NEJM Evidence · doi:10.1056/evidoa2400380 · Cited by 5 · see citing works
Self-citationAnderson, K., Cao, W., Lee, H. S., Crenshaw, M. A., Palumbo, T. B., Fisher-Perez, E., DeGraaf, A., Rogu, P., Beatty, M. A., Gracias, G. M., et al. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1347543 · Cited by 4 · see citing works
Rolan, P., Doolin, E., Paul, D., Crossman, J., Odontiadis, M., Danjou, P., Smith, M., & Papapetropoulos, S. (2026) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.1609 · Cited by 3 · see citing works
Self-citationBarilone, N., Vangelatou, M., Marouf, F. Z., de la Bâtie, G. D., Li, Q., Lafaye, P. J., Aymé, G., Corringer, P., & Prevost, M. S. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2514734123 · Cited by 3 · see citing works
Tae, H., Ortells, M. O., Ciocarlan, A. G., Aricu, A. N., Lungu, L., Blaja, S., Adams, D. J., & Arias, H. R. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00862 · Cited by 1 · see citing works
Towards Mechanism‐Informed Treatments for Mental Health
de Tena, I. B., Sallie, F. N., Abiero, A., Rizzi, B., Champarini, L. G., Corti, E., Masella, G., Dunn, A. L., Binder, L. B., Wenzel, T. J., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70477 · Cited by 1 · see citing works
Tae, H., Ortells, M. O., Targowska‐Duda, K. M., Manetti, D., Romanelli, M. N., Adams, D. J., & Arias, H. R. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117463
Molecular mechanisms of nicotinic acetylcholine receptors in mood dysregulation
Murthy, M. K., & Samal, D. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111880
Wang, C., Li, R., Wu, Y., Hong, Z., Huang, S., Ye, Y., Tang, W., Yang, X., & Gan, D. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111177
Marmouzi, I., Davis, R. L., & Arias, H. R. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag106
Kalinovskii, A. P., Osmakov, D. I., Logashina, Y. A., Andreev, Y. A., & Трухан, В. М. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18111397
- Authors
- O'Connor, S. M., Sleebs, B. E., Street, I. P., Flynn, B. L., Baell, J. B., Coles, C., Quazi, N., Paul, D., Poiraud, E., Huyard, B., Wagner, S., Andriambeloson, E., & de Souza, E. B.
- Affiliations
- Bionomics (Australia) (AU)
- The University of Melbourne (AU)
- Monash University (AU)
- Ningbo University (CN)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Corresponding author
- O'Connor, Susan M.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 246
- Pages
- 109836
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W4390629846
- Cited by
- 15
- References
- 64
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuropharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- alpha7 nicotinic acetylcholine receptor, negative allosteric modulators, anxiolytic effects, antidepressant-like effects, anxiety-like behavior, stress-related disorders, sedation, ligand-gated ion channels, Cys-loop receptors, receptor selectivity, adverse effects
- MeSH terms
- Allosteric Regulation, Animals, Antidepressive Agents, Humans, Hypnotics and Sedatives, Male, Receptors, Nicotinic, Rodentia, Anti-Anxiety Agents, Mice, Rats, alpha7 Nicotinic Acetylcholine Receptor
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