Cited by 205Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsStress Responses and Cortisol

The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.

Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

Open access

Johnson, L.R., Farb, C., Morrison, J.H., McEwen, B.S., Ledoux, J.E.·2005·Neuroscience

DOI 10.1016/j.neuroscience.2005.06.050

Open this paper in CoChat — free account

Abstract

Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and peri-nuclear sites in neuronal somata. Their classically known mode of action is to induce gene promoter receptors to alter gene transcription. Nuclear glucocorticoid receptors are particularly dense in brain regions crucial for memory, including memory of stressful experiences, such as the hippocampus and amygdala. While it has been proposed that glucocorticoids may also act via membrane bound receptors, the existence of the latter remains controversial. Using electron microscopy, we found glucocorticoid receptors localized to non-genomic sites in rat lateral amygdala, glia processes, presynaptic terminals, neuronal dendrites, and dendritic spines including spine organelles and postsynaptic membrane densities. The lateral nucleus of the amygdala is a region specifically implicated in the formation of memories for stressful experiences. These newly observed glucocorticoid receptor immunoreactive sites were in addition to glucocorticoid receptor immunoreactive signals observed using electron and confocal microscopy in lateral amygdala principal neuron and GABA neuron soma and nuclei, cellular domains traditionally associated with glucocorticoid immunoreactivity. In lateral amygdala, glucocorticoid receptors are thus also localized to non-nuclear-membrane translocation sites, particularly dendritic spines, where they show an affinity for postsynaptic membrane densities, and may have a specialized role in modulating synaptic transmission plasticity related to fear and emotional memory.

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2005.06.050

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745
Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543

Show all 117 references

Research works printed but not linked: 1

Diamond, 1996, Psychological stress impairs spatial working memory, Behav Neurosci, 110, 661, 10.1037/0735-7044.110.4.661 · DOI · Paper page

Sorted by citations

Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators
McEwen, B. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.071 · Cited by 1,864
Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574
The neuro-symphony of stress
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications
Godoy, L. D., Rossignoli, M. T., Delfino-Pereira, P., Garcia‐Cairasco, N., & Umeoka, E. H. D. L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00127 · Cited by 991
Neurobiological Interactions Between Stress and the Endocannabinoid System
Morena, M., Patel, S., Bains, J. S., & Hill, M. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.166 · Cited by 698
Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala
Roozendaal, B., Okuda, S., van der Zee, E. A., & McGaugh, J. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601874103 · Cited by 510
Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
Hamilton, J. P., Siemer, M., & Gotlib, I. H. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.57 · Cited by 506
Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse
Hara, Y., Waters, E. M., McEwen, B. S., & Morrison, J. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00036.2014 · Cited by 470
Stress, glucocorticoids and memory: implications for treating fear-related disorders
de Quervain, D., Schwabe, L., & Roozendaal, B. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.155 · Cited by 484
Unraveling the Time Domains of Corticosteroid Hormone Influences on Brain Activity: Rapid, Slow, and Chronic Modes
Joëls, M., Sarabdjitsingh, R. A., & Karst, H. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005892 · Cited by 445
Rapid non-genomic effects of corticosteroids and their role in the central stress response
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0472 · Cited by 414
Steroid hormone receptor expression and function in microglia
Sierra, A., Gottfried‐Blackmore, A., Milner, T. A., McEwen, B. S., & Bulloch, K. (2008) · Glia · doi:10.1002/glia.20644 · Cited by 405
Metaplasticity of amygdalar responses to the stress hormone corticosterone
Karst, H., Berger, S., Erdmann, G., Schütz, G., & Joëls, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914381107 · Cited by 356
Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05568.x · Cited by 335
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
Sigurdsson, T., Doyère, V., Cain, C. K., & LeDoux, J. E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.022 · Cited by 333
Neural regulation of the stress response: glucocorticoid feedback mechanisms
Herman, J. P., McKlveen, J. M., Solomon, M. B., Carvalho-Netto, E., & Myers, B. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500041 · Cited by 307
Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.
McEwen, B. S., Akama, K. T., Spencer-Segal, J. L., Milner, T. A., & Waters, E. M. (2012) · Behavioral Neuroscience · doi:10.1037/a0026708 · Cited by 302
Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.020 · Cited by 289
The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 282
Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders
Radley, J., Morilak, D., Viau, V., & Campeau, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.018 · Cited by 339
Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors
Gray, J. D., Milner, T. A., & McEwen, B. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.034 · Cited by 250
Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course
Karatsoreos, I. N., & McEwen, B. S. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12054 · Cited by 247
Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons
Magariños, A. M., Li, C. J., Gal Toth, J., Bath, K. G., Jing, D., Lee, F. S., & McEwen, B. S. (2011) · Hippocampus · doi:10.1002/hipo.20744 · Cited by 232
Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification
Roozendaal, B., Hernandez, A., Cabrera, S. M., Hagewoud, R., Malvaez, M., Stefanko, D. P., Haettig, J., & Wood, M. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5717-09.2010 · Cited by 233
The clinical use of corticosteroids in pregnancy
Kemp, M. W., Newnham, J. P., Challis, J. R. G., Jobe, A., & Stock, S. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv047 · Cited by 224
MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms?
Feduccia, A. A., & Mithoefer, M. C. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.003 · Cited by 217
Stress and trauma: BDNF control of dendritic-spine formation and regression
Bennett, M. R., & Lagopoulos, J. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.005 · Cited by 199
Hippocampal formation: Shedding light on the influence of sex and stress on the brain
McEwen, B. S., & Milner, T. A. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.006 · Cited by 213
The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings
Haller, J., Mikics, É., & Makara, G. B. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.004 · Cited by 208
Glucocorticoids, chronic stress, and obesity
Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198
Basolateral amygdala noradrenergic activity mediates corticosterone-induced enhancement of auditory fear conditioning
Roozendaal, B., Hui, G. K., HUI, I., Berlau, D. J., McGaugh, J. L., & Weinberger, N. M. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.03.003 · Cited by 191
Neural Regulation of the Stress Response: The Many Faces of Feedback
Myers, B., McKlveen, J. M., & Herman, J. P. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9801-y · Cited by 175
“There is electron microscopy and neurochemical evidence for GR localization to neuronal membranes, in particular postsynaptic membranes, supporting an alternative role for the so-called nuclear receptor (Johnson et al. 2005; Komatsuzaki et al. 2005; Wang and Wang 2009; Prager et al. 2010).”
Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture
Herman, J. P., Nawreen, N., Smail, M. A., & Cotella, E. M. (2020) · Stress · doi:10.1080/10253890.2020.1859475 · Cited by 190
Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis
Steiner, M. S., & Wotjak, C. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00433-0 · Cited by 174
Glucocorticoid Effects on Memory Consolidation Depend on Functional Interactions between the Medial Prefrontal Cortex and Basolateral Amygdala
Roozendaal, B., McReynolds, J. R., van der Zee, E. A., Lee, S., McGaugh, J. L., & McIntyre, C. K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3626-09.2009 · Cited by 175
Interactions between Temperament, Stress, and Immune Function in Cattle
Sanchez, N. C. B., Randel, R. D., Carroll, J. A., & Welsh, T. H. (2011) · International Journal of Zoology · doi:10.1155/2011/373197 · Cited by 171
Novel Aspects of Glucocorticoid Actions
Uchôa, E. T., Aguilera, G., Herman, J. P., Fiedler, J. L., Deak, T., & de Sousa, M. B. C. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12157 · Cited by 150
Are BDNF and glucocorticoid activities calibrated?
Jeanneteau, F. D., & Chao, M. V. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.017 · Cited by 150
Glucocorticoid signaling and stress-related limbic susceptibility pathway: About receptors, transcription machinery and microRNA
de Kloet, E. R., Fitzsimons, C. P., Datson, N. A., Meijer, O. C., & Vreugdenhil, E. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.039 · Cited by 143
Corticotropin-Releasing Factor in the Basolateral Amygdala Enhances Memory Consolidation via an Interaction with the -Adrenoceptor-cAMP Pathway: Dependence on Glucocorticoid Receptor Activation
Roozendaal, B., Schelling, G., & McGaugh, J. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1336-08.2008 · Cited by 115
Stress at the Synapse: Signal Transduction Mechanisms of Adrenal Steroids at Neuronal Membranes
Prager, E. M., & Johnson, L. R. (2009) · Science Signaling · doi:10.1126/scisignal.286re5 · Cited by 116
Memory consolidation during sleep: Interactive effects of sleep stages and HPA regulation: Review
Wagner, U., & Born, J. (2008) · Stress · doi:10.1080/10253890701408822 · Cited by 107
Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History
Polman, J. A. E., Hunter, R. G., Speksnijder, N., van den Oever, J. M. E., Korobko, O. B., McEwen, B. S., de Kloet, E. R., & Datson, N. A. (2012) · Endocrinology · doi:10.1210/en.2012-1255 · Cited by 104
Establishing an Agenda for Translational Research on PTSD
MILLER, M. M., & McEWEN, B. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.023 · Cited by 101
Self-citation
Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking
Simms, J. A., Haass-Koffler, C. L., Bito-Onon, J., Li, R., & Bartlett, S. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.268 · Cited by 97
Role of the endocannabinoid system in regulating glucocorticoid effects on memory for emotional experiences
Atsak, P., Roozendaal, B., & Campolongo, P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.047 · Cited by 98
Endocannabinoids: The silent partner of glucocorticoids in the synapse
Hill, M. N., & McEwen, B. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901519106 · Cited by 98
Stress-Induced Chronic Visceral Pain of Gastrointestinal Origin
Meerveld, B. G., & Johnson, A. C. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00086 · Cited by 102
Actions of Steroids: New Neurotransmitters
Rudolph, L. M., Cornil, C. A., Mittelman‐Smith, M. A., Rainville, J. R., Remage‐Healey, L., Sinchak, K., & Micevych, P. E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2473-16.2016 · Cited by 92
Endocannabinoid Signaling within the Basolateral Amygdala Integrates Multiple Stress Hormone Effects on Memory Consolidation
Atsak, P., Hauer, D., Campolongo, P., Schelling, G., Fornari, R. V., & Roozendaal, B. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.334 · Cited by 85
Increased Amygdalar and Hippocampal Volumes in Young Adults with Social Anxiety
Machado‐de‐Sousa, J. P., Osório, F. D. L., Jackowski, A. P., Bressan, R. A., Chagas, M. H. N., Alves, N. T., DePaula, A. L. D., Crippa, J. A., & Hallak, J. E. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088523 · Cited by 85
Exposure to high- and low-light conditions in an open-field test of anxiety increases c-Fos expression in specific subdivisions of the rat basolateral amygdaloid complex
Hale, M. W., Bouwknecht, J. A., Spiga, F., Shekhar, A., & Lowry, C. A. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.09.001 · Cited by 84
Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume
Holz, N. E., Buchmann, A. F., Boecker, R., Blomeyer, D., Baumeister, S., Wolf, I., Rietschel, M., Witt, S. H., Plichta, M. M., Meyer-Lindenberg, A., et al. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0729-5 · Cited by 82
Localization of Mineralocorticoid Receptors at Mammalian Synapses
Prager, E. M., Brielmaier, J., Bergstrom, H. C., McGuire, J., & Johnson, L. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014344 · Cited by 81
Self-citation
Rapid glucocorticoid feedback inhibition of ACTH secretion involves ligand-dependent membrane association of glucocorticoid receptors
Deng, Q., Riquelme, D., Trinh, L., Low, M. J., Tomić, M., Stojilkovic, S., & Aguilera, G. (2015) · Endocrinology · doi:10.1210/en.2015-1265 · Cited by 77
Genetics of glucocorticoid regulation and posttraumatic stress disorder -what do we know?
Castro-Vale, I., van Rossum, E. F. C., Machado, J. C., Mota-Cardoso, R., & Carvalho, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.005 · Cited by 85
Glucocorticoid-induced enhancement of extinction—from animal models to clinical trials
de Quervain, D. J. ‐., Wolf, O. T., & Roozendaal, B. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5116-0 · Cited by 82
Nongenomic actions of adrenal steroids in the central nervous system
Evanson, N. K., Herman, J. P., Sakai, R. R., & Krause, E. G. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02000.x · Cited by 76
Endocannabinoids: Effectors of glucocorticoid signaling
Balsevich, G., Petrie, G. N., & Hill, M. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.005 · Cited by 82
Membrane Glucocorticoid Receptor Activation Induces Proteomic Changes Aligning with Classical Glucocorticoid Effects
Vernocchi, S., Battello, N., Schmitz, S., Revets, D., Billing, A. M., Turner, J. D., & Muller, C. P. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.022947 · Cited by 75
Stress and Anxiety in Schizophrenia and Depression: Glucocorticoids, Corticotropin-Releasing Hormone and Synapse Regression
Ao, M. R. B. (2008) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802512073 · Cited by 74
Glucocorticoid receptors and β-adrenoceptors in basolateral amygdala modulate synaptic plasticity in hippocampal dentate gyrus, but not in area CA1
Vouimba, R., Yaniv, D., & Richter‐Levin, G. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.007 · Cited by 71
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Lesuis, S. L., Park, S., Hoorn, A., Rashid, A. J., Mocle, A. J., Salter, E. W., Vislavski, S., Gray, M. T., Torelli, A. M., Cristofaro, A. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.034 · Cited by 82
Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders
Jeanneteau, F. D., & Arango-Lievano, M. (2016) · Neural Plasticity · doi:10.1155/2016/3985063 · Cited by 65
Corticosteroids: way upstream
Riedemann, T., Patchev, A. V., Cho, K., & Almeida, O. F. X. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-2 · Cited by 65
Glucocorticoid Receptors are Localized to Dendritic Spines and Influence Local Actin Signaling
Jafari, M., Seese, R. R., Babayan, A. H., Gall, C. M., & Lauterborn, J. C. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8288-3 · Cited by 61
Rapid stress‐induced corticosterone rise in the hippocampus reverses serial memory retrieval pattern
Chauveau, F., Tronche, C., Piérard, C., Liscia, P., Drouet, I., Coutan, M., & Béracochéa, D. (2009) · Hippocampus · doi:10.1002/hipo.20605 · Cited by 60
Unraveling the functions of the membrane‐bound glucocorticoid receptors: first clues on origin and functional activity
Strehl, C., & Buttgereit, F. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12364 · Cited by 63
Glucocorticoid‐mediated mechanisms of hippocampal damage: Contribution of subgranular neurogenesis
Podgorny, O. V., & Gulyaeva, N. V. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15265 · Cited by 59
Astrocytes are a neural target of morphine action via glucocorticoid receptor‐dependent signaling
Ślęzak, M., Korostyński, M., Gieryk, A., Gołda, S., Dzbek, J., Piechota, M., Wlazło, E., Bilecki, W., & Przewłocki, R. (2013) · Glia · doi:10.1002/glia.22460 · Cited by 60
Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals
Wang, C., & Wang, S. (2009) · Synapse · doi:10.1002/syn.20654 · Cited by 61
Factors promoting vulnerability to dysregulated stress reactivity and stress‐related disease
Russell, A. L., Tasker, J. G., Lucion, A. B., Fiedler, J. L., Munhoz, C. D., Wu, T. J., & Deak, T. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12641 · Cited by 66
Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli
Cunningham‐Bussel, A., Root, J. C., Butler, T., Tüscher, O., Pan, H., Epstein, J., Weisholtz, D. S., Pavony, M. T., Silverman, M. E., Goldstein, M. S., et al. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.11.011 · Cited by 57
NMDA neurotransmission as a critical mediator of borderline personality disorder
Grosjean, B., & Tsai, G. E. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0710 · Cited by 57
Membrane-bound glucocorticoid receptors on distinct nociceptive neurons as potential targets for pain control through rapid non-genomic effects
Shaqura, M. A., Li, X., Al‐Khrasani, M., Shakibaei, M., Tafelski, S., Fürst, S., Beyer, A., Kawata, M., Schäfer, M., & Mousa, S. A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.019 · Cited by 57
Stress-Induced Pain: A Target for the Development of Novel Therapeutics
Johnson, A. C., & Meerveld, B. G. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.218065 · Cited by 57
The Interface of Nuclear and Membrane Steroid Signaling
Treviño, L., & Gorelick, D. A. (2021) · Endocrinology · doi:10.1210/endocr/bqab107 · Cited by 43
Role of paraventricular nucleus glutamate signaling in regulation of HPA axis stress responses
EVANSON, N. K., & HERMAN, J. P. (2015) · Interdisciplinary Information Sciences · doi:10.4036/iis.2015.b.10 · Cited by 48
Low-potency glucocorticoid hydrocortisone has similar neurotoxic effects as high-potency glucocorticoid dexamethasone on neurons in the immature chicken cerebellum
Aden, P. K., Goverud, I. L., Liestøl, K., Løberg, E. M., Paulsen, R. E., Mæhlen, J., & Lømo, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.095 · Cited by 48
PTSD and traumatic stress
Ursano, R. J., Zhang, L., He, L., Johnson, L. R., Carlton, J. R., Fullerton, C. S., & Benedek, D. M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.030 · Cited by 48
Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area
Butts, K. A., & Phillips, A. G. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000187 · Cited by 45
Impairment of Fear Memory Consolidation in Maternally Stressed Male Mouse Offspring: Evidence for Nongenomic Glucocorticoid Action on the Amygdala
Lee, E. J., Son, G. H., Chung, S., Lee, S., Kim, J., Choi, S., & Kim, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4692-10.2011 · Cited by 44
Endocannabinoids mediate the glucocorticoid‐induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons
Wang, J., Shen, R., & Haj‐Dahmane, S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238659 · Cited by 43
Na+, K+ ATPase Activity Is Reduced in Amygdala of Rats with Chronic Stress-Induced Anxiety-Like Behavior
Crema, L. M., Schlabitz, M. K., Tagliari, B., da Cunha, A. A., Simão, F., Krolow, R., Pettenuzzo, L. F., Salbego, C. G., Vendite, D., Wyse, Â. T. D. S., et al. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0245-9 · Cited by 44
Hydrocortisone responsiveness in Gulf War veterans with PTSD: Effects on ACTH, declarative memory hippocampal [18F]FDG uptake on PET
Yehuda, R., Golier, J. A., Bierer, L. M., Mikhno, A., Pratchett, L. C., Burton, C. L., Makotkine, I., Devanand, D. P., Pradhaban, G., Harvey, P. D., et al. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.06.010 · Cited by 46
Fat-brain connections: Adipocyte glucocorticoid control of stress and metabolism
de Kloet, A. D., & Herman, J. P. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.005 · Cited by 46
Dendritic spines in the posterodorsal medial amygdala after restraint stress and ageing in rats
Marcuzzo, S., Dall’Oglio, A., Ribeiro, M. F. M., Achaval, M., & Rasia‐Filho, A. A. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.019 · Cited by 39
Membrane-initiated nuclear trafficking of the glucocorticoid receptor in hypothalamic neurons
Rainville, J. R., Weiss, G. L., Evanson, N. K., Herman, J. P., Vasudevan, N., & Tasker, J. G. (2017) · Steroids · doi:10.1016/j.steroids.2017.12.005 · Cited by 40
Angst and the amygdala
Schulkin, J. A. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jschulkin · Cited by 39
Dexamethasone induces cell death which may be blocked by NMDA receptor antagonists but is insensitive to Mg2+ in cerebellar granule neurons
Jacobs, C. M., Trinh, M. D., Rootwelt, T., Lømo, J., & Paulsen, R. E. (2006) · Brain Research · doi:10.1016/j.brainres.2005.10.093 · Cited by 40
Serotonergic neurotransmission in the ventral hippocampus is enhanced by corticosterone and altered by chronic amphetamine treatment
Barr, J. L., & Forster, G. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.020 · Cited by 39
Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala
Wang, G.-Y., Zhao-ming, Z., Cui, S., & Wang, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166535 · Cited by 40
Expression and Functional State of the Corticosteroid Receptors and 11β-Hydroxysteroid Dehydrogenase Type 2 in Schwann Cells
Groyer, G., Eychenne, B., Girard, C., Rajkowski, K. M., Schumacher, M., & Cadepond, F. (2006) · Endocrinology · doi:10.1210/en.2005-1625 · Cited by 38
Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats
Suzuki, H., Sumiyoshi, A., Matsumoto, Y., Duffy, B. A., Yoshikawa, T., Lythgoe, M. F., Yanai, K., Taki, Y., Kawashima, R., & Shimokawa, H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2014.10.040 · Cited by 35
Expression and dexamethasone-induced nuclear translocation of glucocorticoid and mineralocorticoid receptors in guinea pig cochlear cells
Kil, S., & Kalinec, F. (2013) · Hearing Research · doi:10.1016/j.heares.2013.01.020 · Cited by 38
Pro- versus Antinociceptive Nongenomic Effects of Neuronal Mineralocorticoid versus Glucocorticoid Receptors during Rat Hind Paw Inflammation
Li, X., Shaqura, M. A., Mohamed, D. M., Beyer, A., Yamada, S., Mousa, S. A., & Schäfer, M. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002087 · Cited by 38
Imaging the immediate non-genomic effects of stress hormone on brain activity
Ferris, C. F., & Stolberg, T. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.003 · Cited by 37
Chronic Corticosterone Exposure Persistently Elevates the Expression of Memory-Related Genes in the Lateral Amygdala and Enhances the Consolidation of a Pavlovian Fear Memory
Monsey, M. S., Boyle, L. M., Zhang, M. L., Nguyen, C. P., Kronman, H. G., Ota, K. T., Duman, R. S., Taylor, J. R., & Schafe, G. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091530 · Cited by 39

Authors: Johnson, L. R., Farb, C., Morrison, J. H., McEwen, B. S., & Ledoux, J. E.
Affiliations: New York University (US)
ORCID: Johnson, L.R.
Morrison, J.H.
McEwen, B.S.
Ledoux, J.E.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2005-01
Volume: 136
Issue: 1
Pages: 289-299
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2005.06.050
OpenAlex: W2017103890
Cited by: 205
References: 117
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 11 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 17
FWCI: 3.74
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
QUT ePrints (Queensland University of Technology) (submittedVersion)
Figshare (submittedVersion, cc-by)
Faculty of Health; Institute of Health and Biomedical Innovation
Funders: National Institute of Mental Health (MH-58911, P50MH058911)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: glucocorticoid receptor, lateral amygdala, postsynaptic membrane, dendritic spines, non-genomic steroid action, stress memory, fear memory, synaptic plasticity, presynaptic terminals, GABAergic neurons
MeSH terms: Amygdala, Animals, Immunologic Techniques, Male, Microscopy, Electron, Receptors, Glucocorticoid, Synaptic Membranes, Tissue Distribution, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks