Cited by 205Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsStress Responses and Cortisol

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Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

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Johnson, L.R., Farb, C., Morrison, J.H., McEwen, B.S., Ledoux, J.E.·2005·Neuroscience

DOI 10.1016/j.neuroscience.2005.06.050

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Abstract

Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and peri-nuclear sites in neuronal somata. Their classically known mode of action is to induce gene promoter receptors to alter gene transcription. Nuclear glucocorticoid receptors are particularly dense in brain regions crucial for memory, including memory of stressful experiences, such as the hippocampus and amygdala. While it has been proposed that glucocorticoids may also act via membrane bound receptors, the existence of the latter remains controversial. Using electron microscopy, we found glucocorticoid receptors localized to non-genomic sites in rat lateral amygdala, glia processes, presynaptic terminals, neuronal dendrites, and dendritic spines including spine organelles and postsynaptic membrane densities. The lateral nucleus of the amygdala is a region specifically implicated in the formation of memories for stressful experiences. These newly observed glucocorticoid receptor immunoreactive sites were in addition to glucocorticoid receptor immunoreactive signals observed using electron and confocal microscopy in lateral amygdala principal neuron and GABA neuron soma and nuclei, cellular domains traditionally associated with glucocorticoid immunoreactivity. In lateral amygdala, glucocorticoid receptors are thus also localized to non-nuclear-membrane translocation sites, particularly dendritic spines, where they show an affinity for postsynaptic membrane densities, and may have a specialized role in modulating synaptic transmission plasticity related to fear and emotional memory.

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Authors: Johnson, L. R., Farb, C., Morrison, J. H., McEwen, B. S., & Ledoux, J. E.
Affiliations: New York University (US)
ORCID: Johnson, L.R.
Morrison, J.H.
McEwen, B.S.
Ledoux, J.E.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2005-01
Volume: 136
Issue: 1
Pages: 289-299
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2005.06.050
OpenAlex: W2017103890
Cited by: 205
References: 117
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 11 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 17
FWCI: 3.74
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
QUT ePrints (Queensland University of Technology) (submittedVersion)
Figshare (submittedVersion, cc-by)
Faculty of Health; Institute of Health and Biomedical Innovation
Funders: National Institute of Mental Health (MH-58911, P50MH058911)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: glucocorticoid receptor, lateral amygdala, postsynaptic membrane, dendritic spines, non-genomic steroid action, stress memory, fear memory, synaptic plasticity, presynaptic terminals, GABAergic neurons
MeSH terms: Amygdala, Animals, Immunologic Techniques, Male, Microscopy, Electron, Receptors, Glucocorticoid, Synaptic Membranes, Tissue Distribution, Rats, Sprague-Dawley, Rats

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Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

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