The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala
Open accessAbstract
Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and peri-nuclear sites in neuronal somata. Their classically known mode of action is to induce gene promoter receptors to alter gene transcription. Nuclear glucocorticoid receptors are particularly dense in brain regions crucial for memory, including memory of stressful experiences, such as the hippocampus and amygdala. While it has been proposed that glucocorticoids may also act via membrane bound receptors, the existence of the latter remains controversial. Using electron microscopy, we found glucocorticoid receptors localized to non-genomic sites in rat lateral amygdala, glia processes, presynaptic terminals, neuronal dendrites, and dendritic spines including spine organelles and postsynaptic membrane densities. The lateral nucleus of the amygdala is a region specifically implicated in the formation of memories for stressful experiences. These newly observed glucocorticoid receptor immunoreactive sites were in addition to glucocorticoid receptor immunoreactive signals observed using electron and confocal microscopy in lateral amygdala principal neuron and GABA neuron soma and nuclei, cellular domains traditionally associated with glucocorticoid immunoreactivity. In lateral amygdala, glucocorticoid receptors are thus also localized to non-nuclear-membrane translocation sites, particularly dendritic spines, where they show an affinity for postsynaptic membrane densities, and may have a specialized role in modulating synaptic transmission plasticity related to fear and emotional memory.
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“glucocorticoid receptor immunoreactivity in post-synaptic and other non-nuclear regions of neurons in the rodent brain (Liposits and Bohn, 1993,; Johnson et al., 2005)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Johnson et al., 2005
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Physiology and neurobiology of stress and adaptation: central role of the brain
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Metadata
- Authors
- Johnson, L. R., Farb, C., Morrison, J. H., McEwen, B. S., & Ledoux, J. E.
- Affiliations
- New York University (US)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 136
- Issue
- 1
- Pages
- 289-299
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2017103890
- Cited by
- 205
- References
- 117
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 11 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 17
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Faculty of Health; Institute of Health and Biomedical Innovation
- Funders
- National Institute of Mental Health (MH-58911, P50MH058911)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- glucocorticoid receptor, lateral amygdala, postsynaptic membrane, dendritic spines, non-genomic steroid action, stress memory, fear memory, synaptic plasticity, presynaptic terminals, GABAergic neurons
- MeSH terms
- Amygdala, Animals, Immunologic Techniques, Male, Microscopy, Electron, Receptors, Glucocorticoid, Synaptic Membranes, Tissue Distribution, Rats, Sprague-Dawley, Rats
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