The neural correlates of tic inhibition in Gilles de la Tourette syndrome
Abstract
Tics in Gilles de la Tourette syndrome (GTS) resemble fragments of normal motor behaviour but appear in an intrusive, repetitive and context-inappropriate manner. Although tics can be voluntarily inhibited on demand, the neural correlates of this process remain unclear. 14 GTS adults without relevant comorbidities participated in this study. First, tic severity and voluntary tic inhibitory capacity were evaluated outside the scanner. Second, patients were examined with resting state functional magnetic resonance imaging (RS-fMRI) in two states, free ticcing and voluntary tic inhibition. Local synchronization of spontaneous fMRI-signal was analysed with regional homogeneity (ReHo) and differences between both states (free ticcing<tic inhibition) were contrasted. Clinical correlations of the resulting differential ReHo parameters between both states and clinical measures of tic frequency, voluntary tic inhibition and premonitory urges were also performed. ReHo of the left inferior frontal gyrus (IFG) was increased during voluntary tic inhibition compared to free ticcing. ReHo increases were positively correlated with participants׳ ability to inhibit their tics during scanning sessions but also outside the scanner. There was no correlation with ratings of premonitory urges. Voluntary tic inhibition is associated with increased ReHo of the left IFG. Premonitory urges are unrelated to this process.
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In methamphetamine abusers, a specific deficit in inhibiting proponent motor responses during the stop signal task and cognitive inhibition in the Stroop task was observed.
“For example, a specific deficit in inhibiting proponent motor responses during the stop signal task (Mittner et al. 2014) as well as cognitive inhibition in the Stroop task (Lynn et al. 2014; Ganos et al. 2014) was observed in methamphetamine abusers.”
From Large-scale functional neural network correlates of response inhibition: an fMRI meta-analysis (2017) · cites this paper as Ganos et al. 2014
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- Authors
- Ganos, C., Kahl, U., Brandt, V., Schunke, O., Bäumer, T., Thomalla, G., Roessner, V., Haggard, P., Münchau, A., & Kühn, S.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- University of Lübeck (DE)
- Technische Universität Dresden (DE)
- University College London (GB)
- Max Planck Institute for Human Development (DE)
- Corresponding author
- Ganos, Christos
- ORCID
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 65
- Pages
- 297-301
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2017805011
- Cited by
- 97
- References
- 64
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 1
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Tourette syndrome, neural correlates, resting-state functional connectivity, regional homogeneity, tic severity
- MeSH terms
- Adolescent, Adult, Female, Tourette Syndrome, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Middle Aged, Prefrontal Cortex, Tics, Young Adult
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