The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders
Open accessAbstract
Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities. To further explore the neural basis of abnormal emotional face processing in ASD, we conducted an fMRI study of emotional face matching in high-functioning adults with ASD and age, IQ, and gender matched controls. In addition, we investigated whether there was a relationship between self-reported social anxiety and fMRI activation. During fMRI scanning, study participants were instructed to match facial expressions depicting fear or anger. The control condition was a comparable shape-matching task. The control group evidenced significantly increased left prefrontal activation and decreased activation in the occipital lobes compared to the ASD group during emotional face matching. Further, within the ASD group, greater social anxiety was associated with increased activation in right amygdala and left middle temporal gyrus, and decreased activation in the fusiform face area. These results indicate that level of social anxiety mediates the neural response to emotional face perception in ASD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“and aspects of these differences have been associated with anxiety symptom severity [69,70].”
From Functional autonomic nervous system profile in children with autism spectrum disorder (2014) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345
Measurement of social-evaluative anxiety.
Watson, D., & Friend, R. (1969) · Journal of Consulting and Clinical Psychology · doi:10.1037/h0027806 · Cited by 3,467
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083
Gaze fixation and the neural circuitry of face processing in autism
Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., Alexander, A. L., & Davidson, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1421 · Cited by 1,543
Anxiety in children and adolescents with autism spectrum disorders
White, S. W., Oswald, D., Ollendick, T., & Scahill, L. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.01.003 · Cited by 1,427
Modulating emotional responses: effects of a neocortical network on the limbic system
Hariri, A. R., Bookheimer, S. Y., & Mazziotta, J. C. (2000) · NeuroReport · doi:10.1097/00001756-200001170-00009 · Cited by 1,277
Baron-Cohen, S., Ring, H. A., Bullmore, E. T., Wheelwright, S., Ashwin, C., & Williams, S. C. R. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00011-7 · Cited by 1,130
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071
Dawson, G., Webb, S. J., & McPartland, J. (2005) · Developmental Neuropsychology · doi:10.1207/s15326942dn2703_6 · Cited by 989
Self-citationJohnson, M. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1766 · Cited by 969
Courchesne, E., & Pierce, K. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.03.001 · Cited by 968
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846
The functional neuroanatomy of social behaviour
Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C. R., Van Amelsvoort, T., Robertson, D. M., Rowe, A., Phillips, M., McAlonan, G., Howlin, P., et al. (2000) · Brain · doi:10.1093/brain/123.11.2203 · Cited by 816
Functional connectivity in an fMRI working memory task in high-functioning autism
Koshino, H., Carpenter, P. A., Minshew, N. J., Cherkassky, V. L., Keller, T. A., & Just, M. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.09.028 · Cited by 614
Abnormal functional connectivity in autism spectrum disorders during face processing
Kleinhans, N. M., Richards, T., Sterling, L., Stegbauer, K. C., Mahurin, R., Johnson, L. C., Greenson, J., Dawson, G., & Aylward, E. (2008) · Brain · doi:10.1093/brain/awm334 · Cited by 498
Self-citationThe brain response to personally familiar faces in autism: Findings of fusiform activity and beyond
Pierce, K. (2004) · Brain · doi:10.1093/brain/awh289 · Cited by 432
Ashwin, C., Baron‐Cohen, S., Wheelwright, S. J., O’Riordan, M., & Bullmore, E. T. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.014 · Cited by 382
Wang, A. T., Dapretto, M., Hariri, A. R., Sigman, M., & Bookheimer, S. Y. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200404000-00015 · Cited by 372
Impaired recognition of negative basic emotions in autism: A test of the amygdala theory
Ashwin, C., Chapman, E., Colle, L., & Baron‐Cohen, S. (2006) · Social Neuroscience · doi:10.1080/17470910601040772 · Cited by 356
Activation of the fusiform gyrus when individuals with autism spectrum disorder view faces
Hadjikhani, N. K., Joseph, R. M., Snyder, J., Chabris, C. F., Clark, J., Steele, S. D., McGrath, L. M., Vangel, M. G., Aharon, I., Feczko, E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.025 · Cited by 346
Abnormal activation of the social brain during face perception in autism
Hadjikhani, N. K., Joseph, R. M., Snyder, J., & Tager-Flusberg, H. B. (2006) · Human Brain Mapping · doi:10.1002/hbm.20283 · Cited by 317
Perception of dynamic changes in facial affect and identity in autism
Pelphrey, K. A., Morris, J. P., McCarthy, G., & LaBar, K. S. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm010 · Cited by 285
Functional imbalance of visual pathways indicates alternative face processing strategies in autism
Hubl, D., Bölte, S., Feineis–Matthews, S., Lanfermann, H., Federspiel, A., Strik, W., Poustka, F., & Dierks, T. (2003) · Neurology · doi:10.1212/01.wnl.0000091862.22033.1a · Cited by 283
Delayed maturation of the frontal cortex in childhood autism
Zilbovicius, M., Garreau, B., Samson, Y., Rémy, P., Barthélémy, C., Syrota, A., & Lelord, G. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.248 · Cited by 275
Functional anatomy of impaired selective attention and compensatory processing in autism
Belmonte, M. K., & Yurgelun-Todd, D. A. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00189-7 · Cited by 266
Sterling, L., Dawson, G., Estes, A., & Greenson, J. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0477-y · Cited by 263
Self-citationReduced Neural Habituation in the Amygdala and Social Impairments in Autism Spectrum Disorders
Kleinhans, N. M., Johnson, L. C., Richards, T., Mahurin, R., Greenson, J., Dawson, G., & Aylward, E. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101681 · Cited by 255
Self-citationCommon and Distinct Amygdala-Function Perturbations in Depressed vs Anxious Adolescents
Beesdo, K., Lau, J. Y. F., Guyer, A. E., McClure-Tone, E. B., Monk, C. S., Nelson, E. E., Fromm, S. J., Goldwin, M. A., Wittchen, H.-U., Leibenluft, E., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.545 · Cited by 250
Neural circuitry of emotional face processing in autism spectrum disorders
Monk, C. S., Weng, S.-J., Wiggins, J. L., Kurapati, N. T., Louro, H. M. C., Carrasco, M., Maslowsky, J., Risi, S., & Lord, C. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090085 · Cited by 239
Piggot, J., Kwon, H., Mobbs, D., Blasey, C., Lotspeich, L., Menon, V., Bookheimer, S., & Reiss, A. L. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200404000-00014 · Cited by 201
Fusiform function in children with an Autism Spectrum Disorder is a matter of ‘who’
Pierce, K., & Redcay, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.013 · Cited by 196
Müller, R.-A., Kleinhans, N. M., Kemmotsu, N., Pierce, K., & Courchesne, E. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1847 · Cited by 181
Self-citationGaffrey, M. S., Kleinhans, N. M., Haist, F., Akshoomoff, N. A., Campbell, A., Courchesne, E., & Müller, R.-A. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.01.008 · Cited by 149
Self-citationBookheimer, S. Y., Wang, A. T., Scott, A., Sigman, M., & Dapretto, M. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770808140x · Cited by 136
Mazefsky, C. A., Folstein, S. E., & Lainhart, J. E. (2008) · Autism Research · doi:10.1002/aur.23 · Cited by 97
Experimental manipulation of face-evoked activity in the fusiform gyrus of individuals with autism
Perlman, S. B., Hudac, C. M., Pegors, T. K., Minshew, N. J., & Pelphrey, K. A. (2010) · Social Neuroscience · doi:10.1080/17470911003683185 · Cited by 87
Pujol, J., Harrison, B. J., Ortiz, H., Deus, J., Soriano‐Mas, C., López‐Solà, M., Yücel, M., Perich, X., & Cardoner, N. (2009) · Psychological Medicine · doi:10.1017/s003329170800500x · Cited by 78
Kleinhans, N. M., Schweinsburg, B. C., Cohen, D. N., Müller, R.-A., & Courchesne, E. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.081 · Cited by 59
Self-citationControlled scanpath variation alters fusiform face activation
Morris, J. P., Pelphrey, K. A., & McCarthy, G. (2006) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsl023 · Cited by 42
Research works printed but not linked: 1
- Morris, 2007, Vol. 2
Cited by
Sorted by citations
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473
The Role of Emotion Regulation in Autism Spectrum Disorder
Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.006 · Cited by 881
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393
White, S. W., Ollendick, T. H., Albano, A. M., Oswald, D. P., Johnson, C. R., Southam‐Gerow, M. A., Kim, I., & Scahill, L. D. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1577-x · Cited by 331
Annual research review: re-thinking the classification of autism spectrum disorders
Lord, C., & Jones, R. M. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02547.x · Cited by 290
Metadata
- Authors
- Kleinhans, N. M., Richards, T., Weaver, K., Johnson, L. C., Greenson, J., Dawson, G., & Aylward, E.
- Affiliations
- University of Washington (US)
- Corresponding author
- Kleinhans, Natalia M.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 48
- Issue
- 12
- Pages
- 3665-3670
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3426451
- OpenAlex
- W1994847860
- Cited by
- 187
- References
- 43
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 10 · 2018: 12 · 2017: 15 · 2016: 14 · 2015: 15 · 2014: 20 · 2013: 21 · 2012: 15
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NICHD (U19HD34565, P30HD002274)
- NIMH (U54MH066399)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Keywords
- autism spectrum disorder, social anxiety, amygdala, emotional face processing, facial expression recognition, fear and anger, fusiform face area, middle temporal gyrus, prefrontal cortex, high-functioning adults, neural correlates of emotion
- MeSH terms
- Adolescent, Adult, Amygdala, Anxiety, Brain Mapping, Child, Child Development Disorders, Pervasive, Emotions, Face, Facial Expression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Social Perception, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
