Noradrenergic genotype predicts lapses in sustained attention

Greene, Ciara M.; Bellgrove, Mark A.; Gill, Michael; Robertson, Ian H.

doi:10.1016/j.neuropsychologia.2008.10.003

Cited by 86Neurotransmitter Receptor Influence on BehaviorMind wandering and attentionSleep and Work-Related Fatigue

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Noradrenergic genotype predicts lapses in sustained attention

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Greene, Ciara M., Bellgrove, Mark A., Gill, Michael, Robertson, Ian H.·2009·Neuropsychologia

DOI 10.1016/j.neuropsychologia.2008.10.003

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Abstract

Sustained attention is modulated by the neurotransmitter noradrenaline. The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. The principal variant in this gene is a C/T change at position -1021, and the T allele at this locus is hypothesised to result in a slower rate of dopamine to noradrenaline conversion than the C allele. Two hundred participants who were genotyped for the DBH C-1021T marker performed the Sustained Attention to Response Task (SART). DBH genotype was found to significantly predict performance; participants with more copies of the T allele made more errors of commission, indicative of lapses in sustained attention. A significant negative correlation was also observed for all participants between errors of commission and mean reaction time. The decrease in noradrenaline occasioned by the T allele may impair sustained attention by reducing participants' ability to remain alert throughout the task and by increasing their susceptibility to distractors.

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In humans, lower activity of dopamine β-hydroxylase is associated with poor sustained attention, poor executive function, and impulsiveness.
“In humans, lower activity of dopamine β-hydroxylase, the enzyme that synthesizes NE, is associated with poor sustained attention (Greene et al., 2009), poor executive function (Kieling et al., 2008), and impulsiveness (Hess et al., 2009)”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Greene et al., 2009

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Authors: Greene, C. M., Bellgrove, M. A., Gill, M., & Robertson, I. H.
Affiliations: Trinity College Dublin (IE)
The University of Queensland (AU)
Corresponding author: Greene, Ciara M.
ORCID: Greene, Ciara M.
Bellgrove, Mark A.
Gill, Michael
Robertson, Ian H.
Venue: Neuropsychologia
Publisher: Elsevier BV
Published: 2009-01
Volume: 47
Issue: 2
Pages: 591-594
ISSN: 0028-3932 (ISSN-L)
DOI: 10.1016/j.neuropsychologia.2008.10.003
OpenAlex: W2031637761
Cited by: 86
References: 49
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 9 · 2015: 2 · 2014: 7 · 2013: 18 · 2012: 8
FWCI: 3.01
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropsychologia (publishedVersion)
PubMed (publishedVersion)
Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (acceptedVersion)
Research Repository UCD (University College Dublin) (submittedVersion, cc-by-nc-nd)
Arrow@dit (Dublin Institute of Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: sustained attention, norepinephrine, DBH gene, dopamine, genetic polymorphism, attentional lapses, commission errors, reaction time, Sustained Attention to Response Task
MeSH terms: Adolescent, Adult, Alleles, Attention, Dopamine beta-Hydroxylase, Female, Genotype, Humans, Kinetics, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Norepinephrine, Psychomotor Performance, Reaction Time, Regression Analysis, Prefrontal Cortex, Young Adult

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Noradrenergic genotype predicts lapses in sustained attention

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