Functional imbalance of visual pathways indicates alternative face processing strategies in autism
Abstract
OBJECTIVE: To investigate whether autistic subjects show a different pattern of neural activity than healthy individuals during processing of faces and complex patterns. METHODS: Blood oxygen level-dependent (BOLD) signal changes accompanying visual processing of faces and complex patterns were analyzed in an autistic group (n = 7; 25.3 [6.9] years) and a control group (n = 7; 27.7 [7.8] years). RESULTS: Compared with unaffected subjects, autistic subjects demonstrated lower BOLD signals in the fusiform gyrus, most prominently during face processing, and higher signals in the more object-related medial occipital gyrus. Further signal increases in autistic subjects vs controls were found in regions highly important for visual search: the superior parietal lobule and the medial frontal gyrus, where the frontal eye fields are located. CONCLUSIONS: The cortical activation pattern during face processing indicates deficits in the face-specific regions, with higher activations in regions involved in visual search. These findings reflect different strategies for visual processing, supporting models that propose a predisposition to local rather than global modes of information processing in autism.
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Numerous imaging studies show reduced activation in the fusiform face area in individuals with autism spectrum disorder.
“numerous imaging studies have shown reduced activation in the fusiform face area (FFA) in individuals with ASD (Corbett et al., 2009; Hubl et al., 2003; Pierce et al., 2001)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Hubl et al., 2003
Cites
The fusiform face area: a module in human extrastriate cortex specialized for face perception
Kanwisher, N., McDermott, J., & Chun, M. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04302.1997 · Cited by 7,738 · see citing works
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345 · see citing works
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202 · see citing works
Linguistic complexity: locality of syntactic dependencies
Gibson, E. (1998) · Cognition · doi:10.1016/s0010-0277(98)00034-1 · Cited by 2,537 · see citing works
Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex.
Malach, R., Reppas, J. B., Benson, R. R., Kwong, K. K., Jiang, H., Kennedy, W. A., Ledden, P. J., Brady, T. J., Rosen, B. R., & Tootell, R. B. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8135 · Cited by 1,761 · see citing works
Expertise for cars and birds recruits brain areas involved in face recognition
Gauthier, I., Skudlarski, P., Gore, J. C., & Anderson, A. W. (2000) · Nature Neuroscience · doi:10.1038/72140 · Cited by 1,418 · see citing works
Schultz, R. T., Gauthier, I., Klin, A., Fulbright, R. K., Anderson, A. W., Volkmar, F., Skudlarski, P., Lacadie, C., Cohen, D. J., & Gore, J. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.331 · Cited by 1,000 · see citing works
Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI
Pierce, K. (2001) · Brain · doi:10.1093/brain/124.10.2059 · Cited by 898 · see citing works
The fusiform “face area” is part of a network that processes faces at the individual level
Gauthier, I., Tarr, M. J., Moylan, J., Skudlarski, P., Gore, J. C., & Anderson, A. W. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900562165 · Cited by 859 · see citing works
The functional neuroanatomy of social behaviour
Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C. R., Van Amelsvoort, T., Robertson, D. M., Rowe, A., Phillips, M., McAlonan, G., Howlin, P., et al. (2000) · Brain · doi:10.1093/brain/123.11.2203 · Cited by 816 · see citing works
Activation of Heschl’s Gyrus during Auditory Hallucinations
Dierks, T., Linden, D. E. J., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H., & Singer, W. (1999) · Neuron · doi:10.1016/s0896-6273(00)80715-1 · Cited by 752 · see citing works
Self-citationLocation and function of the human frontal eye-field: A selective review
Paus, T. (1996) · Neuropsychologia · doi:10.1016/0028-3932(95)00134-4 · Cited by 746 · see citing works
The Effect of Face Inversion on Activity in Human Neural Systems for Face and Object Perception
Haxby, J. V., Ungerleider, L. G., Clark, V. P., Schouten, J. L., Hoffman, E. A., & Martin, A. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80690-x · Cited by 657 · see citing works
FFA: a flexible fusiform area for subordinate-level visual processing automatized by expertise
Tarr, M. J., & Gauthier, L. (2000) · Nature Neuroscience · doi:10.1038/77666 · Cited by 645 · see citing works
Superior visual search in autism.
O'riordan, M., Plaisted, K., Driver, J., & Baron-Cohen, S. (2001) · Journal of Experimental Psychology: Human Perception and Performance · doi:10.1037/0096-1523.27.3.719 · Cited by 624 · see citing works
Distributed Neural Systems for the Generation of Visual Images
Ishai, A., Ungerleider, L. G., & Haxby, J. V. (2000) · Neuron · doi:10.1016/s0896-6273(00)00168-9 · Cited by 579 · see citing works
Superior visual search in autism.
O’Riordan, M., Plaisted, K. C., Driver, J., & Baron‐Cohen, S. (2001) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.27.3.719 · Cited by 557 · see citing works
The Generality of Parietal Involvement in Visual Attention
Wojciulik, E., & Kanwisher, N. (1999) · Neuron · doi:10.1016/s0896-6273(01)80033-7 · Cited by 537 · see citing works
Face encoding and recognition in the human brain.
Haxby, J. V., Ungerleider, L. G., Horwitz, B., Maisog, J. M., Rapoport, S. I., & Grady, C. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.922 · Cited by 508 · see citing works
What's in a face? The case of autism
Hobson, R. P., Ouston, J., & Lee, A. L. (1988) · British Journal of Psychology · doi:10.1111/j.2044-8295.1988.tb02745.x · Cited by 452 · see citing works
The effect of face inversion on the human fusiform face area
Kanwisher, N., Tong, F., & Nakayama, K. (1998) · Cognition · doi:10.1016/s0010-0277(98)00035-3 · Cited by 434 · see citing works
Unraveling mechanisms for expert object recognition: Bridging brain activity and behavior.
Gauthier, L., & Tarr, M. J. (2002) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.28.2.431 · Cited by 424 · see citing works
Penny, W. D., & Holmes, A. J. (2007) · Elsevier eBooks · doi:10.1016/b978-012372560-8/50012-7 · Cited by 406 · see citing works
Unfamiliar Face Recognition in Relatively Able Autistic Children
Boucher, J., & LEWIS, V. A. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb01960.x · Cited by 363 · see citing works
Image-based object recognition in man, monkey and machine
Tarr, M. J., & Bülthoff, H. (1998) · Cognition · doi:10.1016/s0010-0277(98)00026-2 · Cited by 328 · see citing works
Explicit and Incidental Facial Expression Processing: An fMRI Study
Gorno‐Tempini, M. L., Pradelli, S., Serafini, M., Pagnoni, G., Baraldi, P., Porro, C. A., Nicoletti, R., Umità, C., & Nichelli, P. (2001) · NeuroImage · doi:10.1006/nimg.2001.0811 · Cited by 313 · see citing works
Cerebral correlates of preserved cognitive skills in autism
RING, H. A., Baron‐Cohen, S., Wheelwright, S. J., Williams, S., Brammer, M. J., Andrew, C., & Bullmore, E. T. (1999) · Brain · doi:10.1093/brain/122.7.1305 · Cited by 306 · see citing works
Unraveling mechanisms for expert object recognition: Bridging brain activity and behavior.
Gauthier, L., & Tarr, M. J. (2002) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/0096-1523.28.2.431 · Cited by 302 · see citing works
Graded Functional Activation in the Visuospatial System with the Amount of Task Demand
Carpenter, P. A., Just, M. A., Keller, T. A., Eddy, W., & Thulborn, K. R. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563210 · Cited by 295 · see citing works
Enhanced discrimination in autism
O’Riordan, M., & Plaisted, K. C. (2001) · The Quarterly Journal of Experimental Psychology Section A · doi:10.1080/713756000 · Cited by 231 · see citing works
Do children with autism recognise surprise? A research note
Baron‐Cohen, S., Spitz, A., & Cross, P. (1993) · Cognition & Emotion · doi:10.1080/02699939308409202 · Cited by 208 · see citing works
Functional Imaging of Visuospatial Processing in Alzheimer's Disease
Prvulovic, D., Hubl, D., Sack, A. T., Melillo, L., Maurer, K., Frölich, L., Lanfermann, H., Zanella, F., Goebel, R., Linden, D. E. J., et al. (2002) · NeuroImage · doi:10.1006/nimg.2002.1271 · Cited by 200 · see citing works
Self-citationSamochowiec, J., Lesch, K., Rottmann, M., Smolka, M. N., Syagailo, Y. V., Okladnova, O., Rommelspacher, H., Winterer, G., Schmidt, L. G., & Sander, T. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00020-7 · Cited by 190 · see citing works
Gitelman, D. R., Parrish, T. B., Friston, K. J., & Mesulam, M. M. (2002) · NeuroImage · doi:10.1006/nimg.2001.1006 · Cited by 135 · see citing works
An Investigation of Attention and Affect in Children with Autism and Down Syndrome
Joseph, R. M., & Tager-Flusberg, H. B. (1997) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025853321118 · Cited by 129 · see citing works
Direct comparison of the neural substrates of recognition memory for words and faces
Kim, J., Andreasen, N. C., OʼLeary, D. S., Wiser, A. K., Ponto, L. L. B., Watkins, G. L., & Hichwa, R. D. (1999) · Brain · doi:10.1093/brain/122.6.1069 · Cited by 115 · see citing works
Differential activation in parahippocampal and prefrontal cortex during word and face encoding tasks
Leube, D., Erb, M., Grodd, W., Bartels, M., & Kircher, T. T. J. (2001) · Neuroreport · doi:10.1097/00001756-200108280-00035 · Cited by 70 · see citing works
Poustka, F., Lisch, S., Rühl, D., Sacher, A., Schmötzer, G., & Werner, K. (2010) · Psychopathology · doi:10.1159/000284984 · Cited by 70 · see citing works
Self-citationGitelman, D. R., Parrish, T. B., LaBar, K. S., & Mesulam, M. M. (2000) · NeuroImage · doi:10.1006/nimg.1999.0517 · Cited by 65 · see citing works
Dierks, T., Linden, D. E. J., Hertel, A., Günther, T., Lanfermann, H., Niesen, A., Frölich, L., Zanella, F. E., Hör, G., Goebel, R., et al. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00040-7 · Cited by 45 · see citing works
Self-citationMagnetic Resonance Imaging of Human Brain Function
Bandettini, P. A., & Wong, E. C. (1997) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(18)30309-7 · Cited by 44 · see citing works
Bölte, S., & Poustka, F. (2001) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024//1422-4917.29.3.221 · Cited by 39 · see citing works
Self-citationActivation of Broca's area by syntactic processing under conditions of concurrent articulation
Caplan, D., Alpert, N., Waters, G., & Olivieri, A. (2000) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(200002)9:2
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Sorted by citations
Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception
Mottron, L., Dawson, M., Soulières, I., Hubert, B., & Burack, J. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0040-7 · Cited by 1,957 · see citing works
Blair, R. J. R. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2005.06.004 · Cited by 1,365 · see citing works
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071 · see citing works
Harms, M. B., Martin, A., & Wallace, G. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9138-6 · Cited by 1,028 · see citing works
Vision in autism spectrum disorders
Simmons, D. R., Robertson, A. E., McKay, L. S., Toal, E., McAleer, P., & Pollick, F. E. (2009) · Vision Research · doi:10.1016/j.visres.2009.08.005 · Cited by 827 · see citing works
Martino, A. D., Ross, K. V., Uddin, L. Q., Sklar, A. B., Castellanos, F. X., & Milham, M. P. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.022 · Cited by 574 · see citing works
Bertone, A., Mottron, L., Jelenic, P., & Faubert, J. (2005) · Brain · doi:10.1093/brain/awh561 · Cited by 536 · see citing works
The Intense World Theory – A Unifying Theory of the Neurobiology of Autism
Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 522 · see citing works
Abnormal functional connectivity in autism spectrum disorders during face processing
Kleinhans, N. M., Richards, T., Sterling, L., Stegbauer, K. C., Mahurin, R., Johnson, L. C., Greenson, J., Dawson, G., & Aylward, E. (2008) · Brain · doi:10.1093/brain/awm334 · Cited by 498 · see citing works
Seeing it differently: visual processing in autism
BEHRMANN, M., THOMAS, C., & HUMPHREYS, K. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.05.001 · Cited by 469 · see citing works
Koshino, H., Kana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., & Just, M. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm054 · Cited by 436 · see citing works
The brain response to personally familiar faces in autism: Findings of fusiform activity and beyond
Pierce, K. (2004) · Brain · doi:10.1093/brain/awh289 · Cited by 432 · see citing works
The anterior insula in autism: Under-connected and under-examined
Uddin, L. Q., & Menon, V. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.002 · Cited by 424 · see citing works
The intense world syndrome-an alternative hypothesis for autism
Markram, H. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.006.2007 · Cited by 394 · see citing works
A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders
Philip, R. C. M., Dauvermann, M. R., Whalley, H. C., Baynham, K., Lawrie, S. M., & Stanfield, A. C. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.008 · Cited by 390 · see citing works
Autism, the superior temporal sulcus and social perception
Zilbovicius, M., Meresse, I., Chabane, N., Brunelle, F., Samson, Y., & Boddaert, N. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.06.004 · Cited by 392 · see citing works
Ashwin, C., Baron‐Cohen, S., Wheelwright, S. J., O’Riordan, M., & Bullmore, E. T. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.014 · Cited by 382 · see citing works
Child and adolescent development : an advanced course
Damon, W., & Lerner, R. M. (2008) · Wiley eBooks · Cited by 385 · see citing works
Baum, S. H., Stevenson, R. A., & Wallace, M. T. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.007 · Cited by 370 · see citing works
Oberman, L. M., Ramachandran, V. S., & Pineda, J. A. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.01.010 · Cited by 376 · see citing works
Enhanced visual functioning in autism: An ALE meta-analysis
Samson, F., Mottron, L., Soulières, I., & Zeffiro, T. A. (2012) · Human Brain Mapping · doi:10.1002/hbm.21307 · Cited by 351 · see citing works
AUTISM: A Window Onto the Development of the Social and the Analytic Brain
Baron‐Cohen, S., & Belmonte, M. K. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144137 · Cited by 342 · see citing works
Configural processing in autism and its relationship to face processing
Behrmann, M., Avidan, G., Leonard, G. L., Kimchi, R., Luna, B., Humphreys, K., & Minshew, N. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2005.04.002 · Cited by 334 · see citing works
Konrad, K., Neufang, S., Hanisch, C., Fink, G. R., & Herpertz-Dahlmann, B. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.013 · Cited by 335 · see citing works
Impairments in facial affect recognition associated with autism spectrum disorders: A meta-analysis
Lozier, L. M., VanMeter, J. W., & Marsh, A. A. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000479 · Cited by 299 · see citing works
Zucker, N. L., Losh, M., Bulik, C. M., LaBar, K. S., Piven, J., & Pelphrey, K. A. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.6.976 · Cited by 284 · see citing works
Perception of dynamic changes in facial affect and identity in autism
Pelphrey, K. A., Morris, J. P., McCarthy, G., & LaBar, K. S. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm010 · Cited by 267 · see citing works
Banaschewski, T., & Brandeis, D. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01681.x · Cited by 266 · see citing works
Neurons in the fusiform gyrus are fewer and smaller in autism
van Kooten, I. A. J., Palmen, S. J. M. C., von Cappeln, P., Steinbusch, H. W. M., Korr, H., Heinsen, H., Hof, P. R., van Engeland, H., & Schmitz, C. (2008) · Brain · doi:10.1093/brain/awn033 · Cited by 263 · see citing works
Reduced Neural Habituation in the Amygdala and Social Impairments in Autism Spectrum Disorders
Kleinhans, N. M., Johnson, L. C., Richards, T., Mahurin, R., Greenson, J., Dawson, G., & Aylward, E. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101681 · Cited by 255 · see citing works
Grelotti, D. J., Klin, A. J., Gauthier, I., Skudlarski, P., Cohen, D. J., Gore, J. C., Volkmar, F. R., & Schultz, R. T. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.06.015 · Cited by 254 · see citing works
Impaired face processing in autism: Fact or artifact?
Jemel, B., Mottron, L., & Dawson, M. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0050-5 · Cited by 246 · see citing works
Neuroanatomical substrates of social cognition dysfunction in autism.
Pelphrey, K., Adolphs, R., & Morris, J. P. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20040 · Cited by 233 · see citing works
The autistic brain: birth through adulthood
Courchesne, E., Redcay, E., & Kennedy, D. P. (2004) · Current Opinion in Neurology · doi:10.1097/01.wco.0000137542.14610.b4 · Cited by 228 · see citing works
Wang, A. T., Lee, S. S., Sigman, M., & Dapretto, M. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.6.698 · Cited by 227 · see citing works
Functional magnetic resonance imaging of autism spectrum disorders
Dichter, G. S. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/gdichter · Cited by 215 · see citing works
Enhanced visual processing contributes to matrix reasoning in autism
Soulières, I., Dawson, M., Samson, F., Barbeau, É. B., Sahyoun, C. P., Strangman, G. E., Zeffiro, T. A., & Mottron, L. (2009) · Human Brain Mapping · doi:10.1002/hbm.20831 · Cited by 216 · see citing works
Functional imaging of working memory in obstructive sleep-disordered breathing
THOMAS, R. J., Rosen, B. R., Stern, C. E., Weiss, J. W., & Kwong, K. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01225.2004 · Cited by 209 · see citing works
Structural and functional magnetic resonance imaging of autism spectrum disorders
Stigler, K. A., McDonald, B. C., Anand, A., Saykin, A. J., & McDougle, C. J. (2011) · Brain Research · doi:10.1016/j.brainres.2010.11.076 · Cited by 197 · see citing works
Fusiform function in children with an Autism Spectrum Disorder is a matter of ‘who’
Pierce, K., & Redcay, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.013 · Cited by 196 · see citing works
The study of autism as a distributed disorder
Müller, R. (2007) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20141 · Cited by 194 · see citing works
COURCHESNE, E., REDCAY, E., MORGAN, J. T., & KENNEDY, D. P. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050285 · Cited by 192 · see citing works
Autism and the development of face processing
Golarai, G., Kalanit Grill-spector, A., & Reiss, A. L. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.08.001 · Cited by 187 · see citing works
Nuske, H. J., Vivanti, G., & Dissanayake, C. (2013) · Cognition & Emotion · doi:10.1080/02699931.2012.762900 · Cited by 189 · see citing works
Kleinhans, N. M., Richards, T., Weaver, K., Johnson, L. C., Greenson, J., Dawson, G., & Aylward, E. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.07.022 · Cited by 187 · see citing works
Facial affect recognition training in autism: Can we animate the fusiform gyrus?
Bölte, S., Hubl, D., Feineis-Matthews, S., Prvulovic, D., Dierks, T., & Poustka, F. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.1.211 · Cited by 182 · see citing works
Self-citationSelective attention and perceptual load in autism spectrum disorder
Remington, A. (2010) · UCL Discovery (University College London) · Cited by 179 · see citing works
Gallese, V., Gernsbacher, M. A., Heyes, C. M., Hickok, G. S., & Iacoboni, M. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611413392 · Cited by 175 · see citing works
Oblak, A. L., Gibbs, T. T., & Blatt, G. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.021 · Cited by 175 · see citing works
Neuroanatomical and neurofunctional markers of social cognition in autism spectrum disorder
Patriquin, M. A., DeRamus, T. P., Libero, L. E., Laird, A. R., & Kana, R. K. (2016) · Human Brain Mapping · doi:10.1002/hbm.23288 · Cited by 179 · see citing works
LAHAIE, A., Mottron, L., Arguin, M., Berthiaume, C., Jemel, B., & Saumier, D. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.1.30 · Cited by 175 · see citing works
fMRI evidence of neural abnormalities in the subcortical face processing system in ASD
Kleinhans, N. M., Richards, T. L., Johnson, L. C., Weaver, K. E., Greenson, J., Dawson, G., & Aylward, E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.07.037 · Cited by 169 · see citing works
Face processing in autism spectrum disorders: From brain regions to brain networks
Nomi, J. S., & Uddin, L. Q. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.03.029 · Cited by 155 · see citing works
The neurophysiological correlates of face processing in adults and children with Asperger’s syndrome
O’Connor, K., Hamm, J. P., & Kirk, I. J. (2005) · Brain and Cognition · doi:10.1016/j.bandc.2005.05.004 · Cited by 151 · see citing works
Rosset, D. B., Rondan, C., Fonséca, D. D., Santos, A., Assouline, B., & Deruelle, C. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0465-2 · Cited by 153 · see citing works
Gaigg, S. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00113 · Cited by 152 · see citing works
Gaffrey, M. S., Kleinhans, N. M., Haist, F., Akshoomoff, N. A., Campbell, A., Courchesne, E., & Müller, R.-A. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.01.008 · Cited by 143 · see citing works
Impaired social brain network for processing dynamic facial expressions in autism spectrum disorders
Sato, W., Toichi, M., Uono, S., & Kochiyama, T. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-99 · Cited by 142 · see citing works
Neural dynamics of autistic behaviors: Cognitive, emotional, and timing substrates.
Grossberg, S., & Seidman, D. (2006) · Psychological Review · doi:10.1037/0033-295x.113.3.483 · Cited by 139 · see citing works
Neural Signatures of Autism Spectrum Disorders: Insights into Brain Network Dynamics
Hernandez, L. M., Rudie, J. D., Green, S. A., Bookheimer, S. Y., & Dapretto, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.172 · Cited by 141 · see citing works
Source Localization of Early Stages of Face Processing
Herrmann, M. J., Ehlis, A., Muehlberger, A., & Fallgatter, A. J. (2005) · Brain Topography · doi:10.1007/s10548-005-0277-7 · Cited by 135 · see citing works
Rutherford, M. D., & McIntosh, D. N. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0151-9 · Cited by 126 · see citing works
The other-race effect for face perception: an event-related potential study
Herrmann, M. J., Schreppel, T., Jäger, D., Koehler, S., Ehlis, A., & Fallgatter, A. J. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0624-9 · Cited by 125 · see citing works
On the Application of Quantitative EEG for Characterizing Autistic Brain: A Systematic Review
Billeci, L., Sicca, F., Maharatna, K., Apicella, F., Narzisi, A., Campatelli, G., Calderoni, S., Pioggia, G., & Muratori, F. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00442 · Cited by 123 · see citing works
Amatachaya, A., Auvichayapat, N., Patjanasoontorn, N., Suphakunpinyo, C., Ngernyam, N., Aree-uea, B., Keeratitanont, K., & Auvichayapat, P. (2014) · Behavioural Neurology · doi:10.1155/2014/173073 · Cited by 122 · see citing works
Neurobiological correlates of social functioning in autism
Neuhaus, E., Beauchaine, T. P., & Bernier, R. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.05.007 · Cited by 122 · see citing works
Music: a unique window into the world of autism
Molnar-Szakacs, I., & Heaton, P. F. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06465.x · Cited by 176 · see citing works
Quantitative electroencephalographic profiles for children with autistic spectrum disorder.
Chan, A. S.-Y., Sze, S. L., & Cheung, M. (2007) · Neuropsychology · doi:10.1037/0894-4105.21.1.74 · Cited by 120 · see citing works
Caria, A., Venuti, P., & de Falco, S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr084 · Cited by 118 · see citing works
Conturo, T. E., Williams, D. L., Smith, C. D., Gultepe, E., Akbudak, E., & Minshew, N. J. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617708081381 · Cited by 119 · see citing works
Lightening the load: Perceptual load impairs visual detection in typical adults but not in autism.
Remington, A., Swettenham, J., & Nilli Lavie, C. (2012) · Journal of Abnormal Psychology · doi:10.1037/a0027670 · Cited by 113 · see citing works
The Role of Face Familiarity in Eye Tracking of Faces by Individuals with Autism Spectrum Disorders
Sterling, L., Dawson, G., Webb, S. J., Murias, M., MUNSON, J. A., Panagiotides, H., & Aylward, E. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0550-1 · Cited by 108 · see citing works
Deeley, Q., Daly, E., Surguladze, S., Page, L., Toal, F., Robertson, D., Curran, S. R., Giampietro, V., Seal, M. L., Brammer, M. J., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.037 · Cited by 107 · see citing works
Deruelle, C., Rondan, C., Salle-Collemiche, X., Rosset, D. B., & Fonséca, D. D. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2007.06.001 · Cited by 106 · see citing works
Humphreys, K., Hasson, U., Avidan, G., Minshew, N., & Behrmann, M. (2008) · Autism Research · doi:10.1002/aur.1 · Cited by 104 · see citing works
Kret, M. E., & Ploeger, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.011 · Cited by 115 · see citing works
Multi-voxel pattern analysis of fMRI data predicts clinical symptom severity
Coutanche, M. N., Thompson‐Schill, S. L., & Schultz, R. T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.04.016 · Cited by 102 · see citing works
Neural Bases of Cognitive Development
Nelson, C. A., Thomas, K. M., & de Haan, M. D. H. (2007) · Wiley eBooks · doi:10.1002/9780470147658.chpsy0201 · Cited by 98 · see citing works
Kikuchi, Y., Senju, A., Tojo, Y., Osanai, H., & Hasegawa, T. (2009) · Child Development · doi:10.1111/j.1467-8624.2009.01342.x · Cited by 90 · see citing works
Bara, B. G., Ciaramidaro, A., Walter, H., & Adenzato, M. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00007 · Cited by 92 · see citing works
Scherf, K. S. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00026 · Cited by 91 · see citing works
Differences in discrimination of eye and mouth displacement in autism spectrum disorders
Rutherford, M. D., Clements, K. A., & Sekuler, A. B. (2007) · Vision Research · doi:10.1016/j.visres.2007.01.029 · Cited by 90 · see citing works
Neural bases of atypical emotional face processing in autism: A meta-analysis of fMRI studies
Aoki, Y. Y., Cortese, S., & Tansella, M. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.957719 · Cited by 90 · see citing works
Experimental manipulation of face-evoked activity in the fusiform gyrus of individuals with autism
Perlman, S. B., Hudac, C. M., Pegors, T. K., Minshew, N. J., & Pelphrey, K. A. (2010) · Social Neuroscience · doi:10.1080/17470911003683185 · Cited by 87 · see citing works
Green, S. A., Hernandez, L. M., Bowman, H. C., Bookheimer, S. Y., & Dapretto, M. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.02.005 · Cited by 85 · see citing works
Neural networks related to dysfunctional face processing in autism spectrum disorder
Nickl‐Jockschat, T., Rottschy, C., Thommes, J., Schneider, F. W., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0791-z · Cited by 81 · see citing works
Voxel-based morphometry study on brain structure in children with high-functioning autism
Ke, X., Hong, S., Tang, T., Zou, B., Hui-guo, L., Hang, Y.-Y., Zhou, Z., Ruan, Z., Lu, Z., Tao, G., et al. (2008) · Neuroreport · doi:10.1097/wnr.0b013e328300edf3 · Cited by 79 · see citing works
Oxytocin, sexually dimorphic features of the social brain, and autism
Yamasue, H., Kuwabara, H., Kawakubo, Y., & Kasai, K. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.01944.x · Cited by 78 · see citing works
Guy, M. W., Richards, J. E., Tonnsen, B. L., & Roberts, J. E. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.03.002 · Cited by 76 · see citing works
Altered topology of neural circuits in congenital prosopagnosia
Rosenthal, G., Tanzer, M., Simony, E., Hasson, U., Behrmann, M., & Avidan, G. (2017) · eLife · doi:10.7554/elife.25069 · Cited by 73 · see citing works
Biomarkers for Psychiatric Disorders: Where Are We Standing?
Martins‐de‐Souza, D. (2013) · Disease Markers · doi:10.1155/2013/321071 · Cited by 73 · see citing works
Stroganova, T. A., Orekhova, E. V., Prokofyev, A. O., Tsetlin, M. M., Gratchev, V. V., Morozov, A. A., & Obukhov, Y. V. (2012) · Cortex · doi:10.1016/j.cortex.2011.02.016 · Cited by 71 · see citing works
Pupillometry reveals reduced unconscious emotional reactivity in autism
Nuske, H. J., Vivanti, G., Hudry, K., & Dissanayake, C. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.07.003 · Cited by 72 · see citing works
Understanding autism and related disorders: What has imaging taught us?
Williams, D. L., & Minshew, N. J. (2007) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2007.07.007 · Cited by 71 · see citing works
Social cognition and the superior temporal sulcus: Implications in autism
Saitovitch, A., Bargiacchi, A., Chabane, N., Brunelle, F., Samson, Y., Boddaert, N., & Zilbovicius, M. (2012) · Revue Neurologique · doi:10.1016/j.neurol.2012.07.017 · Cited by 68 · see citing works
An investigation of facial emotion recognition impairments in alexithymia and its neural correlates
Jongen, S., Axmacher, N., Kremers, N. A. W., Hoffmann, H., Limbrecht-Ecklundt, K., Traue, H. C., & Kessler, H. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.069 · Cited by 68 · see citing works
Autism from Developmental and Neuropsychological Perspectives
Sigman, M., Spence, S. J., & Wang, A. T. (2006) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095210 · Cited by 69 · see citing works
Vogan, V. M., Morgan, B. R., Lee, W., Powell, T. L., Smith, M. L., & Taylor, M. J. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-19 · Cited by 70 · see citing works
Di, X., Azeez, A., Li, X., Haque, E., & Biswal, B. B. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.007 · Cited by 68 · see citing works
Eye Movement and Visual Search: Are There Elementary Abnormalities in Autism?
Brenner, L. A., Turner, K. C., & Müller, R. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0277-9 · Cited by 63 · see citing works
- Authors
- Hubl, D., Bölte, S., Feineis–Matthews, S., Lanfermann, H., Federspiel, A., Strik, W., Poustka, F., & Dierks, T.
- Affiliations
- From the Department of Psychiatric Neurophysiology (Drs. Hubl, Federspiel, Strik, and Dierks), University Hospital of Clinical Psychiatry, Bern, Switzerland; and Department of Child and Adolescent Psychiatry (Drs. Bölte and Pousstka, S. Feineis–Matthews) and Institute of Neuroradiology (Dr. Lanfermann), Department of Radiology, University of Frankfurt, Germany.
- Venue
- Neurology
- Published
- 2003-11-11
- Volume
- 61
- Issue
- 9
- Pages
- 1232-1237
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2007787462
- Cited by
- 283
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 14 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 15 · 2013: 19 · 2012: 15
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- autism spectrum disorder, face processing, visual pathway, fusiform gyrus, visual search, frontal eye field, superior parietal lobule, cortical activation
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Autistic Disorder, Behavior, Brain, Brain Mapping, Emotions, Face, Humans, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Photic Stimulation, Visual Pathways
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